From genes to health - challenges and opportunities.

abstract：:Objective: To examine the understanding of the concept peak oxygen uptake (peak VO2) among children and adolescents at different ages from a developmental perspective. Methods: A total of 549 children and adolescents aged 8 to 16 were recruited and instructed to fill in a 20-item Peak VO2Understanding Inventory develo...

journal_title：Frontiers in pediatrics

authors： Wong SWL,Yu CCW,Li AM

更新日期：2021-01-14 00:00:00

abstract：:Background: Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal condition among very and extremely preterm infants. Stem cell therapy has shown some promising protective effects in animal models of intestinal injury, including NEC, but no systematic review has yet evaluated the preclin...

journal_title：Frontiers in pediatrics

authors： Villamor-Martinez E,Hundscheid T,Kramer BW,Hooijmans CR,Villamor E

更新日期：2020-12-09 00:00:00

abstract：:Excessive oxygen (O2) can cause tissue injury, scarring, aging, and even death. Our laboratory is studying O2-sensing pulmonary neuroendocrine cells (PNECs) and the PNEC-derived product gastrin-releasing peptide (GRP). Reactive oxygen species (ROS) generated from exposure to hyperoxia, ozone, or ionizing radiation (RT...

journal_title：Frontiers in pediatrics

authors： Sunday ME

更新日期：2014-07-18 00:00:00

abstract：:Background and Aim: Intestinal failure-associated liver disease (IFALD) affects one-fifth of neonates receiving parenteral nutrition (PN) for more than 2 weeks. We aimed to define the effect of IFALD on hemostasis of preterm infants. Methods: This is an ancillary analysis of a prospective study aimed at defining coagu...

journal_title：Frontiers in pediatrics

authors： Ghirardello S,Raffaeli G,Scalambrino E,Cortesi V,Roggero P,Peyvandi F,Mosca F,Tripodi A

更新日期：2020-08-26 00:00:00

abstract：:Background: Factors surrounding pediatricians' parenting advice and training on parenting during residency have not been well studied. The Resident Parenting Questionnaire (RPQ) was developed to assess (a) the relationship between pediatric residents' upbringing and their parenting advice style and (b) factors associa...

journal_title：Frontiers in pediatrics

authors： Bax AC,Shawler PM,Anderson MP,Wolraich ML

更新日期：2018-12-12 00:00:00

abstract：:It is necessary to conduct Clinical Trials in children, including for novel vaccines. Children cannot legally provide valid consent, but can assent to research participation. Informed consent and assent communications are frequently criticized for their lack of comprehensibility and often, researchers do not involve p...

journal_title：Frontiers in pediatrics

authors： Jackson SM,Daverio M,Perez SL,Gesualdo F,Tozzi AE

更新日期：2021-01-12 00:00:00

abstract：:Puberty is a sensitive period of life characterized by the appearance of secondary sex characteristics which leads to a complete sexual maturation. It physiologically starts between the age of 8 and 13 years in girls and 9 and 14 years in boys. In the last two decades, several studies have showed that start of puberty...

journal_title：Frontiers in pediatrics

authors： Farello G,Altieri C,Cutini M,Pozzobon G,Verrotti A

更新日期：2019-05-08 00:00:00

abstract：:Objective: Magnetic resonance imaging (MRI) and cardiac catheterization are diagnostic tools for right ventricle dysfunction (RVD), but those are expensive and often unavailable techniques. Thus, our objective was to identify clinical and/or echocardiographic variables capable of predicting a catheterization-based dia...

journal_title：Frontiers in pediatrics

authors： Márquez-González H,Vargas MH,Yáñez-Gutiérrez L,Almeida-Gutiérrez E,Garduño-Espinosa J

更新日期：2018-06-26 00:00:00

abstract：:The burden of severe hearing impairment is increasing with two-thirds of these hearing impaired people residing in developing countries. Newborn hearing screening helps to identify early, babies who need intervention in order to prevent future disability. Neither universal nor targeted hearing screening programme is a...

journal_title：Frontiers in pediatrics

authors： Labaeka AA,Tongo OO,Ogunbosi BO,Fasunla JA

更新日期：2018-07-16 00:00:00

abstract：:Background: Primary carnitine deficiency (PCD) is attributed to a variation in the SLC22A5 (OCTN2) gene which encodes the key protein of the carnitine cycle, the OCTN2 carnitine transporter. PCD is typically identified in childhood by either hypoketotic hypoglycemia, or skeletal and cardiac myopathy. The aim of this s...

journal_title：Frontiers in pediatrics

authors： Zhou W,Li H,Huang T,Zhang Y,Wang C,Gu M

更新日期：2019-02-26 00:00:00

abstract：:Background: Pediatric sports-induced concussions have become a topic of interest and concern in the scientific community. Already, the literature is rich with studies that have identified numerous short-term and long-term consequences of childhood sports-induced concussions. However, there are very few studies that ha...

journal_title：Frontiers in pediatrics

authors： Subramaniam A,Tan RMR,Chan D,Ng ZM,Dong CY,Feng JXY,Chong SL

更新日期：2020-09-24 00:00:00

abstract：:In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuploidy, circulating RN...

journal_title：Frontiers in pediatrics

authors： Moufarrej MN,Wong RJ,Shaw GM,Stevenson DK,Quake SR

更新日期：2020-12-14 00:00:00

abstract：:Pontocerebellar hypoplasia (PCH) type 2 is a very rare autosomal recessive neurodegenerative disorder with prenatal onset that disrupts brain development. We present three patients (two siblings and one unrelated child) with PCH 2 linked to the most common mutation c.919G > T (p.Ala307Ser) in TSEN54 gene. The disease ...

journal_title：Frontiers in pediatrics

authors： Pacheva IH,Todorov T,Ivanov I,Tartova D,Gaberova K,Todorova A,Dimitrova D

更新日期：2018-01-23 00:00:00

abstract：:Objective: In many patients with congenital heart disease (CHD) arterial blood flow to the arms is inhibited due to shunt surgery in infancy. This study investigates the handgrip strength of patients with CHD in regard to previous shunt procedures. Patients and Methods: Handgrip was evaluated in 424 patients with vari...

journal_title：Frontiers in pediatrics

authors： Müller J,Röttgers L,Neidenbach RC,Oberhoffer R,Ewert P,Hager A

更新日期：2018-09-06 00:00:00

abstract：:Background: Airway malacia (AM) is a weakness of the airway's frameworks making them collapsible during the respiratory phases. Although the larynx, trachea, and bronchus are the usual sites for malacia to occur, there is another important type of malacia that involves the pharynx. Pharyngomalacia (PM) or concentric p...

journal_title：Frontiers in pediatrics

authors： Moslehi MA

更新日期：2020-10-30 00:00:00

abstract：:Failure of statural growth is one of the major long-term sequelae of chronic kidney disease (CKD) in children. In recent years effective therapeutic strategies have become available that lead to evidence based practice recommendations. To assess the current growth performance of European children and adolescents with ...

journal_title：Frontiers in pediatrics

authors： Behnisch R,Kirchner M,Anarat A,Bacchetta J,Shroff R,Bilginer Y,Mir S,Caliskan S,Paripovic D,Harambat J,Mencarelli F,Büscher R,Arbeiter K,Soylemezoglu O,Zaloszyc A,Zurowska A,Melk A,Querfeld U,Schaefer F,and the 4C S

更新日期：2019-07-05 00:00:00

abstract：:Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is an EBV-associated lymphoproliferative disease characterized by repeated or sustainable infectious mononucleosis (IM)-like symptoms. EBV is usually detected in B cells in patients who have IM or Burkitt's lymphoma and even in patients with X-linked lymphoprol...

journal_title：Frontiers in pediatrics

authors： Tanita K,Hoshino A,Imadome KI,Kamiya T,Inoue K,Okano T,Yeh TW,Yanagimachi M,Shiraishi A,Ishimura M,Schober T,Rohlfs M,Takagi M,Imai K,Takada H,Ohga S,Klein C,Morio T,Kanegane H

更新日期：2019-02-04 00:00:00

abstract：:While awareness and understanding of concussion have improved drastically, post-concussion management in academic settings is still at its infancy. The aim of the study was to examine to what extent concussion influences academic performance and to whether there would be a difference in concussion effects on academic ...

journal_title：Frontiers in pediatrics

authors： Holmes A,Chen Z,Yahng L,Fletcher D,Kawata K

更新日期：2020-03-04 00:00:00

abstract：:Objectives: The incidence and the prevalence of eosinophilic esophagitis (EoE) are increasing, and healthcare utilization among children with EoE is high. This study provides novel insights into the health services and the treatments, including complementary medicines (CMs), used by carers to manage their children's E...

journal_title：Frontiers in pediatrics

authors： Hannan N,Steel A,McMillan SS,Tiralongo E

更新日期：2020-04-17 00:00:00

abstract：:Background: High parent education is protective against youth health risk behaviors such as tobacco use. According to the Minorities' Diminished Returns theory, however, higher parent education seems to exert less protection for the ethnic minority relative to the majority groups. Objectives: To explore ethnic differe...

journal_title：Frontiers in pediatrics

authors： Assari S,Boyce S,Caldwell CH,Bazargan M

更新日期：2020-08-19 00:00:00

abstract：:Introduction: Ventilation causes cerebral white matter inflammation and injury, which is exacerbated by intrauterine inflammation. However, the effects on cortical gray matter are not well-known. Our aim was to examine the effect of ventilation on the cerebral cortex of near-term lambs exposed to intrauterine inflamma...

journal_title：Frontiers in pediatrics

authors： Stojanovska V,Atik A,Nitsos I,Skiöld B,Barton SK,Zahra VA,Rodgers K,Hooper SB,Polglase GR,Galinsky R

更新日期：2018-06-15 00:00:00

abstract：:The evaluation and treatment of the heterogeneous group of kidney diseases poses a challenging field in pediatrics. Many of the pediatric disorders resulting in severe renal affection are exceedingly rare and therapeutic approaches have remained symptomatic for most of these disease entities. The insights obtained fro...

journal_title：Frontiers in pediatrics

authors： Liebau MC

更新日期：2014-07-01 00:00:00

abstract：:Background: Eye exam for Retinopathy of prematurity (ROP) is a painful procedure and pharmacological analgesia might be ineffective. We hypothesized that magnetic auricular acupuncture (MAA) compared to placebo will decrease pain during ROP exam in preterm infants. Methods: Multicentre randomized controlled trial cond...

journal_title：Frontiers in pediatrics

authors： Gan KML,Oei JL,Quah-Smith I,Kamar AA,Lordudass AAD,Liem KD,Lindrea KB,Daly M,Gaunker N,Mangat AK,Yaskina M,Schmölzer GM

更新日期：2020-12-23 00:00:00

abstract：:Objective: To evaluate serial ferritin levels measured in the initial 72 h of admission as a biomarker for new and progressive multi organ dysfunction syndrome (NPMODS) and mortality (unfavorable outcomes) in critically ill children with sepsis due to tropical infections. Material and Methods: In this prospective obse...

journal_title：Frontiers in pediatrics

authors： Williams V,Menon N,Bhatia P,Biswal M,Sreedharanunni S,Rawat A,Jayashree M,Nallasamy K

更新日期：2020-12-03 00:00:00

abstract：:Differences in the development of the male and female brain are an evolving area of investigation. We are beginning to understand the underpinnings of male and female advantages due to differences in brain development as well as the consequences following hypoxic-ischemic brain injury in the newborn. The two main fact...

journal_title：Frontiers in pediatrics

authors： Rosenkrantz TS,Hussain Z,Fitch RH

更新日期：2019-06-26 00:00:00

abstract：:Perianal abscess and fistula-in-ano are well-described in the pediatric population. They are most common in infants less than 1 year of age and often resolve with oral antibiotics; occasionally they require drainage or fistulotomy. The etiology is commonly associated with cryptoglandular obstruction and subsequent inf...

journal_title：Frontiers in pediatrics

authors： Barry WE,Asuelime GE,Zhou S,Hammoudeh J,Ford HR,Kim ES

更新日期：2018-05-16 00:00:00

abstract：:Introduction: Childhood obesity is occurring at alarming rates in both developed and developing countries. "Obesogenic" environmental factors must be associated with variants of different risk alleles to determine polygenic or common obesity, and their impact depends on different developmental stages.The interaction b...

journal_title：Frontiers in pediatrics

authors： Mǎrginean CO,Mǎrginean C,Meliţ LE

更新日期：2018-10-04 00:00:00

abstract：:Objective: Lactate is often used as a surrogate marker of inappropriate oxygen delivery. It has been shown that hyperlactatemia is associated with worse clinical outcome in children after cardiac surgery. The purpose of this study is to evaluate the association of hyperlactatemia, low systemic oxygen delivery, and hyp...

journal_title：Frontiers in pediatrics

authors： Klee P,Rimensberger PC,Karam O

更新日期：2020-06-23 00:00:00

abstract：:In recent years the number of extracorporeal membrane oxygenation (ECMO) cases in neonates has been relatively constant. Future expansion lays in new indications for treatment. Regionalization to high-volume ECMO centers allows for optimal utilization of resources, reduction in costs, morbidity, and mortality. Mobile ...

journal_title：Frontiers in pediatrics

authors： Broman LM

更新日期：2019-08-06 00:00:00

abstract：:The solute carrier family 16 member 1 (SLC16A1) gene encodes for monocarboxylate transporter 1 (MCT1) that mediates the movement of monocarboxylates, such as lactate and pyruvate across cell membranes. Inactivating recessive homozygous or heterozygous mutations in the SLC16A1 gene were described in patients with recur...

journal_title：Frontiers in pediatrics

authors： Al-Khawaga S,AlRayahi J,Khan F,Saraswathi S,Hasnah R,Haris B,Mohammed I,Abdelalim EM,Hussain K

更新日期：2019-07-18 00:00:00