Abstract:
BACKGROUND:Convenient approaches for accurate biopsy are extremely important to the diagnosis of lung cancer. We aimed to systematically review the clinical updates and development trends of approaches for biopsy, i.e., CT-guided PTNB (Percutaneous Transthoracic Needle Biopsy), ENB (Electromagnetic Navigation Bronchoscopy), EBUS-TBNA (Endobroncheal Ultrasonography-Transbronchial Needle Aspiration), mediastinoscopy and CTC (Circulating Tumor Cell). METHODS:Medline and manual searches were performed. We identified the relevant studies, assessed study eligibility, evaluated methodological quality, and summarized diagnostic yields and complications regarding CT-guided PTNB (22 citations), ENB(31 citations), EBUS-TBNA(66 citations), Mediastinoscopy(15 citations) and CTC (19 citations), respectively. RESULTS:The overall sensitivity and specificity of CT-guided PTNB were reported to be 92.52% ± 3.14% and 97.98% ± 3.28%, respectively. The top two complications of CT-guided PTNB was pneumothorax (946/4170:22.69%) and hemorrhage (138/1949:7.08%). The detection rate of lung cancer by ENB increased gradually to 79.79% ± 15.34% with pneumothorax as the top one complication (86/1648:5.2%). Detection rate of EBUS-TBNA was 86.06% ± 9.70% with the top three complications, i.e., hemorrhage (53/8662:0.61%), pneumothorax (46/12432:0.37%) and infection (34/11250:0.30%). The detection rate of mediastinoscopy gradually increased to 92.77% ± 3.99% with .hoarseness as the refractory complication (4/2137:0.19%). Sensitivity and specificity of CTCs detection by using PCR (Polymerase Chain Reaction) were reported to be 78.81% ± 14.72% and 90.88% ± 0.53%, respectively. CONCLUSION:The biopsy approaches should be chosen considering a variety of location and situation of lesions. CT-guided PTNB is effective to reach lung parenchyma, however, diagnostic accuracy and incidence of complications may be impacted by lesion size or needle path length. ENB has an advantage for biopsy of smaller and deeper lesions in lung parenchyma. ENB plus EBUS imaging can further improve the detection rate of lesion in lung parenchyma. EBUS-TBNA is relatively safer and mediastinoscopy provides more tissue acquisition and better diagnostic yield of 4R and 7th lymph node. CTC detection can be considered for adjuvant diagnosis.
journal_name
BMC Pulm Medjournal_title
BMC pulmonary medicineauthors
Deng CJ,Dai FQ,Qian K,Tan QY,Wang RW,Deng B,Zhou JHdoi
10.1186/s12890-018-0713-6subject
Has Abstractpub_date
2018-09-03 00:00:00pages
146issue
1issn
1471-2466pii
10.1186/s12890-018-0713-6journal_volume
18pub_type
杂志文章abstract:BACKGROUND:During the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. With the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12890-016-0332-z
更新日期:2016-11-28 00:00:00
abstract:BACKGROUND:Alveolar volume measured according to the American Thoracic Society-European Respiratory Society (ATS-ERS) guidelines during the single breath diffusion test can be underestimated when there is maldistribution of ventilation. Therefore, the alveolar volume calculated by taking into account the ATS-ERS guidel...
journal_title:BMC pulmonary medicine
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2466-7-18
更新日期:2007-12-19 00:00:00
abstract:BACKGROUND:Although many studies on people with Chronic Obstructive Pulmonary Disease (COPD) have examined the mutual impact of physical status and emotional experience, there is limited knowledge about the way COPD people first-hand perceive their condition. This study was designed to investigate the illness perceptio...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-020-1157-3
更新日期:2020-05-04 00:00:00
abstract:BACKGROUND:The lung-protective ventilation bundle has been shown to reduce mortality in adult acute respiratory distress syndrome (ARDS). This concept has expanded to other areas of acute adult ventilation and is recommended for pediatric ventilation. A component of lung-protective ventilation relies on a prediction of...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-017-0427-1
更新日期:2017-05-23 00:00:00
abstract:BACKGROUND:We have previously shown that diabetic rats are more susceptible to sepsis, but that the Acute lung injury (ALI) secondary to sepsis is less intense than in non-diabetics. In the present study, we further investigated the ALI-secondary to sepsis in diabetic rats and the effect of insulin treatment. METHODS:...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-14-177
更新日期:2014-11-15 00:00:00
abstract:BACKGROUND:There are not enough data on the epidemiology of asthma in the Kingdom of Saudi Arabia (KSA). We analyzed data from a national household survey conducted in KSA in 2013 to estimate prevalence, associated risk factors and control measurements of asthma. METHODS:The Saudi Health Interview Survey was a cross-s...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,多中心研究
doi:10.1186/s12890-015-0080-5
更新日期:2015-07-28 00:00:00
abstract:BACKGROUND:Despite the recent increasing worldwide attention towards pulmonary hypertension (PH), its epidemiology remains poorly described in Africa. Accordingly, we performed a systematic review and meta-analysis of PH prevalence, incidence and etiologies in Africa. METHODS:We searched PubMed, EMBASE, African Journa...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12890-017-0549-5
更新日期:2017-12-08 00:00:00
abstract:BACKGROUND:Cystic Fibrosis (CF) is a monogenic disease with complex expression because of the action of genetic and environmental factors. We investigated whether the ACE gene D/I polymorphism is associated with severity of CF. METHODS:A cross-sectional study was performed, from 2009 to 2011, at University of Campinas...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-12-41
更新日期:2012-08-08 00:00:00
abstract:BACKGROUND:The tracheobronchomalacia is a life-threatening complication of mucopolysaccharidosis (MPS) without known effective, optimal treatment. The severe expiratory collapse of the trachea and bronchi is one of causes of the high rate of deaths in the course of airway impairment in MPSII patients. CASE PRESENTATIO...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-020-1143-9
更新日期:2020-04-20 00:00:00
abstract:BACKGROUND:Mycoplasma pneumoniae is one of the most common pathogens causing community acquired pneumonia in children. Although the rate of macrolide-refractory Mycoplasma pneumoniae (MRMP) has increased, systemic glucocorticoids as a treatment option has not been validated yet. The purpose of this study was to assess ...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,meta分析
doi:10.1186/s12890-019-0990-8
更新日期:2019-12-18 00:00:00
abstract:BACKGROUND:Epithelial-mesenchymal transition (EMT) has been believed to be related with chemotherapy resistance in non-small cell lung cancer (NSCLC). Recent studies have suggested eIF5A-2 may function as a proliferation-related oncogene in tumorigenic processes. METHODS:We used cell viability assays, western blotting...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-14-174
更新日期:2014-11-07 00:00:00
abstract:BACKGROUND:Clinical guidelines specify that diagnosis of interstitial pulmonary fibrosis (IPF) requires identification of usual interstitial pneumonia (UIP) pattern. While UIP can be identified by high resolution CT of the chest, the results are often inconclusive, making surgical lung biopsy necessary to reach a defin...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-017-0485-4
更新日期:2017-11-17 00:00:00
abstract:BACKGROUND:Abediterol is a novel, once-daily long-acting β2-agonist in development for the treatment of chronic obstructive pulmonary disease (COPD) and asthma in combination with an anti-inflammatory agent. This Phase IIa, randomised, double-blind, crossover study investigated the bronchodilation, safety, tolerability...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12890-016-0266-5
更新日期:2016-07-20 00:00:00
abstract:BACKGROUND:To compare the microbiological culture within endotracheal aspirate specimens (ETAs) and endotracheal tube specimens (ETTs) in patients undergoing mechanical ventilation (MV) by statistical tools. METHOD:ETAs and ETTs from a total number of 81 patients, who were undergoing MV at the intensive care unit (ICU...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-019-0926-3
更新日期:2019-08-27 00:00:00
abstract:BACKGROUND:Scleromyxedema is a progressive, systemic connective tissue disorder characterized by fibro-mucous skin lesions and increased serum monoclonal immunoglobulin levels. Pulmonary involvement occurs in a subset of patients, though the overall prevalence of pulmonary lesions in scleromyxedema is unknown. Since pu...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-019-1020-6
更新日期:2020-01-09 00:00:00
abstract:BACKGROUND:The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer improved detection. METHODS:Smear-microscopy, adenosine deaminase (ADA), interferon gamma (IFN-γ), and...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-14-58
更新日期:2014-04-08 00:00:00
abstract:BACKGROUND:Interleukin (IL)-3 amplifies inflammation. However, the effect of IL-3 in acute lung injury (ALI), an acute inflammatory disease, is unclear. The aim of this study was to test the hypothesis that IL-3 plays an important role in hyperoxia-induced ALI. METHODS:Hyperoxic ALI was induced in wild-type (WT) and I...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-018-0725-2
更新日期:2018-10-30 00:00:00
abstract:BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) have increased cardiovascular risk. Natriuretic peptides (NP) in other populations are useful in identifying cardiovascular disease, stratifying risk, and guiding therapy. METHODS:We performed a systematic literature review to examine NP in COPD, ut...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1186/s12890-016-0345-7
更新日期:2017-01-10 00:00:00
abstract:BACKGROUND:The ability to objectively differentiate exacerbations of chronic obstructive pulmonary disease (COPD) from day-to-day symptom variations would be an important development in clinical practice and research. We assessed the ability of domiciliary pulse oximetry to achieve this. METHODS:40 patients with moder...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-10-52
更新日期:2010-10-20 00:00:00
abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a form of chronic fibrosing interstitial pneumonia characterized by progressive worsening of dyspnea and lung function, with a poor prognosis. The objective of this study was to determine treatment patterns, resource use and costs of managing Spanish patients with IPF. ...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-016-0168-6
更新日期:2016-01-12 00:00:00
abstract:BACKGROUND:Influenza is a frequent cause of exacerbations of chronic obstructive pulmonary disease (COPD). Exacerbations are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life, disease progression, death, and ultimately, substantial healthcare-related costs. Despite longstand...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1186/s12890-017-0420-8
更新日期:2017-05-03 00:00:00
abstract:BACKGROUND:Technology offers opportunities to improve healthcare, but little is known about Internet use by COPD patients. We tested two hypotheses: Internet access is associated with socio-demographic disparities and frequency of use is related to perceived needs. METHODS:We analyzed data from a 2007-2008 national co...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-14-66
更新日期:2014-04-22 00:00:00
abstract:BACKGROUND:Asthma is a common chronic disease among young adults, and several studies have reported increased mortality rates in patients with asthma. However, no study has described sudden unexpected death in a nationwide setting in patients with uncontrolled asthma. We defined uncontrolled asthma as a previous hospit...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-015-0033-z
更新日期:2015-04-14 00:00:00
abstract:BACKGROUND:Systemic inflammation plays an important role in the initiation, promotion, and progression of lung carcinogenesis. In patients with non-small cell lung cancer (NSCLC), fibrinogen levels correlate with neoplasia. Here we compared the effects of pulmonary rehabilitation (PR) with chest physical therapy (CPT) ...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2466-14-121
更新日期:2014-07-28 00:00:00
abstract:BACKGROUND:Pseudomonas aeruginosa infections are associated with progressive life threatening decline of lung function in cystic fibrosis sufferers. Growth of Ps. aeruginosa releases a "grape-like" odour that has been identified as the microbial volatile organic compound 2-aminoacetophenone (2-AA). METHODS:We investig...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-10-56
更新日期:2010-11-07 00:00:00
abstract:BACKGROUND:The dysfunction of airway epithelial barrier is closely related to the pathogenesis of asthma. Secreted Hsp90α participates in inflammation and Hsp90 inhibitor protects endothelial dysfunction. In the current study, we aimed to explore the role of secreted Hsp90α in asthmatic airway epithelial barrier functi...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-019-0938-z
更新日期:2019-11-20 00:00:00
abstract:BACKGROUND:It has been recognized that despite previous stability some patients with idiopathic pulmonary fibrosis (IPF) experience acute clinical deteriorations called acute exacerbations of idiopathic pulmonary fibrosis (AEX-IPF). We hypothesized that pulmonary infection can be excluded based on clinical and laborato...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-015-0066-3
更新日期:2015-07-10 00:00:00
abstract:BACKGROUND:The long-term prognosis of chronic cough and its determinants need to be clarified. METHODS:This is a prospective, observational cohort study. Eighty-nine unselected subjects with chronic (> 8 weeks' duration) cough were carefully investigated: Clinical examination, symptom questionnaire, Leicester Cough Qu...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-017-0496-1
更新日期:2017-11-21 00:00:00
abstract:BACKGROUND:Hypoxemia is a major complication of COPD and is a strong predictor of mortality. We previously identified independent risk factors for the presence of resting hypoxemia in the COPDGene cohort. However, little is known about characteristics that predict onset of resting hypoxemia in patients who are normoxic...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,多中心研究
doi:10.1186/s12890-016-0331-0
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a disease with poor prognosis mainly affecting males. Differences in clinical presentation between genders may be important both for the diagnostic work-up and for follow-up. In the present study, we therefore explored potential gender differences at presentation in a S...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-019-0994-4
更新日期:2019-11-27 00:00:00