Abstract:
BACKGROUND:Endotoxin from Gram-negative bacteria are found in different concentrations in dust and on the ground of laboratories dealing with small animals and animal houses. METHODS:Cross-sectional study performed in workplaces of two universities. Dust samples were collected from laboratories and animal facilities housing rats, mice, guinea pigs, rabbits or hamsters and analyzed by the "Limulus amebocyte lysate" (LAL) method. We also sampled workplaces without animals. The concentrations of endotoxin detected in the workplaces were tested for association with wheezing in the last 12 months, asthma defined by self-reported diagnosis and asthma confirmed by bronchial hyperresponsiveness (BHR) to mannitol. RESULTS:Dust samples were obtained at 145 workplaces, 92 with exposure to animals and 53 with no exposure. Exposed group comprised 412 subjects and non-exposed group comprised 339 subjects. Animal-exposed workplaces had higher concentrations of endotoxin, median of 34.2 endotoxin units (EU) per mg of dust (interquartile range, 12.6-65.4), as compared to the non-exposed group, median of 10.2 EU/mg of dust (interquartile range, 2.6-22.2) (p < 0.001). The high concentration of endotoxin (above whole sample median, 20.4 EU/mg) was associated with increased wheezing prevalence (p < 0.001), i.e., 61 % of workers exposed to high endotoxin concentration reported wheezing in the last 12 months compared to 29 % of workers exposed to low endotoxin concentration. The concentration of endotoxin was not associated with asthma report or with BHR confirmed asthma. CONCLUSION:Exposure to endotoxin is associated with a higher prevalence of wheezing, but not with asthma as defined by the mannitol bronchial challenge test or by self-reported asthma. Preventive measures are necessary for these workers.
journal_name
BMC Pulm Medjournal_title
BMC pulmonary medicineauthors
Freitas AS,Simoneti CS,Ferraz E,Bagatin E,Brandão IT,Silva CL,Borges MC,Vianna EOdoi
10.1186/s12890-016-0233-1subject
Has Abstractpub_date
2016-05-06 00:00:00pages
69issue
1issn
1471-2466pii
10.1186/s12890-016-0233-1journal_volume
16pub_type
杂志文章,多中心研究abstract:BACKGROUND:Little is known about whether or how supplemental oxygen affects patients with pulmonary fibrosis. METHODS/DESIGN:A mixed-methods study is described. Patients with pulmonary fibrosis, informal caregivers of pulmonary fibrosis patients and practitioners who prescribe supplemental oxygen will be interviewed t...
journal_title:BMC pulmonary medicine
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2466-14-169
更新日期:2014-11-01 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-017-0545-9
更新日期:2017-12-11 00:00:00
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pub_type: 杂志文章,已发布勘误
doi:10.1186/s12890-020-1051-z
更新日期:2020-01-21 00:00:00
abstract:BACKGROUND:The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (IPF). In this study, we investigated the relationship between FV curve pattern and clinical or radio...
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journal_title:BMC pulmonary medicine
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更新日期:2010-10-25 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2466-14-15
更新日期:2014-02-06 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1186/s12890-015-0139-3
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doi:10.1186/s12890-020-01236-1
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,meta分析
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更新日期:2020-04-29 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,多中心研究
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更新日期:2017-12-02 00:00:00
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pub_type: 杂志文章
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更新日期:2014-04-24 00:00:00
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pub_type: 杂志文章
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更新日期:2016-05-23 00:00:00
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pub_type: 杂志文章
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更新日期:2019-03-14 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-11 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
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