当前位置： SCI文献检索 > BMC Pulmonary Medicine期刊下所有文献 > Treatment with LABA versus LAMA for stable COPD: a systematic review and meta-analysis.

Treatment with LABA versus LAMA for stable COPD: a systematic review and meta-analysis.

Abstract：

BACKGROUND:Inhaled bronchodilators including long-acting beta-agonist (LABA) and long-acting muscarinic antagonist (LAMA) play a central role in the treatment of stable chronic obstructive pulmonary disease (COPD). However, it is still unclear whether LABA or LAMA should be used for the initial treatment. Therefore, we conducted a systematic review and meta-analysis to evaluate the efficacy and safety of LABA versus LAMA in patients with stable COPD. METHODS:We searched relevant randomized control trials (RCTs) with a period of treatment of at least 12 weeks and analyzed the exacerbations, quality of life, dyspnea score, lung function and adverse events as the outcomes of interest. RESULTS:We carefully excluded unblinded data and identified a total of 19 RCTs (N = 28,211). LAMA significantly decreased the exacerbations compared to LABA (OR 0.85, 95% CI 0.74 to 0.98; P = 0.02). In St George's Respiratory Questionnaire and transitional dyspnoea index score, there were no differences between LABA and LAMA treatment. Compared to LABA, there was a small but significant increase in the trough FEV1 after LAMA treatment (Mean difference 0.02, 95% CI 0.01 to 0.03, P = 0.0006). In the safety components, there was no difference in the serious adverse events between LABA and LAMA. However, LAMA showed a significantly lower incidence of total adverse events compared to LABA (OR 0.92, 95% CI 0.86 to 0.98; P = 0.02). CONCLUSION:Treatment with LAMA in stable COPD provided a significantly lower incidence of exacerbation and non-serious adverse events, and a higher trough FEV1 compared to LABA. TRIAL REGISTRATION:(PROSPERO: CRD42019144764).

journal_name

BMC Pulm Med

journal_title

BMC pulmonary medicine

authors

Koarai A,Sugiura H,Yamada M,Ichikawa T,Fujino N,Kawayama T,Ichinose M

doi

10.1186/s12890-020-1152-8

subject

Has Abstract

pub_date

2020-04-29 00:00:00

pages

111

issue

1

issn

1471-2466

pii

10.1186/s12890-020-1152-8

journal_volume

20

pub_type

杂志文章,meta分析

相关文献

BMC Pulmonary Medicine文献大全
  • Role of TLR4-p38 MAPK-Hsp27 signal pathway in LPS-induced pulmonary epithelial hyperpermeability.

    abstract：BACKGROUND:The breakdown of alveolar barrier dysfunction contributes to Lipopolysaccharide stimulated pulmonary edema and acute lung injury. Actin cytoskeleton has been implicated to be critical in regulation of epithelial barrier. Here, we performed in vivo and in vitro study to investigate role of TLR4-p38 MAPK-Hsp27...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-018-0735-0

    authors： Wang W,Weng J,Yu L,Huang Q,Jiang Y,Guo X

    更新日期：2018-11-27 00:00:00

  • Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report.

    abstract：BACKGROUND:Primary Ciliary Dyskinesia (PCD) is also known as immotile-cilia syndrome, an autosomal recessive disorder of ciliary function, leading to mucus retention in the respiratory system in childhood. Our knowledge in the pathophysiological aspect of this devastating disorder is increasing with the advancement of ...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-020-1175-1

    authors： Al Mutairi F,Alkhalaf R,Alkhorayyef A,Alroqi F,Yusra A,Umair M,Nouf F,Khan A,Meshael A,Hamad A,Monira A,Asiri A,Alhamoudi KM,Alfadhel M

    更新日期：2020-05-15 00:00:00

  • High serum concentrations of autoantibodies to HSP47 in nonspecific interstitial pneumonia compared with idiopathic pulmonary fibrosis.

    abstract：BACKGROUND:The pathological diagnosis of idiopathic interstitial pneumonias (IIP) by surgical lung biopsy is important for clinical decision-making. However, there is a need to use less invasive biomarkers to differentiate nonspecific interstitial pneumonia (NSIP) from other IIP such as usual interstitial pneumonia (UI...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1186/1471-2466-8-23

    authors： Kakugawa T,Yokota S,Mukae H,Kubota H,Sakamoto N,Mizunoe S,Matsuoka Y,Kadota J,Fujii N,Nagata K,Kohno S

    更新日期：2008-11-04 00:00:00

  • Genome-wide association study identifies loci and candidate genes for non-idiopathic pulmonary hypertension in Eastern Chinese Han population.

    abstract：BACKGROUND:Pulmonary hypertension (PH) is a rare disease characterized by proliferation and occlusion of small pulmonary arterioles, which has been associated with a high mortality rate. The pathogenesis of PH is complex and incompletely understood, which includes both genetic and environmental factors that alter vascu...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-018-0719-0

    authors： Yin C,Li K,Yu Y,Huang H,Yu Y,Wang Z,Yan J,Pu Y,Li Z,Li D,Chen P,Chen F

    更新日期：2018-10-05 00:00:00

  • Do-not-resuscitate orders in patients with community-acquired pneumonia: a retrospective study.

    abstract：BACKGROUND:To investigate the use of do-not-resuscitate (DNR) orders in patients hospitalized with community-acquired pneumonia (CAP) and the association with mortality. METHODS:We assembled a cohort of 1317 adults hospitalized with radiographically confirmed CAP in three Danish hospitals. Patients were grouped into n...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-020-01236-1

    authors： Egelund GB,Jensen AV,Petersen PT,Andersen SB,Lindhardt BØ,Rohde G,Ravn P,von Plessen C

    更新日期：2020-07-24 00:00:00

  • Seasonal influenza vaccination in patients with COPD: a systematic literature review.

    abstract：BACKGROUND:Influenza is a frequent cause of exacerbations of chronic obstructive pulmonary disease (COPD). Exacerbations are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life, disease progression, death, and ultimately, substantial healthcare-related costs. Despite longstand...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章,评审

    doi：10.1186/s12890-017-0420-8

    authors： Bekkat-Berkani R,Wilkinson T,Buchy P,Dos Santos G,Stefanidis D,Devaster JM,Meyer N

    更新日期：2017-05-03 00:00:00

  • Gender differences at presentation of idiopathic pulmonary fibrosis in Sweden.

    abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a disease with poor prognosis mainly affecting males. Differences in clinical presentation between genders may be important both for the diagnostic work-up and for follow-up. In the present study, we therefore explored potential gender differences at presentation in a S...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-019-0994-4

    authors： Kalafatis D,Gao J,Pesonen I,Carlson L,Sköld CM,Ferrara G

    更新日期：2019-11-27 00:00:00

  • Bilirubin as a prognostic marker in patients with pulmonary arterial hypertension.

    abstract：BACKGROUND:Liver dysfunction reflects the status of heart failure, with congestion and low perfusion of the liver serving as causative mechanisms. Previous studies demonstrated relationship between the results of liver function test and the prognosis in patients with heart failure. However, few studies have examined th...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/1471-2466-10-22

    authors： Takeda Y,Takeda Y,Tomimoto S,Tani T,Narita H,Kimura G

    更新日期：2010-04-22 00:00:00

  • Exposure to high endotoxin concentration increases wheezing prevalence among laboratory animal workers: a cross-sectional study.

    abstract：BACKGROUND:Endotoxin from Gram-negative bacteria are found in different concentrations in dust and on the ground of laboratories dealing with small animals and animal houses. METHODS:Cross-sectional study performed in workplaces of two universities. Dust samples were collected from laboratories and animal facilities h...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12890-016-0233-1

    authors： Freitas AS,Simoneti CS,Ferraz E,Bagatin E,Brandão IT,Silva CL,Borges MC,Vianna EO

    更新日期：2016-05-06 00:00:00

  • Age-specific incidence of allergic and non-allergic asthma.

    abstract：BACKGROUND:Onset of allergic asthma has a strong association with childhood but only a few studies have analyzed incidence of asthma from childhood to late adulthood in relation to allergy. The purpose of the study was to assess age-specific incidence of allergic and non-allergic asthma. METHODS:Questionnaires were se...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-019-1040-2

    authors： Pakkasela J,Ilmarinen P,Honkamäki J,Tuomisto LE,Andersén H,Piirilä P,Hisinger-Mölkänen H,Sovijärvi A,Backman H,Lundbäck B,Rönmark E,Kankaanranta H,Lehtimäki L

    更新日期：2020-01-10 00:00:00

  • Plasma YKL-40 and all-cause mortality in patients with chronic obstructive pulmonary disease.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is hallmarked by inflammatory processes and a progressive decline of lung function. YKL-40 is a potential biomarker of inflammation and mortality in patients suffering from inflammatory lung disease, but its prognostic value in patients with COPD remains unknown. ...

    journal_title：BMC pulmonary medicine

    pub_type： 临床试验,杂志文章

    doi：10.1186/1471-2466-13-77

    authors： Holmgaard DB,Mygind LH,Titlestad IL,Madsen H,Pedersen SS,Johansen JS,Pedersen C

    更新日期：2013-12-30 00:00:00

  • Performance of noninvasive ventilation in acute respiratory failure in critically ill patients: a prospective, observational, cohort study.

    abstract：BACKGROUND:Noninvasive ventilation (NIV) is used in critically ill patients with acute respiratory failure (ARF) to avoid endotracheal intubation. However, the impact of NIV use on ARF patient's outcomes is still unclear. Our objectives were to evaluate the rate of NIV failure in hypoxemic patients with an arterial car...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-015-0139-3

    authors： Corrêa TD,Sanches PR,de Morais LC,Scarin FC,Silva E,Barbas CS

    更新日期：2015-11-11 00:00:00

  • Birt-Hogg-Dubé syndrome: a literature review and case study of a Chinese woman presenting a novel FLCN mutation.

    abstract：BACKGROUND:The Birt-Hogg-Dubé (BHD) syndrome is a very rare autosomal dominant form of genodermatosis caused by germline mutations in the folliculin (FLCN) gene, which is mapped to the p11.2 region in chromosome 17. BHD commonly presents cutaneous fibrofolliculomas, pulmonary cysts, renal cell carcinoma, and recurrent ...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章,评审

    doi：10.1186/s12890-017-0383-9

    authors： Hao S,Long F,Sun F,Liu T,Li D,Jiang S

    更新日期：2017-02-21 00:00:00

  • Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling.

    abstract：BACKGROUND:Eotaxin proteins are a potential therapeutic target in treating the peribronchial eosinophilia associated with allergic airway diseases. Since inflammation is often associated with an increased generation of reactive oxygen species (ROS), oxidative stress is a mechanistically imperative factor in asthma. Ast...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/1471-2466-14-122

    authors： Cho IH,Gong JH,Kang MK,Lee EJ,Park JH,Park SJ,Kang YH

    更新日期：2014-07-29 00:00:00

  • Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma.

    abstract：BACKGROUND:Interleukin-9 (IL-9)-targeted therapies may offer a novel approach for treating asthmatics. Two randomized placebo-controlled studies were conducted to assess the safety profile and potential efficacy of multiple subcutaneous doses of MEDI-528, a humanized anti-IL-9 monoclonal antibody, in asthmatics. METHO...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1471-2466-11-14

    authors： Parker JM,Oh CK,LaForce C,Miller SD,Pearlman DS,Le C,Robbie GJ,White WI,White B,Molfino NA,MEDI-528 Clinical Trials Group.

    更新日期：2011-02-28 00:00:00

  • Development, effectiveness and cost-effectiveness of a new out-patient Breathlessness Support Service: study protocol of a phase III fast-track randomised controlled trial.

    abstract：BACKGROUND:Breathlessness is a common and distressing symptom affecting many patients with advanced disease both from malignant and non-malignant origin. A combination of pharmacological and non-pharmacological measures is necessary to treat this symptom successfully. Breathlessness services in various compositions aim...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1471-2466-12-58

    authors： Bausewein C,Jolley C,Reilly C,Lobo P,Kelly J,Bellas H,Madan P,Panell C,Brink E,De Biase C,Gao W,Murphy C,McCrone P,Moxham J,Higginson IJ

    更新日期：2012-09-19 00:00:00

  • Airway wall thickness on HRCT scans decreases with age and increases with smoking.

    abstract：BACKGROUND:To investigate if age, gender and smoking are associated with airway wall thickness (AWT) measured by high resolution computed tomography (HRCT) and if higher AWT is associated with lower levels of pulmonary function in healthy current- and never-smokers with a wide age range. METHODS:HRCT scans were perfor...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-017-0363-0

    authors： Telenga ED,Oudkerk M,van Ooijen PM,Vliegenthart R,Ten Hacken NH,Postma DS,van den Berge M

    更新日期：2017-02-01 00:00:00

  • Is sweat testing for cystic fibrosis feasible in patients with down syndrome?

    abstract：BACKGROUND:Recurrent airway infections are common in patients with Down's syndrome (DS). Hence, ruling out Cystic Fibrosis (CF) in these patients is often required. In the past, the value of sweat testing - the gold standard to diagnose CF - has been questioned in DS as false positive results have been reported. Howeve...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-018-0580-1

    authors： Ruf K,Demerath A,Hebestreit H,Kunzmann S

    更新日期：2018-01-16 00:00:00

  • Severe but reversible pulmonary hypertension in scleromyxedema and multiple myeloma: a case report.

    abstract：BACKGROUND:Scleromyxedema is a progressive, systemic connective tissue disorder characterized by fibro-mucous skin lesions and increased serum monoclonal immunoglobulin levels. Pulmonary involvement occurs in a subset of patients, though the overall prevalence of pulmonary lesions in scleromyxedema is unknown. Since pu...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-019-1020-6

    authors： Kreidy M,Al-Hilli A,Yachoui R,Resnick J

    更新日期：2020-01-09 00:00:00

  • Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models.

    abstract：BACKGROUND:Activins are members of the TGF-ß superfamily of growth factors. First, we identified by expression array screening that activin-B and follistatin are upregulated in human idiopathic pulmonary fibrosis (IPF). Next, we wanted to clarify their specific role in lung fibrosis formation. METHODS:We used specific...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/1471-2466-14-170

    authors： Myllärniemi M,Tikkanen J,Hulmi JJ,Pasternack A,Sutinen E,Rönty M,Leppäranta O,Ma H,Ritvos O,Koli K

    更新日期：2014-11-01 00:00:00

  • Combined effects of leaks, respiratory system properties and upper airway patency on the performance of home ventilators: a bench study.

    abstract：BACKGROUND:Combined effects of leaks, mechanical property of respiratory system and upper airway (UA) patency on patient-ventilator synchrony (PVA) and the level of clinically "tolerable" leaks are not well established in home ventilators. METHODS:We comparatively assessed on a bench model, the highest leak level tole...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-017-0487-2

    authors： Zhu K,Rabec C,Gonzalez-Bermejo J,Hardy S,Aouf S,Escourrou P,Roisman G

    更新日期：2017-11-21 00:00:00

  • Relationship of flow-volume curve pattern on pulmonary function test with clinical and radiological features in idiopathic pulmonary fibrosis.

    abstract：BACKGROUND:The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (IPF). In this study, we investigated the relationship between FV curve pattern and clinical or radio...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-020-01254-z

    authors： Nakagawa H,Otoshi R,Isomoto K,Katano T,Baba T,Komatsu S,Hagiwara E,Nakano Y,Kuwahira I,Ogura T

    更新日期：2020-08-12 00:00:00

  • Treatment beyond four cycles of first line Platinum and Etoposide chemotherapy in real-life patients with stage IV Small Cell Lung Cancer: a retrospective study of the Merseyside and Cheshire Cancer network.

    abstract：BACKGROUND:Dose intensity and dose density of first line Platinum and Etoposide (PE) do not influence Overall Survival (OS) of Small Cell Lung Cancer (SCLC) patients. The effect of treatment length, however, remains unclear. Current guidelines recommend treating beyond 4 cycles -up to 6-, in patients that respond to an...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12890-019-0948-x

    authors： Sallam M,Wong H,Escriu C

    更新日期：2019-11-01 00:00:00

  • Clinical and radiological characteristics of patients with late-onset severe restrictive lung defect after hematopoietic stem cell transplantation.

    abstract：BACKGROUND:Late-onset noninfectious pulmonary complications (LONIPCs), which occur more than 3 months after allogeneic hematopoietic stem cell transplantation (HSCT), are major causes of morbidity and mortality after transplantation. Among LONIPCs, we occasionally treat patients with late-onset severe restrictive lung ...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-017-0466-7

    authors： Namkoong H,Ishii M,Mori T,Sugiura H,Tasaka S,Sakurai M,Koda Y,Kato J,Hasegawa N,Okamoto S,Betsuyaku T

    更新日期：2017-09-07 00:00:00

  • Assessment of the alveolar volume when sampling exhaled gas at different expired volumes in the single breath diffusion test.

    abstract：BACKGROUND:Alveolar volume measured according to the American Thoracic Society-European Respiratory Society (ATS-ERS) guidelines during the single breath diffusion test can be underestimated when there is maldistribution of ventilation. Therefore, the alveolar volume calculated by taking into account the ATS-ERS guidel...

    journal_title：BMC pulmonary medicine

    pub_type： 临床试验,杂志文章

    doi：10.1186/1471-2466-7-18

    authors： Prediletto R,Fornai E,Catapano G,Carli C

    更新日期：2007-12-19 00:00:00

  • Lumacaftor/ Ivacaftor improves exercise tolerance in patients with Cystic Fibrosis and severe airflow obstruction.

    abstract：BACKGROUND:Treatment of patients with Cystic Fibrosis homozygous for the Phe508del gene, with Lumacaftor /Ivacaftor (LUM/IVA) improves outcomes in patients with FEV1 > 40% predicted. We set out to observe the most sensitive clinical measure that would change with treatment in terms of exercise capacity or lung function...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-019-0866-y

    authors： Wark PAB,Cookson K,Thiruchelvam T,Brannan J,Dorahy DJ

    更新日期：2019-06-17 00:00:00

  • Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease.

    abstract：BACKGROUND:In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact of ...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-017-0544-x

    authors： Kamata H,Asakura T,Suzuki S,Namkoong H,Yagi K,Funatsu Y,Okamori S,Uno S,Uwamino Y,Fujiwara H,Nishimura T,Ishii M,Betsuyaku T,Hasegawa N

    更新日期：2017-12-13 00:00:00

  • Comparison between breathing and aerobic exercise on clinical control in patients with moderate-to-severe asthma: protocol of a randomized trial.

    abstract：BACKGROUND:Asthma is a chronic inflammatory airway disease characterized by reversible obstruction, inflammation and hyperresponsiveness to different stimulus. Aerobic and breathing exercises have been demonstrated to benefit asthmatic patients; however, there is no evidence comparing the effectiveness of these treatme...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1471-2466-14-160

    authors： Evaristo KB,Saccomani MG,Martins MA,Cukier A,Stelmach R,Rodrigues MR,Santaella DF,Carvalho CR

    更新日期：2014-10-17 00:00:00

  • Survival of bronchiectatic patients with respiratory failure in ICU.

    abstract：BACKGROUND:The outcome of patients with bronchiectasis during and after their stay in the intensive care unit (ICU) has seldom been reported in the literature. Managing these patients in the ICU can be challenging because of the complex nature of their disease. This study aims to identify the in-hospital and long-term ...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/1471-2466-7-17

    authors： Alzeer AH,Masood M,Basha SJ,Shaik SA

    更新日期：2007-12-10 00:00:00

  • Association of circulating irisin and cardiopulmonary exercise capacity in healthy volunteers: results of the Study of Health in Pomerania.

    abstract：BACKGROUND:Irisin, a recently discovered myokine, is assumed to be secreted by muscle cells in response to exercise and is involved in the regulation of energy metabolism by browning white adipose tissue cells. However, due to the fact that previous studies revealed conflicting results concerning the association betwee...

    journal_title：BMC pulmonary medicine

    pub_type： 杂志文章

    doi：10.1186/s12890-015-0035-x

    authors： Kerstholt N,Ewert R,Nauck M,Spielhagen T,Bollmann T,Stubbe B,Felix SB,Wallaschofski H,Gläser S,Friedrich N

    更新日期：2015-04-22 00:00:00