Targeting FLT3 Signaling in Childhood Acute Myeloid Leukemia.

abstract：:Background: High parent education is protective against youth health risk behaviors such as tobacco use. According to the Minorities' Diminished Returns theory, however, higher parent education seems to exert less protection for the ethnic minority relative to the majority groups. Objectives: To explore ethnic differe...

journal_title：Frontiers in pediatrics

authors： Assari S,Boyce S,Caldwell CH,Bazargan M

更新日期：2020-08-19 00:00:00

abstract：:Introduction: Ventilation causes cerebral white matter inflammation and injury, which is exacerbated by intrauterine inflammation. However, the effects on cortical gray matter are not well-known. Our aim was to examine the effect of ventilation on the cerebral cortex of near-term lambs exposed to intrauterine inflamma...

journal_title：Frontiers in pediatrics

authors： Stojanovska V,Atik A,Nitsos I,Skiöld B,Barton SK,Zahra VA,Rodgers K,Hooper SB,Polglase GR,Galinsky R

更新日期：2018-06-15 00:00:00

abstract：OBJECTIVE:We investigated the relationship between influenza seasonality and outcome of very low birth weight infants (VLBWI) in a large observational cohort study of the German Neonatal Network. MATERIALS AND METHODS:Within the observational period (July 2009 until December 2014), five influenza seasons occurred (mea...

journal_title：Frontiers in pediatrics

authors： Härtel C,Humberg A,Viemann D,Stein A,Orlikowsky T,Rupp J,Kopp MV,Herting E,Göpel W

更新日期：2016-11-30 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) affects 1 in 400 to 1,000 live births, making it the most common monogenic cause of renal failure. Although no definite cure is available yet, it is important to affect disease progression by influencing modifiable factors such as hypertension and proteinuria. Besid...

journal_title：Frontiers in pediatrics

authors： De Rechter S,Breysem L,Mekahli D

更新日期：2017-12-20 00:00:00

abstract：:A 3-year-old girl was admitted to our hospital for the correction of atrial septal defect (ASD). Open heart operation with cardiopulmonary bypass is dangerous because the patient also had hereditary spherocytosis, which put her at risk for hemolytic anemia. Therefore, percutaneous transcatheter closure for ASD was cho...

journal_title：Frontiers in pediatrics

authors： Ji Z,Liu N,Du Z,Luo G,Bing Z,Xing Q,Pan S

更新日期：2019-12-17 00:00:00

abstract：:Over the past decade, there has been a growing awareness of the vital role of the microbiome in the function of the immune system. Recently, several studies have demonstrated a relationship between the composition of the microbiome and the vaccine-specific immune response. As a result of these findings, the administra...

journal_title：Frontiers in pediatrics

authors： Ruck CE,Odumade OA,Smolen KK

更新日期：2020-11-26 00:00:00

abstract：:Objectives: Mutations in the neuroblastoma-amplified sequence (NBAS) gene were originally described in patients with skeletal dysplasia or isolated liver disease of variable severity. Subsequent publications reported a more complex phenotype. Among multisystemic clinical symptoms, we were particularly interested in th...

journal_title：Frontiers in pediatrics

authors： Khoreva A,Pomerantseva E,Belova N,Povolotskaya I,Konovalov F,Kaimonov V,Gavrina A,Zimin S,Pershin D,Davydova N,Burlakov V,Viktorova E,Roppelt A,Kalinina E,Novichkova G,Shcherbina A

更新日期：2020-09-15 00:00:00

abstract：:Objectives: Severe congenital neutropenia (SCN) is a primary immunodeficiency disease characterized by the early onset of recurrent infections and persistent severe neutropenia, with or without genetic defect. We aimed to study the different clinical features and hematological and bone marrow characteristics of patien...

journal_title：Frontiers in pediatrics

authors： Gong RL,Wu J,Chen TX

更新日期：2018-10-16 00:00:00

abstract：:Emerging literature suggests that delayed identification of childhood asthma results in an increased risk of long-term and various morbidities compared to those with timely diagnosis and intervention, and yet this risk is still overlooked. Even when children and adolescents have a history of recurrent asthma-like symp...

journal_title：Frontiers in pediatrics

authors： Seol HY,Sohn S,Liu H,Wi CI,Ryu E,Park MA,Juhn YJ

更新日期：2019-04-02 00:00:00

abstract：:Background: Childhood refractory mycoplasma pneumoniae (MP) pneumonia (RMPP) is a lung disease with elevated level of C-reactive protein and severe clinical and radiological deterioration. Whether bacterial co-infection contributes to disease of RMPP and whether inclusion of non-anti-MP antibiotics in treatment regime...

journal_title：Frontiers in pediatrics

authors： Liu JR,Lu J,Dong F,Li HM,Liu H,Tang XL,Guo YL,Zhao SY

更新日期：2018-10-26 00:00:00

abstract：:Background: Placenta shows high transcription levels of human endogenous retroviruses (HERVs) that are overexpressed during embryonic and fetal development. Methods: In order to gather further information on the degree of HERV activation in maternal and fetal tissues we assessed the transcription levels of pol genes o...

journal_title：Frontiers in pediatrics

authors： Bergallo M,Marozio L,Botta G,Tancredi A,Daprà V,Galliano I,Montanari P,Coscia A,Benedetto C,Tovo PA

更新日期：2020-05-14 00:00:00

abstract：:Purpose of Review: A significant number of pregnancies are complicated by a fetus with a life-limiting diagnosis. As diagnoses are made earlier in the pregnancy, families experience anticipatory grief and are faced with navigating goals of care for a baby that has yet to be born. With the support of the care team, fam...

journal_title：Frontiers in pediatrics

authors： Cortezzo DE,Ellis K,Schlegel A

更新日期：2020-09-08 00:00:00

abstract：:Introduction: Primary repair of esophageal atresia (EA) in infants with very low birth weight (VLBW) and extremely low birth weight (ELBW) has been widely performed in pediatric surgery. However, several studies have shown that complication rates in infants with VLBW are high. We hypothesize preterm children benefit f...

journal_title：Frontiers in pediatrics

authors： Ritz LA,Widenmann-Grolig A,Jechalke S,Bergmann S,von Schweinitz D,Lurz E,Hubertus J

更新日期：2020-11-17 00:00:00

abstract：:Objective: To compare the Neonatal Behavior Assessment Scale results in two groups of infants with or without somatic disorder (N = 26). Method: The Neonatal Behavior Assessment Scale was administered to two groups (clinical and control) of 13 infants each, aged from 5 to 18 weeks, matched 2 by 2 according to sex, age...

journal_title：Frontiers in pediatrics

authors： Belot RA,Bouteloup M,Mariage A,Candilis-Huisman D,Mottet N,Mellier D

更新日期：2021-01-13 00:00:00

abstract：UNLABELLED:Pediatric acute encephalopathy (AE) was sometimes attributed to virus infection. However, viral infection does not always result in AE. The risk factors for developing infantile AE upon virus infection remain to be determined. Here, we report an infant with AE co-infected with human herpesvirus-6 (HHV-6) and...

journal_title：Frontiers in pediatrics

authors： Nakata K,Kashiwagi M,Masuda M,Shigehara S,Oba C,Murata S,Kase T,Komano JA

更新日期：2015-04-02 00:00:00

abstract：:Introduction: Anterior lens capsule vascularity (ALCV) is resorbed in the developing fetus from 27 to 35 weeks gestation. In this pilot study, we evaluated the feasibility and validity of combining smartphone ophthalmoscope videos of ALCV and image analysis for gestational age estimation. Methods: ALCV videos were cap...

journal_title：Frontiers in pediatrics

authors： Patel M,Mukherjee D,Farsiu S,Munoz B,Blood AB,Wilson CG,Griffin JB

更新日期：2019-02-20 00:00:00

abstract：:Introduction: Children younger than 2 years have an increased risk of complications associated with tuberculosis (TB) due to the immaturity of the innate and adaptive immune response. We aimed to identify TB clinical presentations and outcomes as well as risk factors for complications in this age group. Materials and ...

journal_title：Frontiers in pediatrics

authors： Soriano-Arandes A,Brugueras S,Rodríguez Chitiva A,Noguera-Julian A,Orcau À,Martín-Nalda A,Millet JP,Vallmanya T,Méndez M,Coll-Sibina M,Mayol L,Clopés A,Pineda V,García L,López N,Calavia O,Rius N,Pérez-Porcuna TM,Soler

更新日期：2019-06-11 00:00:00

abstract：:Background: Eye exam for Retinopathy of prematurity (ROP) is a painful procedure and pharmacological analgesia might be ineffective. We hypothesized that magnetic auricular acupuncture (MAA) compared to placebo will decrease pain during ROP exam in preterm infants. Methods: Multicentre randomized controlled trial cond...

journal_title：Frontiers in pediatrics

authors： Gan KML,Oei JL,Quah-Smith I,Kamar AA,Lordudass AAD,Liem KD,Lindrea KB,Daly M,Gaunker N,Mangat AK,Yaskina M,Schmölzer GM

更新日期：2020-12-23 00:00:00

abstract：:Introduction: The pediatric perineal microbiomes inhabit a dynamic environment with changes related to diet, toileting habits, and hormonal development. We hypothesized that next-generation sequencing would reveal different perineal bacterial signatures associated with developmental milestones in premenstrual females....

journal_title：Frontiers in pediatrics

authors： Lucas EJ,Ching CB,Saraswat S,Dabdoub SM,Kumar PP,Justice SS

更新日期：2020-12-08 00:00:00

abstract：:Aim: The aim of this study was to evaluate the surgical outcome, in terms of gait improvement, of endoscopic transverse Vulpius gastrocsoleus recession in children with cerebral palsy compared to the traditional open surgery. Methods: Twenty-seven children with cerebral palsy who had undergone endoscopic transverse Vu...

journal_title：Frontiers in pediatrics

authors： Kim DW,Kim HW,Yoon JY,Rhee I,Oh MK,Park KB

更新日期：2020-03-24 00:00:00

abstract：:Background: Autosomal recessive primary microcephaly (Microcephaly Primary Hereditary, MCPH) is a rare disorder, affecting 1 in 10,000 children in areas where consanguineous marriages are common. WDR62 gene mutations are the second most common cause of MCPH. Herein, we report a case of primary microcephaly caused by t...

journal_title：Frontiers in pediatrics

authors： Yi YG,Lee DW,Kim J,Jang JH,Lee SM,Jang DH

更新日期：2019-11-07 00:00:00

abstract：:Isoflavones are dietary phytoestrogens commonly found in soy-based products. The widespread presence of isoflavones in soy infant formula and breast milk may have long-lasting effects on the development of sex hormone-sensitive organs like the skeleton. Animal early-life programming models are suitable for testing the...

journal_title：Frontiers in pediatrics

authors： Chin KY,Pang KL

更新日期：2020-09-11 00:00:00

abstract：:Pertussis, caused by Bordetella (B.) pertussis, a Gram-negative bacterium, is a highly contagious airway infection. Especially in infants, pertussis remains a major health concern. Acute infection with B. pertussis can cause severe illness characterized by severe respiratory failure, pulmonary hypertension, leucocytos...

journal_title：Frontiers in pediatrics

authors： Zlamy M

更新日期：2016-06-08 00:00:00

abstract：:Background: Improved diagnostic tests are needed for the early identification of Mycobacterium tuberculosis-infected young children exposed to an active TB (aTB) index case. We aimed to compare the diagnostic accuracy of new blood-based tests to that of the tuberculin skin test (TST) for the identification of all infe...

journal_title：Frontiers in pediatrics

authors： Dreesman A,Dirix V,Smits K,Corbière V,Van Praet A,Debulpaep S,De Schutter I,Felderhof MK,Malfroot A,Singh M,Locht C,Mouchet F,Mascart F

更新日期：2019-07-25 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic, immune-mediated, non-curable disease. The incidence of IBD appears to have risen over the last few decades especially in the pediatric age group. IBD usually presents with gastrointestinal symptoms, including abdominal pain, diarrhea, and bleeding per rectum but can also ...

journal_title：Frontiers in pediatrics

authors： El-Matary W,Bernstein CN

更新日期：2020-07-17 00:00:00

abstract：:Chronic active Epstein-Barr virus infection (CAEBV) is one of the Epstein-Barr virus (EBV)-positive T- or NK-lymphoproliferative diseases. It is considered rare and geographically limited to Japan and East Asia. However, CAEBV is drawing international attention, and the number of case reported worldwide is increasing,...

journal_title：Frontiers in pediatrics

authors： Arai A

更新日期：2019-02-05 00:00:00

abstract：INTRODUCTION:The usefulness of qualitative or quantitative volumetric magnetic resonance imaging (MRI) in early detection of brain structural changes and prediction of adverse outcomes in neonatal illnesses warrants further investigation. Our aim was to correlate certain brain injuries and the brain volume of feeding-r...

journal_title：Frontiers in pediatrics

authors： Kashou NH,Dar IA,El-Mahdy MA,Pluto C,Smith M,Gulati IK,Lo W,Jadcherla SR

更新日期：2017-04-10 00:00:00

abstract：:Animal models provide convenient and clinically relevant tools in the research on neurodegenerative diseases. Studies on developmental disorders extensively rely on the use of laboratory rodents. The present mini-review proposes an alternative translational model based on the use of fetal bovine brain tissue. The bovi...

journal_title：Frontiers in pediatrics

authors： Peruffo A,Cozzi B

更新日期：2014-07-10 00:00:00

abstract：:Neonatal Encephalopathy (NE) describes neonates with disturbed neurological function in the first post-natal days of life. NE is an overall term that does not specify the etiology of the encephalopathy although it often involves hypoxia-ischaemia. In NE, although neurological dysfunction is part of the injury and is m...

journal_title：Frontiers in pediatrics

authors： O'Dea M,Sweetman D,Bonifacio SL,El-Dib M,Austin T,Molloy EJ

更新日期：2020-05-15 00:00:00

abstract：:Background: The occurrence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated coronavirus disease 2019 (COVID-19) have profoundly affected adult kidney disease patients. In contrast, pediatric solid organ transplant recipients, including pediatric kidney transplant (KT) recipients, ...

journal_title：Frontiers in pediatrics

authors： Nailescu C,Khalid M,Wilson AC,Amanat F,Arregui S,Canas J,Hooks J,Krammer F,Schwaderer AL,Hains DS

更新日期：2020-10-30 00:00:00