Early Identification of Childhood Asthma: The Role of Informatics in an Era of Electronic Health Records.

abstract：:Introduction: Surfactant proteins (SP) have been shown to be inherent proteins of the human CNS and are altered during acute and chronic disturbances of CSF circulation. Aim of the study was to examine the changes of surfactant protein concentrations in CSF of preterm babies suffering from intraventricular hemorrhage....

journal_title：Frontiers in pediatrics

authors： Krause M,Härtig W,Mahr CV,Richter C,Schob J,Puchta J,Hoffmann KT,Nestler U,Thome U,Knüpfer M,Gebauer C,Schob S

更新日期：2020-09-25 00:00:00

abstract：OBJECTIVE:We investigated the relationship between influenza seasonality and outcome of very low birth weight infants (VLBWI) in a large observational cohort study of the German Neonatal Network. MATERIALS AND METHODS:Within the observational period (July 2009 until December 2014), five influenza seasons occurred (mea...

journal_title：Frontiers in pediatrics

authors： Härtel C,Humberg A,Viemann D,Stein A,Orlikowsky T,Rupp J,Kopp MV,Herting E,Göpel W

更新日期：2016-11-30 00:00:00

abstract：:Selective attention and efficacy are important components of scholastic performance in school children. While attempts are being made to introduce new methods to improve academic performance either as part of curricular or extracurricular activities in schools, the success rates are minimal. Hence, this study assessed...

journal_title：Frontiers in pediatrics

authors： Das M,Deepeshwar S,Subramanya P,Manjunath NK

更新日期：2016-06-15 00:00:00

abstract：:Objective: 11β-hydroxylase deficiency (11βOHD) is a rare autosomal recessive disorder caused by mutations in the CYP11B1 gene. It is characterized by virilization, hypertension, and significant final height impairment. In this study, we aim to investigate the clinical and molecular characteristics of four unrelated Ch...

journal_title：Frontiers in pediatrics

authors： Zhou Q,Wang D,Wang C,Zheng B,Liu Q,Zhu Z,Jia Z,Gu W

更新日期：2020-07-24 00:00:00

abstract：:Purpose: To explore the lung function of bronchopulmonary dysplasia (BPD) in premature infants to guide clinical prevention, early diagnosis and treatment. Methods: Thirty infants with BPD at 4-36 months of corrected gestational age were enrolled and divided into mild BPD and moderate and severe BPD groups. Thirty ful...

journal_title：Frontiers in pediatrics

authors： Chen D,Chen J,Cui N,Cui M,Chen X,Zhu X,Zhu X

更新日期：2020-01-10 00:00:00

abstract：:Autosomal dominant hyper-IgE syndrome caused by mutations in the transcription factor STAT3 (AD-HIES) is characterized by a collection of immunologic and non-immune features including eczema, recurrent infections, elevated IgE levels, and connective tissue anomalies. We report the case of a Qatari child with a history...

journal_title：Frontiers in pediatrics

authors： Chaimowitz NS,Branch J,Reyes A,Vargas-Hernández A,Orange JS,Forbes LR,Ehlayel M,Purayil SC,Al-Nesf MA,Vogel TP

更新日期：2019-04-24 00:00:00

abstract：:Ataxia-telangiectasia (A-T) is an autosomal recessive disorder characterized by neurodegeneration, combined immunodeficiency, and oculocutaneous telangiectasia. The hyper-IgM phenotype of A-T, correlating with a class-switch recombination defect, IgG and IgA deficiency, T helper and B cell lymphopenia, immune dysregul...

journal_title：Frontiers in pediatrics

authors： Szczawińska-Popłonyk A,Ossowska L,Jończyk-Potoczna K

更新日期：2020-11-19 00:00:00

abstract：:Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder characterized by early onset of severe rickets, with a complete triad of clinical, biochemical and skeletal abnormalities. Homozygous or heterozygous mutations in the vitamin D receptor (VDR) gene leading to complete or partial target or...

journal_title：Frontiers in pediatrics

authors： Nicolescu RC,Lombet J,Cavalier E

更新日期：2018-11-28 00:00:00

abstract：OBJECTIVES:To determine the influence of family, peers, school, and physicians on exercise in pediatric oncology patients and evaluate the barriers to physical activity (PA) levels in this population. METHODS:A search of PubMed and Google Scholar resulted in 12 related articles. The articles were assessed for the infl...

journal_title：Frontiers in pediatrics

authors： Yelton L,Forbis S

更新日期：2016-12-19 00:00:00

abstract：:During early post-natal life, neonates must adjust to the transition from the sheltered intra-uterine environment to the microbe-laden external world, wherein they encounter a constellation of antigens and the colonization by the microbiome. At this vulnerable stage, neonatal immune responses are considered immature a...

journal_title：Frontiers in pediatrics

authors： Tsafaras GP,Ntontsi P,Xanthou G

更新日期：2020-01-28 00:00:00

abstract：:It is necessary to conduct Clinical Trials in children, including for novel vaccines. Children cannot legally provide valid consent, but can assent to research participation. Informed consent and assent communications are frequently criticized for their lack of comprehensibility and often, researchers do not involve p...

journal_title：Frontiers in pediatrics

authors： Jackson SM,Daverio M,Perez SL,Gesualdo F,Tozzi AE

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Acute gastroenteritis (AGE) causing dehydration with or without dysnatremias is a common childhood health challenge. While it is accepted that oral rehydration therapy is preferred, clinical factors or parent and healthcare provider preferences may lead to intravenous rehydration (IVR). Isotonic solutions ar...

journal_title：Frontiers in pediatrics

authors： Grisaru S,Xie J,Samuel S,Freedman SB

更新日期：2017-10-06 00:00:00

abstract：:Informed consent is a process ensuring that subjects enrolled in research are appropriately informed of the risks and benefits. While this process is well-defined when it is possible and practical to obtain consent prior to the research intervention, it can be less clear in cases of deferred or waived consent. Definin...

journal_title：Frontiers in pediatrics

authors： Rich WD,Katheria AC

更新日期：2019-11-26 00:00:00

abstract：:Introduction: Emergency vascular access is rarely required during neonatal resuscitation. We aimed to analyze frequency of use, success, and complication rates of intraosseous (IO) vascular access in neonates at a single tertiary neonatal intensive care unit. Method: We performed a questionnaire-based survey among ped...

journal_title：Frontiers in pediatrics

authors： Mileder LP,Urlesberger B,Schwaberger B

更新日期：2020-09-18 00:00:00

abstract：:Asthma is the most frequent chronic disease in children, and its pathogenesis involves genetic, epigenetic, and environmental factors. The rapid rise in the prevalence of asthma registered over the last few decades has stressed the need to identify the environmental and modifiable factors associated with the developme...

journal_title：Frontiers in pediatrics

authors： Trambusti I,Nuzzi G,Costagliola G,Verduci E,D'Auria E,Peroni DG,Comberiati P

更新日期：2020-08-18 00:00:00

abstract：:Abdominal lipoblastomas are uncommon soft tissue tumors in children and rarely arise from the mesentery. Due to intraabdominal location and slow growth, these masses can go unnoticed for long periods of time and often found on surgical exploration. We present a case of a 12-year-old male with years of abdominal disten...

journal_title：Frontiers in pediatrics

authors： Squillaro AI,Chow MD,Arias F,Sadimin ET,Lee YH

更新日期：2020-07-24 00:00:00

abstract：:A 3-year-old girl was admitted to our hospital for the correction of atrial septal defect (ASD). Open heart operation with cardiopulmonary bypass is dangerous because the patient also had hereditary spherocytosis, which put her at risk for hemolytic anemia. Therefore, percutaneous transcatheter closure for ASD was cho...

journal_title：Frontiers in pediatrics

authors： Ji Z,Liu N,Du Z,Luo G,Bing Z,Xing Q,Pan S

更新日期：2019-12-17 00:00:00

abstract：:Background: Abernethy malformation is a rare vascular anomaly of the portal venous system, which is also known as congenital portosystemic shunts (CPSS). The clinical manifestations of this anomaly can be serious, including hepatopulmonary syndrome(HPS), which can lead to significant hypoxemia and cyanosis. Case Prese...

journal_title：Frontiers in pediatrics

authors： Lin Y,Li X,Li S,Ba H,Wang H,Zhu L

更新日期：2020-10-27 00:00:00

abstract：:Being able to appropriately process different emotional prosodies is an important cognitive ability normally present at birth. In this study, we used event-related potential (ERP) to assess whether brain injury impacts the ability to process different emotional prosodies (happy, fear, and neutral) in neonates; whether...

journal_title：Frontiers in pediatrics

authors： Sun G,Xie H,Liu Y,Chen Y,Hou X,Zhang D

更新日期：2019-05-09 00:00:00

abstract：:Objective: Lactate is often used as a surrogate marker of inappropriate oxygen delivery. It has been shown that hyperlactatemia is associated with worse clinical outcome in children after cardiac surgery. The purpose of this study is to evaluate the association of hyperlactatemia, low systemic oxygen delivery, and hyp...

journal_title：Frontiers in pediatrics

authors： Klee P,Rimensberger PC,Karam O

更新日期：2020-06-23 00:00:00

abstract：:Objectives: In 2014 probiotic supplementation (Lactobacillus acidophilus and Bifidobacterium longum subspecies infantis; InfloranⓇ) was introduced as standard of care to prevent necrotizing enterocolitis (NEC) in extremely preterm infants in Norway. We aimed to evaluate the influence of probiotics and antibiotic thera...

journal_title：Frontiers in pediatrics

authors： Esaiassen E,Hjerde E,Cavanagh JP,Pedersen T,Andresen JH,Rettedal SI,Støen R,Nakstad B,Willassen NP,Klingenberg C

更新日期：2018-11-16 00:00:00

abstract：:Objective: To investigate the relationship of overnutrition (obese and overweight) with severity of illness in children hospitalized with acute lower respiratory infections (ALRIs), frequency of viral coinfections and leptin levels. Methods: We studied 124 children <2 years old that were hospitalized for ALRI. Nutriti...

journal_title：Frontiers in pediatrics

authors： Arias-Bravo G,Valderrama G,Inostroza J,Reyes-Farías M,Garcia-Diaz DF,Zorondo-Rodríguez F,Fuenzalida LF

更新日期：2020-02-18 00:00:00

abstract：:Excessive oxygen (O2) can cause tissue injury, scarring, aging, and even death. Our laboratory is studying O2-sensing pulmonary neuroendocrine cells (PNECs) and the PNEC-derived product gastrin-releasing peptide (GRP). Reactive oxygen species (ROS) generated from exposure to hyperoxia, ozone, or ionizing radiation (RT...

journal_title：Frontiers in pediatrics

authors： Sunday ME

更新日期：2014-07-18 00:00:00

abstract：Aim:The purpose of this study is to describe the development of an external 3-dimensional (3D) scanner as a noninvasive method for imaging chest wall deformities. It allows objective assessment, reconstruction of the area of interest, and evaluation of the severity of the deformity by using external indexes. External ...

journal_title：Frontiers in pediatrics

authors： Lain A,Garcia L,Gine C,Tiffet O,Lopez M

更新日期：2017-12-04 00:00:00

abstract：:X-linked lymphoproliferative disease (XLP) is one of the X-linked primary immunodeficiency diseases (PIDs) with defective immune response to Epstein-Barr virus (EBV) infection. Chronic active EBV infection (CAEBV) and EBV-hemophagocytic lymphohistiocytosis (HLH) are recognized as systemic EBV-positive T-cell and natur...

journal_title：Frontiers in pediatrics

authors： Ishimura M,Eguchi K,Shiraishi A,Sonoda M,Azuma Y,Yamamoto H,Imadome KI,Ohga S

更新日期：2019-05-21 00:00:00

abstract：:Dedicator of cytokinesis 8 (DOCK8) deficiency is an autosomal recessive, combined immunodeficiency within the spectrum of hyper-IgE syndromes. Epstein-Barr virus-positive lymphomatoid granulomatosis (LYG) (EBV + LYG) is a rare diagnosis and a previously unreported presentation of DOCK8 deficiency. A 10-year-old girl w...

journal_title：Frontiers in pediatrics

authors： Dimitriades VR,Devlin V,Pittaluga S,Su HC,Holland SM,Wilson W,Dunleavy K,Shah NN,Freeman AF

更新日期：2017-02-28 00:00:00

abstract：:The term osteopetrosis describes a group of rare hereditary diseases of the skeleton, characterized by an increase in bone density, caused by a defect in the development or function of osteoclasts. It comprises a clinically and genetically heterogeneous conditions ranging from infantile onset life-threatening forms to...

journal_title：Frontiers in pediatrics

authors： di Palmo E,Gallucci M,Tronconi E,Bergamaschi R,Cazzato S,La Scola C,Ricci G,Pession A

更新日期：2018-07-31 00:00:00

abstract：:The burden of asthma in childhood is considerable worldwide, although some populations are much more affected than others. Many attempts have been made by different investigators to identify the factors that could predict asthma development or persistence in childhood. In this review, the relation between atopic sensi...

journal_title：Frontiers in pediatrics

authors： Moustaki M,Loukou I,Tsabouri S,Douros K

更新日期：2017-07-31 00:00:00

abstract：:Maternal primary and non-primary cytomegalovirus (CMV) infection during pregnancy can result in in utero transmission to the developing fetus. Congenital CMV (cCMV) can result in significant morbidity, mortality or long-term sequelae, including sensorineural hearing loss, the most common sequela. As a leading cause of...

journal_title：Frontiers in pediatrics

authors： Lazzarotto T,Blázquez-Gamero D,Delforge ML,Foulon I,Luck S,Modrow S,Leruez-Ville M

更新日期：2020-01-31 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the gastrointestinal tract associated with significant morbidity. While IBD occurs in genetically susceptible individuals, the etiology is multifactorial, involving environmental influences, intestinal dysbiosis, and altered immune respon...

journal_title：Frontiers in pediatrics

authors： Foster A,Jacobson K

更新日期：2013-11-06 00:00:00