Prevalence of Respiratory Polyomaviruses Among Pediatric Patients With Respiratory Symptoms in Singapore.

Abstract:

:Background: Although WU polyomavirus (WU) and KI polyomavirus (KI) have been demonstrated to infect the human respiratory tract, it remains unclear if WU or KI cause human disease. We sought to further investigate the relationship between WU and KI infection and respiratory disease in a pediatric population with respiratory symptoms in Singapore. Methods: We conducted a cross-sectional study of pediatric patients with respiratory symptoms in a Singaporean pediatrics hospital. Upon consent, residual respiratory samples from pediatric inpatients, previously screened for common respiratory viruses, were collected and further screened for WU and KI using qPCR. The amplicons of positive samples were sequenced for confirmation. The severity of a patient's illness was assessed by chart review post-discharge looking for clinical markers of respiratory status such as presenting symptoms, diagnoses, and interventions. Results: From December 2016 to April 2017, 201 patients with residual respiratory samples were enrolled in the study. The average age of all participants recruited was 45 months. WU and KI were detected in 13% (26/201) and 3% (6/201) of patients, respectively. Conducting bivariate and multivariate modeling, patients with WU or KI positivity were not at increased risk of SARI, need for additional oxygen, intravenous fluids, and did not receive additional oral antibiotics or bronchodilators during admission. In contrast, patients with RSV detections were at increased risk of requiring supplemental oxygen during hospital admission. Conclusion: While limited in sample size, our pilot study data do not support the hypothesis that molecular evidence of WU or KI was associated with increased morbidity among a sample of general, pediatric patients with respiratory illness in Singapore.

journal_name

Front Pediatr

journal_title

Frontiers in pediatrics

authors

Hansen-Estruch C,Coleman KK,Thoon KC,Low JG,Anderson BD,Gray GC

doi

10.3389/fped.2018.00228

subject

Has Abstract

pub_date

2018-08-17 00:00:00

pages

228

issn

2296-2360

journal_volume

6

pub_type

杂志文章
  • Early Gut Fungal and Bacterial Microbiota and Childhood Growth.

    abstract::Introduction: Childhood growth is a sensitive marker of health. Animal studies show increased height and weight velocity in the presence of fungal as well as antibiotic supplement in feed. Human studies on early gut microbiota and anthropometrics have mainly focused on bacteria only and overweight, with diverging resu...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.572538

    authors: Schei K,Simpson MR,Avershina E,Rudi K,Øien T,Júlíusson PB,Underhill D,Salamati S,Ødegård RA

    更新日期:2020-11-09 00:00:00

  • CSF Surfactant Protein Changes in Preterm Infants After Intraventricular Hemorrhage.

    abstract::Introduction: Surfactant proteins (SP) have been shown to be inherent proteins of the human CNS and are altered during acute and chronic disturbances of CSF circulation. Aim of the study was to examine the changes of surfactant protein concentrations in CSF of preterm babies suffering from intraventricular hemorrhage....

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.572851

    authors: Krause M,Härtig W,Mahr CV,Richter C,Schob J,Puchta J,Hoffmann KT,Nestler U,Thome U,Knüpfer M,Gebauer C,Schob S

    更新日期:2020-09-25 00:00:00

  • Pre-pregnancy Maternal Weight and Gestational Weight Gain Increase the Risk for Childhood Asthma and Wheeze: An Updated Meta-Analysis.

    abstract::Background: Mounting evidence suggests that childhood asthma is closely associated with maternal weight before pregnancy and gestational weight gain (GWG), yet the results are not often reproducible. Objectives: We conducted a comprehensive meta-analysis, aiming to evaluate the association of pre-pregnancy maternal ob...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2020.00134

    authors: Liu S,Zhou B,Wang Y,Wang K,Zhang Z,Niu W

    更新日期:2020-04-03 00:00:00

  • Prevalence and Management of Severe Hand, Foot, and Mouth Disease in Xiangyang, China, From 2008 to 2013.

    abstract::Therapeutic strategies for severe hand, foot, and mouth disease (HFMD) are currently either inconsequent or deficient in evidence. We retrospectively surveyed HFMD outbreaks in Xiangyang from June 2008 to December 2013. HFMD is staged from I to V according to clinical severity. Severe HFMD is defined as a case involvi...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00323

    authors: Liu J,Qi J

    更新日期:2020-07-10 00:00:00

  • Where Children Live: Examining Whether Neighborhood Crime and Poverty Is Associated With Overweight and Obesity Among Low-Income Preschool-Aged Primary Care Patients.

    abstract::Introduction: Low-income and racial/ethnic minority preschoolers (aged 2-5 years) are disproportionately affected by obesity and its associated health consequences. Individual-level factors (e.g., diet) and environmental factors (e.g., neighborhood conditions) contribute to these disparities. However, there is limited...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2018.00433

    authors: Showell NN,Jennings JM,Johnson KA,Perin J,Thornton RLJ

    更新日期:2019-01-22 00:00:00

  • Cancer Risk in Pediatric-Onset Inflammatory Bowel Disease.

    abstract::Inflammatory bowel disease (IBD) is a chronic, immune-mediated, non-curable disease. The incidence of IBD appears to have risen over the last few decades especially in the pediatric age group. IBD usually presents with gastrointestinal symptoms, including abdominal pain, diarrhea, and bleeding per rectum but can also ...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2020.00400

    authors: El-Matary W,Bernstein CN

    更新日期:2020-07-17 00:00:00

  • Infants of Mothers With Diabetes and Subsequent Attention Deficit Hyperactivity Disorder: A Retrospective Cohort Study.

    abstract::Background: Maternal diabetes mellitus (DM) increases the risk of fetal, neonatal, and long-term complications in offspring. Although this has been widely known for decades, data are limited regarding the effect of maternal pregestational and gestational diabetes on the subsequent neurodevelopmental outcome of offspri...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2019.00452

    authors: Lin CH,Lin WD,Chou IC,Lee IC,Hong SY

    更新日期:2019-11-04 00:00:00

  • Bone-Anchored Hearing Aid vs. Reconstruction of the External Auditory Canal in Children and Adolescents with Congenital Aural Atresia: A Comparison Study of Outcomes.

    abstract:OBJECTIVES/HYPOTHESIS:Congenital aural atresia is a rare condition affecting 1 in 10,000-20,000 children a year. Surgery is required to restore hearing to facilitate normal development. The objective of this study was to compare outcomes in hearing, complications, and quality of life of surgical reconstruction of the e...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2014.00005

    authors: Farnoosh S,Mitsinikos FT,Maceri D,Don DM

    更新日期:2014-01-22 00:00:00

  • Asymptomatic Congenital Lung Malformations: Timing of Resection Does Not Affect Adverse Surgical Outcomes.

    abstract::Background: Optimal timing for resection of asymptomatic congenital lung malformations (CLMs) remains controversial. The aim of this study is to define optimal timing for surgical intervention of patients with CLMs and define clinical variables that affect surgical outcomes. Methods: An IRB-approved retrospective anal...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00035

    authors: Duron V,Zenilman A,Griggs C,DeFazio J,Price JC,Fan W,Vivero M,Castrillon J,Schmaedick M,Iqbal E,Rothenberg S

    更新日期:2020-02-14 00:00:00

  • Henoch-Schönlein Purpura Presenting in Association With Neuroblastoma: A Case Report.

    abstract::Henoch-Schönlein purpura (HSP) is a common systemic vasculitis affecting children. It is managed in the outpatient setting and rarely associated with malignancy. We present a case of neuroblastoma in a 7-year-old boy diagnosed after suspected HSP. Our case highlights the importance of maintaining a broad differential ...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2020.00077

    authors: Alfath Z,Ferdjallah A,Greengard E,Askari SK,Sadak KT,Correll CK

    更新日期:2020-02-28 00:00:00

  • A child with acute encephalopathy associated with quadruple viral infection.

    abstract:UNLABELLED:Pediatric acute encephalopathy (AE) was sometimes attributed to virus infection. However, viral infection does not always result in AE. The risk factors for developing infantile AE upon virus infection remain to be determined. Here, we report an infant with AE co-infected with human herpesvirus-6 (HHV-6) and...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2015.00026

    authors: Nakata K,Kashiwagi M,Masuda M,Shigehara S,Oba C,Murata S,Kase T,Komano JA

    更新日期:2015-04-02 00:00:00

  • Effects of Intrauterine Inflammation on Cortical Gray Matter of Near-Term Lambs.

    abstract::Introduction: Ventilation causes cerebral white matter inflammation and injury, which is exacerbated by intrauterine inflammation. However, the effects on cortical gray matter are not well-known. Our aim was to examine the effect of ventilation on the cerebral cortex of near-term lambs exposed to intrauterine inflamma...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2018.00145

    authors: Stojanovska V,Atik A,Nitsos I,Skiöld B,Barton SK,Zahra VA,Rodgers K,Hooper SB,Polglase GR,Galinsky R

    更新日期:2018-06-15 00:00:00

  • DNA Methylation Profile in Human Cord Blood Mononuclear Leukocytes From Term Neonates: Effects of Histological Chorioamnionitis.

    abstract::Background: Histological chorioamnionitis (HCA) is an infection/inflammation of fetal membranes and complicates 5.2-28.5% of all live births. Exposure to HCA can have long-term consequences including abnormal neurodevelopment and an increased risk for allergic disorders and asthma later in childhood. HCA may incite ep...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00437

    authors: Fong G,Gayen Nee' Betal S,Murthy S,Favara M,Chan JSY,Addya S,Shaffer TH,Greenspan J,Bhandari V,Li D,Rahman I,Aghai ZH

    更新日期:2020-08-04 00:00:00

  • Management of Multi Organ Dysfunction in Neonatal Encephalopathy.

    abstract::Neonatal Encephalopathy (NE) describes neonates with disturbed neurological function in the first post-natal days of life. NE is an overall term that does not specify the etiology of the encephalopathy although it often involves hypoxia-ischaemia. In NE, although neurological dysfunction is part of the injury and is m...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2020.00239

    authors: O'Dea M,Sweetman D,Bonifacio SL,El-Dib M,Austin T,Molloy EJ

    更新日期:2020-05-15 00:00:00

  • Health Service Use and Treatment Choices for Pediatric Eosinophilic Esophagitis: Findings From a Cross-Sectional Survey of Australian Carers.

    abstract::Objectives: The incidence and the prevalence of eosinophilic esophagitis (EoE) are increasing, and healthcare utilization among children with EoE is high. This study provides novel insights into the health services and the treatments, including complementary medicines (CMs), used by carers to manage their children's E...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00147

    authors: Hannan N,Steel A,McMillan SS,Tiralongo E

    更新日期:2020-04-17 00:00:00

  • Immunomodulation in Pediatric Asthma.

    abstract::Childhood asthma is actually defined as a heterogeneous disease, including different clinical variants and partially sharing similar immune mechanisms. Asthma management is mainly focused on maintaining the control of the disease and reducing the risk of adverse outcomes. Most children achieve good control with standa...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2019.00289

    authors: Licari A,Manti S,Castagnoli R,Marseglia A,Foiadelli T,Brambilla I,Marseglia GL

    更新日期:2019-07-12 00:00:00

  • Corrigendum: Off-Label Use of Ataluren in Four Non-ambulatory Patients With Duchenne Muscular Dystrophy: Effects on Cardiac and Pulmonary Function and Muscle Strength.

    abstract::[This corrects the article DOI: 10.3389/fped.2018.00316.]. ...

    journal_title:Frontiers in pediatrics

    pub_type: 已发布勘误

    doi:10.3389/fped.2019.00284

    authors: Ebrahimi-Fakhari D,Dillmann U,Flotats-Bastardas M,Poryo M,Abdul-Khaliq H,Shamdeen MG,Mischo B,Zemlin M,Meyer S

    更新日期:2019-07-25 00:00:00

  • Advances in the Study of Chronic Active Epstein-Barr Virus Infection: Clinical Features Under the 2016 WHO Classification and Mechanisms of Development.

    abstract::Chronic active Epstein-Barr virus infection (CAEBV) is one of the Epstein-Barr virus (EBV)-positive T- or NK-lymphoproliferative diseases. It is considered rare and geographically limited to Japan and East Asia. However, CAEBV is drawing international attention, and the number of case reported worldwide is increasing,...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2019.00014

    authors: Arai A

    更新日期:2019-02-05 00:00:00

  • Oxidative Stress and Bronchial Asthma in Children-Causes or Consequences?

    abstract::Bronchial asthma is one of the most common chronic inflammatory diseases of the airways. In the pathogenesis of this disease, the interplay among the genes, intrinsic, and extrinsic factors are crucial. Various combinations of the involved factors determine and modify the final clinical phenotype/endotype of asthma. O...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2017.00162

    authors: Jesenak M,Zelieskova M,Babusikova E

    更新日期:2017-07-24 00:00:00

  • Giant Gastric Bezoar Complicating Congenital Esophageal Atresia Repaired by Gastric Interposition-A Case Report.

    abstract::We describe a giant gastric phytobezoar in a child with repaired congenital esophageal atresia. At age two, a gastric interposition (pull-up) procedure was performed for severe and recurrent esophageal strictures. For 12 months post-gastric interposition, he experienced frequent respiratory illnesses requiring hospita...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2017.00098

    authors: Chacko A,Masters BI,Isles A

    更新日期:2017-06-19 00:00:00

  • Challenges in Maintaining the Hemostatic Balance in Children Undergoing Extracorporeal Membrane Oxygenation: A Systematic Literature Review.

    abstract::Background: Despite advances in technology and clinical experience, the incidence of hemostatic complications, including bleeding and thrombosis, remains high in children supported with extracorporeal membrane oxygenation (ECMO). These hemostatic complications are important to prevent, since they are associated with i...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2020.612467

    authors: Drop JGF,Wildschut ED,Gunput STG,de Hoog M,van Ommen CH

    更新日期:2020-12-16 00:00:00

  • Brain Lesions among Orally Fed and Gastrostomy-Fed Dysphagic Preterm Infants: Can Routine Qualitative or Volumetric Quantitative Magnetic Resonance Imaging Predict Feeding Outcomes?

    abstract:INTRODUCTION:The usefulness of qualitative or quantitative volumetric magnetic resonance imaging (MRI) in early detection of brain structural changes and prediction of adverse outcomes in neonatal illnesses warrants further investigation. Our aim was to correlate certain brain injuries and the brain volume of feeding-r...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2017.00073

    authors: Kashou NH,Dar IA,El-Mahdy MA,Pluto C,Smith M,Gulati IK,Lo W,Jadcherla SR

    更新日期:2017-04-10 00:00:00

  • Spaced scenario demonstrations improve knowledge and confidence in pediatric acute illness management.

    abstract:OBJECTIVES:Nationally accredited simulation courses such as advance pediatric life support and pediatric advance life support are recommended for health care professionals (HCPs) at two yearly intervals as a minimum requirement, despite literature evidence suggesting rapid decline in knowledge shortly after course comp...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2014.00133

    authors: Ojha R,Liu A,Champion BL,Hibbert E,Nanan RK

    更新日期:2014-11-24 00:00:00

  • Prediction of Bronchopulmonary Dysplasia in Preterm Infants Using Postnatal Risk Factors.

    abstract::Objective: To identify postnatal risk factors for bronchopulmonary dysplasia (BPD) development in preterm infants with gestational age ≤32 weeks. Methods: Seventy-two preterm infants(30 with BPD and 42 non-BPD controls) admitted in the neonatal intensive care unit (NICU) of the Children's Hospital of Soochow Universit...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00349

    authors: Ding L,Wang H,Geng H,Cui N,Huang F,Zhu X,Zhu X

    更新日期:2020-06-26 00:00:00

  • Age-related psychophysiological vulnerability to phenylalanine in phenylketonuria.

    abstract:BACKGROUND:Phenylketonuria (PKU) is caused by the inherited defect of the phenylalanine hydroxylase enzyme, which converts phenylalanine (Phe) into tyrosine (Tyr). Neonatal screening programs and early treatment have radically changed the natural history of PKU. Nevertheless, an increased risk of neurocognitive and psy...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2014.00057

    authors: Leuzzi V,Mannarelli D,Manti F,Pauletti C,Locuratolo N,Carducci C,Carducci C,Vanacore N,Fattapposta F

    更新日期:2014-06-23 00:00:00

  • New Methods for Imaging Evaluation of Chest Wall Deformities.

    abstract:Aim:The purpose of this study is to describe the development of an external 3-dimensional (3D) scanner as a noninvasive method for imaging chest wall deformities. It allows objective assessment, reconstruction of the area of interest, and evaluation of the severity of the deformity by using external indexes. External ...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2017.00257

    authors: Lain A,Garcia L,Gine C,Tiffet O,Lopez M

    更新日期:2017-12-04 00:00:00

  • New Insights into Congenital Diaphragmatic Hernia - A Surgeon's Introduction to CDH Animal Models.

    abstract::In recent decades, new research into the developmental defects and pathophysiological basis of congenital diaphragmatic hernia (CDH) has revealed opportunities for the development of innovative therapies. Importantly, the use of animal models to represent this anomaly in the laboratory has resulted in the discovery of...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2014.00036

    authors: Chiu PP

    更新日期:2014-04-29 00:00:00

  • Relevant Outcomes in Pediatric Acute Respiratory Distress Syndrome Studies.

    abstract::Despite distinct epidemiology and outcomes, pediatric acute respiratory distress syndrome (PARDS) is often managed based on evidence extrapolated from treatment of adults. The impact of non-pulmonary processes on mortality as well as the lower mortality rate compared to adults with acute respiratory distress syndrome ...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2016.00051

    authors: Yehya N,Thomas NJ

    更新日期:2016-05-13 00:00:00

  • The Role of Sensitization to Allergen in Asthma Prediction and Prevention.

    abstract::The burden of asthma in childhood is considerable worldwide, although some populations are much more affected than others. Many attempts have been made by different investigators to identify the factors that could predict asthma development or persistence in childhood. In this review, the relation between atopic sensi...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2017.00166

    authors: Moustaki M,Loukou I,Tsabouri S,Douros K

    更新日期:2017-07-31 00:00:00

  • A Successful Whole Body Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy During an ECMO Run in a Newborn.

    abstract::Data regarding the safety of using therapeutic hypothermia (TH) with extracorporeal membrane oxygenation (ECMO) in neonates with both hypoxic ischemic encephalopathy (HIE), and respiratory failure are lacking. TH is not associated with an increased incidence of hemostatic complications, but hypothermia may impair coag...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2019.00095

    authors: Okulu E,Erdeve O,Pekcici BB,Kendirli T,Eyileten Z,Atasay B,Arsan S

    更新日期:2019-03-22 00:00:00