Abstract：
BACKGROUND:Pulmonary sequestration (PS) is a form of congenital pulmonary malformation that is generally diagnosed in childhood or adolescence and usually resected when diagnosed. We aim to identify the clinical presentation and course of patients diagnosed to have PS during adulthood. METHODS:Using a computer-assisted search of Mayo clinic medical records, we identified adult patients with PS diagnosed between 1997 and 2016. Clinical and radiological data were collected including postoperative course for those who underwent surgical resection. RESULTS:We identified 32 adult patients with PS; median age at diagnosis was 42 years (IQR 28-53); 17 patients (53%) were men. The median sequestration size was 6.6 cm (IQR 4.4-9.3). The type of sequestration was intralobar in 81% and extralobar in 19%. The most common location was left lower lobe posteromedially (56%). Forty-seven percent of the patients presented with no relevant symptoms. The most common radiographic finding was mass/consolidation in 61% and the most common feeding artery origin was the thoracic aorta (54%). Surgical resection was performed in 18 patients (56%) and postoperative complication was reported in 5 patients (28%). There was no surgical mortality. Median duration of follow-up after diagnosis for unresected cases, most of whom were asymptomatic, was 19 months (IQR 4-26) with no complications related to the PS reported. CONCLUSIONS:Nearly one-half of adult patients with PS present with no relevant symptoms. The decision regarding surgical resection needs to weigh various factors including clinical manifestations related to PS, risk of surgical complications, comorbidities, and individual patient preferences.
journal_name
BMC Pulm Medjournal_title
BMC pulmonary medicineauthors
Alsumrain M,Ryu JHdoi
10.1186/s12890-018-0663-zsubject
Has Abstractpub_date
2018-06-05 00:00:00pages
97issue
1issn
1471-2466pii
10.1186/s12890-018-0663-zjournal_volume
18pub_type
杂志文章abstract：BACKGROUND:Idiopathic Pulmonary Fibrosis (IPF) is a fatal fibrotic lung disease occurring predominantly in middle-aged and older adults. The traditional diagnostic classification of IPF is based on clinical, radiological, and histopathological features. However, the considerable heterogeneity in IPF presentation sugges...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-017-0472-9
更新日期：2017-10-20 00:00:00
abstract：BACKGROUND:Activins are members of the TGF-ß superfamily of growth factors. First, we identified by expression array screening that activin-B and follistatin are upregulated in human idiopathic pulmonary fibrosis (IPF). Next, we wanted to clarify their specific role in lung fibrosis formation. METHODS:We used specific...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/1471-2466-14-170
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Abediterol is a novel, once-daily long-acting β2-agonist in development for the treatment of chronic obstructive pulmonary disease (COPD) and asthma in combination with an anti-inflammatory agent. This Phase IIa, randomised, double-blind, crossover study investigated the bronchodilation, safety, tolerability...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/s12890-016-0266-5
更新日期：2016-07-20 00:00:00
abstract：BACKGROUND:Irisin, a recently discovered myokine, is assumed to be secreted by muscle cells in response to exercise and is involved in the regulation of energy metabolism by browning white adipose tissue cells. However, due to the fact that previous studies revealed conflicting results concerning the association betwee...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-015-0035-x
更新日期：2015-04-22 00:00:00
abstract：BACKGROUND:Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by accumulation of phospholipoproteinaceous material in the alveoli. The presentation is nonspecific but typically includes dyspnea; the spectrum of disease includes rapidly progressive hypoxic respiratory failure. Whole lung lavage (W...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-019-0822-x
更新日期：2019-03-12 00:00:00
abstract：BACKGROUND:The lung-protective ventilation bundle has been shown to reduce mortality in adult acute respiratory distress syndrome (ARDS). This concept has expanded to other areas of acute adult ventilation and is recommended for pediatric ventilation. A component of lung-protective ventilation relies on a prediction of...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-017-0427-1
更新日期：2017-05-23 00:00:00
abstract：BACKGROUND:Clinically hypomyopathic dermatomyositis is a rare disease that is important to recognize, investigate and treat early as it is associated with poor prognosis. In a proportion of patients, myositis specific antibodies could be negative, but with high clinical suspicion, myositis associated antibodies should ...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-018-0622-8
更新日期：2018-04-17 00:00:00
abstract：BACKGROUND:The assessment of airway inflammation for the diagnosis of asthma or COPD is still uncommon in pneumology-specialized general practices. In this respect, the measurement of exhaled nitric oxide (NO), as a fast and simple methodology, is increasingly used. The indirect assessment of airway inflammation, howev...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/1471-2466-8-5
更新日期：2008-02-28 00:00:00
abstract：BACKGROUND:The purpose of the current study was to determine the association between sedentary time and physical activity with clinically relevant health outcomes among adults with impaired spirometry and those with or without self-reported obstructive lung disease (asthma or COPD). METHODS:Data from participants of t...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-018-0659-8
更新日期：2018-06-07 00:00:00
abstract：BACKGROUND:(18)F-FDG PET/CT (PET) is useful in assessing inflammatory activity in sarcoidosis. However, no appropriate indications are available. The aim of this study was to develop a prediction rule that can be used to identify symptomatic sarcoidosis patients who have a high probability of PET-positivity. METHODS:W...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/1471-2466-12-57
更新日期：2012-09-14 00:00:00
abstract：BACKGROUND:The purpose of our study was to assess the frequency of occult foreign body aspiration (FBA) and to evaluate the diagnostic difficulties and therapeutic methods for these patients. METHODS:Between May 2000 and May 2020, 3557 patients with the diagnosis of FBA were treated in our department. Thirty-five pati...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-020-01356-8
更新日期：2020-12-09 00:00:00
abstract：BACKGROUND:IL-17A directly induces epithelial-mesenchymal transition (EMT) in alveolar epithelial cells. It could coordinate with cigarette smoke extract (CSE) to promote proliferation of bronchial epithelial cells. In this study, we aim to explore the direct effect of IL-17A and CSE on EMT in bronchial epithelial cell...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-020-1057-6
更新日期：2020-01-30 00:00:00
abstract：BACKGROUND:There is emerging evidence regarding the efficacy of exercise training to improve exercise capacity for individuals with non-small cell lung cancer (NSCLC). Cardiopulmonary exercise testing (CPET) is the gold standard measure of exercise capacity; however this laboratory test has limitations for use in resea...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-015-0075-2
更新日期：2015-08-12 00:00:00
abstract：BACKGROUND:The 2013 GOLD classification system for COPD distinguishes four stages: A (low symptoms, low exacerbation risk), B (high symptoms, low risk), C (low symptoms, high risk) and D (high symptoms, high risk). Assessment of risk is based on exacerbation history and airflow obstruction, whatever results in a higher...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-2466-14-163
更新日期：2014-10-18 00:00:00
abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rare life-threating interstitial lung disease (ILD). This study characterizes demographics, health care utilization, and comorbidities among elderly IPF patients and estimates prevalence and incidence rates for selected outcomes. METHODS:Cohort study using a large US...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-018-0759-5
更新日期：2019-01-10 00:00:00
abstract：BACKGROUND:Although many studies on people with Chronic Obstructive Pulmonary Disease (COPD) have examined the mutual impact of physical status and emotional experience, there is limited knowledge about the way COPD people first-hand perceive their condition. This study was designed to investigate the illness perceptio...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-020-1157-3
更新日期：2020-05-04 00:00:00
abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) has been believed to be related with chemotherapy resistance in non-small cell lung cancer (NSCLC). Recent studies have suggested eIF5A-2 may function as a proliferation-related oncogene in tumorigenic processes. METHODS:We used cell viability assays, western blotting...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/1471-2466-14-174
更新日期：2014-11-07 00:00:00
abstract：BACKGROUND:Pulmonary non-Hodgkin lymphoma (NHL) is rare. The most frequent subtype of pulmonary NHL is low-grade B-cell lymphoma, such as lymphoma of mucosa-associated lymphoma tissue. Extranodal natural killer cell/T-cell lymphoma, nasal type (ENKL) is characterized by predominant extranodal involvement and associatio...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-019-0815-9
更新日期：2019-02-21 00:00:00
abstract：BACKGROUND:Inhaled bronchodilators including long-acting beta-agonist (LABA) and long-acting muscarinic antagonist (LAMA) play a central role in the treatment of stable chronic obstructive pulmonary disease (COPD). However, it is still unclear whether LABA or LAMA should be used for the initial treatment. Therefore, we...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章,meta分析
doi：10.1186/s12890-020-1152-8
更新日期：2020-04-29 00:00:00
abstract：BACKGROUND:US mentholated cigarette sales have increased considerably over 50 years. Preference for mentholated cigarettes is markedly higher in Black people. While menthol itself is not genotoxic or carcinogenic, its acute respiratory effects might affect inhalation of cigarette smoke. This possibility seems consisten...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章,评审
doi：10.1186/1471-2466-11-18
更新日期：2011-04-18 00:00:00
abstract：BACKGROUND:The long-term prognosis of chronic cough and its determinants need to be clarified. METHODS:This is a prospective, observational cohort study. Eighty-nine unselected subjects with chronic (> 8 weeks' duration) cough were carefully investigated: Clinical examination, symptom questionnaire, Leicester Cough Qu...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-017-0496-1
更新日期：2017-11-21 00:00:00
abstract：BACKGROUND:Asthma patients are enrolled in multimodal pulmonary rehabilitation (PR) programs. However, available data for the effectiveness of PR in asthma are sparse. Therefore, the primary aim of this randomized control trial (RCT) is to evaluate short-term (end of rehabilitation) and intermediate-term effectiveness ...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12890-017-0389-3
更新日期：2017-03-09 00:00:00
abstract：BACKGROUND:CHCHD2 was identified a novel cell migration-promoting gene, which could promote cell migration and altered cell adhesion when ectopically overexpressed in NIH3T3 fibroblasts, and it was identified as a protein necessary for OxPhos function as well. However, the clinic relevance of CHCHD2 expression in NSCLC...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-020-1079-0
更新日期：2020-02-13 00:00:00
abstract：BACKGROUND:Neutrophil-to-lymphocyte ratio (NLR) is a biomarker of inflammation in chronic obstructive pulmonary disease (COPD) patients. But, a meaningful threshold and the longitudinal changes are unknown. We aimed to investigate the association between NLR and the clinical characteristics of COPD patients and to dete...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-018-0639-z
更新日期：2018-05-02 00:00:00
abstract：BACKGROUND:Systemic inflammation plays an important role in the initiation, promotion, and progression of lung carcinogenesis. In patients with non-small cell lung cancer (NSCLC), fibrinogen levels correlate with neoplasia. Here we compared the effects of pulmonary rehabilitation (PR) with chest physical therapy (CPT) ...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-2466-14-121
更新日期：2014-07-28 00:00:00
abstract：BACKGROUND:The FACED score is an easy-to-use multidimensional grading system that has demonstrated an excellent prognostic value for mortality in patients with bronchiectasis. A Spanish group developed the score but no multicenter international validation has yet been published. METHODS:Retrospective and multicenter s...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章,多中心研究
doi：10.1186/s12890-017-0417-3
更新日期：2017-04-26 00:00:00
abstract：BACKGROUND:In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact of ...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-017-0544-x
更新日期：2017-12-13 00:00:00
abstract：BACKGROUND:Dose intensity and dose density of first line Platinum and Etoposide (PE) do not influence Overall Survival (OS) of Small Cell Lung Cancer (SCLC) patients. The effect of treatment length, however, remains unclear. Current guidelines recommend treating beyond 4 cycles -up to 6-, in patients that respond to an...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章,多中心研究
doi：10.1186/s12890-019-0948-x
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Omega-3 fatty acids, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and derivatives, play a key role in the resolution of inflammation. Higher intake has been linked to decreased morbidity in several diseases, though effects on respiratory diseases like COPD are...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/s12890-019-0852-4
更新日期：2019-05-21 00:00:00
abstract：BACKGROUND:The collection of exhaled breath condensate (EBC) is a suitable and non-invasive method for evaluation of airway inflammation. Several studies indicate that the composition of the condensate and the recovery of biomarkers are affected by physical characteristics of the condensing device and collecting circum...
journal_title：BMC pulmonary medicine
pub_type： 杂志文章
doi：10.1186/1471-2466-9-48
更新日期：2009-11-30 00:00:00
