Determinants of cardiac troponin T elevation in COPD exacerbation - a cross-sectional study.

Abstract:

BACKGROUND:Cardiac Troponin T (cTnT) elevation during exacerbations of chronic obstructive pulmonary disease (COPD) is associated with increased mortality the first year after hospital discharge. The factors associated with cTnT elevation in COPD are not known. METHODS:From our hospital's database, all patients admitted with COPD exacerbation in 2000-03 were identified. 441 had measurement of cTnT performed. Levels of cTnT > or = 0.04 microg/l were considered elevated. Clinical and historical data were retrieved from patient records, hospital and laboratory databases. Odds ratios for cTnT elevation were calculated using logistic regression. RESULTS:120 patients (27%) had elevated cTnT levels. The covariates independently associated with elevated cTnT were increasing neutrophil count, creatinine concentration, heart rate and Cardiac Infarction Injury Score (CIIS), and decreasing hemoglobin concentration. The adjusted odds ratios (95% confidence intervals in parentheses) for cTnT elevation were 1.52 (1.20-1.94) for a 5 x 106/ml increase in neutrophils, 1.21 (1.12-1.32) for a 10 micromol/l increase in creatinine, 0.80 (0.69-0.92) for a 1 mg/dl increase in hemoglobin, 1.24 (1.09-1.42) for a 10 beats/minute increase in heart rate and 1.44 (1.15-1.82) for a 10 point increase in CIIS. CONCLUSION:Multiple factors are associated with cTnT elevation, probably reflecting the wide panorama of comorbid conditions typically seen in COPD. The positive association between neutrophils and cTnT elevation is compatible with the concept that an exaggerated inflammatory response in COPD exacerbation may predispose for myocardial injury.

journal_name

BMC Pulm Med

journal_title

BMC pulmonary medicine

authors

Brekke PH,Omland T,Holmedal SH,Smith P,Søyseth V

doi

10.1186/1471-2466-9-35

subject

Has Abstract

pub_date

2009-07-19 00:00:00

pages

35

issn

1471-2466

pii

1471-2466-9-35

journal_volume

9

pub_type

杂志文章
  • Real-world treatment patterns for patients 80 years and older with early lung cancer: a nationwide claims study.

    abstract:BACKGROUND:Old age is an important factor that could affect the treatment of early-stage lung cancer. In this study, we evaluated the treatment patterns and outcomes of patients over the age of 80 years who had been diagnosed with early-stage lung cancer in real-world practice. METHODS:Elderly patients who were diagno...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-018-0699-0

    authors: Lee K,Kim HO,Choi HK,Seo GH

    更新日期:2018-08-03 00:00:00

  • Birt-Hogg-Dubé syndrome: a literature review and case study of a Chinese woman presenting a novel FLCN mutation.

    abstract:BACKGROUND:The Birt-Hogg-Dubé (BHD) syndrome is a very rare autosomal dominant form of genodermatosis caused by germline mutations in the folliculin (FLCN) gene, which is mapped to the p11.2 region in chromosome 17. BHD commonly presents cutaneous fibrofolliculomas, pulmonary cysts, renal cell carcinoma, and recurrent ...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1186/s12890-017-0383-9

    authors: Hao S,Long F,Sun F,Liu T,Li D,Jiang S

    更新日期:2017-02-21 00:00:00

  • Changes in healthcare utilization and costs associated with sildenafil therapy for pulmonary arterial hypertension: a retrospective cohort study.

    abstract:BACKGROUND:Little is known concerning the degree to which initiation of sildenafil for pulmonary arterial hypertension (PAH) impacts patterns of healthcare utilization and costs. METHODS:Using a large US health insurance claims database, we identified all patients with evidence of PAH (ICD-9-CM diagnosis codes 416.0, ...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-12-75

    authors: Berger A,Edelsberg J,Teal S,Mychaskiw MA,Oster G

    更新日期:2012-12-11 00:00:00

  • Symptom profiles and inflammatory markers in moderate to severe COPD.

    abstract:BACKGROUND:Physical and psychological symptoms are the hallmark of patients' subjective perception of their illness. The purpose of this analysis was to determine if patients with COPD have distinctive symptom profiles and to examine the association of symptom profiles with systemic biomarkers of inflammation. METHODS...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12890-016-0330-1

    authors: Nguyen HQ,Herting JR,Pike KC,Gharib SA,Matute-Bello G,Borson S,Kohen R,Adams SG,Fan VS

    更新日期:2016-12-03 00:00:00

  • Respiratory tract mortality in cement workers: a proportionate mortality study.

    abstract:BACKGROUND:The evidence regarding the association between lung cancer and occupational exposure to cement is controversial. This study investigated causes of deaths from cancer of respiratory tract among cement workers. METHODS:The deaths of the Greek Cement Workers Compensation Scheme were analyzed covering the perio...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-12-30

    authors: Rachiotis G,Drivas S,Kostikas K,Makropoulos V,Hadjichristodoulou C

    更新日期:2012-06-27 00:00:00

  • Role of bronchoalveolar lavage in the diagnosis of acute exacerbations of idiopathic pulmonary fibrosis: a retrospective study.

    abstract:BACKGROUND:It has been recognized that despite previous stability some patients with idiopathic pulmonary fibrosis (IPF) experience acute clinical deteriorations called acute exacerbations of idiopathic pulmonary fibrosis (AEX-IPF). We hypothesized that pulmonary infection can be excluded based on clinical and laborato...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-015-0066-3

    authors: Petrosyan F,Culver DA,Reddy AJ

    更新日期:2015-07-10 00:00:00

  • Case report: atypical presentation of vancomycin induced DRESS syndrome: a case report and review of the literature.

    abstract:BACKGROUND:Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems. The symptoms typically present with fever and skin rash, and rapidly progress to multiple organ failures. Vancomycin is a rare drug to cause DRESS s...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1186/s12890-017-0564-6

    authors: Wilcox O,Hassanein M,Armstrong J,Kassis N

    更新日期:2017-12-28 00:00:00

  • Sepsis-induced lung inflammation is modulated by insulin.

    abstract:BACKGROUND:We have previously shown that diabetic rats are more susceptible to sepsis, but that the Acute lung injury (ALI) secondary to sepsis is less intense than in non-diabetics. In the present study, we further investigated the ALI-secondary to sepsis in diabetic rats and the effect of insulin treatment. METHODS:...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-14-177

    authors: Filgueiras LR,Capelozzi VL,Martins JO,Jancar S

    更新日期:2014-11-15 00:00:00

  • Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease.

    abstract:BACKGROUND:In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact of ...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-017-0544-x

    authors: Kamata H,Asakura T,Suzuki S,Namkoong H,Yagi K,Funatsu Y,Okamori S,Uno S,Uwamino Y,Fujiwara H,Nishimura T,Ishii M,Betsuyaku T,Hasegawa N

    更新日期:2017-12-13 00:00:00

  • Omega-3 fatty acid intake and prevalent respiratory symptoms among U.S. adults with COPD.

    abstract:BACKGROUND:Omega-3 fatty acids, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and derivatives, play a key role in the resolution of inflammation. Higher intake has been linked to decreased morbidity in several diseases, though effects on respiratory diseases like COPD are...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-019-0852-4

    authors: Lemoine S CM,Brigham EP,Woo H,Hanson CK,McCormack MC,Koch A,Putcha N,Hansel NN

    更新日期:2019-05-21 00:00:00

  • Latin America validation of FACED score in patients with bronchiectasis: an analysis of six cohorts.

    abstract:BACKGROUND:The FACED score is an easy-to-use multidimensional grading system that has demonstrated an excellent prognostic value for mortality in patients with bronchiectasis. A Spanish group developed the score but no multicenter international validation has yet been published. METHODS:Retrospective and multicenter s...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12890-017-0417-3

    authors: Athanazio R,Pereira MC,Gramblicka G,Cavalcanti-Lundgren F,de Figueiredo MF,Arancibia F,Rached S,de la Rosa D,Máiz-Carro L,Girón R,Olveira C,Prados C,Martinez-Garcia MA

    更新日期:2017-04-26 00:00:00

  • Comparison between breathing and aerobic exercise on clinical control in patients with moderate-to-severe asthma: protocol of a randomized trial.

    abstract:BACKGROUND:Asthma is a chronic inflammatory airway disease characterized by reversible obstruction, inflammation and hyperresponsiveness to different stimulus. Aerobic and breathing exercises have been demonstrated to benefit asthmatic patients; however, there is no evidence comparing the effectiveness of these treatme...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2466-14-160

    authors: Evaristo KB,Saccomani MG,Martins MA,Cukier A,Stelmach R,Rodrigues MR,Santaella DF,Carvalho CR

    更新日期:2014-10-17 00:00:00

  • Prevalence of asthma in Saudi adults: findings from a national household survey, 2013.

    abstract:BACKGROUND:There are not enough data on the epidemiology of asthma in the Kingdom of Saudi Arabia (KSA). We analyzed data from a national household survey conducted in KSA in 2013 to estimate prevalence, associated risk factors and control measurements of asthma. METHODS:The Saudi Health Interview Survey was a cross-s...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12890-015-0080-5

    authors: Moradi-Lakeh M,El Bcheraoui C,Daoud F,Tuffaha M,Kravitz H,Al Saeedi M,Basulaiman M,Memish ZA,AlMazroa MA,Al Rabeeah AA,Mokdad AH

    更新日期:2015-07-28 00:00:00

  • Microbiological analysis of endotracheal aspirate and endotracheal tube cultures in mechanically ventilated patients.

    abstract:BACKGROUND:To compare the microbiological culture within endotracheal aspirate specimens (ETAs) and endotracheal tube specimens (ETTs) in patients undergoing mechanical ventilation (MV) by statistical tools. METHOD:ETAs and ETTs from a total number of 81 patients, who were undergoing MV at the intensive care unit (ICU...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-019-0926-3

    authors: Shen L,Wang F,Shi J,Xu W,Jiang T,Tang H,Yu X,Yin H,Hu S,Wu X,Chan SK,Sun J,Chang Q

    更新日期:2019-08-27 00:00:00

  • Real-life use of fluticasone propionate/salmeterol in patients with chronic obstructive pulmonary disease: a French observational study.

    abstract:BACKGROUND:In Europe, administration of an inhaled corticosteroid (ICS) combined with a long-acting β2 agonist is approved in chronic obstructive pulmonary disease (COPD) patients with a pre-bronchodilator FEV1 < 60% predicted normal, a history of repeated exacerbations, and who have significant symptoms despite regula...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-14-56

    authors: Roche N,Pribil C,Van Ganse E,Serrier P,Housset B,Poirier D,Texier N,Schück S,Boucot I

    更新日期:2014-04-02 00:00:00

  • Performance of noninvasive ventilation in acute respiratory failure in critically ill patients: a prospective, observational, cohort study.

    abstract:BACKGROUND:Noninvasive ventilation (NIV) is used in critically ill patients with acute respiratory failure (ARF) to avoid endotracheal intubation. However, the impact of NIV use on ARF patient's outcomes is still unclear. Our objectives were to evaluate the rate of NIV failure in hypoxemic patients with an arterial car...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-015-0139-3

    authors: Corrêa TD,Sanches PR,de Morais LC,Scarin FC,Silva E,Barbas CS

    更新日期:2015-11-11 00:00:00

  • Prevalence and etiologies of pulmonary hypertension in Africa: a systematic review and meta-analysis.

    abstract:BACKGROUND:Despite the recent increasing worldwide attention towards pulmonary hypertension (PH), its epidemiology remains poorly described in Africa. Accordingly, we performed a systematic review and meta-analysis of PH prevalence, incidence and etiologies in Africa. METHODS:We searched PubMed, EMBASE, African Journa...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12890-017-0549-5

    authors: Bigna JJ,Noubiap JJ,Nansseu JR,Aminde LN

    更新日期:2017-12-08 00:00:00

  • 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung.

    abstract:BACKGROUND:Pseudomonas aeruginosa infections are associated with progressive life threatening decline of lung function in cystic fibrosis sufferers. Growth of Ps. aeruginosa releases a "grape-like" odour that has been identified as the microbial volatile organic compound 2-aminoacetophenone (2-AA). METHODS:We investig...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-10-56

    authors: Scott-Thomas AJ,Syhre M,Pattemore PK,Epton M,Laing R,Pearson J,Chambers ST

    更新日期:2010-11-07 00:00:00

  • Temporal changes of haematological and radiological findings of the COVID-19 infection-a review of literature.

    abstract:BACKGROUND:COVID-19 is a systemic viral infection which mainly targets the human respiratory system with many secondary clinical manifestations especially affecting the hematopoietic system and haemostasis. Few studies have highlighted the prognostic value of blood findings such as lymphopenia, neutrophil/lymphocyte ra...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-01389-z

    authors: Lim AYH,Goh JL,Chua MCW,Heng BH,Abisheganaden JA,George PP

    更新日期:2021-01-22 00:00:00

  • Reduced forced vital capacity is independently associated with ethnicity, metabolic factors and respiratory symptoms in a Caribbean population: a cross-sectional study.

    abstract:BACKGROUND:Relationships between low forced vital capacity (FVC), and morbidity have previously been studied but there are no data available for the Caribbean population. This study assessed the association of low FVC with risk factors, health variables and socioeconomic status in a community-based study of the Trinida...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-019-0823-9

    authors: Sakhamuri S,Lutchmansingh F,Simeon D,Conyette L,Burney P,Seemungal T

    更新日期:2019-03-14 00:00:00

  • Airway wall thickness on HRCT scans decreases with age and increases with smoking.

    abstract:BACKGROUND:To investigate if age, gender and smoking are associated with airway wall thickness (AWT) measured by high resolution computed tomography (HRCT) and if higher AWT is associated with lower levels of pulmonary function in healthy current- and never-smokers with a wide age range. METHODS:HRCT scans were perfor...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-017-0363-0

    authors: Telenga ED,Oudkerk M,van Ooijen PM,Vliegenthart R,Ten Hacken NH,Postma DS,van den Berge M

    更新日期:2017-02-01 00:00:00

  • Can severe asthmatic patients achieve asthma control? A systematic approach in patients with difficult to control asthma followed in a specialized clinic.

    abstract:BACKGROUND:Despite advances in asthma treatment, severe asthma (SA) still results in high morbidity and use of health resources. Our hypothesis was that SA patients would achieve adequate control with a systematic protocol, including oral corticosteroids, budesonide/formoterol maintenance and reliever therapy and a mul...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-016-0314-1

    authors: Athanazio R,Carvalho-Pinto R,Fernandes FL,Rached S,Rabe K,Cukier A,Stelmach R

    更新日期:2016-11-16 00:00:00

  • Treatment of acute exacerbation of idiopathic pulmonary fibrosis with direct hemoperfusion using a polymyxin B-immobilized fiber column improves survival.

    abstract:BACKGROUND:Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) has an extremely poor prognosis and there is currently no effective treatment for this condition. Direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) improves oxygenation, but it is unclear whether treatment of AE-IPF with PM...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-015-0004-4

    authors: Enomoto N,Mikamo M,Oyama Y,Kono M,Hashimoto D,Fujisawa T,Inui N,Nakamura Y,Yasuda H,Kato A,Mimuro S,Doi M,Sato S,Suda T

    更新日期:2015-02-22 00:00:00

  • Clinical updates of approaches for biopsy of pulmonary lesions based on systematic review.

    abstract:BACKGROUND:Convenient approaches for accurate biopsy are extremely important to the diagnosis of lung cancer. We aimed to systematically review the clinical updates and development trends of approaches for biopsy, i.e., CT-guided PTNB (Percutaneous Transthoracic Needle Biopsy), ENB (Electromagnetic Navigation Bronchosc...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-018-0713-6

    authors: Deng CJ,Dai FQ,Qian K,Tan QY,Wang RW,Deng B,Zhou JH

    更新日期:2018-09-03 00:00:00

  • Comparison of next generation sequencing, SNaPshot assay and real-time polymerase chain reaction for lung adenocarcinoma EGFR mutation assessment.

    abstract:BACKGROUND:The epidermal growth factor receptor (EGFR) mutation status assessment has become increasingly important given the significant impact of tyrosine kinase inhibitors in lung cancer management. Our aim was to compare real life operational characteristics for three EGFR mutation assays - two targeted approaches ...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-016-0250-0

    authors: Cernomaz AT,Macovei II,Pavel I,Grigoriu C,Marinca M,Baty F,Peter S,Zonda R,Brutsche M,Grigoriu B

    更新日期:2016-05-23 00:00:00

  • Novel biomarker genes which distinguish between smokers and chronic obstructive pulmonary disease patients with machine learning approach.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is combination of progressive lung diseases. The diagnosis of COPD is generally based on the pulmonary function testing, however, difficulties underlie in prognosis of smokers or early stage of COPD patients due to the complexity and heterogeneity of the pathogene...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-1062-9

    authors: Matsumura K,Ito S

    更新日期:2020-02-03 00:00:00

  • Is sweat testing for cystic fibrosis feasible in patients with down syndrome?

    abstract:BACKGROUND:Recurrent airway infections are common in patients with Down's syndrome (DS). Hence, ruling out Cystic Fibrosis (CF) in these patients is often required. In the past, the value of sweat testing - the gold standard to diagnose CF - has been questioned in DS as false positive results have been reported. Howeve...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-018-0580-1

    authors: Ruf K,Demerath A,Hebestreit H,Kunzmann S

    更新日期:2018-01-16 00:00:00

  • Quantitative analysis of lung elastic fibers in idiopathic pleuroparenchymal fibroelastosis (IPPFE): comparison of clinical, radiological, and pathological findings with those of idiopathic pulmonary fibrosis (IPF).

    abstract:BACKGROUND:The pathological appearance of idiopathic pleuroparenchymal fibroelastosis (IPPFE) with hematoxylin-eosin staining is similar to that of usual interstitial pneumonia (UIP) in patients with idiopathic pulmonary fibrosis (IPF). The amount of elastic fibers (EF) and detailed differences between IPPFE and IPF ha...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-14-91

    authors: Enomoto N,Kusagaya H,Oyama Y,Kono M,Kaida Y,Kuroishi S,Hashimoto D,Fujisawa T,Yokomura K,Inui N,Nakamura Y,Suda T

    更新日期:2014-05-28 00:00:00

  • Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2.

    abstract:BACKGROUND:Epithelial-mesenchymal transition (EMT) has been believed to be related with chemotherapy resistance in non-small cell lung cancer (NSCLC). Recent studies have suggested eIF5A-2 may function as a proliferation-related oncogene in tumorigenic processes. METHODS:We used cell viability assays, western blotting...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-14-174

    authors: Xu G,Yu H,Shi X,Sun L,Zhou Q,Zheng D,Shi H,Li N,Zhang X,Shao G

    更新日期:2014-11-07 00:00:00

  • Impact of clinical pathway on clinical outcomes in the management of COPD exacerbation.

    abstract:BACKGROUND:Exacerbations, a leading cause of hospitalization in patients with chronic obstructive pulmonary disease (COPD), affect the quality of life and prognosis. Treatment recommendations as provided in the evidence-based guidelines are not consistently followed, partly due to absence of simplified task-oriented ap...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-12-27

    authors: Ban A,Ismail A,Harun R,Abdul Rahman A,Sulung S,Syed Mohamed A

    更新日期:2012-06-22 00:00:00