Abstract:
BACKGROUND:Little is known concerning the degree to which initiation of sildenafil for pulmonary arterial hypertension (PAH) impacts patterns of healthcare utilization and costs. METHODS:Using a large US health insurance claims database, we identified all patients with evidence of PAH (ICD-9-CM diagnosis codes 416.0, 416.8) who received sildenafil between 1/1/2005 and 9/30/2008. Date of the first-noted prescription for sildenafil was designated the "index date," and claims data were compiled for all study subjects for 6 months prior to their index date ("pretreatment") and 6 months thereafter ("follow-up"); patients with incomplete data during either of these periods were excluded. Healthcare utilization and costs were then compared between pretreatment and follow-up for all study subjects. RESULTS:A total of 567 PAH patients were identified who began therapy with sildenafil and met all other study entry criteria. Mean (SD) age was 52 (10) years; 73% were women. Healthcare utilization was largely unchanged between pretreatment and follow-up, the only exceptions being decreases in the mean number of emergency department visits (from 0.7 to 0.5 per patient; p<0.01) and the percentage of patients hospitalized (from 35% to 29%; p=0.01). The mean cost of all PAH-related medication was $7139 during pretreatment and $14,095 during follow-up (sildenafil cost during follow-up= $5236); exclusive of PAH-related medications, however, total healthcare costs decreased modestly (from $30,104 to $27,605) (p<0.01 for all comparisons). CONCLUSIONS:The cost of sildenafil therapy may be partially offset by reductions in other healthcare costs.
journal_name
BMC Pulm Medjournal_title
BMC pulmonary medicineauthors
Berger A,Edelsberg J,Teal S,Mychaskiw MA,Oster Gdoi
10.1186/1471-2466-12-75subject
Has Abstractpub_date
2012-12-11 00:00:00pages
75issn
1471-2466pii
1471-2466-12-75journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Irisin, a recently discovered myokine, is assumed to be secreted by muscle cells in response to exercise and is involved in the regulation of energy metabolism by browning white adipose tissue cells. However, due to the fact that previous studies revealed conflicting results concerning the association betwee...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-015-0035-x
更新日期:2015-04-22 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1186/s12890-018-0663-z
更新日期:2018-06-05 00:00:00
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pub_type: 杂志文章,评审
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,已发布勘误
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更新日期:2020-05-20 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-05-24 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,多中心研究
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
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更新日期:2017-12-16 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
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更新日期:2018-04-03 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-11 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-12-28 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-12-77
更新日期:2012-12-13 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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更新日期:2019-11-27 00:00:00
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更新日期:2019-12-30 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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