Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report.

abstract：BACKGROUND:Asthma is a chronic inflammatory airway disease characterized by reversible obstruction, inflammation and hyperresponsiveness to different stimulus. Aerobic and breathing exercises have been demonstrated to benefit asthmatic patients; however, there is no evidence comparing the effectiveness of these treatme...

journal_title：BMC pulmonary medicine

authors： Evaristo KB,Saccomani MG,Martins MA,Cukier A,Stelmach R,Rodrigues MR,Santaella DF,Carvalho CR

更新日期：2014-10-17 00:00:00

abstract：BACKGROUND:Cystic Fibrosis (CF) is a monogenic disease with complex expression because of the action of genetic and environmental factors. We investigated whether the ACE gene D/I polymorphism is associated with severity of CF. METHODS:A cross-sectional study was performed, from 2009 to 2011, at University of Campinas...

journal_title：BMC pulmonary medicine

authors： Marson FA,Bertuzzo CS,Hortencio TD,Ribeiro JD,Bonadia LC,Ribeiro AF

更新日期：2012-08-08 00:00:00

abstract：BACKGROUND:Fine needle aspiration is an important tool for diagnosis and preoperative evaluation of solitary nodules of the lung. It provides a definitive diagnosis in most patients at low cost with minimal trauma. However, because of the nature of the study and the presentation of the cells in a more distorted and inc...

journal_title：BMC pulmonary medicine

authors： Torkian B,Kanthan R,Burbridge B

更新日期：2003-09-08 00:00:00

abstract：BACKGROUND:Pulmonary sequestration (PS) is a form of congenital pulmonary malformation that is generally diagnosed in childhood or adolescence and usually resected when diagnosed. We aim to identify the clinical presentation and course of patients diagnosed to have PS during adulthood. METHODS:Using a computer-assiste...

journal_title：BMC pulmonary medicine

authors： Alsumrain M,Ryu JH

更新日期：2018-06-05 00:00:00

abstract：BACKGROUND:Despite advances in asthma treatment, severe asthma (SA) still results in high morbidity and use of health resources. Our hypothesis was that SA patients would achieve adequate control with a systematic protocol, including oral corticosteroids, budesonide/formoterol maintenance and reliever therapy and a mul...

journal_title：BMC pulmonary medicine

authors： Athanazio R,Carvalho-Pinto R,Fernandes FL,Rached S,Rabe K,Cukier A,Stelmach R

更新日期：2016-11-16 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPC) in patients with pulmonary diseases remain to be resolved clinical issue. However, most evidence regarding PPC has been established more than 10 years ago. Therefore, it is necessary to evaluate perioperative management using new inhalant drugs in patients with obs...

journal_title：BMC pulmonary medicine

authors： Numata T,Nakayama K,Fujii S,Yumino Y,Saito N,Yoshida M,Kurita Y,Kobayashi K,Ito S,Utsumi H,Yanagisawa H,Hashimoto M,Wakui H,Minagawa S,Ishikawa T,Hara H,Araya J,Kaneko Y,Kuwano K

更新日期：2018-01-09 00:00:00

abstract：BACKGROUND:Treatment of patients with Cystic Fibrosis homozygous for the Phe508del gene, with Lumacaftor /Ivacaftor (LUM/IVA) improves outcomes in patients with FEV1 > 40% predicted. We set out to observe the most sensitive clinical measure that would change with treatment in terms of exercise capacity or lung function...

journal_title：BMC pulmonary medicine

authors： Wark PAB,Cookson K,Thiruchelvam T,Brannan J,Dorahy DJ

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:One forth whole-world population is infected with Mycobacterium tuberculosis (Mtb), but 90% of them are asymptotic latent infection without any symptoms but positive result in IFN-γ release assay. There is lack of ideal strategy to distinguish active tuberculosis (TB) and latent tuberculosis infection (LTBI)...

journal_title：BMC pulmonary medicine

authors： Wei Z,Li Y,Wei C,Li Y,Xu H,Wu Y,Jia Y,Guo R,Jia J,Qi X,Li Z,Gao X

更新日期：2020-09-18 00:00:00

abstract：:Chemo-radiotherapy and systemic therapies have proven satisfactory outcomes as standard treatments for various thoracic malignancies; however, adverse pulmonary effects, like pneumonitis, can be life-threatening. Pneumonitis is caused by direct cytotoxic effect, oxidative stress, and immune-mediated injury. Radiothera...

journal_title：BMC pulmonary medicine

authors： Arroyo-Hernández M,Maldonado F,Lozano-Ruiz F,Muñoz-Montaño W,Nuñez-Baez M,Arrieta O

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Aspergillus fumigatus is frequently encountered in sputum samples of patients with cystic fibrosis (CF), which traditionally has been interpreted as saprophytic airway colonization. However, this mere bystander role has been challenged by recent data. There is now evidence that Aspergillus fumigatus accelera...

journal_title：BMC pulmonary medicine

authors： Träger J,Melichar VO,Meyer R,Rauh M,Bogdan C,Held J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Anemia is prevalent not only in COPD but also in pulmonary hypertension. We postulated that anemia may have certain prognostic value in COPD concomitant with PH due to COPD (COPD-PH). METHODS:We performed a 12-month prospective investigation to follow up COPD patients with or without PH assessed by right he...

journal_title：BMC pulmonary medicine

authors： Xiong W,Xu M,Pudasaini B,Guo X,Liu J

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Exacerbations, a leading cause of hospitalization in patients with chronic obstructive pulmonary disease (COPD), affect the quality of life and prognosis. Treatment recommendations as provided in the evidence-based guidelines are not consistently followed, partly due to absence of simplified task-oriented ap...

journal_title：BMC pulmonary medicine

authors： Ban A,Ismail A,Harun R,Abdul Rahman A,Sulung S,Syed Mohamed A

更新日期：2012-06-22 00:00:00

abstract：BACKGROUND:Vascular air embolism (VAE) is a rare but important complication that has not been paid enough attention to in the medical process such as surgery and anesthesia. CASE PRESENTATION:We report for the first time that a 54-year-old male patient with central lung cancer developed severe complications of CAE aft...

journal_title：BMC pulmonary medicine

authors： Mo Y,Lin L,Yan J,Zhong C,Kuang J,Guo Q,Li D,Wu M,Sui Z,Zhang J

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:The tracheobronchomalacia is a life-threatening complication of mucopolysaccharidosis (MPS) without known effective, optimal treatment. The severe expiratory collapse of the trachea and bronchi is one of causes of the high rate of deaths in the course of airway impairment in MPSII patients. CASE PRESENTATIO...

journal_title：BMC pulmonary medicine

authors： Gocyk W,Warmus J,Olechnowicz H,Bik-Multanowski M,Pawlinski L,Kiec-Wilk B

更新日期：2020-04-20 00:00:00

abstract：BACKGROUND:Zosteriform skin metastasis (ZSM) is rare, and its etiology is not well understood. ZSM is possibly derived from the retrograde movement of cancer cells through the lymphatic vessels during disease development. However, it has been difficult to demonstrate it, as no specific findings have been observed. CAS...

journal_title：BMC pulmonary medicine

authors： Maki Y,Kimizuka Y,Murakami K,Sato K,Sasaki H,Yamamoto T,Watanabe C,Sano T,Miyata J,Fujikura Y,Kawana A

更新日期：2021-01-26 00:00:00

abstract：BACKGROUND:This study aims to investigate the effects of CCAAT/enhancer binding protein alpha (C/EBPα) overexpression on cell proliferation, apoptosis and surfactant protein-C(SP-C) in alveolar epithelial type II (AEC II) cells after exposure to hyperoxia. METHODS:pcDNA3.1(+)-C/EBPα plasmid or air-empty vector were tr...

journal_title：BMC pulmonary medicine

authors： Lu H,Chen X,Lu Y,Zhu H,Tang W,Wang Q

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Although pleural fluid lactate dehydrogenase (LDH) and adenosine deaminase (ADA) levels are often used to distinguish between tuberculous pleural effusion (TPE) and parapneumonic pleural effusion (PPE), this can be challenging as the LDH level may vary from normal to severely increased in PPE and a significa...

journal_title：BMC pulmonary medicine

authors： Wang J,Liu J,Xie X,Shen P,He J,Zeng Y

更新日期：2017-12-04 00:00:00

abstract：BACKGROUND:The acute respiratory distress syndrome (ARDS) is a serious disease in critically ill patients that is characterized by pulmonary dysfunctions, hypoxemia and significant mortality. Patients with immunodeficiency (e.g. SCID with T and B cell deficiency) are particularly susceptible to the development of sever...

journal_title：BMC pulmonary medicine

authors： Verjans E,Kanzler S,Ohl K,Rieg AD,Ruske N,Schippers A,Wagner N,Tenbrock K,Uhlig S,Martin C

更新日期：2018-11-22 00:00:00

abstract：BACKGROUND:The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and the Medical Outcomes Study Short Form 36 (SF-36) are widely used to assess patient-reported outcome in individuals with pulmonary hypertension (PH). The aim of the study was to compare the psychometric properties of the two measures. METHODS:...

journal_title：BMC pulmonary medicine

authors： Twiss J,McKenna S,Ganderton L,Jenkins S,Ben-L'amri M,Gain K,Fowler R,Gabbay E

更新日期：2013-07-12 00:00:00

abstract：BACKGROUND:Subcutaneous treprostinil is a prostacyclin analogue used to treat pulmonary arterial hypertension (PAH). Due to local pain it can cause a deterioration of heart related quality of life (HRQoL) or even abandonment of treatment. The aim of this paper was to assess the feasibility of treatment with intravenous...

journal_title：BMC pulmonary medicine

authors： Kurzyna M,Małaczyńska-Rajpold K,Koteja A,Pawlak A,Chrzanowski Ł,Furdal M,Gąsior Z,Jacheć W,Sobkowicz B,Norwa J,Mularek-Kubzdela T,Torbicki A

更新日期：2017-12-02 00:00:00

abstract：:Following publication of the original article [1], the authors flagged that the article had published with an error in 'Table 1'. ...

journal_title：BMC pulmonary medicine

authors： Kindermann A,Binder L,Baier J,Gündel B,Simm A,Haase R,Bartling B

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:Despite the recent increasing worldwide attention towards pulmonary hypertension (PH), its epidemiology remains poorly described in Africa. Accordingly, we performed a systematic review and meta-analysis of PH prevalence, incidence and etiologies in Africa. METHODS:We searched PubMed, EMBASE, African Journa...

journal_title：BMC pulmonary medicine

authors： Bigna JJ,Noubiap JJ,Nansseu JR,Aminde LN

更新日期：2017-12-08 00:00:00

abstract：BACKGROUND:The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (IPF). In this study, we investigated the relationship between FV curve pattern and clinical or radio...

journal_title：BMC pulmonary medicine

authors： Nakagawa H,Otoshi R,Isomoto K,Katano T,Baba T,Komatsu S,Hagiwara E,Nakano Y,Kuwahira I,Ogura T

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems. The symptoms typically present with fever and skin rash, and rapidly progress to multiple organ failures. Vancomycin is a rare drug to cause DRESS s...

journal_title：BMC pulmonary medicine

authors： Wilcox O,Hassanein M,Armstrong J,Kassis N

更新日期：2017-12-28 00:00:00

abstract：BACKGROUND:Neurohumoral activation is present in COPD and might provide a link between pulmonary and systemic effects, especially cardiovascular disease. Because long acting inhaled β-agonists reduce hyperinflation, they could reduce sympathoexcitation by improving the inflation reflex. We aimed to evaluate if inhaled ...

journal_title：BMC pulmonary medicine

authors： Haarmann H,Mohrlang C,Tschiesner U,Rubin DB,Bornemann T,Rüter K,Bonev S,Raupach T,Hasenfuß G,Andreas S

更新日期：2015-04-30 00:00:00

abstract：BACKGROUND:Exercise capacity is impaired in pulmonary arterial hypertension (PAH). We hypothesized that cardiovascular reserve abnormalities would be associated with impaired hemodynamic response to pharmacological stress and worse outcome in PAH. METHODS:Eighteen PAH patients (p) group 1 NYHA class II/III and ten con...

journal_title：BMC pulmonary medicine

authors： Domingo E,Grignola JC,Aguilar R,Arredondo C,Bouteldja N,Messeguer ML,Roman A

更新日期：2014-04-24 00:00:00

abstract：BACKGROUND:Although many studies on people with Chronic Obstructive Pulmonary Disease (COPD) have examined the mutual impact of physical status and emotional experience, there is limited knowledge about the way COPD people first-hand perceive their condition. This study was designed to investigate the illness perceptio...

journal_title：BMC pulmonary medicine

authors： Pozzar M,Volpato E,Valota C,Pagnini F,Banfi PI

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:Despite optimal pharmacological therapy and pulmonary rehabilitation, patients with COPD continue to be breathless. There is a need to develop additional strategies to alleviate symptoms. Learning to sing requires control of breathing and posture and might have benefits that translate into daily life. METHO...

journal_title：BMC pulmonary medicine

authors： Lord VM,Cave P,Hume VJ,Flude EJ,Evans A,Kelly JL,Polkey MI,Hopkinson NS

更新日期：2010-08-03 00:00:00

abstract：BACKGROUND:A variety of large randomized controlled trials (RCT's) evaluating pharmacotherapy in chronic obstructive pulmonary disease (COPD) patients does exist. One of the drugs that has been tested is the new long-acting anticholinergic glycopyrronium bromide. METHODS:As the generalizability of results from RCT's i...

journal_title：BMC pulmonary medicine

authors： Kardos P,Vogelmeier C,Buhl R,Criée CP,Worth H

更新日期：2015-01-12 00:00:00

abstract：BACKGROUND:Convenient approaches for accurate biopsy are extremely important to the diagnosis of lung cancer. We aimed to systematically review the clinical updates and development trends of approaches for biopsy, i.e., CT-guided PTNB (Percutaneous Transthoracic Needle Biopsy), ENB (Electromagnetic Navigation Bronchosc...

journal_title：BMC pulmonary medicine

authors： Deng CJ,Dai FQ,Qian K,Tan QY,Wang RW,Deng B,Zhou JH

更新日期：2018-09-03 00:00:00