The ACE gene D/I polymorphism as a modulator of severity of cystic fibrosis.

abstract：BACKGROUND:This study aims to investigate the effects of CCAAT/enhancer binding protein alpha (C/EBPα) overexpression on cell proliferation, apoptosis and surfactant protein-C(SP-C) in alveolar epithelial type II (AEC II) cells after exposure to hyperoxia. METHODS:pcDNA3.1(+)-C/EBPα plasmid or air-empty vector were tr...

journal_title：BMC pulmonary medicine

authors： Lu H,Chen X,Lu Y,Zhu H,Tang W,Wang Q

更新日期：2019-08-06 00:00:00

abstract：:Following publication of the original article [1], the authors flagged that the article had published with an error in 'Table 1'. ...

journal_title：BMC pulmonary medicine

authors： Kindermann A,Binder L,Baier J,Gündel B,Simm A,Haase R,Bartling B

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:Preterm newborns typically require supplemental oxygen but hyperoxic conditions also damage the premature lung. Oxygen-induced lung damages are mainly studied in newborn mouse models using oxygen concentrations above 75% and looking at short-term effects. Therefore, we aimed at the investigation of long-term...

journal_title：BMC pulmonary medicine

authors： Kindermann A,Binder L,Baier J,Gündel B,Simm A,Haase R,Bartling B

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:Despite the recent increasing worldwide attention towards pulmonary hypertension (PH), its epidemiology remains poorly described in Africa. Accordingly, we performed a systematic review and meta-analysis of PH prevalence, incidence and etiologies in Africa. METHODS:We searched PubMed, EMBASE, African Journa...

journal_title：BMC pulmonary medicine

authors： Bigna JJ,Noubiap JJ,Nansseu JR,Aminde LN

更新日期：2017-12-08 00:00:00

abstract：BACKGROUND:Very few data exist on the management of community-acquired pneumonia (CAP) in patients admitted to hospitals in the Gulf region. The objectives of this study were to describe treatment patterns for CAP in 38 hospitals in five Gulf countries (United Arab Emirates, Kuwait, Bahrain, Oman, and Qatar) and to com...

journal_title：BMC pulmonary medicine

authors： Mahboub B,Al Zaabi A,Al Ali OM,Ahmed R,Niederman MS,El-Bishbishi R

更新日期：2015-09-30 00:00:00

abstract：BACKGROUND:Fine needle aspiration is an important tool for diagnosis and preoperative evaluation of solitary nodules of the lung. It provides a definitive diagnosis in most patients at low cost with minimal trauma. However, because of the nature of the study and the presentation of the cells in a more distorted and inc...

journal_title：BMC pulmonary medicine

authors： Torkian B,Kanthan R,Burbridge B

更新日期：2003-09-08 00:00:00

abstract：BACKGROUND:Asthma is a common chronic disease among young adults, and several studies have reported increased mortality rates in patients with asthma. However, no study has described sudden unexpected death in a nationwide setting in patients with uncontrolled asthma. We defined uncontrolled asthma as a previous hospit...

journal_title：BMC pulmonary medicine

authors： Gullach AJ,Risgaard B,Lynge TH,Jabbari R,Glinge C,Haunsø S,Backer V,Winkel BG,Tfelt-Hansen J

更新日期：2015-04-14 00:00:00

abstract：BACKGROUND:A variety of large randomized controlled trials (RCT's) evaluating pharmacotherapy in chronic obstructive pulmonary disease (COPD) patients does exist. One of the drugs that has been tested is the new long-acting anticholinergic glycopyrronium bromide. METHODS:As the generalizability of results from RCT's i...

journal_title：BMC pulmonary medicine

authors： Kardos P,Vogelmeier C,Buhl R,Criée CP,Worth H

更新日期：2015-01-12 00:00:00

abstract：BACKGROUND:Telehealth has the potential to improve asthma management through regular monitoring of lung function and/or asthma symptoms by health professionals in conjunction with feedback to patients. Although the benefits of telehealth for improving asthma management have been extensively studied, the feasibility of ...

journal_title：BMC pulmonary medicine

authors： Zairina E,Abramson MJ,McDonald CF,Li J,Dharmasiri T,Stewart K,Walker SP,Paul E,George J

更新日期：2015-07-31 00:00:00

abstract：BACKGROUND:Mechanical ventilation (MV), compared to spontaneous breathing (SB), has been found to increase abdominal edema and inflammation in experimental sepsis. Our hypothesis was that in primary acute respiratory distress syndrome (ARDS) MV would enhance inflammation and edema in the abdomen. METHODS:Thirteen pigl...

journal_title：BMC pulmonary medicine

authors： Marchesi S,Hedenstierna G,Hata A,Feinstein R,Larsson A,Larsson AO,Lipcsey M

更新日期：2020-04-25 00:00:00

abstract：BACKGROUND:Pulmonary surfactant D (SP-D) has important regulatory functions for innate immunity and has been implicated as a biomarker for chronic obstructive pulmonary disease (COPD). We hypothesized that COPD patients would have reduced bronchoalveolar lavage (BAL) fluid SP-D levels compared to healthy smoking and no...

journal_title：BMC pulmonary medicine

authors： Moré JM,Voelker DR,Silveira LJ,Edwards MG,Chan ED,Bowler RP

更新日期：2010-10-25 00:00:00

abstract：BACKGROUND:Neurohumoral activation is present in COPD and might provide a link between pulmonary and systemic effects, especially cardiovascular disease. Because long acting inhaled β-agonists reduce hyperinflation, they could reduce sympathoexcitation by improving the inflation reflex. We aimed to evaluate if inhaled ...

journal_title：BMC pulmonary medicine

authors： Haarmann H,Mohrlang C,Tschiesner U,Rubin DB,Bornemann T,Rüter K,Bonev S,Raupach T,Hasenfuß G,Andreas S

更新日期：2015-04-30 00:00:00

abstract：BACKGROUND:We have previously shown that diabetic rats are more susceptible to sepsis, but that the Acute lung injury (ALI) secondary to sepsis is less intense than in non-diabetics. In the present study, we further investigated the ALI-secondary to sepsis in diabetic rats and the effect of insulin treatment. METHODS:...

journal_title：BMC pulmonary medicine

authors： Filgueiras LR,Capelozzi VL,Martins JO,Jancar S

更新日期：2014-11-15 00:00:00

abstract：BACKGROUND:Each year, more than 13.7 million people became an active case of tuberculosis and more than 1.5 million cases of TB patient will die. The association between TB and malnutrition is bi-directional, TB leads the patient to malnutrition, and malnutrition increases the risk of developing active TB by 6 to 10 ti...

journal_title：BMC pulmonary medicine

authors： Feleke BE,Feleke TE,Biadglegne F

更新日期：2019-10-21 00:00:00

abstract：BACKGROUND:The pathological diagnosis of idiopathic interstitial pneumonias (IIP) by surgical lung biopsy is important for clinical decision-making. However, there is a need to use less invasive biomarkers to differentiate nonspecific interstitial pneumonia (NSIP) from other IIP such as usual interstitial pneumonia (UI...

journal_title：BMC pulmonary medicine

authors： Kakugawa T,Yokota S,Mukae H,Kubota H,Sakamoto N,Mizunoe S,Matsuoka Y,Kadota J,Fujii N,Nagata K,Kohno S

更新日期：2008-11-04 00:00:00

abstract：BACKGROUND:Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood. METHODS:TSLP, IL-25, and IL-33 concen...

journal_title：BMC pulmonary medicine

authors： Lee JU,Chang HS,Lee HJ,Jung CA,Bae DJ,Song HJ,Park JS,Uh ST,Kim YH,Seo KH,Park CS

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:In adults, overweight is associated with reduced lung function, in children evidence on this association is conflicting. We examined the association of body mass index (BMI) and waist circumference (WC) at age 12, and of persistently (at ages 8 and 12 years) high BMI and large WC, with forced vital capacity ...

journal_title：BMC pulmonary medicine

authors： Bekkers MB,Wijga AH,Gehring U,Koppelman GH,de Jongste JC,Smit HA,Brunekreef B

更新日期：2015-04-22 00:00:00

abstract：BACKGROUND:The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (IPF). In this study, we investigated the relationship between FV curve pattern and clinical or radio...

journal_title：BMC pulmonary medicine

authors： Nakagawa H,Otoshi R,Isomoto K,Katano T,Baba T,Komatsu S,Hagiwara E,Nakano Y,Kuwahira I,Ogura T

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:US mentholated cigarette sales have increased considerably over 50 years. Preference for mentholated cigarettes is markedly higher in Black people. While menthol itself is not genotoxic or carcinogenic, its acute respiratory effects might affect inhalation of cigarette smoke. This possibility seems consisten...

journal_title：BMC pulmonary medicine

authors： Lee PN

更新日期：2011-04-18 00:00:00

abstract：BACKGROUND:The collection of exhaled breath condensate (EBC) is a suitable and non-invasive method for evaluation of airway inflammation. Several studies indicate that the composition of the condensate and the recovery of biomarkers are affected by physical characteristics of the condensing device and collecting circum...

journal_title：BMC pulmonary medicine

authors： Hoffmeyer F,Raulf-Heimsoth M,Harth V,Bünger J,Brüning T

更新日期：2009-11-30 00:00:00

abstract：BACKGROUND:Diagnosis of lower respiratory tract infections (LRTI) depends on the presence of clinical, radiological and microbiological findings. Endotracheal suction aspirate (ETSA) is the commonest respiratory sample sent for culture from intubated patients. Very few studies have compared quantitative and semi-quanti...

journal_title：BMC pulmonary medicine

authors： Rattani S,Farooqi J,Jabeen G,Chandio S,Kash Q,Khan A,Jabeen K

更新日期：2020-10-29 00:00:00

abstract：BACKGROUND:Zosteriform skin metastasis (ZSM) is rare, and its etiology is not well understood. ZSM is possibly derived from the retrograde movement of cancer cells through the lymphatic vessels during disease development. However, it has been difficult to demonstrate it, as no specific findings have been observed. CAS...

journal_title：BMC pulmonary medicine

authors： Maki Y,Kimizuka Y,Murakami K,Sato K,Sasaki H,Yamamoto T,Watanabe C,Sano T,Miyata J,Fujikura Y,Kawana A

更新日期：2021-01-26 00:00:00

abstract：BACKGROUND:Interleukin-9 (IL-9)-targeted therapies may offer a novel approach for treating asthmatics. Two randomized placebo-controlled studies were conducted to assess the safety profile and potential efficacy of multiple subcutaneous doses of MEDI-528, a humanized anti-IL-9 monoclonal antibody, in asthmatics. METHO...

journal_title：BMC pulmonary medicine

authors： Parker JM,Oh CK,LaForce C,Miller SD,Pearlman DS,Le C,Robbie GJ,White WI,White B,Molfino NA,MEDI-528 Clinical Trials Group.

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:Alveolar volume measured according to the American Thoracic Society-European Respiratory Society (ATS-ERS) guidelines during the single breath diffusion test can be underestimated when there is maldistribution of ventilation. Therefore, the alveolar volume calculated by taking into account the ATS-ERS guidel...

journal_title：BMC pulmonary medicine

authors： Prediletto R,Fornai E,Catapano G,Carli C

更新日期：2007-12-19 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a form of chronic fibrosing interstitial pneumonia characterized by progressive worsening of dyspnea and lung function, with a poor prognosis. The objective of this study was to determine treatment patterns, resource use and costs of managing Spanish patients with IPF. ...

journal_title：BMC pulmonary medicine

authors： Morell F,Esser D,Lim J,Stowasser S,Villacampa A,Nieves D,Brosa M

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:Idiopathic Pulmonary Fibrosis (IPF) is a fatal fibrotic lung disease occurring predominantly in middle-aged and older adults. The traditional diagnostic classification of IPF is based on clinical, radiological, and histopathological features. However, the considerable heterogeneity in IPF presentation sugges...

journal_title：BMC pulmonary medicine

authors： Wang Y,Yella J,Chen J,McCormack FX,Madala SK,Jegga AG

更新日期：2017-10-20 00:00:00

abstract：BACKGROUND:Breathlessness is a common and distressing symptom affecting many patients with advanced disease both from malignant and non-malignant origin. A combination of pharmacological and non-pharmacological measures is necessary to treat this symptom successfully. Breathlessness services in various compositions aim...

journal_title：BMC pulmonary medicine

authors： Bausewein C,Jolley C,Reilly C,Lobo P,Kelly J,Bellas H,Madan P,Panell C,Brink E,De Biase C,Gao W,Murphy C,McCrone P,Moxham J,Higginson IJ

更新日期：2012-09-19 00:00:00

abstract：BACKGROUND:Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems. The symptoms typically present with fever and skin rash, and rapidly progress to multiple organ failures. Vancomycin is a rare drug to cause DRESS s...

journal_title：BMC pulmonary medicine

authors： Wilcox O,Hassanein M,Armstrong J,Kassis N

更新日期：2017-12-28 00:00:00

abstract：BACKGROUND:The dysfunction of airway epithelial barrier is closely related to the pathogenesis of asthma. Secreted Hsp90α participates in inflammation and Hsp90 inhibitor protects endothelial dysfunction. In the current study, we aimed to explore the role of secreted Hsp90α in asthmatic airway epithelial barrier functi...

journal_title：BMC pulmonary medicine

authors： Ye C,Huang C,Zou M,Hu Y,Luo L,Wei Y,Wan X,Zhao H,Li W,Cai S,Dong H

更新日期：2019-11-20 00:00:00

abstract：BACKGROUND:Telehealth and telemonitoring is an emerging area of study in people with cystic fibrosis (CF), with the potential of increasing access to care, and minimising infection control risks to patients without compromising their health outcomes. To date, limited evidence is available to support the use of teleheal...

journal_title：BMC pulmonary medicine

authors： Lang RL,Wilson C,Stockton K,Russell T,Johnston LM

更新日期：2019-01-24 00:00:00