Abstract:
BACKGROUND:Although the heterogeneous nature of asthma has prompted asthma phenotyping with physiological or biomarker data, these studies have been mostly cross-sectional. Longitudinal studies that assess the stability of phenotypes based on a combination of physiological, clinical and biomarker data are currently lacking. Our objective was to assess the longitudinal stability of clusters derived from repeated measures of airway and physiological data over a 1-year period in moderate and severe asthmatics. METHODS:A total of 125 subjects, 48 with moderate asthma (MA) and 77 with severe asthma (SA) were evaluated every 3 months and monthly, respectively, over a 1-year period. At each 3-month time point, subjects were grouped into 4 asthma clusters (A, B, C, D) based on a combination of clinical (duration of asthma), physiological (FEV1 and BMI) and biomarker (sputum eosinophil count) variables, using k-means clustering. RESULTS:Majority of subjects in clusters A and C had severe asthma (93 % of subjects in cluster A and 79.5 % of subjects in cluster C at baseline). Overall, a total of 59 subjects (47 %) had stable cluster membership, remaining in clusters with the same subjects at each evaluation time. Cluster A was the least stable (21 % stability) and cluster B was the most stable cluster (71 % stability). Cluster stability was not influenced by changes in the dosage of inhaled corticosteroids. CONCLUSION:Asthma phenotyping based on clinical, physiologic and biomarker data identified clusters with significant differences in longitudinal stability over a 1-year period. This finding indicates that the majority of patients within stable clusters can be phenotyped with reasonable accuracy after a single measurement of lung function and sputum eosinophilia, while patients in unstable clusters will require more frequent evaluation of these variables to be properly characterized.
journal_name
BMC Pulm Medjournal_title
BMC pulmonary medicineauthors
Zaihra T,Walsh CJ,Ahmed S,Fugère C,Hamid QA,Olivenstein R,Martin JG,Benedetti Adoi
10.1186/s12890-016-0232-2subject
Has Abstractpub_date
2016-05-10 00:00:00pages
74issue
1issn
1471-2466pii
10.1186/s12890-016-0232-2journal_volume
16pub_type
杂志文章abstract:BACKGROUND:Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality all over the world. Acute exacerbation of COPD (AECOPD) not only accelerates the progression of disease, but also causes hospital administration and death events. Epidemiologic studies have shown air pollution is a high ...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-018-0771-9
更新日期:2019-01-25 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-11-40
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1186/1471-2466-12-27
更新日期:2012-06-22 00:00:00
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journal_title:BMC pulmonary medicine
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更新日期:2020-05-15 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-017-0398-2
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,meta分析
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更新日期:2014-11-01 00:00:00
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更新日期:2014-11-15 00:00:00
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更新日期:2020-07-24 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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更新日期:2015-03-08 00:00:00
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pub_type: 杂志文章
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更新日期:2020-04-25 00:00:00