Serological assessment of neutrophil elastase activity on elastin during lung ECM remodeling.

abstract：BACKGROUND:Despite the recent increasing worldwide attention towards pulmonary hypertension (PH), its epidemiology remains poorly described in Africa. Accordingly, we performed a systematic review and meta-analysis of PH prevalence, incidence and etiologies in Africa. METHODS:We searched PubMed, EMBASE, African Journa...

journal_title：BMC pulmonary medicine

authors： Bigna JJ,Noubiap JJ,Nansseu JR,Aminde LN

更新日期：2017-12-08 00:00:00

abstract：BACKGROUND:The six-minute walk test (6MWT) is a simple, low tech, safe and well established, self-paced assessment tool to quantify functional exercise capacity in adults. The definition of normal 6MWT in children is especially demanding since not only parameters like height, weight and ethnical background influence th...

journal_title：BMC pulmonary medicine

authors： Ulrich S,Hildenbrand FF,Treder U,Fischler M,Keusch S,Speich R,Fasnacht M

更新日期：2013-08-05 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPC) in patients with pulmonary diseases remain to be resolved clinical issue. However, most evidence regarding PPC has been established more than 10 years ago. Therefore, it is necessary to evaluate perioperative management using new inhalant drugs in patients with obs...

journal_title：BMC pulmonary medicine

authors： Numata T,Nakayama K,Fujii S,Yumino Y,Saito N,Yoshida M,Kurita Y,Kobayashi K,Ito S,Utsumi H,Yanagisawa H,Hashimoto M,Wakui H,Minagawa S,Ishikawa T,Hara H,Araya J,Kaneko Y,Kuwano K

更新日期：2018-01-09 00:00:00

abstract：BACKGROUND:In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact of ...

journal_title：BMC pulmonary medicine

authors： Kamata H,Asakura T,Suzuki S,Namkoong H,Yagi K,Funatsu Y,Okamori S,Uno S,Uwamino Y,Fujiwara H,Nishimura T,Ishii M,Betsuyaku T,Hasegawa N

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:The outcome of patients with bronchiectasis during and after their stay in the intensive care unit (ICU) has seldom been reported in the literature. Managing these patients in the ICU can be challenging because of the complex nature of their disease. This study aims to identify the in-hospital and long-term ...

journal_title：BMC pulmonary medicine

authors： Alzeer AH,Masood M,Basha SJ,Shaik SA

更新日期：2007-12-10 00:00:00

abstract：BACKGROUND:Cystic Fibrosis (CF) is a monogenic disease with complex expression because of the action of genetic and environmental factors. We investigated whether the ACE gene D/I polymorphism is associated with severity of CF. METHODS:A cross-sectional study was performed, from 2009 to 2011, at University of Campinas...

journal_title：BMC pulmonary medicine

authors： Marson FA,Bertuzzo CS,Hortencio TD,Ribeiro JD,Bonadia LC,Ribeiro AF

更新日期：2012-08-08 00:00:00

abstract：BACKGROUND:Lung ultrasound and echocardiography are mainly applied in critical care and emergency medicine. However, the diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress syndrome (ARDS) is still unclear. METHODS:Consecutive patients admitted to ICU with the diagnosis o...

journal_title：BMC pulmonary medicine

authors： Huang D,Ma H,Xiao Z,Blaivas M,Chen Y,Wen J,Guo W,Liang J,Liao X,Wang Z,Li H,Li J,Chao Y,Wang XT,Wu Y,Qin T,Su K,Wang S,Tan N

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Sarcoidosis is a systemic granulomatous disease caused by CD4+ cell-dominant inflammation. Meanwhile, diffuse panbronchiolitis is a chronic inflammatory respiratory disease predominantly caused by CD8+ lymphocytes and neutrophils. Herein, we report a rare case of sarcoidosis in which the clinical presentatio...

journal_title：BMC pulmonary medicine

authors： Akaba T,Takeyama K,Kondo M,Kobayashi F,Okabayashi A,Sawada T,Tagaya E

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Asthma patients are enrolled in multimodal pulmonary rehabilitation (PR) programs. However, available data for the effectiveness of PR in asthma are sparse. Therefore, the primary aim of this randomized control trial (RCT) is to evaluate short-term (end of rehabilitation) and intermediate-term effectiveness ...

journal_title：BMC pulmonary medicine

authors： Schultz K,Seidl H,Jelusic D,Wagner R,Wittmann M,Faller H,Nowak D,Schuler M

更新日期：2017-03-09 00:00:00

abstract：BACKGROUND:The importance of the lung parenchyma in the pathophysiology of asthma has previously been demonstrated. Considering that nitric oxide synthases (NOS) and arginases compete for the same substrate, it is worthwhile to elucidate the effects of complex NOS-arginase dysfunction in the pathophysiology of asthma, ...

journal_title：BMC pulmonary medicine

authors： Aristoteles LR,Righetti RF,Pinheiro NM,Franco RB,Starling CM,da Silva JC,Pigati PA,Caperuto LC,Prado CM,Dolhnikoff M,Martins MA,Leick EA,Tibério IF

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:The acute respiratory distress syndrome (ARDS) is a serious disease in critically ill patients that is characterized by pulmonary dysfunctions, hypoxemia and significant mortality. Patients with immunodeficiency (e.g. SCID with T and B cell deficiency) are particularly susceptible to the development of sever...

journal_title：BMC pulmonary medicine

authors： Verjans E,Kanzler S,Ohl K,Rieg AD,Ruske N,Schippers A,Wagner N,Tenbrock K,Uhlig S,Martin C

更新日期：2018-11-22 00:00:00

abstract：BACKGROUND:Although many studies on people with Chronic Obstructive Pulmonary Disease (COPD) have examined the mutual impact of physical status and emotional experience, there is limited knowledge about the way COPD people first-hand perceive their condition. This study was designed to investigate the illness perceptio...

journal_title：BMC pulmonary medicine

authors： Pozzar M,Volpato E,Valota C,Pagnini F,Banfi PI

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:Reduced lung function in patients with chronic obstructive pulmonary disease (COPD) is likely due to both environmental and genetic factors. We report here a targeted high-throughput DNA sequencing approach to identify new and previously known genetic variants in a set of candidate genes for COPD. METHODS:E...

journal_title：BMC pulmonary medicine

authors： Matsson H,Söderhäll C,Einarsdottir E,Lamontagne M,Gudmundsson S,Backman H,Lindberg A,Rönmark E,Kere J,Sin D,Postma DS,Bossé Y,Lundbäck B,Klar J

更新日期：2016-11-11 00:00:00

abstract：BACKGROUND:Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality all over the world. Acute exacerbation of COPD (AECOPD) not only accelerates the progression of disease, but also causes hospital administration and death events. Epidemiologic studies have shown air pollution is a high ...

journal_title：BMC pulmonary medicine

authors： Zhou T,Zhong Y,Liao J,Wang G,Li X,Qian X,Xiang P,Chen X,Xu Z,Zhang F,Wang X,Wang S,Li X,Yu C,Zhang Y,Xia G,Dai L

更新日期：2019-01-25 00:00:00

abstract：BACKGROUND:Pulmonary non-Hodgkin lymphoma (NHL) is rare. The most frequent subtype of pulmonary NHL is low-grade B-cell lymphoma, such as lymphoma of mucosa-associated lymphoma tissue. Extranodal natural killer cell/T-cell lymphoma, nasal type (ENKL) is characterized by predominant extranodal involvement and associatio...

journal_title：BMC pulmonary medicine

authors： Yabushita T,Yoshioka S,Furumiya T,Nakamura M,Yamashita D,Imai Y,Ishikawa T

更新日期：2019-02-21 00:00:00

abstract：BACKGROUND:Lower respiratory tract infection (LRIs) is very common both in terms of community-acquired infection and hospital-acquired infection. Sputum and bronchoalveolar lavage fluid (BALF) are the most important specimens obtained from patients with LRI. The choice of antibiotic with which to treat LRI usually depe...

journal_title：BMC pulmonary medicine

authors： Peng Z,Zhou J,Tian L

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Asthma is a chronic inflammatory airway disease characterized by reversible obstruction, inflammation and hyperresponsiveness to different stimulus. Aerobic and breathing exercises have been demonstrated to benefit asthmatic patients; however, there is no evidence comparing the effectiveness of these treatme...

journal_title：BMC pulmonary medicine

authors： Evaristo KB,Saccomani MG,Martins MA,Cukier A,Stelmach R,Rodrigues MR,Santaella DF,Carvalho CR

更新日期：2014-10-17 00:00:00

abstract：BACKGROUND:The aim of this substudy of the ghrelin treatment, multicenter, randomized, double-blind, placebo-controlled trial was to investigate the effects of ghrelin administration on exercise capacity and the underlying mechanisms in underweight patients with chronic obstructive pulmonary disease (COPD) using cardio...

journal_title：BMC pulmonary medicine

authors： Miki K,Maekura R,Nagaya N,Kitada S,Miki M,Yoshimura K,Tateishi Y,Motone M,Hiraga T,Mori M,Kangawa K

更新日期：2013-06-10 00:00:00

abstract：BACKGROUND:Pulmonary rehabilitation offers potential benefits to people with asthma. It is however unknown if rehabilitation favourably affects patients' health care needs. We therefore examined if rehabilitation reduced needs and, in addition, if it improved asthma control. METHODS:One hundred fifty patients with ast...

journal_title：BMC pulmonary medicine

authors： Salandi J,Icks A,Gholami J,Hummel S,Schultz K,Apfelbacher C,Sheikh A,Loerbroks A

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:The lung-protective ventilation bundle has been shown to reduce mortality in adult acute respiratory distress syndrome (ARDS). This concept has expanded to other areas of acute adult ventilation and is recommended for pediatric ventilation. A component of lung-protective ventilation relies on a prediction of...

journal_title：BMC pulmonary medicine

authors： Martin DC,Richards GN

更新日期：2017-05-23 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PH) is a rare disease characterized by proliferation and occlusion of small pulmonary arterioles, which has been associated with a high mortality rate. The pathogenesis of PH is complex and incompletely understood, which includes both genetic and environmental factors that alter vascu...

journal_title：BMC pulmonary medicine

authors： Yin C,Li K,Yu Y,Huang H,Yu Y,Wang Z,Yan J,Pu Y,Li Z,Li D,Chen P,Chen F

更新日期：2018-10-05 00:00:00

abstract：BACKGROUND:Idiopathic Pulmonary Fibrosis (IPF) is a fatal fibrotic lung disease occurring predominantly in middle-aged and older adults. The traditional diagnostic classification of IPF is based on clinical, radiological, and histopathological features. However, the considerable heterogeneity in IPF presentation sugges...

journal_title：BMC pulmonary medicine

authors： Wang Y,Yella J,Chen J,McCormack FX,Madala SK,Jegga AG

更新日期：2017-10-20 00:00:00

abstract：BACKGROUND:Many studies have investigated whether pleural cholesterol levels can aid in diagnosis of pleural exudates, and the results have varied considerably. To gain a more reliable answer to this question, we meta-analyzed the literature on using pleural cholesterol or the ratio of cholesterol in pleural fluid to c...

journal_title：BMC pulmonary medicine

authors： Shen Y,Zhu H,Wan C,Chen L,Wang T,Yang T,Wen F

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood. METHODS:TSLP, IL-25, and IL-33 concen...

journal_title：BMC pulmonary medicine

authors： Lee JU,Chang HS,Lee HJ,Jung CA,Bae DJ,Song HJ,Park JS,Uh ST,Kim YH,Seo KH,Park CS

更新日期：2017-02-15 00:00:00

abstract：:Following publication of the original article [1], the authors flagged that the article had published with an error in 'Table 1'. ...

journal_title：BMC pulmonary medicine

authors： Kindermann A,Binder L,Baier J,Gündel B,Simm A,Haase R,Bartling B

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:A variety of large randomized controlled trials (RCT's) evaluating pharmacotherapy in chronic obstructive pulmonary disease (COPD) patients does exist. One of the drugs that has been tested is the new long-acting anticholinergic glycopyrronium bromide. METHODS:As the generalizability of results from RCT's i...

journal_title：BMC pulmonary medicine

authors： Kardos P,Vogelmeier C,Buhl R,Criée CP,Worth H

更新日期：2015-01-12 00:00:00

abstract：BACKGROUND:Interleukin-9 (IL-9)-targeted therapies may offer a novel approach for treating asthmatics. Two randomized placebo-controlled studies were conducted to assess the safety profile and potential efficacy of multiple subcutaneous doses of MEDI-528, a humanized anti-IL-9 monoclonal antibody, in asthmatics. METHO...

journal_title：BMC pulmonary medicine

authors： Parker JM,Oh CK,LaForce C,Miller SD,Pearlman DS,Le C,Robbie GJ,White WI,White B,Molfino NA,MEDI-528 Clinical Trials Group.

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:IL-17A directly induces epithelial-mesenchymal transition (EMT) in alveolar epithelial cells. It could coordinate with cigarette smoke extract (CSE) to promote proliferation of bronchial epithelial cells. In this study, we aim to explore the direct effect of IL-17A and CSE on EMT in bronchial epithelial cell...

journal_title：BMC pulmonary medicine

authors： Ma L,Jiang M,Zhao X,Sun J,Pan Q,Chu S

更新日期：2020-01-30 00:00:00

abstract：BACKGROUND:In adults, overweight is associated with reduced lung function, in children evidence on this association is conflicting. We examined the association of body mass index (BMI) and waist circumference (WC) at age 12, and of persistently (at ages 8 and 12 years) high BMI and large WC, with forced vital capacity ...

journal_title：BMC pulmonary medicine

authors： Bekkers MB,Wijga AH,Gehring U,Koppelman GH,de Jongste JC,Smit HA,Brunekreef B

更新日期：2015-04-22 00:00:00

abstract：BACKGROUND:Despite advances in asthma treatment, severe asthma (SA) still results in high morbidity and use of health resources. Our hypothesis was that SA patients would achieve adequate control with a systematic protocol, including oral corticosteroids, budesonide/formoterol maintenance and reliever therapy and a mul...

journal_title：BMC pulmonary medicine

authors： Athanazio R,Carvalho-Pinto R,Fernandes FL,Rached S,Rabe K,Cukier A,Stelmach R

更新日期：2016-11-16 00:00:00