A 12-month, moderate-intensity exercise training program improves fitness and quality of life in adults with asthma: a controlled trial.

abstract：BACKGROUND:The Darlington and Northallerton Asthma Study is an observational cohort study started in 1983. At that time little was published about long term outcome in asthma and the contribution of change in reversible disease or airway remodelling to any excess deterioration in function. The study design included reg...

journal_title：BMC pulmonary medicine

authors： Connolly CK,Prescott RJ

更新日期：2005-01-31 00:00:00

abstract：BACKGROUND:CHCHD2 was identified a novel cell migration-promoting gene, which could promote cell migration and altered cell adhesion when ectopically overexpressed in NIH3T3 fibroblasts, and it was identified as a protein necessary for OxPhos function as well. However, the clinic relevance of CHCHD2 expression in NSCLC...

journal_title：BMC pulmonary medicine

authors： Yin X,Xia J,Sun Y,Zhang Z

更新日期：2020-02-13 00:00:00

abstract：BACKGROUND:Liver dysfunction reflects the status of heart failure, with congestion and low perfusion of the liver serving as causative mechanisms. Previous studies demonstrated relationship between the results of liver function test and the prognosis in patients with heart failure. However, few studies have examined th...

journal_title：BMC pulmonary medicine

authors： Takeda Y,Takeda Y,Tomimoto S,Tani T,Narita H,Kimura G

更新日期：2010-04-22 00:00:00

abstract：BACKGROUND:Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) has an extremely poor prognosis and there is currently no effective treatment for this condition. Direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) improves oxygenation, but it is unclear whether treatment of AE-IPF with PM...

journal_title：BMC pulmonary medicine

authors： Enomoto N,Mikamo M,Oyama Y,Kono M,Hashimoto D,Fujisawa T,Inui N,Nakamura Y,Yasuda H,Kato A,Mimuro S,Doi M,Sato S,Suda T

更新日期：2015-02-22 00:00:00

abstract：BACKGROUND:Omega-3 fatty acids, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and derivatives, play a key role in the resolution of inflammation. Higher intake has been linked to decreased morbidity in several diseases, though effects on respiratory diseases like COPD are...

journal_title：BMC pulmonary medicine

authors： Lemoine S CM,Brigham EP,Woo H,Hanson CK,McCormack MC,Koch A,Putcha N,Hansel NN

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:YKL-40 is an extracellular matrix glycoprotein with a significant role in tissue inflammation and remodeling. MIP-1a has chemotactic and pro-inflammatory properties, and is induced by YKL-40 in several lung disorders. The aim of this study was to determine the levels of YKL-40 and MIP-1a in blood serum and p...

journal_title：BMC pulmonary medicine

authors： Adamidi T,Soulitzis N,Neofytou E,Zannetos S,Georgiou A,Benidis K,Papadopoulos A,Siafakas NM,Schiza SE

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the relationship between dynamic hyperinflation and daily physical activity (DPA) in adults with cystic fibrosis (CF). METHODS:Thirty-four clinically stable CF were studied. All patients undertook incremental cardiopulmonary exercise testing (CPET). CPET-related meas...

journal_title：BMC pulmonary medicine

authors： Savi D,Di Paolo M,Simmonds NJ,Pascucci C,Quattrucci S,Palange P

更新日期：2018-04-19 00:00:00

abstract：BACKGROUND:The purpose of our study was to assess the frequency of occult foreign body aspiration (FBA) and to evaluate the diagnostic difficulties and therapeutic methods for these patients. METHODS:Between May 2000 and May 2020, 3557 patients with the diagnosis of FBA were treated in our department. Thirty-five pati...

journal_title：BMC pulmonary medicine

authors： Liu B,Ding F,An Y,Li Y,Pan Z,Wang G,Dai J,Li H,Wu C

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:The tissue factor (TF)-dependent extrinsic pathway has been suggested to be a central mechanism by which the coagulation cascade is locally activated in the lungs of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) and thus represents an attractive target for therapeutic int...

journal_title：BMC pulmonary medicine

authors： Morris PE,Steingrub JS,Huang BY,Tang S,Liu PM,Rhode PR,Wong HC

更新日期：2012-02-16 00:00:00

abstract：BACKGROUND:Exposure to perinatal anxiety affects disease susceptibility in offspring but studies on the association between perinatal anxiety and gene polymorphisms are lacking. This study aimed to elucidate the interaction between perinatal anxiety and polymorphisms in antioxidant defense and innate immunity genes on ...

journal_title：BMC pulmonary medicine

authors： Lee E,Chang HY,Lee KS,Suh DI,Yu HS,Kang MJ,Choi IA,Park J,Kim KW,Shin YH,Ahn KM,Kwon JY,Choi SJ,Lee KJ,Won HS,Yang SI,Jung YH,Kim HY,Seo JH,Kwon JW,Kim BJ,Kim HB,Lee SY,Kim EJ,Lee JS,Keyes KM,Shin YJ,

更新日期：2014-09-29 00:00:00

abstract：BACKGROUND:Reduced lung function in patients with chronic obstructive pulmonary disease (COPD) is likely due to both environmental and genetic factors. We report here a targeted high-throughput DNA sequencing approach to identify new and previously known genetic variants in a set of candidate genes for COPD. METHODS:E...

journal_title：BMC pulmonary medicine

authors： Matsson H,Söderhäll C,Einarsdottir E,Lamontagne M,Gudmundsson S,Backman H,Lindberg A,Rönmark E,Kere J,Sin D,Postma DS,Bossé Y,Lundbäck B,Klar J

更新日期：2016-11-11 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rare life-threating interstitial lung disease (ILD). This study characterizes demographics, health care utilization, and comorbidities among elderly IPF patients and estimates prevalence and incidence rates for selected outcomes. METHODS:Cohort study using a large US...

journal_title：BMC pulmonary medicine

authors： Mortimer K,Hartmann N,Chan C,Norman H,Wallace L,Enger C

更新日期：2019-01-10 00:00:00

abstract：BACKGROUND:Programmed cell death 5 (PDCD5) was first identified as an apoptosis-promoting protein and involved in some autoimmune diseases and inflammatory processes. Our previous study demonstrated greater expression of serum PDCD5 in asthmatic patients than controls. This study aimed to further explore the significan...

journal_title：BMC pulmonary medicine

authors： Diao X,Wang J,Zhu H,He B

更新日期：2016-11-15 00:00:00

abstract：BACKGROUND:Aspergillus fumigatus is frequently encountered in sputum samples of patients with cystic fibrosis (CF), which traditionally has been interpreted as saprophytic airway colonization. However, this mere bystander role has been challenged by recent data. There is now evidence that Aspergillus fumigatus accelera...

journal_title：BMC pulmonary medicine

authors： Träger J,Melichar VO,Meyer R,Rauh M,Bogdan C,Held J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Pulsus paradoxus estimated by dynamic change in area under the oximeter plethysmograph waveform (PEP) might provide a measure of acute asthma severity. Our primary objective was to determine how well PEP correlates with forced expiratory volume in 1-second (%FEV1) (criterion validity) and change of %FEV1 (re...

journal_title：BMC pulmonary medicine

authors： Arnold DH,Jenkins CA,Hartert TV

更新日期：2010-03-29 00:00:00

abstract：BACKGROUND:Lower respiratory tract infection (LRIs) is very common both in terms of community-acquired infection and hospital-acquired infection. Sputum and bronchoalveolar lavage fluid (BALF) are the most important specimens obtained from patients with LRI. The choice of antibiotic with which to treat LRI usually depe...

journal_title：BMC pulmonary medicine

authors： Peng Z,Zhou J,Tian L

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Anti-tuberculosis therapy requires at least six-month treatment with continuous administration of combined antibiotics, including isoniazid, rifampicin, pyrazinamide, and ethambutol. The long-term exposure to antibiotics could cause consequent changes in gut microbiota, which may alter the gastrointestinal f...

journal_title：BMC pulmonary medicine

authors： Shi W,Hu Y,Zheng X,Ning Z,Wu M,Xia F,Prast-Nielsen S,Hu YOO,Xu B

更新日期：2019-11-11 00:00:00

abstract：BACKGROUND:Noninvasive ventilation (NIV) is used in critically ill patients with acute respiratory failure (ARF) to avoid endotracheal intubation. However, the impact of NIV use on ARF patient's outcomes is still unclear. Our objectives were to evaluate the rate of NIV failure in hypoxemic patients with an arterial car...

journal_title：BMC pulmonary medicine

authors： Corrêa TD,Sanches PR,de Morais LC,Scarin FC,Silva E,Barbas CS

更新日期：2015-11-11 00:00:00

abstract：BACKGROUND:Interleukin (IL)-3 amplifies inflammation. However, the effect of IL-3 in acute lung injury (ALI), an acute inflammatory disease, is unclear. The aim of this study was to test the hypothesis that IL-3 plays an important role in hyperoxia-induced ALI. METHODS:Hyperoxic ALI was induced in wild-type (WT) and I...

journal_title：BMC pulmonary medicine

authors： Huang Z,Zhang W,Yang J,Sun F,Zhou H

更新日期：2018-10-30 00:00:00

abstract：BACKGROUND:Cardiac Troponin T (cTnT) elevation during exacerbations of chronic obstructive pulmonary disease (COPD) is associated with increased mortality the first year after hospital discharge. The factors associated with cTnT elevation in COPD are not known. METHODS:From our hospital's database, all patients admitt...

journal_title：BMC pulmonary medicine

authors： Brekke PH,Omland T,Holmedal SH,Smith P,Søyseth V

更新日期：2009-07-19 00:00:00

abstract：BACKGROUND:Systemic inflammation plays an important role in the initiation, promotion, and progression of lung carcinogenesis. In patients with non-small cell lung cancer (NSCLC), fibrinogen levels correlate with neoplasia. Here we compared the effects of pulmonary rehabilitation (PR) with chest physical therapy (CPT) ...

journal_title：BMC pulmonary medicine

authors： Morano MT,Mesquita R,Da Silva GP,Araújo AS,Pinto JM,Neto AG,Viana CM,De Moraes Filho MO,Pereira ED

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:Telehealth and telemonitoring is an emerging area of study in people with cystic fibrosis (CF), with the potential of increasing access to care, and minimising infection control risks to patients without compromising their health outcomes. To date, limited evidence is available to support the use of teleheal...

journal_title：BMC pulmonary medicine

authors： Lang RL,Wilson C,Stockton K,Russell T,Johnston LM

更新日期：2019-01-24 00:00:00

abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) has been believed to be related with chemotherapy resistance in non-small cell lung cancer (NSCLC). Recent studies have suggested eIF5A-2 may function as a proliferation-related oncogene in tumorigenic processes. METHODS:We used cell viability assays, western blotting...

journal_title：BMC pulmonary medicine

authors： Xu G,Yu H,Shi X,Sun L,Zhou Q,Zheng D,Shi H,Li N,Zhang X,Shao G

更新日期：2014-11-07 00:00:00

abstract：BACKGROUND:The six-minute walk test (6MWT) is a simple, low tech, safe and well established, self-paced assessment tool to quantify functional exercise capacity in adults. The definition of normal 6MWT in children is especially demanding since not only parameters like height, weight and ethnical background influence th...

journal_title：BMC pulmonary medicine

authors： Ulrich S,Hildenbrand FF,Treder U,Fischler M,Keusch S,Speich R,Fasnacht M

更新日期：2013-08-05 00:00:00

abstract：BACKGROUND:People with cystic fibrosis (CF) may work in healthcare settings risking nosocomial pathogen acquisition. The aim of this study was to determine the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection in adult healthcare workers with CF (HCWcf). METHODS:Data was collected in this obser...

journal_title：BMC pulmonary medicine

authors： Wood ME,Sherrard LJ,Ramsay KA,Yerkovich ST,Reid DW,Kidd TJ,Bell SC

更新日期：2016-05-11 00:00:00

abstract：BACKGROUND:Skeletal muscle function dysfunction has been reported in patients with cystic fibrosis (CF). Studies so far showed inconclusive data whether reduced exercise capacity is related to intrinsic muscle dysfunction in CF. METHODS:Twenty patients with CF and 23 age-matched controls completed an incremental cardi...

journal_title：BMC pulmonary medicine

authors： Ruf K,Beer M,Köstler H,Weng AM,Neubauer H,Klein A,Platek K,Roth K,Beneke R,Hebestreit H

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (IPF). In this study, we investigated the relationship between FV curve pattern and clinical or radio...

journal_title：BMC pulmonary medicine

authors： Nakagawa H,Otoshi R,Isomoto K,Katano T,Baba T,Komatsu S,Hagiwara E,Nakano Y,Kuwahira I,Ogura T

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:Diagnosis of lower respiratory tract infections (LRTI) depends on the presence of clinical, radiological and microbiological findings. Endotracheal suction aspirate (ETSA) is the commonest respiratory sample sent for culture from intubated patients. Very few studies have compared quantitative and semi-quanti...

journal_title：BMC pulmonary medicine

authors： Rattani S,Farooqi J,Jabeen G,Chandio S,Kash Q,Khan A,Jabeen K

更新日期：2020-10-29 00:00:00

abstract：BACKGROUND:The ability to objectively differentiate exacerbations of chronic obstructive pulmonary disease (COPD) from day-to-day symptom variations would be an important development in clinical practice and research. We assessed the ability of domiciliary pulse oximetry to achieve this. METHODS:40 patients with moder...

journal_title：BMC pulmonary medicine

authors： Hurst JR,Donaldson GC,Quint JK,Goldring JJ,Patel AR,Wedzicha JA

更新日期：2010-10-20 00:00:00

abstract：BACKGROUND:Asthma is a heterogeneous disease and understanding this heterogeneity will enable the realisation of precision medicine. We sought to compare the sputum and serum inflammatory profiles in moderate-to-severe asthma during stable disease and exacerbation events. METHODS:We recruited 102 adults and 34 childre...

journal_title：BMC pulmonary medicine

authors： Ghebre MA,Pang PH,Desai D,Hargadon B,Newby C,Woods J,Rapley L,Cohen SE,Herath A,Gaillard EA,May RD,Brightling CE

更新日期：2019-08-08 00:00:00