Markers of NETosis Do Not Predict Neonatal Early Onset Sepsis: A Pilot Study.

abstract：:Objective: 11β-hydroxylase deficiency (11βOHD) is a rare autosomal recessive disorder caused by mutations in the CYP11B1 gene. It is characterized by virilization, hypertension, and significant final height impairment. In this study, we aim to investigate the clinical and molecular characteristics of four unrelated Ch...

journal_title：Frontiers in pediatrics

authors： Zhou Q,Wang D,Wang C,Zheng B,Liu Q,Zhu Z,Jia Z,Gu W

更新日期：2020-07-24 00:00:00

abstract：:Bronchiectasis is a complex chronic respiratory condition traditionally characterized by chronic infection, airway inflammation, and progressive decline in lung function. Early diagnosis and intensive treatment protocols can stabilize or even improve the clinical prognosis of children with bronchiectasis. However, und...

journal_title：Frontiers in pediatrics

authors： Pizzutto SJ,Hare KM,Upham JW

更新日期：2017-05-29 00:00:00

abstract：:Objectives: Mutations in the neuroblastoma-amplified sequence (NBAS) gene were originally described in patients with skeletal dysplasia or isolated liver disease of variable severity. Subsequent publications reported a more complex phenotype. Among multisystemic clinical symptoms, we were particularly interested in th...

journal_title：Frontiers in pediatrics

authors： Khoreva A,Pomerantseva E,Belova N,Povolotskaya I,Konovalov F,Kaimonov V,Gavrina A,Zimin S,Pershin D,Davydova N,Burlakov V,Viktorova E,Roppelt A,Kalinina E,Novichkova G,Shcherbina A

更新日期：2020-09-15 00:00:00

abstract：:Objectives: In 2014 probiotic supplementation (Lactobacillus acidophilus and Bifidobacterium longum subspecies infantis; InfloranⓇ) was introduced as standard of care to prevent necrotizing enterocolitis (NEC) in extremely preterm infants in Norway. We aimed to evaluate the influence of probiotics and antibiotic thera...

journal_title：Frontiers in pediatrics

authors： Esaiassen E,Hjerde E,Cavanagh JP,Pedersen T,Andresen JH,Rettedal SI,Støen R,Nakstad B,Willassen NP,Klingenberg C

更新日期：2018-11-16 00:00:00

abstract：:Background: Pediatric sports-induced concussions have become a topic of interest and concern in the scientific community. Already, the literature is rich with studies that have identified numerous short-term and long-term consequences of childhood sports-induced concussions. However, there are very few studies that ha...

journal_title：Frontiers in pediatrics

authors： Subramaniam A,Tan RMR,Chan D,Ng ZM,Dong CY,Feng JXY,Chong SL

更新日期：2020-09-24 00:00:00

abstract：:Excessive oxygen (O2) can cause tissue injury, scarring, aging, and even death. Our laboratory is studying O2-sensing pulmonary neuroendocrine cells (PNECs) and the PNEC-derived product gastrin-releasing peptide (GRP). Reactive oxygen species (ROS) generated from exposure to hyperoxia, ozone, or ionizing radiation (RT...

journal_title：Frontiers in pediatrics

authors： Sunday ME

更新日期：2014-07-18 00:00:00

abstract：:Background: Optimal timing for resection of asymptomatic congenital lung malformations (CLMs) remains controversial. The aim of this study is to define optimal timing for surgical intervention of patients with CLMs and define clinical variables that affect surgical outcomes. Methods: An IRB-approved retrospective anal...

journal_title：Frontiers in pediatrics

authors： Duron V,Zenilman A,Griggs C,DeFazio J,Price JC,Fan W,Vivero M,Castrillon J,Schmaedick M,Iqbal E,Rothenberg S

更新日期：2020-02-14 00:00:00

abstract：:Although antibiotics confer significant health benefits in treating or preventing bacterial infections, an accumulating wealth of evidence illustrates their detrimental effect on host-microbiota homeostasis, posing a serious menace to the global public health. In recent years, it is becoming evident that infants, who ...

journal_title：Frontiers in pediatrics

authors： Shekhar S,Petersen FC

更新日期：2020-10-15 00:00:00

abstract：:Despite distinct epidemiology and outcomes, pediatric acute respiratory distress syndrome (PARDS) is often managed based on evidence extrapolated from treatment of adults. The impact of non-pulmonary processes on mortality as well as the lower mortality rate compared to adults with acute respiratory distress syndrome ...

journal_title：Frontiers in pediatrics

authors： Yehya N,Thomas NJ

更新日期：2016-05-13 00:00:00

abstract：:Background: Improved diagnostic tests are needed for the early identification of Mycobacterium tuberculosis-infected young children exposed to an active TB (aTB) index case. We aimed to compare the diagnostic accuracy of new blood-based tests to that of the tuberculin skin test (TST) for the identification of all infe...

journal_title：Frontiers in pediatrics

authors： Dreesman A,Dirix V,Smits K,Corbière V,Van Praet A,Debulpaep S,De Schutter I,Felderhof MK,Malfroot A,Singh M,Locht C,Mouchet F,Mascart F

更新日期：2019-07-25 00:00:00

abstract：:[This corrects the article on p. 82 in vol. 5, PMID: 28484690.]. ...

journal_title：Frontiers in pediatrics

authors： Tsabouri S,Mavroudi A,Feketea G,Guibas GV

更新日期：2017-09-11 00:00:00

abstract：:Non-cystic fibrosis bronchiectasis (NCFB) has gained renewed interest, due to its increasing health-care burden. Annual mortality statistics in England and Wales showed that under 1,000 people die from bronchiectasis each year, and this number is increasing by 3% yearly. Unfortunately, there is a severe lack of well-p...

journal_title：Frontiers in pediatrics

authors： Nathan AM,de Bruyne JA,Eg KP,Thavagnanam S

更新日期：2017-04-24 00:00:00

abstract：:Objective: To present 8-year follow-up outcomes, treatment of complications, and prognosis in children with congenital tracheal stenosis after metallic airway stent implantation. Methods: Retrospective analysis was performed on the clinical records of children who had airway stents placed between May 20, 2011 and May ...

journal_title：Frontiers in pediatrics

authors： Wang M,Zhu B,Xu X

更新日期：2020-10-26 00:00:00

abstract：:This mini review provides an overview of the issues and challenges inherent in autosomal recessive polycystic kidney disease (ARPKD), with a particular focus on the neurological factors and neurocognitive functioning of this population. ARPKD typically is discovered at the end of pregnancy or during the neonatal devel...

journal_title：Frontiers in pediatrics

authors： Hooper SR

更新日期：2017-05-15 00:00:00

abstract：:Background: The occurrence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated coronavirus disease 2019 (COVID-19) have profoundly affected adult kidney disease patients. In contrast, pediatric solid organ transplant recipients, including pediatric kidney transplant (KT) recipients, ...

journal_title：Frontiers in pediatrics

authors： Nailescu C,Khalid M,Wilson AC,Amanat F,Arregui S,Canas J,Hooks J,Krammer F,Schwaderer AL,Hains DS

更新日期：2020-10-30 00:00:00

abstract：:Background: The impact of a sedentary and unhealthy lifestyle on cardiovascular health is well-documented, however the current obesity and hypertension trends among children is concerning. The ExAMIN Youth SA study aims to investigate the impact of lifestyle behaviors (physical fitness/activity, dietary intake and psy...

journal_title：Frontiers in pediatrics

authors： Kruger R,Monyeki MA,Schutte AE,Smith W,Mels CMC,Kruger HS,Pienaar AE,Gafane-Matemane LF,Breet Y,Lammertyn L,Mokwatsi GG,Kruger A,Deacon E,Hanssen H

更新日期：2020-04-29 00:00:00

abstract：:To date, the only known effective treatment for celiac disease (CD) is a strict gluten-free diet (GFD) for life. Patients with CD often find it difficult to adhere to strict GFD. Oats, compared with wheat, barley, and rye, contain less amounts of prolamins. Inclusion of oats in a GFD might be valuable due to their nut...

journal_title：Frontiers in pediatrics

authors： Spector Cohen I,Day AS,Shaoul R

更新日期：2019-09-26 00:00:00

abstract：:Therapeutic strategies for severe hand, foot, and mouth disease (HFMD) are currently either inconsequent or deficient in evidence. We retrospectively surveyed HFMD outbreaks in Xiangyang from June 2008 to December 2013. HFMD is staged from I to V according to clinical severity. Severe HFMD is defined as a case involvi...

journal_title：Frontiers in pediatrics

authors： Liu J,Qi J

更新日期：2020-07-10 00:00:00

abstract：:Background: Placenta shows high transcription levels of human endogenous retroviruses (HERVs) that are overexpressed during embryonic and fetal development. Methods: In order to gather further information on the degree of HERV activation in maternal and fetal tissues we assessed the transcription levels of pol genes o...

journal_title：Frontiers in pediatrics

authors： Bergallo M,Marozio L,Botta G,Tancredi A,Daprà V,Galliano I,Montanari P,Coscia A,Benedetto C,Tovo PA

更新日期：2020-05-14 00:00:00

abstract：:In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuploidy, circulating RN...

journal_title：Frontiers in pediatrics

authors： Moufarrej MN,Wong RJ,Shaw GM,Stevenson DK,Quake SR

更新日期：2020-12-14 00:00:00

abstract：:Introduction: Acute respiratory infections with cough (ARIwC) contribute considerably to childhood morbidity, yet few studies have examined the cost of these illnesses among Australian children. Moreover, of the few studies that have, none are inclusive of Aboriginal and/or Torres Strait Islander children, despite thi...

journal_title：Frontiers in pediatrics

authors： Lovie-Toon YG,McPhail SM,Au-Yeung YT,Hall KK,Chang AB,Vagenas D,Otim ME,O'Grady KF

更新日期：2018-12-03 00:00:00

abstract：:Introduction: Malignant brain tumors in infants less than 12 months of age are extremely rare, and they have poor prognosis. We evaluated genetic characteristics and response rates of infants with congenital brain tumors subjected to high-dose chemotherapy and autologous stem cell transplant after gross total tumor re...

journal_title：Frontiers in pediatrics

authors： Guidi M,Giunti L,Buccoliero AM,Santi M,Spacca B,De Masi S,Genitori L,Sardi I

更新日期：2020-04-09 00:00:00

abstract：BACKGROUND:Acute gastroenteritis (AGE) causing dehydration with or without dysnatremias is a common childhood health challenge. While it is accepted that oral rehydration therapy is preferred, clinical factors or parent and healthcare provider preferences may lead to intravenous rehydration (IVR). Isotonic solutions ar...

journal_title：Frontiers in pediatrics

authors： Grisaru S,Xie J,Samuel S,Freedman SB

更新日期：2017-10-06 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fped.2018.00316.]. ...

journal_title：Frontiers in pediatrics

authors： Ebrahimi-Fakhari D,Dillmann U,Flotats-Bastardas M,Poryo M,Abdul-Khaliq H,Shamdeen MG,Mischo B,Zemlin M,Meyer S

更新日期：2019-07-25 00:00:00

abstract：:In genome science, the advancement in high-throughput sequencing technologies and bioinformatics analysis is facilitating the better understanding of Mendelian and complex trait inheritance. Charting the genetic basis of complex diseases - including pediatric cancer, and interpreting huge amount of next-generation seq...

journal_title：Frontiers in pediatrics

authors： Manwar Hussain MR,Khan A,Ali Mohamoud HS

更新日期：2014-03-03 00:00:00

abstract：:Objective: The objective of the study is to test whether the use of edible oil might be an early treatment strategy for reducing button battery-induced esophageal injury. Methods: A button battery was inserted into esophageal segments collected from pigs. The esophageal segments were randomly allotted to one of the fo...

journal_title：Frontiers in pediatrics

authors： Jia W,Zhang B,Xu G,Xie J,Wei H,Shan N,Wang Q,Yin W,Zhao W

更新日期：2020-03-13 00:00:00

abstract：:Asthma is no longer considered a single disease, but a common label for a set of heterogeneous conditions with shared clinical symptoms but associated with different cellular and molecular mechanisms. Several wheezing phenotypes coexist at preschool age but not all preschoolers with recurrent wheezing develop asthma a...

journal_title：Frontiers in pediatrics

authors： Castro-Rodriguez JA,Cifuentes L,Martinez FD

更新日期：2019-07-31 00:00:00

abstract：:Pertussis, caused by Bordetella (B.) pertussis, a Gram-negative bacterium, is a highly contagious airway infection. Especially in infants, pertussis remains a major health concern. Acute infection with B. pertussis can cause severe illness characterized by severe respiratory failure, pulmonary hypertension, leucocytos...

journal_title：Frontiers in pediatrics

authors： Zlamy M

更新日期：2016-06-08 00:00:00

abstract：:Introduction: Hospital response to the COVID-19 outbreak has involved the cancellation of elective, deferrable surgeries throughout Europe in order to ensure capacity for emergent surgery and a selection of elective but non-deferrable surgeries. The purpose of this document is to propose technical strategies to assist...

journal_title：Frontiers in pediatrics

authors： Pini Prato A,Conforti A,Almstrom M,Van Gemert W,Scuderi MG,Khen-Dunlop N,Draghici I,Mendoza-Sagaon M,Giné Prades C,Chiarenza F,Steyaert H

更新日期：2020-05-07 00:00:00

abstract：:Introduction: Hemolytic-uremic syndrome (HUS) is a common cause for intrarenal acute kidney injury in childhood. More than 90% of HUS cases are associated with an infection by Shigatoxin-producing Escherichia coli (STEC) whereas the reminder comprises a heterogeneous group (here classified as Non-STEC-HUS). Renal impa...

journal_title：Frontiers in pediatrics

authors： Vaterodt L,Holle J,Hüseman D,Müller D,Thumfart J

更新日期：2018-08-07 00:00:00