Short- and Long-Term Renal Outcome of Hemolytic-Uremic Syndrome in Childhood.

Abstract:

:Introduction: Hemolytic-uremic syndrome (HUS) is a common cause for intrarenal acute kidney injury in childhood. More than 90% of HUS cases are associated with an infection by Shigatoxin-producing Escherichia coli (STEC) whereas the reminder comprises a heterogeneous group (here classified as Non-STEC-HUS). Renal impairment can persist in patients with HUS. This study presents data from four decades investigating the short- and long-term outcome of HUS in childhood. Materials and Methods: In a retrospective single-center-study clinical and laboratory data of the acute phase and of 1- to 10-year follow-up visits of children with HUS were analyzed. Results: 92 HUS-patients were identified from 1996 to 2014 (STEC-HUS-group: n = 76; Non-STEC-HUS-group: n = 16) and 220 HUS-patients between 1976 and 1995. STEC-HUS was increasingly caused by Non-O157 strains and mortality rate declined over the past decades (1.3 vs. 9.5%). Renal sequelae persisted more often in the group 1976-1995 (39.3%) than in the group 1996-2014 (28.3%), but more than 50% of all patients were lost to follow-up. Conclusion: Although renal outcome has improved over the investigated last decades, patients with HUS still face a high risk of permanent renal damage. These findings underline the importance of a consequent long-term follow-up in HUS-patients.

journal_name

Front Pediatr

journal_title

Frontiers in pediatrics

authors

Vaterodt L,Holle J,Hüseman D,Müller D,Thumfart J

doi

10.3389/fped.2018.00220

subject

Has Abstract

pub_date

2018-08-07 00:00:00

pages

220

issn

2296-2360

journal_volume

6

pub_type

杂志文章
  • Heart Rate Variability is Related to Disease Severity in Children and Young Adults with Pulmonary Hypertension.

    abstract:BACKGROUND:Pulmonary hypertension (PH) is frequently associated with an increase in sympathetic tone. This may adversely affect cardiac autonomic control. Knowledge about the clinical impact of autonomic dysfunction in patients with PH is limited. We aimed to assess whether parameters of heart rate variability (HRV) ar...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2015.00063

    authors: Latus H,Bandorski D,Rink F,Tiede H,Siaplaouras J,Ghofrani A,Seeger W,Schranz D,Apitz C

    更新日期:2015-07-07 00:00:00

  • Challenges in Maintaining the Hemostatic Balance in Children Undergoing Extracorporeal Membrane Oxygenation: A Systematic Literature Review.

    abstract::Background: Despite advances in technology and clinical experience, the incidence of hemostatic complications, including bleeding and thrombosis, remains high in children supported with extracorporeal membrane oxygenation (ECMO). These hemostatic complications are important to prevent, since they are associated with i...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2020.612467

    authors: Drop JGF,Wildschut ED,Gunput STG,de Hoog M,van Ommen CH

    更新日期:2020-12-16 00:00:00

  • Bedside Measurement of Volatile Organic Compounds in the Atmosphere of Neonatal Incubators Using Ion Mobility Spectrometry.

    abstract::Background: Early and non-invasive diagnosis of common diseases is of great importance in the care of preterm infants. We hypothesized that volatile organic compounds (VOC) can be successfully measured in the neonatal incubator atmosphere. Methods: This is a feasibility study to investigate whether the discrimination ...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2019.00248

    authors: Steinbach J,Goedicke-Fritz S,Tutdibi E,Stutz R,Kaiser E,Meyer S,Baumbach JI,Zemlin M

    更新日期:2019-06-18 00:00:00

  • Basement Membrane Defects in Genetic Kidney Diseases.

    abstract::The glomerular basement membrane (GBM) is a specialized structure with a significant role in maintaining the glomerular filtration barrier. This GBM is formed from the fusion of two basement membranes during development and its function in the filtration barrier is achieved by key extracellular matrix components inclu...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2018.00011

    authors: Chew C,Lennon R

    更新日期:2018-01-29 00:00:00

  • Clinical Presentation and Outcomes among Children with Sepsis Presenting to a Public Tertiary Hospital in Tanzania.

    abstract:Background:Pediatric sepsis causes significant global morbidity and mortality and low- and middle-income countries (LMICs) bear the bulk of the burden. International sepsis guidelines may not be relevant in LMICs, especially in sub-Saharan Africa (SSA), due to resource constraints and population differences. There is a...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2017.00278

    authors: Kortz TB,Sawe HR,Murray B,Enanoria W,Matthay MA,Reynolds T

    更新日期:2017-12-22 00:00:00

  • Vasculitis in a Child With the Hyper-IgM Variant of Ataxia-Telangiectasia.

    abstract::A subset of patients with Ataxia-Telangiectasia (A-T) have dramatically reduced levels of IgG, IgA, and IgE with retained or elevated IgM levels. Several reports suggest that these A-T patients with a "hyper-IgM phenotype" (HIgM) suffer more clinical immunologic consequences than other A-T patients. The immunopatholog...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2019.00390

    authors: Meyer AK,Banks M,Nadasdy T,Clark JJ,Zheng R,Gelfand EW,Abbott JK

    更新日期:2019-10-24 00:00:00

  • Beta Blocker Therapy for Congenital Hepatic Arteriovenous Fistula in Two Neonates.

    abstract::Introduction: Hepatic arteriovenous fistula (HAVF) is an abnormal communication between the hepatic arteries and hepatic veins. This condition is treated mainly using interventional closure and surgery. However, these procedures are associated with many postoperative complications and high mortality. Propranolol and o...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2020.00163

    authors: Ba H,Xu L,Peng H,Lin Y,Li X,Qin Y,Wang H

    更新日期:2020-04-21 00:00:00

  • Predictors of Sleep Duration and Sleep Disturbance in Children of a Culturally Diverse Region in North-Eastern Greece.

    abstract::Background Aim: The aim of this study was to examine the sleep characteristics of children and explore associations with various socio-demographic factors in an area of Greece characterized by cultural diversity. Methods: A questionnaire about children's sleep habits had been distributed to parents of children who vis...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00023

    authors: Nena E,Cassimos D,Kaditis A,Kourantzi M,Trakada G,Economou NT,Nikolaidis PT,Rosemann T,Knechtle B,Steiropoulos P,Tsalkidis A

    更新日期:2020-02-12 00:00:00

  • Relevance of Neonatal Behavior Assessment Scale for Infants With Somatic Disorders: Comparison on One Matched Group of Control.

    abstract::Objective: To compare the Neonatal Behavior Assessment Scale results in two groups of infants with or without somatic disorder (N = 26). Method: The Neonatal Behavior Assessment Scale was administered to two groups (clinical and control) of 13 infants each, aged from 5 to 18 weeks, matched 2 by 2 according to sex, age...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.506384

    authors: Belot RA,Bouteloup M,Mariage A,Candilis-Huisman D,Mottet N,Mellier D

    更新日期:2021-01-13 00:00:00

  • Case Series of COVID-19 Asymptomatic Newborns With Possible Intrapartum Transmission of SARS-CoV-2.

    abstract::Background: Despite the pandemic, data are limited regarding COVID-19 infection in pregnant women and newborns. This report aimed to bring new information about presentation that could modify precautionary measures for infants born of mothers with a remote history of COVID-19. Methods: We report two infants with possi...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2020.568979

    authors: Hascoët JM,Jellimann JM,Hartard C,Wittwer A,Jeulin H,Franck P,Morel O

    更新日期:2020-09-29 00:00:00

  • Giant Gastric Bezoar Complicating Congenital Esophageal Atresia Repaired by Gastric Interposition-A Case Report.

    abstract::We describe a giant gastric phytobezoar in a child with repaired congenital esophageal atresia. At age two, a gastric interposition (pull-up) procedure was performed for severe and recurrent esophageal strictures. For 12 months post-gastric interposition, he experienced frequent respiratory illnesses requiring hospita...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2017.00098

    authors: Chacko A,Masters BI,Isles A

    更新日期:2017-06-19 00:00:00

  • An emerging molecular understanding and novel targeted treatment approaches in pediatric kidney diseases.

    abstract::The evaluation and treatment of the heterogeneous group of kidney diseases poses a challenging field in pediatrics. Many of the pediatric disorders resulting in severe renal affection are exceedingly rare and therapeutic approaches have remained symptomatic for most of these disease entities. The insights obtained fro...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2014.00068

    authors: Liebau MC

    更新日期:2014-07-01 00:00:00

  • The Relationship Between Pediatric Residents' Experiences Being Parented and Their Provision of Parenting Advice.

    abstract::Background: Factors surrounding pediatricians' parenting advice and training on parenting during residency have not been well studied. The Resident Parenting Questionnaire (RPQ) was developed to assess (a) the relationship between pediatric residents' upbringing and their parenting advice style and (b) factors associa...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2018.00395

    authors: Bax AC,Shawler PM,Anderson MP,Wolraich ML

    更新日期:2018-12-12 00:00:00

  • Interactive Block Games for Assessing Children's Cognitive Skills: Design and Preliminary Evaluation.

    abstract::Background: This paper presents design and results from preliminary evaluation of Tangible Geometric Games (TAG-Games) for cognitive assessment in young children. The TAG-Games technology employs a set of sensor-integrated cube blocks, called SIG-Blocks, and graphical user interfaces for test administration and real-t...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2018.00111

    authors: Lee K,Jeong D,Schindler RC,Hlavaty LE,Gross SI,Short EJ

    更新日期:2018-05-08 00:00:00

  • Acquisition, Divergence, and Personalization of the Female Perineal Microbiomes Are Driven by Developmental Milestones and Disrupted by Urinary Tract Infection: A Pilot Study.

    abstract::Introduction: The pediatric perineal microbiomes inhabit a dynamic environment with changes related to diet, toileting habits, and hormonal development. We hypothesized that next-generation sequencing would reveal different perineal bacterial signatures associated with developmental milestones in premenstrual females....

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.542413

    authors: Lucas EJ,Ching CB,Saraswat S,Dabdoub SM,Kumar PP,Justice SS

    更新日期:2020-12-08 00:00:00

  • Routine Pediatric Vaccination in Pakistan During COVID-19: How Can Healthcare Professionals Help?

    abstract::Pakistan is still fighting to overcome vaccine-preventable diseases (VPD). The vaccination coverage in rural children remains unsatisfactory amid various barriers including price, hesitancy, and low level of awareness. COVID-19 has decreased the immunization rate in Pakistan due to restricted movements, shortage of va...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.613433

    authors: Khan A,Bibi A,Sheraz Khan K,Raza Butt A,Alvi HA,Zahra Naqvi A,Mushtaq S,Khan YH,Ahmad N

    更新日期:2020-12-10 00:00:00

  • Impact of Brain Injury on Processing of Emotional Prosodies in Neonates.

    abstract::Being able to appropriately process different emotional prosodies is an important cognitive ability normally present at birth. In this study, we used event-related potential (ERP) to assess whether brain injury impacts the ability to process different emotional prosodies (happy, fear, and neutral) in neonates; whether...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2019.00192

    authors: Sun G,Xie H,Liu Y,Chen Y,Hou X,Zhang D

    更新日期:2019-05-09 00:00:00

  • Assessment of Seroconversion to SARS-CoV-2 in a Cohort of Pediatric Kidney Transplant Recipients.

    abstract::Background: The occurrence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated coronavirus disease 2019 (COVID-19) have profoundly affected adult kidney disease patients. In contrast, pediatric solid organ transplant recipients, including pediatric kidney transplant (KT) recipients, ...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.601327

    authors: Nailescu C,Khalid M,Wilson AC,Amanat F,Arregui S,Canas J,Hooks J,Krammer F,Schwaderer AL,Hains DS

    更新日期:2020-10-30 00:00:00

  • Prevalence and Management of Severe Hand, Foot, and Mouth Disease in Xiangyang, China, From 2008 to 2013.

    abstract::Therapeutic strategies for severe hand, foot, and mouth disease (HFMD) are currently either inconsequent or deficient in evidence. We retrospectively surveyed HFMD outbreaks in Xiangyang from June 2008 to December 2013. HFMD is staged from I to V according to clinical severity. Severe HFMD is defined as a case involvi...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00323

    authors: Liu J,Qi J

    更新日期:2020-07-10 00:00:00

  • Influence of Sex on Gestational Complications, Fetal-to-Neonatal Transition, and Postnatal Adaptation.

    abstract::Fetal sex is associated with striking differences during in utero development, fetal-to-neonatal transition, and postnatal morbidity and mortality. Male sex fetuses are apparently protected while in utero resulting in a higher secondary sex rate for males than for females. However, during fetal-to-neonatal transition ...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2018.00063

    authors: Lorente-Pozo S,Parra-Llorca A,Torres B,Torres-Cuevas I,Nuñez-Ramiro A,Cernada M,García-Robles A,Vento M

    更新日期:2018-04-23 00:00:00

  • A Successful Whole Body Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy During an ECMO Run in a Newborn.

    abstract::Data regarding the safety of using therapeutic hypothermia (TH) with extracorporeal membrane oxygenation (ECMO) in neonates with both hypoxic ischemic encephalopathy (HIE), and respiratory failure are lacking. TH is not associated with an increased incidence of hemostatic complications, but hypothermia may impair coag...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2019.00095

    authors: Okulu E,Erdeve O,Pekcici BB,Kendirli T,Eyileten Z,Atasay B,Arsan S

    更新日期:2019-03-22 00:00:00

  • Changing incidence of inflammatory bowel disease: environmental influences and lessons learnt from the South asian population.

    abstract::Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the gastrointestinal tract associated with significant morbidity. While IBD occurs in genetically susceptible individuals, the etiology is multifactorial, involving environmental influences, intestinal dysbiosis, and altered immune respon...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2013.00034

    authors: Foster A,Jacobson K

    更新日期:2013-11-06 00:00:00

  • Relationship Between Oxidative Stress Markers and Endothelin-1 Levels in Newborns of Different Gestational Ages.

    abstract::Oxidative stress results from excessive reactive oxygen species formation and/or inadequate antioxidant defense. Premature and critically ill infants are especially susceptible due to an immature intrinsic antioxidant system that cannot fully compensate for a free radical load. Oxidative stress is also associated with...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00279

    authors: Stefanov G,Briyal S,Pais G,Puppala B,Gulati A

    更新日期:2020-06-02 00:00:00

  • Stem Cells as Therapy for Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis of Preclinical Studies.

    abstract::Background: Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal condition among very and extremely preterm infants. Stem cell therapy has shown some promising protective effects in animal models of intestinal injury, including NEC, but no systematic review has yet evaluated the preclin...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2020.578984

    authors: Villamor-Martinez E,Hundscheid T,Kramer BW,Hooijmans CR,Villamor E

    更新日期:2020-12-09 00:00:00

  • Health Service Use and Treatment Choices for Pediatric Eosinophilic Esophagitis: Findings From a Cross-Sectional Survey of Australian Carers.

    abstract::Objectives: The incidence and the prevalence of eosinophilic esophagitis (EoE) are increasing, and healthcare utilization among children with EoE is high. This study provides novel insights into the health services and the treatments, including complementary medicines (CMs), used by carers to manage their children's E...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00147

    authors: Hannan N,Steel A,McMillan SS,Tiralongo E

    更新日期:2020-04-17 00:00:00

  • Autoimmune Congenital Heart Block: A Review of Biomarkers and Management of Pregnancy.

    abstract::Autoimmune Congenital Heart Block (CHB) is an immune-mediated disease due to transplacental passage of circulating anti-Ro/SSA and anti-La/SSB autoantibodies. It occurs in 2% of anti-Ro/SSA-exposed pregnancies, and recurrence rate is nine times higher in subsequent pregnancies. Aim of this review is to identify biomar...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2020.607515

    authors: De Carolis S,Garufi C,Garufi E,De Carolis MP,Botta A,Tabacco S,Salvi S

    更新日期:2020-12-22 00:00:00

  • Failing to Make Ends Meet: The Broad Clinical Spectrum of DNA Ligase IV Deficiency. Case Series and Review of the Literature.

    abstract::DNA repair defects are inborn errors of immunity that result in increased apoptosis and oncogenesis. DNA Ligase 4-deficient patients suffer from a wide range of clinical manifestations since early in life, including: microcephaly, dysmorphic facial features, growth failure, developmental delay, mental retardation; hip...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2018.00426

    authors: Staines Boone AT,Chinn IK,Alaez-Versón C,Yamazaki-Nakashimada MA,Carrillo-Sánchez K,García-Cruz MLH,Poli MC,González Serrano ME,Medina Torres EA,Muzquiz Zermeño D,Forbes LR,Espinosa-Rosales FJ,Espinosa-Padilla SE,Orange JS,Lu

    更新日期:2019-01-21 00:00:00

  • Vitamin D-Resistant Rickets and Cinacalcet-One More Favorable Experience.

    abstract::Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder characterized by early onset of severe rickets, with a complete triad of clinical, biochemical and skeletal abnormalities. Homozygous or heterozygous mutations in the vitamin D receptor (VDR) gene leading to complete or partial target or...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2018.00376

    authors: Nicolescu RC,Lombet J,Cavalier E

    更新日期:2018-11-28 00:00:00

  • Intellectual Functioning in Children with Congenital Heart Defects Treated with Surgery or by Catheter Interventions.

    abstract:BACKGROUND:Studies suggest that children with congenital heart defects (CHD) are at risk for adverse intellectual functioning. However, factors related to lower intellectual functioning in this group are largely unknown. This study describes intellectual functioning in children with CHD in relation to severity of the h...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2016.00113

    authors: Ryberg C,Sunnegårdh J,Thorson M,Broberg M

    更新日期:2016-11-17 00:00:00

  • Prevalence of Respiratory Polyomaviruses Among Pediatric Patients With Respiratory Symptoms in Singapore.

    abstract::Background: Although WU polyomavirus (WU) and KI polyomavirus (KI) have been demonstrated to infect the human respiratory tract, it remains unclear if WU or KI cause human disease. We sought to further investigate the relationship between WU and KI infection and respiratory disease in a pediatric population with respi...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2018.00228

    authors: Hansen-Estruch C,Coleman KK,Thoon KC,Low JG,Anderson BD,Gray GC

    更新日期:2018-08-17 00:00:00