New Drugs for Pediatric Asthma.

abstract：:Severe Combined Immunodeficiencies (SCID) are a heterogeneous group of monogenetic diseases. We describe the typical clinical presentation of patients with SCID as well as basic principles in diagnosis and therapy by hematopoietic stem cell transplantation. Therapeutic strategies may differ between subtypes and the in...

journal_title：Frontiers in pediatrics

authors： Haddad E,Hoenig M

更新日期：2019-11-19 00:00:00

abstract：:Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative diseases (EBV-T/NK-LPDs) are a group of rare diseases resulting from ectopic infection of T or natural killer (NK) lymphocytes with Epstein-Barr virus (EBV). EBV-T/NK-LPDs include chronic active EBV infection, EBV-associated hemophagocytic lymphoh...

journal_title：Frontiers in pediatrics

authors： Kimura H,Fujiwara S

更新日期：2019-01-04 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension is a potentially curable form of pre-capillary pulmonary hypertension (PH) resulting from incomplete resolution of pulmonary thromboemboli. We describe an 11-year-old boy with homozygous sickle cell disease with an indwelling catheter found to have severe PH on routine scr...

journal_title：Frontiers in pediatrics

authors： Spencer R,Valencia Villeda G,Takeda K,Rosenzweig EB

更新日期：2020-07-24 00:00:00

abstract：:Hypertension after kidney transplant is a frequent occurrence in pediatric patients. It is a risk factor for graft loss and contributes to the significant burden of cardiovascular disease (CVD) in this population. The etiology of posttransplant hypertension is multifactorial including donor factors, recipient factors,...

journal_title：Frontiers in pediatrics

authors： Charnaya O,Moudgil A

更新日期：2017-05-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is the second most common leukemia of childhood and is associated with high rates of chemotherapy resistance and relapse. Clinical outcomes for children with AML treated with maximally intensive multi-agent chemotherapy lag far behind those of children with the more common acute lymphoblas...

journal_title：Frontiers in pediatrics

authors： Sexauer AN,Tasian SK

更新日期：2017-11-20 00:00:00

abstract：:Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is an EBV-associated lymphoproliferative disease characterized by repeated or sustainable infectious mononucleosis (IM)-like symptoms. EBV is usually detected in B cells in patients who have IM or Burkitt's lymphoma and even in patients with X-linked lymphoprol...

journal_title：Frontiers in pediatrics

authors： Tanita K,Hoshino A,Imadome KI,Kamiya T,Inoue K,Okano T,Yeh TW,Yanagimachi M,Shiraishi A,Ishimura M,Schober T,Rohlfs M,Takagi M,Imai K,Takada H,Ohga S,Klein C,Morio T,Kanegane H

更新日期：2019-02-04 00:00:00

abstract：:Neonatal encephalopathy (NE) is associated with high mortality and morbidity. Factors predisposing to NE can be antenatal, perinatal, or a combination of both. Antenatal maternal factors, familial factors, genetic predisposition, hypoxic ischemic encephalopathy, infections, placental abnormalities, thrombophilia, coag...

journal_title：Frontiers in pediatrics

authors： Aslam S,Strickland T,Molloy EJ

更新日期：2019-04-16 00:00:00

abstract：:We report a novel homozygous JAK3 mutation in two female Brazilian SCID infants from two unrelated kindreds. Patient 1 was referred at 2 months of age due to a family history of immunodeficiency and the appearance of a facial rash. The infant was screened for TRECs (T-cell receptor excision circles) and KRECs (kappa-d...

journal_title：Frontiers in pediatrics

authors： Barreiros LA,Segundo GRS,Grumach AS,Roxo-Júnior P,Torgerson TR,Ochs HD,Condino-Neto A

更新日期：2018-08-20 00:00:00

abstract：:Objective: Intravenous immunoglobulin (IVIG) therapy is a useful first-line treatment for Kawasaki disease (KD); however, 10-20% of patients fail to respond and require additional IVIG. Soluble CD163 (sCD163) is considered a biomarker for macrophage activation. There are no reports measuring serum sCD163 in KD patient...

journal_title：Frontiers in pediatrics

authors： Azuma Y,Suzuki Y,Okada S,Matsuguma C,Wakiguchi H,Ohnishi Y,Furuta T,Miyake A,Yasudo H,Ichihara K,Ohga S,Hasegawa S

更新日期：2020-04-07 00:00:00

abstract：:Sickle cell disease (SCD) is a severe autosomal recessively inherited disorder of the red blood cell characterized by erythrocyte deformation caused by the polymerization of the abnormal hemoglobin, which leads to erythrocyte deformation and triggers downstream pathological changes. These include abnormal rheology, va...

journal_title：Frontiers in pediatrics

authors： Krishnamurti L

更新日期：2021-01-05 00:00:00

abstract：:In recent decades, new research into the developmental defects and pathophysiological basis of congenital diaphragmatic hernia (CDH) has revealed opportunities for the development of innovative therapies. Importantly, the use of animal models to represent this anomaly in the laboratory has resulted in the discovery of...

journal_title：Frontiers in pediatrics

authors： Chiu PP

更新日期：2014-04-29 00:00:00

abstract：:Premature births continue to rise globally with a corresponding increase in various morbidities among this population. Rates of respiratory distress syndrome and the consequent development of Bronchopulmonary Dysplasia (BPD) are highest among the extremely preterm infants. The majority of extremely low birth weight pr...

journal_title：Frontiers in pediatrics

authors： Sammour I,Karnati S

更新日期：2020-05-08 00:00:00

abstract：:Objective: To examine the understanding of the concept peak oxygen uptake (peak VO2) among children and adolescents at different ages from a developmental perspective. Methods: A total of 549 children and adolescents aged 8 to 16 were recruited and instructed to fill in a 20-item Peak VO2Understanding Inventory develo...

journal_title：Frontiers in pediatrics

authors： Wong SWL,Yu CCW,Li AM

更新日期：2021-01-14 00:00:00

abstract：:Severe accidental hypothermia has been demonstrated to affect ventricular systolic and diastolic functions, and rewarming might be responsible of cardiovascular collapse. Until now, there have been only a few reports on severe accidental hypothermia, none of which involved children. Herein, we describe here a rare cas...

journal_title：Frontiers in pediatrics

authors： Vicinanza A,De Laet C,Rooze S,Willems A,Beretta-Piccoli X,Vens D,Voglet C,Jacquemart C,Massin M,Biarent D

更新日期：2019-03-29 00:00:00

abstract：:Introduction: Low-income and racial/ethnic minority preschoolers (aged 2-5 years) are disproportionately affected by obesity and its associated health consequences. Individual-level factors (e.g., diet) and environmental factors (e.g., neighborhood conditions) contribute to these disparities. However, there is limited...

journal_title：Frontiers in pediatrics

authors： Showell NN,Jennings JM,Johnson KA,Perin J,Thornton RLJ

更新日期：2019-01-22 00:00:00

abstract：:We report on the results of a literature review regarding the indications and results of operations to increase bladder outlet resistance to achieve dryness in children with neurogenic sphincter incompetence (NSBD). The relative advantages and disadvantages of injection of bulking agents, periurethral slings, bladder ...

journal_title：Frontiers in pediatrics

authors： Ludwikowski BM,Bieda JC,Lingnau A,González R

更新日期：2019-03-26 00:00:00

abstract：:A subset of patients with Ataxia-Telangiectasia (A-T) have dramatically reduced levels of IgG, IgA, and IgE with retained or elevated IgM levels. Several reports suggest that these A-T patients with a "hyper-IgM phenotype" (HIgM) suffer more clinical immunologic consequences than other A-T patients. The immunopatholog...

journal_title：Frontiers in pediatrics

authors： Meyer AK,Banks M,Nadasdy T,Clark JJ,Zheng R,Gelfand EW,Abbott JK

更新日期：2019-10-24 00:00:00

abstract：:Emerging literature suggests that delayed identification of childhood asthma results in an increased risk of long-term and various morbidities compared to those with timely diagnosis and intervention, and yet this risk is still overlooked. Even when children and adolescents have a history of recurrent asthma-like symp...

journal_title：Frontiers in pediatrics

authors： Seol HY,Sohn S,Liu H,Wi CI,Ryu E,Park MA,Juhn YJ

更新日期：2019-04-02 00:00:00

abstract：:To date, the only known effective treatment for celiac disease (CD) is a strict gluten-free diet (GFD) for life. Patients with CD often find it difficult to adhere to strict GFD. Oats, compared with wheat, barley, and rye, contain less amounts of prolamins. Inclusion of oats in a GFD might be valuable due to their nut...

journal_title：Frontiers in pediatrics

authors： Spector Cohen I,Day AS,Shaoul R

更新日期：2019-09-26 00:00:00

abstract：:Background and Aim: Intestinal failure-associated liver disease (IFALD) affects one-fifth of neonates receiving parenteral nutrition (PN) for more than 2 weeks. We aimed to define the effect of IFALD on hemostasis of preterm infants. Methods: This is an ancillary analysis of a prospective study aimed at defining coagu...

journal_title：Frontiers in pediatrics

authors： Ghirardello S,Raffaeli G,Scalambrino E,Cortesi V,Roggero P,Peyvandi F,Mosca F,Tripodi A

更新日期：2020-08-26 00:00:00

abstract：:Fetal sex is associated with striking differences during in utero development, fetal-to-neonatal transition, and postnatal morbidity and mortality. Male sex fetuses are apparently protected while in utero resulting in a higher secondary sex rate for males than for females. However, during fetal-to-neonatal transition ...

journal_title：Frontiers in pediatrics

authors： Lorente-Pozo S,Parra-Llorca A,Torres B,Torres-Cuevas I,Nuñez-Ramiro A,Cernada M,García-Robles A,Vento M

更新日期：2018-04-23 00:00:00

abstract：:Background: Survival of very-low-birth-weight infants is improving in neonatology and family-centered-care might contribute to premature infants' clinical outcomes. Aim: To evaluate a family-centered care intervention on clinical outcomes of very-low-birth-weight infants. Methods: A quasi-experimental study was conduc...

journal_title：Frontiers in pediatrics

authors： Lv B,Gao XR,Sun J,Li TT,Liu ZY,Zhu LH,Latour JM

更新日期：2019-04-12 00:00:00

abstract：:Although antibiotics confer significant health benefits in treating or preventing bacterial infections, an accumulating wealth of evidence illustrates their detrimental effect on host-microbiota homeostasis, posing a serious menace to the global public health. In recent years, it is becoming evident that infants, who ...

journal_title：Frontiers in pediatrics

authors： Shekhar S,Petersen FC

更新日期：2020-10-15 00:00:00

abstract：:Like most specialties, pediatric surgery is becoming more complex, and changes to health systems have not always been in the best interests of trainees or their surgical teachers. This paper outlines four of the current challenges faced by training boards in pediatric surgery worldwide, and documents their implication...

journal_title：Frontiers in pediatrics

authors： Beasley SW

更新日期：2013-09-11 00:00:00

abstract：:Background: Improved diagnostic tests are needed for the early identification of Mycobacterium tuberculosis-infected young children exposed to an active TB (aTB) index case. We aimed to compare the diagnostic accuracy of new blood-based tests to that of the tuberculin skin test (TST) for the identification of all infe...

journal_title：Frontiers in pediatrics

authors： Dreesman A,Dirix V,Smits K,Corbière V,Van Praet A,Debulpaep S,De Schutter I,Felderhof MK,Malfroot A,Singh M,Locht C,Mouchet F,Mascart F

更新日期：2019-07-25 00:00:00

abstract：:Background: Clinical practice guidelines recommended that hypertension in children and adolescents should be defined based on elevated blood pressure (BP) on at least three separate occasions. Therefore, in the present study, we aimed to estimate the prevalence of hypertension based on three separate visits among Chin...

journal_title：Frontiers in pediatrics

authors： Zhang Q,Yang L,Zhang Y,Zhao M,Liang Y,Xi B

更新日期：2019-07-24 00:00:00

abstract：:Autosomal dominant hyper-IgE syndrome caused by mutations in the transcription factor STAT3 (AD-HIES) is characterized by a collection of immunologic and non-immune features including eczema, recurrent infections, elevated IgE levels, and connective tissue anomalies. We report the case of a Qatari child with a history...

journal_title：Frontiers in pediatrics

authors： Chaimowitz NS,Branch J,Reyes A,Vargas-Hernández A,Orange JS,Forbes LR,Ehlayel M,Purayil SC,Al-Nesf MA,Vogel TP

更新日期：2019-04-24 00:00:00

abstract：:Objective: The objective of the study is to test whether the use of edible oil might be an early treatment strategy for reducing button battery-induced esophageal injury. Methods: A button battery was inserted into esophageal segments collected from pigs. The esophageal segments were randomly allotted to one of the fo...

journal_title：Frontiers in pediatrics

authors： Jia W,Zhang B,Xu G,Xie J,Wei H,Shan N,Wang Q,Yin W,Zhao W

更新日期：2020-03-13 00:00:00

abstract：:Autoimmune Congenital Heart Block (CHB) is an immune-mediated disease due to transplacental passage of circulating anti-Ro/SSA and anti-La/SSB autoantibodies. It occurs in 2% of anti-Ro/SSA-exposed pregnancies, and recurrence rate is nine times higher in subsequent pregnancies. Aim of this review is to identify biomar...

journal_title：Frontiers in pediatrics

authors： De Carolis S,Garufi C,Garufi E,De Carolis MP,Botta A,Tabacco S,Salvi S

更新日期：2020-12-22 00:00:00

abstract：:Bronchial asthma is one of the most common chronic inflammatory diseases of the airways. In the pathogenesis of this disease, the interplay among the genes, intrinsic, and extrinsic factors are crucial. Various combinations of the involved factors determine and modify the final clinical phenotype/endotype of asthma. O...

journal_title：Frontiers in pediatrics

authors： Jesenak M,Zelieskova M,Babusikova E

更新日期：2017-07-24 00:00:00