Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters.

Abstract:

BACKGROUND:Although the heterogeneous nature of asthma has prompted asthma phenotyping with physiological or biomarker data, these studies have been mostly cross-sectional. Longitudinal studies that assess the stability of phenotypes based on a combination of physiological, clinical and biomarker data are currently lacking. Our objective was to assess the longitudinal stability of clusters derived from repeated measures of airway and physiological data over a 1-year period in moderate and severe asthmatics. METHODS:A total of 125 subjects, 48 with moderate asthma (MA) and 77 with severe asthma (SA) were evaluated every 3 months and monthly, respectively, over a 1-year period. At each 3-month time point, subjects were grouped into 4 asthma clusters (A, B, C, D) based on a combination of clinical (duration of asthma), physiological (FEV1 and BMI) and biomarker (sputum eosinophil count) variables, using k-means clustering. RESULTS:Majority of subjects in clusters A and C had severe asthma (93 % of subjects in cluster A and 79.5 % of subjects in cluster C at baseline). Overall, a total of 59 subjects (47 %) had stable cluster membership, remaining in clusters with the same subjects at each evaluation time. Cluster A was the least stable (21 % stability) and cluster B was the most stable cluster (71 % stability). Cluster stability was not influenced by changes in the dosage of inhaled corticosteroids. CONCLUSION:Asthma phenotyping based on clinical, physiologic and biomarker data identified clusters with significant differences in longitudinal stability over a 1-year period. This finding indicates that the majority of patients within stable clusters can be phenotyped with reasonable accuracy after a single measurement of lung function and sputum eosinophilia, while patients in unstable clusters will require more frequent evaluation of these variables to be properly characterized.

journal_name

BMC Pulm Med

journal_title

BMC pulmonary medicine

authors

Zaihra T,Walsh CJ,Ahmed S,Fugère C,Hamid QA,Olivenstein R,Martin JG,Benedetti A

doi

10.1186/s12890-016-0232-2

subject

Has Abstract

pub_date

2016-05-10 00:00:00

pages

74

issue

1

issn

1471-2466

pii

10.1186/s12890-016-0232-2

journal_volume

16

pub_type

杂志文章
  • Targeted high-throughput sequencing of candidate genes for chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Reduced lung function in patients with chronic obstructive pulmonary disease (COPD) is likely due to both environmental and genetic factors. We report here a targeted high-throughput DNA sequencing approach to identify new and previously known genetic variants in a set of candidate genes for COPD. METHODS:E...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-016-0309-y

    authors: Matsson H,Söderhäll C,Einarsdottir E,Lamontagne M,Gudmundsson S,Backman H,Lindberg A,Rönmark E,Kere J,Sin D,Postma DS,Bossé Y,Lundbäck B,Klar J

    更新日期:2016-11-11 00:00:00

  • The Prospective Non-Interventional DACCORD Study in the National COPD Registry in Germany: design and methods.

    abstract:BACKGROUND:A variety of large randomized controlled trials (RCT's) evaluating pharmacotherapy in chronic obstructive pulmonary disease (COPD) patients does exist. One of the drugs that has been tested is the new long-acting anticholinergic glycopyrronium bromide. METHODS:As the generalizability of results from RCT's i...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-2466-15-2

    authors: Kardos P,Vogelmeier C,Buhl R,Criée CP,Worth H

    更新日期:2015-01-12 00:00:00

  • Clinical utility of blood neutrophil-lymphocyte ratio in Japanese COPD patients.

    abstract:BACKGROUND:Neutrophil-to-lymphocyte ratio (NLR) is a biomarker of inflammation in chronic obstructive pulmonary disease (COPD) patients. But, a meaningful threshold and the longitudinal changes are unknown. We aimed to investigate the association between NLR and the clinical characteristics of COPD patients and to dete...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-018-0639-z

    authors: Sakurai K,Chubachi S,Irie H,Tsutsumi A,Kameyama N,Kamatani T,Koh H,Terashima T,Nakamura H,Asano K,Betsuyaku T

    更新日期:2018-05-02 00:00:00

  • A novel finding related to bulla and bleb formation in patients with primary spontaneous pneumothorax.

    abstract:BACKGROUND:Spontaneous pneumothorax is a common problem globally. Bullas and blebs have been implicated in this problem, but the etiology of their formation is unknown. We aim to show the relation between a novel clinical finding, the pulmonary delayed inflation (PDI) sign, and the etiology of bulla and bleb formation ...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-021-01402-z

    authors: Iyoda A,Azuma Y,Sakai T,Koezuka S,Otsuka H,Sano A

    更新日期:2021-01-09 00:00:00

  • Methicillin-resistant Staphylococcus aureus acquisition in healthcare workers with cystic fibrosis: a retrospective cross-sectional study.

    abstract:BACKGROUND:People with cystic fibrosis (CF) may work in healthcare settings risking nosocomial pathogen acquisition. The aim of this study was to determine the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection in adult healthcare workers with CF (HCWcf). METHODS:Data was collected in this obser...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-016-0243-z

    authors: Wood ME,Sherrard LJ,Ramsay KA,Yerkovich ST,Reid DW,Kidd TJ,Bell SC

    更新日期:2016-05-11 00:00:00

  • Comparison of the effects of pulmonary rehabilitation with chest physical therapy on the levels of fibrinogen and albumin in patients with lung cancer awaiting lung resection: a randomized clinical trial.

    abstract:BACKGROUND:Systemic inflammation plays an important role in the initiation, promotion, and progression of lung carcinogenesis. In patients with non-small cell lung cancer (NSCLC), fibrinogen levels correlate with neoplasia. Here we compared the effects of pulmonary rehabilitation (PR) with chest physical therapy (CPT) ...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2466-14-121

    authors: Morano MT,Mesquita R,Da Silva GP,Araújo AS,Pinto JM,Neto AG,Viana CM,De Moraes Filho MO,Pereira ED

    更新日期:2014-07-28 00:00:00

  • Circulating tumor cells prior to initial treatment is an important prognostic factor of survival in non-small cell lung cancer: a meta-analysis and system review.

    abstract:BACKGROUND:Our study aimed to verify the prognostic value of circulating tumor cells (CTCs) prior to initial treatment on survival of non-small cell lung cancer (NSCLC) by using meta-analysis and system review of published studies. MATERIALS AND METHODS:The PubMed, EMBASE and Cochrane Library were searched, respective...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12890-019-1029-x

    authors: Jiang SS,Deng B,Feng YG,Qian K,Tan QY,Wang RW

    更新日期:2019-12-26 00:00:00

  • Impact of air pollution on respiratory diseases in children with recurrent wheezing or asthma.

    abstract:BACKGROUND:Air pollution has many negative health effects on the general population, especially children, subjects with underlying chronic disease and the elderly. The aims of this study were to evaluate the effects of traffic-related pollution on the exacerbation of asthma and development of respiratory infections in ...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-14-130

    authors: Esposito S,Galeone C,Lelii M,Longhi B,Ascolese B,Senatore L,Prada E,Montinaro V,Malerba S,Patria MF,Principi N

    更新日期:2014-08-07 00:00:00

  • A 12-month, moderate-intensity exercise training program improves fitness and quality of life in adults with asthma: a controlled trial.

    abstract:BACKGROUND:Physical training has been shown to improve exercise capabilities in patients with asthma. Most studies focused on children and younger adults. Previously, the maximum program duration was six months. It is not known whether the same results may be obtained with lower intensity programs and sustained for tim...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-015-0053-8

    authors: Meyer A,Günther S,Volmer T,Taube K,Baumann HJ

    更新日期:2015-05-07 00:00:00

  • Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease.

    abstract:BACKGROUND:In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact of ...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-017-0544-x

    authors: Kamata H,Asakura T,Suzuki S,Namkoong H,Yagi K,Funatsu Y,Okamori S,Uno S,Uwamino Y,Fujiwara H,Nishimura T,Ishii M,Betsuyaku T,Hasegawa N

    更新日期:2017-12-13 00:00:00

  • Interleukin-3 plays a vital role in hyperoxic acute lung injury in mice via mediating inflammation.

    abstract:BACKGROUND:Interleukin (IL)-3 amplifies inflammation. However, the effect of IL-3 in acute lung injury (ALI), an acute inflammatory disease, is unclear. The aim of this study was to test the hypothesis that IL-3 plays an important role in hyperoxia-induced ALI. METHODS:Hyperoxic ALI was induced in wild-type (WT) and I...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-018-0725-2

    authors: Huang Z,Zhang W,Yang J,Sun F,Zhou H

    更新日期:2018-10-30 00:00:00

  • Zosteriform skin metastasis caused by retrograde lymphatic migration of metastatic squamous cell lung carcinoma.

    abstract:BACKGROUND:Zosteriform skin metastasis (ZSM) is rare, and its etiology is not well understood. ZSM is possibly derived from the retrograde movement of cancer cells through the lymphatic vessels during disease development. However, it has been difficult to demonstrate it, as no specific findings have been observed. CAS...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-021-01414-9

    authors: Maki Y,Kimizuka Y,Murakami K,Sato K,Sasaki H,Yamamoto T,Watanabe C,Sano T,Miyata J,Fujikura Y,Kawana A

    更新日期:2021-01-26 00:00:00

  • Diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress syndrome.

    abstract:BACKGROUND:Lung ultrasound and echocardiography are mainly applied in critical care and emergency medicine. However, the diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress syndrome (ARDS) is still unclear. METHODS:Consecutive patients admitted to ICU with the diagnosis o...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-018-0666-9

    authors: Huang D,Ma H,Xiao Z,Blaivas M,Chen Y,Wen J,Guo W,Liang J,Liao X,Wang Z,Li H,Li J,Chao Y,Wang XT,Wu Y,Qin T,Su K,Wang S,Tan N

    更新日期:2018-08-13 00:00:00

  • Spontaneous regression of ALK fusion protein-positive non-small cell lung carcinoma: a case report and review of the literature.

    abstract:BACKGROUND:ALK-rearrangement is observed in < 5% non-small cell lung cancer (NSCLC) cases and prior to the advent of oral tyrosine kinase inhibitors, the natural history of oncogenic NSCLC was typically poor. Literature relating to regression of treatment-naïve NSCLC is limited, and regression without treatment has not...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-01249-w

    authors: Walls M,Walls GM,James JA,Crawford KT,Abdulkhalek H,Lynch TB,Peace AJ,McManus TE,Evans OR

    更新日期:2020-08-06 00:00:00

  • Relationship of flow-volume curve pattern on pulmonary function test with clinical and radiological features in idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (IPF). In this study, we investigated the relationship between FV curve pattern and clinical or radio...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-01254-z

    authors: Nakagawa H,Otoshi R,Isomoto K,Katano T,Baba T,Komatsu S,Hagiwara E,Nakano Y,Kuwahira I,Ogura T

    更新日期:2020-08-12 00:00:00

  • Gene expression analysis in asthma using a targeted multiplex array.

    abstract:BACKGROUND:Gene expression changes in the structural cells of the airways are thought to play a role in the development of asthma and airway hyperresponsiveness. This includes changes to smooth muscle contractile machinery and epithelial barrier integrity genes. We used a targeted gene expression arrays to identify cha...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-017-0545-9

    authors: Pascoe CD,Obeidat M,Arsenault BA,Nie Y,Warner S,Stefanowicz D,Wadsworth SJ,Hirota JA,Jasemine Yang S,Dorscheid DR,Carlsten C,Hackett TL,Seow CY,Paré PD

    更新日期:2017-12-11 00:00:00

  • Comparison between breathing and aerobic exercise on clinical control in patients with moderate-to-severe asthma: protocol of a randomized trial.

    abstract:BACKGROUND:Asthma is a chronic inflammatory airway disease characterized by reversible obstruction, inflammation and hyperresponsiveness to different stimulus. Aerobic and breathing exercises have been demonstrated to benefit asthmatic patients; however, there is no evidence comparing the effectiveness of these treatme...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2466-14-160

    authors: Evaristo KB,Saccomani MG,Martins MA,Cukier A,Stelmach R,Rodrigues MR,Santaella DF,Carvalho CR

    更新日期:2014-10-17 00:00:00

  • Combined effects of leaks, respiratory system properties and upper airway patency on the performance of home ventilators: a bench study.

    abstract:BACKGROUND:Combined effects of leaks, mechanical property of respiratory system and upper airway (UA) patency on patient-ventilator synchrony (PVA) and the level of clinically "tolerable" leaks are not well established in home ventilators. METHODS:We comparatively assessed on a bench model, the highest leak level tole...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-017-0487-2

    authors: Zhu K,Rabec C,Gonzalez-Bermejo J,Hardy S,Aouf S,Escourrou P,Roisman G

    更新日期:2017-11-21 00:00:00

  • 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung.

    abstract:BACKGROUND:Pseudomonas aeruginosa infections are associated with progressive life threatening decline of lung function in cystic fibrosis sufferers. Growth of Ps. aeruginosa releases a "grape-like" odour that has been identified as the microbial volatile organic compound 2-aminoacetophenone (2-AA). METHODS:We investig...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-10-56

    authors: Scott-Thomas AJ,Syhre M,Pattemore PK,Epton M,Laing R,Pearson J,Chambers ST

    更新日期:2010-11-07 00:00:00

  • Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis.

    abstract:BACKGROUND:Plasma levels of cell-free DNA (cf-DNA) are known to be elevated in sepsis and high levels are associated with a poor prognosis. Mechanical ventilation affects systemic inflammation in which lung-protective ventilation attenuates the inflammatory response. The aim was to study the effect of a lung protective...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-01239-y

    authors: Nyberg A,Larsson A,Jylhävä J,Hurme M,Sperber J,Lipcsey M,Castegren M

    更新日期:2020-07-31 00:00:00

  • Respiratory tract mortality in cement workers: a proportionate mortality study.

    abstract:BACKGROUND:The evidence regarding the association between lung cancer and occupational exposure to cement is controversial. This study investigated causes of deaths from cancer of respiratory tract among cement workers. METHODS:The deaths of the Greek Cement Workers Compensation Scheme were analyzed covering the perio...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-12-30

    authors: Rachiotis G,Drivas S,Kostikas K,Makropoulos V,Hadjichristodoulou C

    更新日期:2012-06-27 00:00:00

  • Data driven decision making to characterize clinical personas of parents of children with cystic fibrosis: a mixed methods study.

    abstract:BACKGROUND:Beginning at a young age, children with cystic fibrosis (CF) embark on demanding care regimens that pose challenges to parents. We examined the extent to which clinical, demographic and psychosocial features inform patterns of adherence to pulmonary therapies and how these patterns can be used to develop cli...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-01202-x

    authors: Szczesniak RD,Pestian T,Duan LL,Li D,Stamper S,Ferrara B,Kramer E,Clancy JP,Grossoehme D

    更新日期:2020-06-18 00:00:00

  • Assessing airway inflammation in clinical practice - experience with spontaneous sputum analysis.

    abstract:BACKGROUND:The assessment of airway inflammation for the diagnosis of asthma or COPD is still uncommon in pneumology-specialized general practices. In this respect, the measurement of exhaled nitric oxide (NO), as a fast and simple methodology, is increasingly used. The indirect assessment of airway inflammation, howev...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-8-5

    authors: Holz O,Seiler T,Karmeier A,Fraedrich J,Leiner H,Magnussen H,Jörres RA,Welker L

    更新日期:2008-02-28 00:00:00

  • Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-γ for the evaluation of pleural tuberculosis: a prospective cohort study.

    abstract:BACKGROUND:The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer improved detection. METHODS:Smear-microscopy, adenosine deaminase (ADA), interferon gamma (IFN-γ), and...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/1471-2466-14-58

    authors: Meldau R,Peter J,Theron G,Calligaro G,Allwood B,Symons G,Khalfey H,Ntombenhle G,Govender U,Binder A,van Zyl-Smit R,Dheda K

    更新日期:2014-04-08 00:00:00

  • Singing teaching as a therapy for chronic respiratory disease--a randomised controlled trial and qualitative evaluation.

    abstract:BACKGROUND:Despite optimal pharmacological therapy and pulmonary rehabilitation, patients with COPD continue to be breathless. There is a need to develop additional strategies to alleviate symptoms. Learning to sing requires control of breathing and posture and might have benefits that translate into daily life. METHO...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2466-10-41

    authors: Lord VM,Cave P,Hume VJ,Flude EJ,Evans A,Kelly JL,Polkey MI,Hopkinson NS

    更新日期:2010-08-03 00:00:00

  • Early exposure to hyperoxia and mortality in critically ill patients with severe traumatic injuries.

    abstract:BACKGROUND:Hyperoxia is common early in the course of resuscitation of critically ill patients. It has been associated with mortality in some, but not all, studies of cardiac arrest patients and other critically ill cohorts. Reasons for the inconsistency are unclear and may depend on unmeasured patient confounders, the...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-017-0370-1

    authors: Russell DW,Janz DR,Emerson WL,May AK,Bernard GR,Zhao Z,Koyama T,Ware LB

    更新日期:2017-02-03 00:00:00

  • Enhancing vigilance for cerebral air embolism after pneumonectomy: a case report.

    abstract:BACKGROUND:Vascular air embolism (VAE) is a rare but important complication that has not been paid enough attention to in the medical process such as surgery and anesthesia. CASE PRESENTATION:We report for the first time that a 54-year-old male patient with central lung cancer developed severe complications of CAE aft...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-01358-6

    authors: Mo Y,Lin L,Yan J,Zhong C,Kuang J,Guo Q,Li D,Wu M,Sui Z,Zhang J

    更新日期:2021-01-07 00:00:00

  • Development, effectiveness and cost-effectiveness of a new out-patient Breathlessness Support Service: study protocol of a phase III fast-track randomised controlled trial.

    abstract:BACKGROUND:Breathlessness is a common and distressing symptom affecting many patients with advanced disease both from malignant and non-malignant origin. A combination of pharmacological and non-pharmacological measures is necessary to treat this symptom successfully. Breathlessness services in various compositions aim...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2466-12-58

    authors: Bausewein C,Jolley C,Reilly C,Lobo P,Kelly J,Bellas H,Madan P,Panell C,Brink E,De Biase C,Gao W,Murphy C,McCrone P,Moxham J,Higginson IJ

    更新日期:2012-09-19 00:00:00

  • Worsening pulmonary outcomes during sex reassignment therapy in a transgender female with cystic fibrosis (CF) and asthma/allergic bronchopulmonary aspergillosis: a case report.

    abstract:BACKGROUND:Cystic Fibrosis (CF) is a hereditary pulmonary and extra-pulmonary disease that occurs equally in men and women. However, a difference in morbidity and mortality rates between the sexes has been long documented. Similarly, a sex-disparity in disease severity has been reported in asthma as well. Studies done ...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章

    doi:10.1186/s12890-020-01272-x

    authors: Lam GY,Goodwin J,Wilcox P,Quon BS

    更新日期:2020-08-31 00:00:00

  • Exposure to high endotoxin concentration increases wheezing prevalence among laboratory animal workers: a cross-sectional study.

    abstract:BACKGROUND:Endotoxin from Gram-negative bacteria are found in different concentrations in dust and on the ground of laboratories dealing with small animals and animal houses. METHODS:Cross-sectional study performed in workplaces of two universities. Dust samples were collected from laboratories and animal facilities h...

    journal_title:BMC pulmonary medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12890-016-0233-1

    authors: Freitas AS,Simoneti CS,Ferraz E,Bagatin E,Brandão IT,Silva CL,Borges MC,Vianna EO

    更新日期:2016-05-06 00:00:00