当前位置： SCI文献检索 > BMC Pulmonary Medicine期刊下所有文献 > Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis.

Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis.

Abstract：

BACKGROUND:Plasma levels of cell-free DNA (cf-DNA) are known to be elevated in sepsis and high levels are associated with a poor prognosis. Mechanical ventilation affects systemic inflammation in which lung-protective ventilation attenuates the inflammatory response. The aim was to study the effect of a lung protective ventilator regime on arterial and organ-specific venous blood as well as on trans-organ differences in cf-DNA levels in a porcine post-operative sepsis model. METHOD:One group of anaesthetised, domestic-breed, 9-12 weeks old, pigs were ventilated with protective ventilation (VT 6 mL x kg- 1, PEEP 10 cmH2O) n = 20. Another group, ventilated with a medium high tidal volume and lower PEEP, served as a control group (VT 10 mL x kg- 1, PEEP 5 cm H2O) n = 10. Blood samples were taken from four sources: artery, hepatic vein, portal vein and, jugular bulb. A continuous endotoxin infusion at 0.25 μg x kg- 1 x h- 1 for 5 h was started following 2 h of laparotomy, which simulated a surgical procedure. Inflammatory cytokines and cf-DNA in plasma were analysed and trans-organ differences calculated. RESULTS:The protective ventilation group had lower levels of cf-DNA in arterial (p = 0.02) and hepatic venous blood (p = 0.03) compared with the controls. Transhepatic differences in cf-DNA were lower in the protective group, compared with the controls (p = 0.03). No differences between the groups were noted as regards the transcerebral, transsplanchnic or the transpulmonary cf-DNA differences. CONCLUSIONS:Protective ventilation suppresses arterial levels of cf-DNA. The liver seems to be a net contributor to the systemic cf-DNA levels, but this effect is attenuated by protective ventilation.

journal_name

BMC Pulm Med

journal_title

BMC pulmonary medicine

authors

Nyberg A,Larsson A,Jylhävä J,Hurme M,Sperber J,Lipcsey M,Castegren M

doi

10.1186/s12890-020-01239-y

subject

Has Abstract

pub_date

2020-07-31 00:00:00

pages

206

issue

1

issn

1471-2466

pii

10.1186/s12890-020-01239-y

journal_volume

20

pub_type

杂志文章

相关文献

BMC Pulmonary Medicine文献大全
  • Treatment with LABA versus LAMA for stable COPD: a systematic review and meta-analysis.

    abstract：BACKGROUND:Inhaled bronchodilators including long-acting beta-agonist (LABA) and long-acting muscarinic antagonist (LAMA) play a central role in the treatment of stable chronic obstructive pulmonary disease (COPD). However, it is still unclear whether LABA or LAMA should be used for the initial treatment. Therefore, we...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12890-020-1152-8

    authors： Koarai A,Sugiura H,Yamada M,Ichikawa T,Fujino N,Kawayama T,Ichinose M

    更新日期：2020-04-29 00:00:00

  • Effects of C/EBPα overexpression on alveolar epithelial type II cell proliferation, apoptosis and surfactant protein-C expression after exposure to hyperoxia.

    abstract：BACKGROUND:This study aims to investigate the effects of CCAAT/enhancer binding protein alpha (C/EBPα) overexpression on cell proliferation, apoptosis and surfactant protein-C(SP-C) in alveolar epithelial type II (AEC II) cells after exposure to hyperoxia. METHODS:pcDNA3.1(+)-C/EBPα plasmid or air-empty vector were tr...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-019-0911-x

    authors： Lu H,Chen X,Lu Y,Zhu H,Tang W,Wang Q

    更新日期：2019-08-06 00:00:00

  • Age-specific incidence of allergic and non-allergic asthma.

    abstract：BACKGROUND:Onset of allergic asthma has a strong association with childhood but only a few studies have analyzed incidence of asthma from childhood to late adulthood in relation to allergy. The purpose of the study was to assess age-specific incidence of allergic and non-allergic asthma. METHODS:Questionnaires were se...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-019-1040-2

    authors： Pakkasela J,Ilmarinen P,Honkamäki J,Tuomisto LE,Andersén H,Piirilä P,Hisinger-Mölkänen H,Sovijärvi A,Backman H,Lundbäck B,Rönmark E,Kankaanranta H,Lehtimäki L

    更新日期：2020-01-10 00:00:00

  • 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung.

    abstract：BACKGROUND:Pseudomonas aeruginosa infections are associated with progressive life threatening decline of lung function in cystic fibrosis sufferers. Growth of Ps. aeruginosa releases a "grape-like" odour that has been identified as the microbial volatile organic compound 2-aminoacetophenone (2-AA). METHODS:We investig...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/1471-2466-10-56

    authors： Scott-Thomas AJ,Syhre M,Pattemore PK,Epton M,Laing R,Pearson J,Chambers ST

    更新日期：2010-11-07 00:00:00

  • Radiological pleuroparenchymal fibroelastosis associated to limited cutaneous systemic sclerosis: a case report.

    abstract：BACKGROUND:Pleuroparenchymal fibroelastosis (PPFE) is a very rare interstitial lung disease (ILD) characterized by progressive fibrotic lesions of the visceral pleura and the sub-pleural parenchyma, affecting predominantly the upper lobes. PPFE may occur in different contextes like bone marrow or lung transplantations,...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-018-0641-5

    authors： Hassoun D,Dirou S,Arrigoni PP,Durant C,Hamidou M,Néel A,Agard C

    更新日期：2018-05-18 00:00:00

  • An implantable pump Lenus pro® in the treatment of pulmonary arterial hypertension with intravenous treprostinil.

    abstract：BACKGROUND:Subcutaneous treprostinil is a prostacyclin analogue used to treat pulmonary arterial hypertension (PAH). Due to local pain it can cause a deterioration of heart related quality of life (HRQoL) or even abandonment of treatment. The aim of this paper was to assess the feasibility of treatment with intravenous...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12890-017-0474-7

    authors： Kurzyna M,Małaczyńska-Rajpold K,Koteja A,Pawlak A,Chrzanowski Ł,Furdal M,Gąsior Z,Jacheć W,Sobkowicz B,Norwa J,Mularek-Kubzdela T,Torbicki A

    更新日期：2017-12-02 00:00:00

  • Cigarette and IL-17A synergistically induce bronchial epithelial-mesenchymal transition via activating IL-17R/NF-κB signaling.

    abstract：BACKGROUND:IL-17A directly induces epithelial-mesenchymal transition (EMT) in alveolar epithelial cells. It could coordinate with cigarette smoke extract (CSE) to promote proliferation of bronchial epithelial cells. In this study, we aim to explore the direct effect of IL-17A and CSE on EMT in bronchial epithelial cell...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-020-1057-6

    authors： Ma L,Jiang M,Zhao X,Sun J,Pan Q,Chu S

    更新日期：2020-01-30 00:00:00

  • The application of metagenomic next-generation sequencing in diagnosing Chlamydia psittaci pneumonia: a report of five cases.

    abstract：BACKGROUND:Chlamydia psittaci pneumonia is a zoonotic infectious disease caused by Chlamydia psittaci. Diagnostic tools, including culture, serologic test and PCR-based methods, are available but prone to false negative results. CASE PRESENTATION:This report included five cases of Chlamydia psittaci pneumonia. Symptom...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-020-1098-x

    authors： Gu L,Liu W,Ru M,Lin J,Yu G,Ye J,Zhu ZA,Liu Y,Chen J,Lai G,Wen W

    更新日期：2020-03-17 00:00:00

  • Impact of a countywide smoke-free workplace law on emergency department visits for respiratory diseases: a retrospective cohort study.

    abstract：BACKGROUND:With the goal of reducing exposure to secondhand smoke, the state of Minnesota (MN), enacted a smoke-free law (i.e., Freedom to Breathe Act) in all workplaces, restaurants, and bars in 2007. This retrospective cohort study analyzes emergency department (ED) visits in Olmsted County, MN, for chronic obstructi...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/1471-2466-15-6

    authors： Croghan IT,Ebbert JO,Hays JT,Schroeder DR,Chamberlain AM,Roger VL,Hurt RD

    更新日期：2015-01-22 00:00:00

  • Diagnostic accuracy of an integrated respiratory guideline in identifying patients with respiratory symptoms requiring screening for pulmonary tuberculosis: a cross-sectional study.

    abstract：BACKGROUND:To evaluate the diagnostic accuracy of the integrated Practical Approach to Lung Health in South Africa (PALSA) guideline in identifying patients requiring bacteriological screening for tuberculosis (TB), and to determine which clinical features best predict suspected and bacteriologically-confirmed tubercul...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/1471-2466-6-22

    authors： English RG,Bachmann MO,Bateman ED,Zwarenstein MF,Fairall LR,Bheekie A,Majara BP,Lombard C,Scherpbier R,Ottomani SE

    更新日期：2006-08-25 00:00:00

  • Evaluation of semi-quantitative compared to quantitative cultures of tracheal aspirates for the yield of culturable respiratory pathogens - a cross-sectional study.

    abstract：BACKGROUND:Diagnosis of lower respiratory tract infections (LRTI) depends on the presence of clinical, radiological and microbiological findings. Endotracheal suction aspirate (ETSA) is the commonest respiratory sample sent for culture from intubated patients. Very few studies have compared quantitative and semi-quanti...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-020-01311-7

    authors： Rattani S,Farooqi J,Jabeen G,Chandio S,Kash Q,Khan A,Jabeen K

    更新日期：2020-10-29 00:00:00

  • Analytical performance of Envisia: a genomic classifier for usual interstitial pneumonia.

    abstract：BACKGROUND:Clinical guidelines specify that diagnosis of interstitial pulmonary fibrosis (IPF) requires identification of usual interstitial pneumonia (UIP) pattern. While UIP can be identified by high resolution CT of the chest, the results are often inconclusive, making surgical lung biopsy necessary to reach a defin...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-017-0485-4

    authors： Choi Y,Lu J,Hu Z,Pankratz DG,Jiang H,Cao M,Marchisano C,Huiras J,Fedorowicz G,Wong MG,Anderson JR,Tom EY,Babiarz J,Imtiaz U,Barth NM,Walsh PS,Kennedy GC,Huang J

    更新日期：2017-11-17 00:00:00

  • Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models.

    abstract：BACKGROUND:Activins are members of the TGF-ß superfamily of growth factors. First, we identified by expression array screening that activin-B and follistatin are upregulated in human idiopathic pulmonary fibrosis (IPF). Next, we wanted to clarify their specific role in lung fibrosis formation. METHODS:We used specific...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/1471-2466-14-170

    authors： Myllärniemi M,Tikkanen J,Hulmi JJ,Pasternack A,Sutinen E,Rönty M,Leppäranta O,Ma H,Ritvos O,Koli K

    更新日期：2014-11-01 00:00:00

  • Effect of altering breathing frequency on maximum voluntary ventilation in healthy adults.

    abstract：BACKGROUND:Compared to other pulmonary function tests, there is a lack of standardization regarding how a maximum voluntary ventilation (MVV) maneuver is performed. Specifically, little is known about the variation in breathing frequency (fR) and its potential impact on the accuracy of test results. This study examines...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-018-0650-4

    authors： Neufeld EV,Dolezal BA,Speier W,Cooper CB

    更新日期：2018-05-24 00:00:00

  • Spontaneous regression of ALK fusion protein-positive non-small cell lung carcinoma: a case report and review of the literature.

    abstract：BACKGROUND:ALK-rearrangement is observed in < 5% non-small cell lung cancer (NSCLC) cases and prior to the advent of oral tyrosine kinase inhibitors, the natural history of oncogenic NSCLC was typically poor. Literature relating to regression of treatment-naïve NSCLC is limited, and regression without treatment has not...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-020-01249-w

    authors： Walls M,Walls GM,James JA,Crawford KT,Abdulkhalek H,Lynch TB,Peace AJ,McManus TE,Evans OR

    更新日期：2020-08-06 00:00:00

  • Lumacaftor/ Ivacaftor improves exercise tolerance in patients with Cystic Fibrosis and severe airflow obstruction.

    abstract：BACKGROUND:Treatment of patients with Cystic Fibrosis homozygous for the Phe508del gene, with Lumacaftor /Ivacaftor (LUM/IVA) improves outcomes in patients with FEV1 > 40% predicted. We set out to observe the most sensitive clinical measure that would change with treatment in terms of exercise capacity or lung function...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-019-0866-y

    authors： Wark PAB,Cookson K,Thiruchelvam T,Brannan J,Dorahy DJ

    更新日期：2019-06-17 00:00:00

  • A controlled study of community-based exercise training in patients with moderate COPD.

    abstract：BACKGROUND:The effectiveness of clinic-based pulmonary rehabilitation in advanced COPD is well established, but few data exist for less severe patients treated in alternative settings. The purpose of this study was to investigate whether a novel, community-based exercise program (CBE) was feasible and effective for pat...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1471-2466-14-125

    authors： Amin S,Abrazado M,Quinn M,Storer TW,Tseng CH,Cooper CB

    更新日期：2014-08-04 00:00:00

  • Correction to: The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study.

    abstract：:Following publication of the original article [1], the author flagged aspects of the article that affected readability of some of the article's scientific content. ...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章,已发布勘误

    doi：10.1186/s12890-018-0717-2

    authors： Fuchs O,Bahmer T,Weckmann M,Dittrich AM,Schaub B,Rösler B,Happle C,Brinkmann F,Ricklefs I,König IR,Watz H,Rabe KF,Kopp MV,Hansen G,von Mutius E,ALLIANCE Study Group as part of the German Centre for Lung Research (DZL).

    更新日期：2018-11-07 00:00:00

  • Zosteriform skin metastasis caused by retrograde lymphatic migration of metastatic squamous cell lung carcinoma.

    abstract：BACKGROUND:Zosteriform skin metastasis (ZSM) is rare, and its etiology is not well understood. ZSM is possibly derived from the retrograde movement of cancer cells through the lymphatic vessels during disease development. However, it has been difficult to demonstrate it, as no specific findings have been observed. CAS...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-021-01414-9

    authors： Maki Y,Kimizuka Y,Murakami K,Sato K,Sasaki H,Yamamoto T,Watanabe C,Sano T,Miyata J,Fujikura Y,Kawana A

    更新日期：2021-01-26 00:00:00

  • Assessing airway inflammation in clinical practice - experience with spontaneous sputum analysis.

    abstract：BACKGROUND:The assessment of airway inflammation for the diagnosis of asthma or COPD is still uncommon in pneumology-specialized general practices. In this respect, the measurement of exhaled nitric oxide (NO), as a fast and simple methodology, is increasingly used. The indirect assessment of airway inflammation, howev...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/1471-2466-8-5

    authors： Holz O,Seiler T,Karmeier A,Fraedrich J,Leiner H,Magnussen H,Jörres RA,Welker L

    更新日期：2008-02-28 00:00:00

  • Overexpression of programmed cell death 5 in a mouse model of ovalbumin-induced allergic asthma.

    abstract：BACKGROUND:Programmed cell death 5 (PDCD5) was first identified as an apoptosis-promoting protein and involved in some autoimmune diseases and inflammatory processes. Our previous study demonstrated greater expression of serum PDCD5 in asthmatic patients than controls. This study aimed to further explore the significan...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-016-0317-y

    authors： Diao X,Wang J,Zhu H,He B

    更新日期：2016-11-15 00:00:00

  • Comparison of next generation sequencing, SNaPshot assay and real-time polymerase chain reaction for lung adenocarcinoma EGFR mutation assessment.

    abstract：BACKGROUND:The epidermal growth factor receptor (EGFR) mutation status assessment has become increasingly important given the significant impact of tyrosine kinase inhibitors in lung cancer management. Our aim was to compare real life operational characteristics for three EGFR mutation assays - two targeted approaches ...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-016-0250-0

    authors： Cernomaz AT,Macovei II,Pavel I,Grigoriu C,Marinca M,Baty F,Peter S,Zonda R,Brutsche M,Grigoriu B

    更新日期：2016-05-23 00:00:00

  • Serum (1→3)-β-D-glucan and galactomannan levels in patients with cystic fibrosis: a retrospective cohort study.

    abstract：BACKGROUND:Aspergillus fumigatus is frequently encountered in sputum samples of patients with cystic fibrosis (CF), which traditionally has been interpreted as saprophytic airway colonization. However, this mere bystander role has been challenged by recent data. There is now evidence that Aspergillus fumigatus accelera...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-018-0614-8

    authors： Träger J,Melichar VO,Meyer R,Rauh M,Bogdan C,Held J

    更新日期：2018-03-27 00:00:00

  • Elevation of sputum matrix metalloproteinase-9 persists up to 6 months after smoking cessation: a research study.

    abstract：BACKGROUND:Smoking cessation is the best possible way to prevent the progression of smoking related airway diseases. However, the effect and time scale of smoking cessation on airway inflammation/remodelling are largely unknown. This prospective study evaluated the effects of smoking cessation on induced sputum (IS) ne...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/1471-2466-10-13

    authors： Louhelainen N,Stark H,Mazur W,Rytilä P,Djukanovic R,Kinnula VL

    更新日期：2010-03-14 00:00:00

  • Occult foreign body aspirations in pediatric patients: 20-years of experience.

    abstract：BACKGROUND:The purpose of our study was to assess the frequency of occult foreign body aspiration (FBA) and to evaluate the diagnostic difficulties and therapeutic methods for these patients. METHODS:Between May 2000 and May 2020, 3557 patients with the diagnosis of FBA were treated in our department. Thirty-five pati...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-020-01356-8

    authors： Liu B,Ding F,An Y,Li Y,Pan Z,Wang G,Dai J,Li H,Wu C

    更新日期：2020-12-09 00:00:00

  • Risk factors of postoperative pulmonary complications in patients with asthma and COPD.

    abstract：BACKGROUND:Postoperative pulmonary complications (PPC) in patients with pulmonary diseases remain to be resolved clinical issue. However, most evidence regarding PPC has been established more than 10 years ago. Therefore, it is necessary to evaluate perioperative management using new inhalant drugs in patients with obs...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-017-0570-8

    authors： Numata T,Nakayama K,Fujii S,Yumino Y,Saito N,Yoshida M,Kurita Y,Kobayashi K,Ito S,Utsumi H,Yanagisawa H,Hashimoto M,Wakui H,Minagawa S,Ishikawa T,Hara H,Araya J,Kaneko Y,Kuwano K

    更新日期：2018-01-09 00:00:00

  • Case report of endoprosthesis -Y implantation in severe respiratory failure in the MPSII patient; comparison with literature data.

    abstract：BACKGROUND:The tracheobronchomalacia is a life-threatening complication of mucopolysaccharidosis (MPS) without known effective, optimal treatment. The severe expiratory collapse of the trachea and bronchi is one of causes of the high rate of deaths in the course of airway impairment in MPSII patients. CASE PRESENTATIO...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-020-1143-9

    authors： Gocyk W,Warmus J,Olechnowicz H,Bik-Multanowski M,Pawlinski L,Kiec-Wilk B

    更新日期：2020-04-20 00:00:00

  • Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers.

    abstract：BACKGROUND:Idiopathic Pulmonary Fibrosis (IPF) is a fatal fibrotic lung disease occurring predominantly in middle-aged and older adults. The traditional diagnostic classification of IPF is based on clinical, radiological, and histopathological features. However, the considerable heterogeneity in IPF presentation sugges...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-017-0472-9

    authors： Wang Y,Yella J,Chen J,McCormack FX,Madala SK,Jegga AG

    更新日期：2017-10-20 00:00:00

  • CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression.

    abstract：BACKGROUND:CHCHD2 was identified a novel cell migration-promoting gene, which could promote cell migration and altered cell adhesion when ectopically overexpressed in NIH3T3 fibroblasts, and it was identified as a protein necessary for OxPhos function as well. However, the clinic relevance of CHCHD2 expression in NSCLC...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-020-1079-0

    authors： Yin X,Xia J,Sun Y,Zhang Z

    更新日期：2020-02-13 00:00:00

  • The features of AECOPD with carbon dioxide retention.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) with carbon dioxide retention is associated with a worsening clinical condition and the beginning of pulmonary ventilation decompensation. This study aimed to identify the factors associated with carbon dioxide retention. METHODS:This was a retrospective study of...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-018-0691-8

    authors： Wei X,Yu N,Ding Q,Ren J,Mi J,Bai L,Li J,Qi M,Guo Y

    更新日期：2018-07-31 00:00:00