Abstract:
BACKGROUND:Interleukin (IL)-3 amplifies inflammation. However, the effect of IL-3 in acute lung injury (ALI), an acute inflammatory disease, is unclear. The aim of this study was to test the hypothesis that IL-3 plays an important role in hyperoxia-induced ALI. METHODS:Hyperoxic ALI was induced in wild-type (WT) and IL-3 gene disrupted (IL-3-/-) mice by exposure to 100% O2 for 72 h. RESULTS:Hyperoxia increased IL-3 levels in plasma and lung tissues in WT mice. Pulmonary inflammation and edema were detected by histological assay in WT mice exposed to 100% O2 for 72 h. However, the hyperoxia-induced lung histological changes were improved in IL-3-/- mice. The hyperoxia-induced elevation of neutrophils in bronchoalveolar lavage fluids and circulation were reduced in IL-3-/- mice. Meanwhile, the levels of tumor necrosis factor-α and IL-6 were suppressed in IL-3-/- mice compared with WT mice. Moreover, the hyperoxia-induced the activation of IκBα kinase (IKK) β, IκBα phosphorylation, and nuclear factor-κB translocation were inhibited in IL-3-/- mice compared with WT mice. CONCLUSIONS:Our results suggest IL-3 is a potential therapeutic target for hyperoxia-induced ALI.
journal_name
BMC Pulm Medjournal_title
BMC pulmonary medicineauthors
Huang Z,Zhang W,Yang J,Sun F,Zhou Hdoi
10.1186/s12890-018-0725-2subject
Has Abstractpub_date
2018-10-30 00:00:00pages
164issue
1issn
1471-2466pii
10.1186/s12890-018-0725-2journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) has an extremely poor prognosis and there is currently no effective treatment for this condition. Direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) improves oxygenation, but it is unclear whether treatment of AE-IPF with PM...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-015-0004-4
更新日期:2015-02-22 00:00:00
abstract:BACKGROUND:During the past decades, numerous efforts have been made to decrease the death rate among lung cancer patients. Nonetheless, the improvement in long-term survival has been limited and lung cancer is still a devastating disease. DISCUSSION:With this article we would like to point out that survival of lung ca...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-12-77
更新日期:2012-12-13 00:00:00
abstract:BACKGROUND:Exercise capacity is impaired in pulmonary arterial hypertension (PAH). We hypothesized that cardiovascular reserve abnormalities would be associated with impaired hemodynamic response to pharmacological stress and worse outcome in PAH. METHODS:Eighteen PAH patients (p) group 1 NYHA class II/III and ten con...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-14-69
更新日期:2014-04-24 00:00:00
abstract:BACKGROUND:People with cystic fibrosis (CF) may work in healthcare settings risking nosocomial pathogen acquisition. The aim of this study was to determine the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection in adult healthcare workers with CF (HCWcf). METHODS:Data was collected in this obser...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-016-0243-z
更新日期:2016-05-11 00:00:00
abstract:BACKGROUND:The pathological appearance of idiopathic pleuroparenchymal fibroelastosis (IPPFE) with hematoxylin-eosin staining is similar to that of usual interstitial pneumonia (UIP) in patients with idiopathic pulmonary fibrosis (IPF). The amount of elastic fibers (EF) and detailed differences between IPPFE and IPF ha...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-14-91
更新日期:2014-05-28 00:00:00
abstract:BACKGROUND:Mechanical ventilation (MV), compared to spontaneous breathing (SB), has been found to increase abdominal edema and inflammation in experimental sepsis. Our hypothesis was that in primary acute respiratory distress syndrome (ARDS) MV would enhance inflammation and edema in the abdomen. METHODS:Thirteen pigl...
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pub_type: 杂志文章
doi:10.1186/s12890-020-1138-6
更新日期:2020-04-25 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-020-01311-7
更新日期:2020-10-29 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-015-0053-8
更新日期:2015-05-07 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-12-57
更新日期:2012-09-14 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
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更新日期:2017-12-16 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-019-0823-9
更新日期:2019-03-14 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-015-0066-3
更新日期:2015-07-10 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-10-53
更新日期:2010-10-25 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-9-48
更新日期:2009-11-30 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2466-14-160
更新日期:2014-10-17 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12890-019-0926-3
更新日期:2019-08-27 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,meta分析
doi:10.1186/s12890-020-1152-8
更新日期:2020-04-29 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2466-6-S1-S2
更新日期:2006-11-30 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-019-0993-5
更新日期:2019-12-16 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12890-019-0994-4
更新日期:2019-11-27 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1186/1471-2466-13-77
更新日期:2013-12-30 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-11-07 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2466-11-14
更新日期:2011-02-28 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-8-1
更新日期:2008-01-26 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-07-20 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12890-017-0389-3
更新日期:2017-03-09 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1186/s12890-017-0383-9
更新日期:2017-02-21 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-017-0496-1
更新日期:2017-11-21 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2466-12-5
更新日期:2012-02-16 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12890-020-1057-6
更新日期:2020-01-30 00:00:00