Smoking reduces surfactant protein D and phospholipids in patients with and without chronic obstructive pulmonary disease.

abstract：BACKGROUND:This study aims to investigate the effects of CCAAT/enhancer binding protein alpha (C/EBPα) overexpression on cell proliferation, apoptosis and surfactant protein-C(SP-C) in alveolar epithelial type II (AEC II) cells after exposure to hyperoxia. METHODS:pcDNA3.1(+)-C/EBPα plasmid or air-empty vector were tr...

journal_title：BMC pulmonary medicine

authors： Lu H,Chen X,Lu Y,Zhu H,Tang W,Wang Q

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:The tracheobronchomalacia is a life-threatening complication of mucopolysaccharidosis (MPS) without known effective, optimal treatment. The severe expiratory collapse of the trachea and bronchi is one of causes of the high rate of deaths in the course of airway impairment in MPSII patients. CASE PRESENTATIO...

journal_title：BMC pulmonary medicine

authors： Gocyk W,Warmus J,Olechnowicz H,Bik-Multanowski M,Pawlinski L,Kiec-Wilk B

更新日期：2020-04-20 00:00:00

abstract：BACKGROUND:To investigate if age, gender and smoking are associated with airway wall thickness (AWT) measured by high resolution computed tomography (HRCT) and if higher AWT is associated with lower levels of pulmonary function in healthy current- and never-smokers with a wide age range. METHODS:HRCT scans were perfor...

journal_title：BMC pulmonary medicine

authors： Telenga ED,Oudkerk M,van Ooijen PM,Vliegenthart R,Ten Hacken NH,Postma DS,van den Berge M

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Influenza is a frequent cause of exacerbations of chronic obstructive pulmonary disease (COPD). Exacerbations are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life, disease progression, death, and ultimately, substantial healthcare-related costs. Despite longstand...

journal_title：BMC pulmonary medicine

authors： Bekkat-Berkani R,Wilkinson T,Buchy P,Dos Santos G,Stefanidis D,Devaster JM,Meyer N

更新日期：2017-05-03 00:00:00

abstract：BACKGROUND:This study was conducted in order to determine the prevalence of asthma and associated risk factors in the adult population of Karachi, Pakistan. METHODS:This multi-stage, cross-sectional survey was conducted from May 2014-August 2015; comprising 1629 adults in 75 randomly selected clusters in Karachi, Paki...

journal_title：BMC pulmonary medicine

authors： Razzaq S,Nafees AA,Rabbani U,Irfan M,Naeem S,Khan MA,Fatmi Z,Burney P

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rare life-threating interstitial lung disease (ILD). This study characterizes demographics, health care utilization, and comorbidities among elderly IPF patients and estimates prevalence and incidence rates for selected outcomes. METHODS:Cohort study using a large US...

journal_title：BMC pulmonary medicine

authors： Mortimer K,Hartmann N,Chan C,Norman H,Wallace L,Enger C

更新日期：2019-01-10 00:00:00

abstract：BACKGROUND:The breakdown of alveolar barrier dysfunction contributes to Lipopolysaccharide stimulated pulmonary edema and acute lung injury. Actin cytoskeleton has been implicated to be critical in regulation of epithelial barrier. Here, we performed in vivo and in vitro study to investigate role of TLR4-p38 MAPK-Hsp27...

journal_title：BMC pulmonary medicine

authors： Wang W,Weng J,Yu L,Huang Q,Jiang Y,Guo X

更新日期：2018-11-27 00:00:00

abstract：BACKGROUND:Interleukin-9 (IL-9)-targeted therapies may offer a novel approach for treating asthmatics. Two randomized placebo-controlled studies were conducted to assess the safety profile and potential efficacy of multiple subcutaneous doses of MEDI-528, a humanized anti-IL-9 monoclonal antibody, in asthmatics. METHO...

journal_title：BMC pulmonary medicine

authors： Parker JM,Oh CK,LaForce C,Miller SD,Pearlman DS,Le C,Robbie GJ,White WI,White B,Molfino NA,MEDI-528 Clinical Trials Group.

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:Pleuroparenchymal fibroelastosis (PPFE) is a very rare interstitial lung disease (ILD) characterized by progressive fibrotic lesions of the visceral pleura and the sub-pleural parenchyma, affecting predominantly the upper lobes. PPFE may occur in different contextes like bone marrow or lung transplantations,...

journal_title：BMC pulmonary medicine

authors： Hassoun D,Dirou S,Arrigoni PP,Durant C,Hamidou M,Néel A,Agard C

更新日期：2018-05-18 00:00:00

abstract：BACKGROUND:The acute respiratory distress syndrome (ARDS) is a serious disease in critically ill patients that is characterized by pulmonary dysfunctions, hypoxemia and significant mortality. Patients with immunodeficiency (e.g. SCID with T and B cell deficiency) are particularly susceptible to the development of sever...

journal_title：BMC pulmonary medicine

authors： Verjans E,Kanzler S,Ohl K,Rieg AD,Ruske N,Schippers A,Wagner N,Tenbrock K,Uhlig S,Martin C

更新日期：2018-11-22 00:00:00

abstract：BACKGROUND:Telehealth and telemonitoring is an emerging area of study in people with cystic fibrosis (CF), with the potential of increasing access to care, and minimising infection control risks to patients without compromising their health outcomes. To date, limited evidence is available to support the use of teleheal...

journal_title：BMC pulmonary medicine

authors： Lang RL,Wilson C,Stockton K,Russell T,Johnston LM

更新日期：2019-01-24 00:00:00

abstract：BACKGROUND:The use of extracorporeal membrane oxygenation (ECMO) in awake, spontaneously breathing and non-intubated patients (awake ECMO) may be a novel therapeutic strategy for severe acute respiratory distress syndrome (ARDS) patients. The purpose of this study is to assess the feasibility and safety of awake ECMO i...

journal_title：BMC pulmonary medicine

authors： Xia J,Gu S,Li M,Liu D,Huang X,Yi L,Wu L,Fan G,Zhan Q

更新日期：2019-12-09 00:00:00

abstract：BACKGROUND:The effectiveness of clinic-based pulmonary rehabilitation in advanced COPD is well established, but few data exist for less severe patients treated in alternative settings. The purpose of this study was to investigate whether a novel, community-based exercise program (CBE) was feasible and effective for pat...

journal_title：BMC pulmonary medicine

authors： Amin S,Abrazado M,Quinn M,Storer TW,Tseng CH,Cooper CB

更新日期：2014-08-04 00:00:00

abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) has been believed to be related with chemotherapy resistance in non-small cell lung cancer (NSCLC). Recent studies have suggested eIF5A-2 may function as a proliferation-related oncogene in tumorigenic processes. METHODS:We used cell viability assays, western blotting...

journal_title：BMC pulmonary medicine

authors： Xu G,Yu H,Shi X,Sun L,Zhou Q,Zheng D,Shi H,Li N,Zhang X,Shao G

更新日期：2014-11-07 00:00:00

abstract：:Following publication of the original article [1], the author flagged aspects of the article that affected readability of some of the article's scientific content. ...

journal_title：BMC pulmonary medicine

authors： Fuchs O,Bahmer T,Weckmann M,Dittrich AM,Schaub B,Rösler B,Happle C,Brinkmann F,Ricklefs I,König IR,Watz H,Rabe KF,Kopp MV,Hansen G,von Mutius E,ALLIANCE Study Group as part of the German Centre for Lung Research (DZL).

更新日期：2018-11-07 00:00:00

abstract：BACKGROUND:US mentholated cigarette sales have increased considerably over 50 years. Preference for mentholated cigarettes is markedly higher in Black people. While menthol itself is not genotoxic or carcinogenic, its acute respiratory effects might affect inhalation of cigarette smoke. This possibility seems consisten...

journal_title：BMC pulmonary medicine

authors： Lee PN

更新日期：2011-04-18 00:00:00

abstract：BACKGROUND:In Europe, administration of an inhaled corticosteroid (ICS) combined with a long-acting β2 agonist is approved in chronic obstructive pulmonary disease (COPD) patients with a pre-bronchodilator FEV1 < 60% predicted normal, a history of repeated exacerbations, and who have significant symptoms despite regula...

journal_title：BMC pulmonary medicine

authors： Roche N,Pribil C,Van Ganse E,Serrier P,Housset B,Poirier D,Texier N,Schück S,Boucot I

更新日期：2014-04-02 00:00:00

abstract：BACKGROUND:Cystic Fibrosis (CF) is a monogenic disease with complex expression because of the action of genetic and environmental factors. We investigated whether the ACE gene D/I polymorphism is associated with severity of CF. METHODS:A cross-sectional study was performed, from 2009 to 2011, at University of Campinas...

journal_title：BMC pulmonary medicine

authors： Marson FA,Bertuzzo CS,Hortencio TD,Ribeiro JD,Bonadia LC,Ribeiro AF

更新日期：2012-08-08 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a distinct form of interstitial pneumonia with unknown origin and poor prognosis. Current pharmacologic treatments are limited and lung transplantation is a viable option for appropriate patients. The aim of this review was to summarize lung transplantation survival in ...

journal_title：BMC pulmonary medicine

authors： Kistler KD,Nalysnyk L,Rotella P,Esser D

更新日期：2014-08-16 00:00:00

abstract：BACKGROUND:Patients with a primary spontaneous pneumothorax (PSP) who are treated with chest tube drainage are traditionally connected to an analogue chest drainage system, containing a water seal and using a visual method of monitoring air leakage. Electronic systems with continuous digital monitoring of air leakage p...

journal_title：BMC pulmonary medicine

authors： Ruigrok D,Kunst PWA,Blacha MMJ,Tomlow B,Herbrink JW,Japenga EJ,Boersma W,Bresser P,van der Lee I,Mooren K

更新日期：2020-05-11 00:00:00

abstract：BACKGROUND:Despite optimal pharmacological therapy and pulmonary rehabilitation, patients with COPD continue to be breathless. There is a need to develop additional strategies to alleviate symptoms. Learning to sing requires control of breathing and posture and might have benefits that translate into daily life. METHO...

journal_title：BMC pulmonary medicine

authors： Lord VM,Cave P,Hume VJ,Flude EJ,Evans A,Kelly JL,Polkey MI,Hopkinson NS

更新日期：2010-08-03 00:00:00

abstract：BACKGROUND:The outcome of patients with bronchiectasis during and after their stay in the intensive care unit (ICU) has seldom been reported in the literature. Managing these patients in the ICU can be challenging because of the complex nature of their disease. This study aims to identify the in-hospital and long-term ...

journal_title：BMC pulmonary medicine

authors： Alzeer AH,Masood M,Basha SJ,Shaik SA

更新日期：2007-12-10 00:00:00

abstract：BACKGROUND:Late-onset noninfectious pulmonary complications (LONIPCs), which occur more than 3 months after allogeneic hematopoietic stem cell transplantation (HSCT), are major causes of morbidity and mortality after transplantation. Among LONIPCs, we occasionally treat patients with late-onset severe restrictive lung ...

journal_title：BMC pulmonary medicine

authors： Namkoong H,Ishii M,Mori T,Sugiura H,Tasaka S,Sakurai M,Koda Y,Kato J,Hasegawa N,Okamoto S,Betsuyaku T

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:It has been recognized that despite previous stability some patients with idiopathic pulmonary fibrosis (IPF) experience acute clinical deteriorations called acute exacerbations of idiopathic pulmonary fibrosis (AEX-IPF). We hypothesized that pulmonary infection can be excluded based on clinical and laborato...

journal_title：BMC pulmonary medicine

authors： Petrosyan F,Culver DA,Reddy AJ

更新日期：2015-07-10 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is hallmarked by inflammatory processes and a progressive decline of lung function. YKL-40 is a potential biomarker of inflammation and mortality in patients suffering from inflammatory lung disease, but its prognostic value in patients with COPD remains unknown. ...

journal_title：BMC pulmonary medicine

authors： Holmgaard DB,Mygind LH,Titlestad IL,Madsen H,Pedersen SS,Johansen JS,Pedersen C

更新日期：2013-12-30 00:00:00

abstract：BACKGROUND:Abediterol is a novel, once-daily long-acting β2-agonist in development for the treatment of chronic obstructive pulmonary disease (COPD) and asthma in combination with an anti-inflammatory agent. This Phase IIa, randomised, double-blind, crossover study investigated the bronchodilation, safety, tolerability...

journal_title：BMC pulmonary medicine

authors： Beier J,Pujol H,Seoane B,Jimenez E,Astbury C,Massana E,Ruiz S,de Miquel G

更新日期：2016-07-20 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is combination of progressive lung diseases. The diagnosis of COPD is generally based on the pulmonary function testing, however, difficulties underlie in prognosis of smokers or early stage of COPD patients due to the complexity and heterogeneity of the pathogene...

journal_title：BMC pulmonary medicine

authors： Matsumura K,Ito S

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:The purpose of our study was to assess the frequency of occult foreign body aspiration (FBA) and to evaluate the diagnostic difficulties and therapeutic methods for these patients. METHODS:Between May 2000 and May 2020, 3557 patients with the diagnosis of FBA were treated in our department. Thirty-five pati...

journal_title：BMC pulmonary medicine

authors： Liu B,Ding F,An Y,Li Y,Pan Z,Wang G,Dai J,Li H,Wu C

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact of ...

journal_title：BMC pulmonary medicine

authors： Kamata H,Asakura T,Suzuki S,Namkoong H,Yagi K,Funatsu Y,Okamori S,Uno S,Uwamino Y,Fujiwara H,Nishimura T,Ishii M,Betsuyaku T,Hasegawa N

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:The incidence and prevalence of chronic kidney disease (CKD) continue to rise worldwide. Increasing age, diabetes, hypertension, and cigarette smoking are well-recognized risk factors for CKD. Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation leading to airway obstr...

journal_title：BMC pulmonary medicine

authors： Gaddam S,Gunukula SK,Lohr JW,Arora P

更新日期：2016-11-24 00:00:00