The application of metagenomic next-generation sequencing in diagnosing Chlamydia psittaci pneumonia: a report of five cases.

Abstract:

BACKGROUND:Chlamydia psittaci pneumonia is a zoonotic infectious disease caused by Chlamydia psittaci. Diagnostic tools, including culture, serologic test and PCR-based methods, are available but prone to false negative results. CASE PRESENTATION:This report included five cases of Chlamydia psittaci pneumonia. Symptoms and signs common to all 5 cases included fever, coughing, generalized muscle ache, and most notably, inflammatory infiltration of the lungs upon chest CT and X-ray. Metagenomic next-generation sequencing (mNGS) revealed the presence of Chlamydia psittaci in biopsy lung tissue in 3 cases and bronchoalveolar lavage fluid in the remaining 2 cases. Three patients responded to doxycycline plus moxifloxacin; two patients responded to moxifloxacin alone. CONCLUSIONS:mNGS could be used to diagnose Chlamydia psittaci pneumonia.

journal_name

BMC Pulm Med

journal_title

BMC pulmonary medicine

authors

Gu L,Liu W,Ru M,Lin J,Yu G,Ye J,Zhu ZA,Liu Y,Chen J,Lai G,Wen W

doi

10.1186/s12890-020-1098-x

subject

Has Abstract

pub_date

2020-03-17 00:00:00

pages

65

issue

1

issn

1471-2466

pii

10.1186/s12890-020-1098-x

journal_volume

20

pub_type

杂志文章
  • Real life management of community-acquired Pneumonia in adults in the Gulf region and comparison with practice guidelines: a prospective study.

    abstract:BACKGROUND:Very few data exist on the management of community-acquired pneumonia (CAP) in patients admitted to hospitals in the Gulf region. The objectives of this study were to describe treatment patterns for CAP in 38 hospitals in five Gulf countries (United Arab Emirates, Kuwait, Bahrain, Oman, and Qatar) and to com...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-015-0108-x

    authors: Mahboub B,Al Zaabi A,Al Ali OM,Ahmed R,Niederman MS,El-Bishbishi R

    更新日期:2015-09-30 00:00:00

  • Comparison of the effects of pulmonary rehabilitation with chest physical therapy on the levels of fibrinogen and albumin in patients with lung cancer awaiting lung resection: a randomized clinical trial.

    abstract:BACKGROUND:Systemic inflammation plays an important role in the initiation, promotion, and progression of lung carcinogenesis. In patients with non-small cell lung cancer (NSCLC), fibrinogen levels correlate with neoplasia. Here we compared the effects of pulmonary rehabilitation (PR) with chest physical therapy (CPT) ...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2466-14-121

    authors: Morano MT,Mesquita R,Da Silva GP,Araújo AS,Pinto JM,Neto AG,Viana CM,De Moraes Filho MO,Pereira ED

    更新日期:2014-07-28 00:00:00

  • Quantitative analysis of lung elastic fibers in idiopathic pleuroparenchymal fibroelastosis (IPPFE): comparison of clinical, radiological, and pathological findings with those of idiopathic pulmonary fibrosis (IPF).

    abstract:BACKGROUND:The pathological appearance of idiopathic pleuroparenchymal fibroelastosis (IPPFE) with hematoxylin-eosin staining is similar to that of usual interstitial pneumonia (UIP) in patients with idiopathic pulmonary fibrosis (IPF). The amount of elastic fibers (EF) and detailed differences between IPPFE and IPF ha...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-14-91

    authors: Enomoto N,Kusagaya H,Oyama Y,Kono M,Kaida Y,Kuroishi S,Hashimoto D,Fujisawa T,Yokomura K,Inui N,Nakamura Y,Suda T

    更新日期:2014-05-28 00:00:00

  • Serum (1→3)-β-D-glucan and galactomannan levels in patients with cystic fibrosis: a retrospective cohort study.

    abstract:BACKGROUND:Aspergillus fumigatus is frequently encountered in sputum samples of patients with cystic fibrosis (CF), which traditionally has been interpreted as saprophytic airway colonization. However, this mere bystander role has been challenged by recent data. There is now evidence that Aspergillus fumigatus accelera...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-018-0614-8

    authors: Träger J,Melichar VO,Meyer R,Rauh M,Bogdan C,Held J

    更新日期:2018-03-27 00:00:00

  • Noninvasive assessment of asthma severity using pulse oximeter plethysmograph estimate of pulsus paradoxus physiology.

    abstract:BACKGROUND:Pulsus paradoxus estimated by dynamic change in area under the oximeter plethysmograph waveform (PEP) might provide a measure of acute asthma severity. Our primary objective was to determine how well PEP correlates with forced expiratory volume in 1-second (%FEV1) (criterion validity) and change of %FEV1 (re...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-10-17

    authors: Arnold DH,Jenkins CA,Hartert TV

    更新日期:2010-03-29 00:00:00

  • 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung.

    abstract:BACKGROUND:Pseudomonas aeruginosa infections are associated with progressive life threatening decline of lung function in cystic fibrosis sufferers. Growth of Ps. aeruginosa releases a "grape-like" odour that has been identified as the microbial volatile organic compound 2-aminoacetophenone (2-AA). METHODS:We investig...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-10-56

    authors: Scott-Thomas AJ,Syhre M,Pattemore PK,Epton M,Laing R,Pearson J,Chambers ST

    更新日期:2010-11-07 00:00:00

  • Protocol for a mixed-methods study of supplemental oxygen in pulmonary fibrosis.

    abstract:BACKGROUND:Little is known about whether or how supplemental oxygen affects patients with pulmonary fibrosis. METHODS/DESIGN:A mixed-methods study is described. Patients with pulmonary fibrosis, informal caregivers of pulmonary fibrosis patients and practitioners who prescribe supplemental oxygen will be interviewed t...

    journal_title:BMC pulmonary medicine

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2466-14-169

    authors: Belkin A,Fier K,Albright K,Baird S,Crowe B,Eres L,Korn M,Maginn L,McCormick M,Root ED,Vierzba T,Wamboldt FS,Swigris JJ

    更新日期:2014-11-01 00:00:00

  • Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling.

    abstract:BACKGROUND:Eotaxin proteins are a potential therapeutic target in treating the peribronchial eosinophilia associated with allergic airway diseases. Since inflammation is often associated with an increased generation of reactive oxygen species (ROS), oxidative stress is a mechanistically imperative factor in asthma. Ast...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-14-122

    authors: Cho IH,Gong JH,Kang MK,Lee EJ,Park JH,Park SJ,Kang YH

    更新日期:2014-07-29 00:00:00

  • Longitudinal profiling of gut microbiome among tuberculosis patients under anti-tuberculosis treatment in China: protocol of a prospective cohort study.

    abstract:BACKGROUND:Anti-tuberculosis therapy requires at least six-month treatment with continuous administration of combined antibiotics, including isoniazid, rifampicin, pyrazinamide, and ethambutol. The long-term exposure to antibiotics could cause consequent changes in gut microbiota, which may alter the gastrointestinal f...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12890-019-0981-9

    authors: Shi W,Hu Y,Zheng X,Ning Z,Wu M,Xia F,Prast-Nielsen S,Hu YOO,Xu B

    更新日期:2019-11-11 00:00:00

  • Can cholesterol be used to distinguish pleural exudates from transudates? evidence from a bivariate meta-analysis.

    abstract:BACKGROUND:Many studies have investigated whether pleural cholesterol levels can aid in diagnosis of pleural exudates, and the results have varied considerably. To gain a more reliable answer to this question, we meta-analyzed the literature on using pleural cholesterol or the ratio of cholesterol in pleural fluid to c...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/1471-2466-14-61

    authors: Shen Y,Zhu H,Wan C,Chen L,Wang T,Yang T,Wen F

    更新日期:2014-04-15 00:00:00

  • Evaluation of semi-quantitative compared to quantitative cultures of tracheal aspirates for the yield of culturable respiratory pathogens - a cross-sectional study.

    abstract:BACKGROUND:Diagnosis of lower respiratory tract infections (LRTI) depends on the presence of clinical, radiological and microbiological findings. Endotracheal suction aspirate (ETSA) is the commonest respiratory sample sent for culture from intubated patients. Very few studies have compared quantitative and semi-quanti...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-01311-7

    authors: Rattani S,Farooqi J,Jabeen G,Chandio S,Kash Q,Khan A,Jabeen K

    更新日期:2020-10-29 00:00:00

  • The Darlington and Northallerton long term asthma study: pulmonary function.

    abstract:BACKGROUND:The Darlington and Northallerton Asthma Study is an observational cohort study started in 1983. At that time little was published about long term outcome in asthma and the contribution of change in reversible disease or airway remodelling to any excess deterioration in function. The study design included reg...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-5-2

    authors: Connolly CK,Prescott RJ

    更新日期:2005-01-31 00:00:00

  • CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression.

    abstract:BACKGROUND:CHCHD2 was identified a novel cell migration-promoting gene, which could promote cell migration and altered cell adhesion when ectopically overexpressed in NIH3T3 fibroblasts, and it was identified as a protein necessary for OxPhos function as well. However, the clinic relevance of CHCHD2 expression in NSCLC...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-1079-0

    authors: Yin X,Xia J,Sun Y,Zhang Z

    更新日期:2020-02-13 00:00:00

  • Health-related quality of life and chronic obstructive pulmonary disease in early stages - longitudinal results from the population-based KORA cohort in a working age population.

    abstract:BACKGROUND:It is widely recognized that health-related quality of life (HRQL) is impaired in patients with Chronic Obstructive Pulmonary Disease (COPD), but there is a lack of research on longitudinal associations of COPD and HRQL. This study examined the effects of COPD in early stages of disease on HRQL over ten year...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-14-134

    authors: Wacker ME,Hunger M,Karrasch S,Heinrich J,Peters A,Schulz H,Holle R

    更新日期:2014-08-09 00:00:00

  • The features of AECOPD with carbon dioxide retention.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) with carbon dioxide retention is associated with a worsening clinical condition and the beginning of pulmonary ventilation decompensation. This study aimed to identify the factors associated with carbon dioxide retention. METHODS:This was a retrospective study of...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-018-0691-8

    authors: Wei X,Yu N,Ding Q,Ren J,Mi J,Bai L,Li J,Qi M,Guo Y

    更新日期:2018-07-31 00:00:00

  • Pathogenic characteristics of sputum and bronchoalveolar lavage fluid samples from patients with lower respiratory tract infection in a large teaching hospital in China: a retrospective study.

    abstract:BACKGROUND:Lower respiratory tract infection (LRIs) is very common both in terms of community-acquired infection and hospital-acquired infection. Sputum and bronchoalveolar lavage fluid (BALF) are the most important specimens obtained from patients with LRI. The choice of antibiotic with which to treat LRI usually depe...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-01275-8

    authors: Peng Z,Zhou J,Tian L

    更新日期:2020-08-31 00:00:00

  • Performance of noninvasive ventilation in acute respiratory failure in critically ill patients: a prospective, observational, cohort study.

    abstract:BACKGROUND:Noninvasive ventilation (NIV) is used in critically ill patients with acute respiratory failure (ARF) to avoid endotracheal intubation. However, the impact of NIV use on ARF patient's outcomes is still unclear. Our objectives were to evaluate the rate of NIV failure in hypoxemic patients with an arterial car...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-015-0139-3

    authors: Corrêa TD,Sanches PR,de Morais LC,Scarin FC,Silva E,Barbas CS

    更新日期:2015-11-11 00:00:00

  • Smoking reduces surfactant protein D and phospholipids in patients with and without chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Pulmonary surfactant D (SP-D) has important regulatory functions for innate immunity and has been implicated as a biomarker for chronic obstructive pulmonary disease (COPD). We hypothesized that COPD patients would have reduced bronchoalveolar lavage (BAL) fluid SP-D levels compared to healthy smoking and no...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-10-53

    authors: Moré JM,Voelker DR,Silveira LJ,Edwards MG,Chan ED,Bowler RP

    更新日期:2010-10-25 00:00:00

  • Evaluation of sensitivity and specificity of CanPatrol™ technology for detection of circulating tumor cells in patients with non-small cell lung cancer.

    abstract:BACKGROUND:The early diagnosis of non-small cell lung cancer is of great significance to the prognosis of patients. However, traditional histopathology and imaging screening have certain limitations. Therefore, new diagnostical methods are urgently needed for the current clinical diagnosis. In this study we evaluated t...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-01314-4

    authors: Li J,Liao Y,Ran Y,Wang G,Wu W,Qiu Y,Liu J,Wen N,Jing T,Wang H,Zhang S

    更新日期:2020-10-20 00:00:00

  • Comparative analysis of selected exhaled breath biomarkers obtained with two different temperature-controlled devices.

    abstract:BACKGROUND:The collection of exhaled breath condensate (EBC) is a suitable and non-invasive method for evaluation of airway inflammation. Several studies indicate that the composition of the condensate and the recovery of biomarkers are affected by physical characteristics of the condensing device and collecting circum...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-9-48

    authors: Hoffmeyer F,Raulf-Heimsoth M,Harth V,Bünger J,Brüning T

    更新日期:2009-11-30 00:00:00

  • The Prospective Non-Interventional DACCORD Study in the National COPD Registry in Germany: design and methods.

    abstract:BACKGROUND:A variety of large randomized controlled trials (RCT's) evaluating pharmacotherapy in chronic obstructive pulmonary disease (COPD) patients does exist. One of the drugs that has been tested is the new long-acting anticholinergic glycopyrronium bromide. METHODS:As the generalizability of results from RCT's i...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-2466-15-2

    authors: Kardos P,Vogelmeier C,Buhl R,Criée CP,Worth H

    更新日期:2015-01-12 00:00:00

  • How people with chronic obstructive pulmonary disease perceive their illness: a qualitative study between mind and body.

    abstract:BACKGROUND:Although many studies on people with Chronic Obstructive Pulmonary Disease (COPD) have examined the mutual impact of physical status and emotional experience, there is limited knowledge about the way COPD people first-hand perceive their condition. This study was designed to investigate the illness perceptio...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-1157-3

    authors: Pozzar M,Volpato E,Valota C,Pagnini F,Banfi PI

    更新日期:2020-05-04 00:00:00

  • A controlled study of community-based exercise training in patients with moderate COPD.

    abstract:BACKGROUND:The effectiveness of clinic-based pulmonary rehabilitation in advanced COPD is well established, but few data exist for less severe patients treated in alternative settings. The purpose of this study was to investigate whether a novel, community-based exercise program (CBE) was feasible and effective for pat...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2466-14-125

    authors: Amin S,Abrazado M,Quinn M,Storer TW,Tseng CH,Cooper CB

    更新日期:2014-08-04 00:00:00

  • Is sweat testing for cystic fibrosis feasible in patients with down syndrome?

    abstract:BACKGROUND:Recurrent airway infections are common in patients with Down's syndrome (DS). Hence, ruling out Cystic Fibrosis (CF) in these patients is often required. In the past, the value of sweat testing - the gold standard to diagnose CF - has been questioned in DS as false positive results have been reported. Howeve...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-018-0580-1

    authors: Ruf K,Demerath A,Hebestreit H,Kunzmann S

    更新日期:2018-01-16 00:00:00

  • Treatment beyond four cycles of first line Platinum and Etoposide chemotherapy in real-life patients with stage IV Small Cell Lung Cancer: a retrospective study of the Merseyside and Cheshire Cancer network.

    abstract:BACKGROUND:Dose intensity and dose density of first line Platinum and Etoposide (PE) do not influence Overall Survival (OS) of Small Cell Lung Cancer (SCLC) patients. The effect of treatment length, however, remains unclear. Current guidelines recommend treating beyond 4 cycles -up to 6-, in patients that respond to an...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12890-019-0948-x

    authors: Sallam M,Wong H,Escriu C

    更新日期:2019-11-01 00:00:00

  • Impact of pulmonary rehabilitation on patients' health care needs and asthma control: a quasi-experimental study.

    abstract:BACKGROUND:Pulmonary rehabilitation offers potential benefits to people with asthma. It is however unknown if rehabilitation favourably affects patients' health care needs. We therefore examined if rehabilitation reduced needs and, in addition, if it improved asthma control. METHODS:One hundred fifty patients with ast...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-01301-9

    authors: Salandi J,Icks A,Gholami J,Hummel S,Schultz K,Apfelbacher C,Sheikh A,Loerbroks A

    更新日期:2020-10-15 00:00:00

  • Domiciliary pulse-oximetry at exacerbation of chronic obstructive pulmonary disease: prospective pilot study.

    abstract:BACKGROUND:The ability to objectively differentiate exacerbations of chronic obstructive pulmonary disease (COPD) from day-to-day symptom variations would be an important development in clinical practice and research. We assessed the ability of domiciliary pulse oximetry to achieve this. METHODS:40 patients with moder...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-10-52

    authors: Hurst JR,Donaldson GC,Quint JK,Goldring JJ,Patel AR,Wedzicha JA

    更新日期:2010-10-20 00:00:00

  • Comparison between breathing and aerobic exercise on clinical control in patients with moderate-to-severe asthma: protocol of a randomized trial.

    abstract:BACKGROUND:Asthma is a chronic inflammatory airway disease characterized by reversible obstruction, inflammation and hyperresponsiveness to different stimulus. Aerobic and breathing exercises have been demonstrated to benefit asthmatic patients; however, there is no evidence comparing the effectiveness of these treatme...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2466-14-160

    authors: Evaristo KB,Saccomani MG,Martins MA,Cukier A,Stelmach R,Rodrigues MR,Santaella DF,Carvalho CR

    更新日期:2014-10-17 00:00:00

  • The effect of perinatal anxiety on bronchiolitis is influenced by polymorphisms in ROS-related genes.

    abstract:BACKGROUND:Exposure to perinatal anxiety affects disease susceptibility in offspring but studies on the association between perinatal anxiety and gene polymorphisms are lacking. This study aimed to elucidate the interaction between perinatal anxiety and polymorphisms in antioxidant defense and innate immunity genes on ...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-14-154

    authors: Lee E,Chang HY,Lee KS,Suh DI,Yu HS,Kang MJ,Choi IA,Park J,Kim KW,Shin YH,Ahn KM,Kwon JY,Choi SJ,Lee KJ,Won HS,Yang SI,Jung YH,Kim HY,Seo JH,Kwon JW,Kim BJ,Kim HB,Lee SY,Kim EJ,Lee JS,Keyes KM,Shin YJ,

    更新日期:2014-09-29 00:00:00

  • Psychometric performance of the CAMPHOR and SF-36 in pulmonary hypertension.

    abstract:BACKGROUND:The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and the Medical Outcomes Study Short Form 36 (SF-36) are widely used to assess patient-reported outcome in individuals with pulmonary hypertension (PH). The aim of the study was to compare the psychometric properties of the two measures. METHODS:...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2466-13-45

    authors: Twiss J,McKenna S,Ganderton L,Jenkins S,Ben-L'amri M,Gain K,Fowler R,Gabbay E

    更新日期:2013-07-12 00:00:00