Abstract:
BACKGROUND:Asthma is a chronic inflammatory airway disease characterized by reversible obstruction, inflammation and hyperresponsiveness to different stimulus. Aerobic and breathing exercises have been demonstrated to benefit asthmatic patients; however, there is no evidence comparing the effectiveness of these treatments. METHODS/DESIGN:This is a prospective, comparative, blinded, and randomized clinical trial with 2 groups that will receive distinct interventions. Forty-eight asthmatic adults with optimized medical treatment will be randomly divided into either aerobic (AG) or breathing exercises (BG). Patients will perform breathing or aerobic exercise twice a week for 3 months, totalizing 24 sessions of 40 minutes each. Before intervention, both groups will complete an educational program consisting of 2 educational classes. Before and after interventions, the following parameters will be quantified: clinical control (main outcome), health related quality of life, levels of anxiety and depression, daily living physical activity and maximal exercise capacity (secondary outcome). Hyperventilation syndrome symptoms, autonomic nervous imbalance, thoracoabdominal kinematics, inflammatory cells in the sputum, fraction of exhaled nitric oxide (FENO) and systemic inflammatory cytokines will also be evaluated as possible mechanisms to explain the benefits of both interventions. DISCUSSION:Although the benefits of breathing and aerobic exercises have been extensively studied, the comparison between both has never been investigated. Furthermore, the findings of our results will allow us to understand its application and suitability to patients that will have more benefits for every intervention optimizing its effect. TRIAL REGISTRATION:Clinicaltrials.gov; Identifier: NCT02065258.
journal_name
BMC Pulm Medjournal_title
BMC pulmonary medicineauthors
Evaristo KB,Saccomani MG,Martins MA,Cukier A,Stelmach R,Rodrigues MR,Santaella DF,Carvalho CRdoi
10.1186/1471-2466-14-160subject
Has Abstractpub_date
2014-10-17 00:00:00pages
160issn
1471-2466pii
1471-2466-14-160journal_volume
14pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Fine needle aspiration is an important tool for diagnosis and preoperative evaluation of solitary nodules of the lung. It provides a definitive diagnosis in most patients at low cost with minimal trauma. However, because of the nature of the study and the presentation of the cells in a more distorted and inc...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
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更新日期:2003-09-08 00:00:00
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更新日期:2018-08-23 00:00:00
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
doi:10.1186/1471-2466-15-6
更新日期:2015-01-22 00:00:00
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-03-21 00:00:00
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pub_type: 杂志文章,评审
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
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