Non-invasive Respiratory Support of the Premature Neonate: From Physics to Bench to Practice.

Abstract:

:Premature births continue to rise globally with a corresponding increase in various morbidities among this population. Rates of respiratory distress syndrome and the consequent development of Bronchopulmonary Dysplasia (BPD) are highest among the extremely preterm infants. The majority of extremely low birth weight premature neonates need some form of respiratory support during their early days of life. Invasive modes of respiratory assistance have been popular amongst care providers for many years. However, the practice of prolonged invasive mechanical ventilation is associated with an increased likelihood of developing BPD along with other comorbidities. Due to the improved understanding of the pathophysiology of BPD, and technological advances, non-invasive respiratory support is gaining popularity; whether as an initial mode of support, or for post-extubation of extremely preterm infants with respiratory insufficiency. Due to availability of a wide range of modalities, wide variations in practice exist among care providers. This review article aims to address the physical and biological basis for providing non-invasive respiratory support, the current clinical evidence, and the most recent developments in this field of Neonatology.

journal_name

Front Pediatr

journal_title

Frontiers in pediatrics

authors

Sammour I,Karnati S

doi

10.3389/fped.2020.00214

subject

Has Abstract

pub_date

2020-05-08 00:00:00

pages

214

issn

2296-2360

journal_volume

8

pub_type

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