Low Bacterial Co-infection Invalidates the Early Use of Non-anti-Mycoplasma pneumoniae Antibiotics in Pediatric Refractory Mycoplasma pneumoniae Pneumonia Patients.

abstract：Background:Pediatric sepsis causes significant global morbidity and mortality and low- and middle-income countries (LMICs) bear the bulk of the burden. International sepsis guidelines may not be relevant in LMICs, especially in sub-Saharan Africa (SSA), due to resource constraints and population differences. There is a...

journal_title：Frontiers in pediatrics

authors： Kortz TB,Sawe HR,Murray B,Enanoria W,Matthay MA,Reynolds T

更新日期：2017-12-22 00:00:00

abstract：:The solute carrier family 16 member 1 (SLC16A1) gene encodes for monocarboxylate transporter 1 (MCT1) that mediates the movement of monocarboxylates, such as lactate and pyruvate across cell membranes. Inactivating recessive homozygous or heterozygous mutations in the SLC16A1 gene were described in patients with recur...

journal_title：Frontiers in pediatrics

authors： Al-Khawaga S,AlRayahi J,Khan F,Saraswathi S,Hasnah R,Haris B,Mohammed I,Abdelalim EM,Hussain K

更新日期：2019-07-18 00:00:00

abstract：:Background: Viral respiratory tract infections (VRTI) may cause severe respiratory and sepsis-like symptoms in infants hospitalized in the neonatal intensive care unit (NICU). Little is known about the frequencies of VRTI in relation to visiting policies in the NICU. Objective: Aim of this study was to evaluate the fr...

journal_title：Frontiers in pediatrics

authors： Kidszun A,Neurohr A,Gröndahl B,Tippmann S,Schreiner D,Winter J,Mahmoudpour SH,Gehring S,Mildenberger E

更新日期：2020-11-16 00:00:00

abstract：:Objective: The primary goal of this study was to assess current maintenance intravenous fluid (mIVF) prescribing practices of pediatric hospitalists after the release of the American Academy of Pediatrics Clinical Practice Guideline (AAP CPG), specifically assessing the rates of various isotonic vs. hypotonic solution...

journal_title：Frontiers in pediatrics

authors： Hall AM,Ayus JC,Moritz ML

更新日期：2020-01-15 00:00:00

abstract：:Background: To evaluate the effects of pressure levels on cerebral hemodynamics in premature infants receiving nasal continuous positive airway pressure (nCPAP) during the first 3 days of life. Methods: Forty-four preterm infants treated with nCPAP were divided into two groups: very preterm infants [gestational age 1 ...

journal_title：Frontiers in pediatrics

authors： Zhou H,Hou X,Cheng R,Zhao Y,Qiu J

更新日期：2020-08-21 00:00:00

abstract：:The concept of orthostatic hypertension in children was first proposed in 2012. The pathogenesis is not clear by now. Orthostatic hypertension is one of the important causes of orthostatic intolerance in children and is related to the development of essential hypertension in the future. It is commonly seen in older ch...

journal_title：Frontiers in pediatrics

authors： Hu Y,Jin H,Du J

更新日期：2020-07-29 00:00:00

abstract：:Hypertension after kidney transplant is a frequent occurrence in pediatric patients. It is a risk factor for graft loss and contributes to the significant burden of cardiovascular disease (CVD) in this population. The etiology of posttransplant hypertension is multifactorial including donor factors, recipient factors,...

journal_title：Frontiers in pediatrics

authors： Charnaya O,Moudgil A

更新日期：2017-05-01 00:00:00

abstract：:Objectives: Low hydration has a deleterious effect on many conditions. In the absence of a urine concentrating defect, urine concentration is a marker of hydration status. However, markers to evaluate hydration status have not been well studied in children. The objectives of this paper are to compare measures of thirs...

journal_title：Frontiers in pediatrics

authors： Walawender L,Patterson J,Strouse R,Ketz J,Saxena V,Alexy E,Schwaderer A

更新日期：2018-06-06 00:00:00

abstract：:Abdominal lipoblastomas are uncommon soft tissue tumors in children and rarely arise from the mesentery. Due to intraabdominal location and slow growth, these masses can go unnoticed for long periods of time and often found on surgical exploration. We present a case of a 12-year-old male with years of abdominal disten...

journal_title：Frontiers in pediatrics

authors： Squillaro AI,Chow MD,Arias F,Sadimin ET,Lee YH

更新日期：2020-07-24 00:00:00

abstract：:A variety of surgical techniques exist for the management of urolithiasis. Minimally invasive techniques have replaced open surgery in the last few decades. For complex stone management, robotic-assisted laparoscopic surgery (RALS) has emerged as a safe and feasible alternative in adults. The literature for RALS for u...

journal_title：Frontiers in pediatrics

authors： Ballesteros N,Snow ZA,Moscardi PRM,Ransford GA,Gomez P,Castellan M

更新日期：2019-08-22 00:00:00

abstract：:Introduction: Emergency vascular access is rarely required during neonatal resuscitation. We aimed to analyze frequency of use, success, and complication rates of intraosseous (IO) vascular access in neonates at a single tertiary neonatal intensive care unit. Method: We performed a questionnaire-based survey among ped...

journal_title：Frontiers in pediatrics

authors： Mileder LP,Urlesberger B,Schwaberger B

更新日期：2020-09-18 00:00:00

abstract：:Autosomal dominant hyper-IgE syndrome caused by mutations in the transcription factor STAT3 (AD-HIES) is characterized by a collection of immunologic and non-immune features including eczema, recurrent infections, elevated IgE levels, and connective tissue anomalies. We report the case of a Qatari child with a history...

journal_title：Frontiers in pediatrics

authors： Chaimowitz NS,Branch J,Reyes A,Vargas-Hernández A,Orange JS,Forbes LR,Ehlayel M,Purayil SC,Al-Nesf MA,Vogel TP

更新日期：2019-04-24 00:00:00

abstract：:Genetic polymorphisms in genes coding for inflammasome components nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) and caspase recruitment domain-containing protein 8 (CARD8) have been associated with autoinflammatory and autoimmune diseases. On the other hand...

journal_title：Frontiers in pediatrics

authors： Smigoc Schweiger D,Goricar K,Hovnik T,Mendez A,Bratina N,Brecelj J,Vidan-Jeras B,Battelino T,Dolzan V

更新日期：2019-03-12 00:00:00

abstract：:Introduction: Inborn errors of primary bile acid (BA) synthesis are rare autosomal recessive disorders responsible for 1-2% of cases of neonatal cholestasis. Among them, cerebrotendinous xanthomatosis (CTX) is caused by mutations in the CYP27A1 gene resulting in the impairment of sterol 27-hydroxylase enzyme activity....

journal_title：Frontiers in pediatrics

authors： Lipiński P,Klaudel-Dreszler M,Ciara E,Jurkiewicz D,Płoski R,Cielecka-Kuszyk J,Socha P,Jankowska I

更新日期：2021-01-13 00:00:00

abstract：:Background: Necrotizing enterocolitis (NEC) is an often-fatal neonatal disease involving intestinal hyperinflammation leading to necrosis. Despite ongoing research, (1) conflicting results and (2) comorbidities of NEC patients make early NEC detection challenging and may complicate therapy development. Most research s...

journal_title：Frontiers in pediatrics

authors： Klinke M,Wiskemann H,Bay B,Schäfer HJ,Pagerols Raluy L,Reinshagen K,Vincent D,Boettcher M

更新日期：2021-01-06 00:00:00

abstract：:Background: Placenta shows high transcription levels of human endogenous retroviruses (HERVs) that are overexpressed during embryonic and fetal development. Methods: In order to gather further information on the degree of HERV activation in maternal and fetal tissues we assessed the transcription levels of pol genes o...

journal_title：Frontiers in pediatrics

authors： Bergallo M,Marozio L,Botta G,Tancredi A,Daprà V,Galliano I,Montanari P,Coscia A,Benedetto C,Tovo PA

更新日期：2020-05-14 00:00:00

abstract：:Background: Despite advances in technology and clinical experience, the incidence of hemostatic complications, including bleeding and thrombosis, remains high in children supported with extracorporeal membrane oxygenation (ECMO). These hemostatic complications are important to prevent, since they are associated with i...

journal_title：Frontiers in pediatrics

authors： Drop JGF,Wildschut ED,Gunput STG,de Hoog M,van Ommen CH

更新日期：2020-12-16 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic, immune-mediated, non-curable disease. The incidence of IBD appears to have risen over the last few decades especially in the pediatric age group. IBD usually presents with gastrointestinal symptoms, including abdominal pain, diarrhea, and bleeding per rectum but can also ...

journal_title：Frontiers in pediatrics

authors： El-Matary W,Bernstein CN

更新日期：2020-07-17 00:00:00

abstract：:It is necessary to conduct Clinical Trials in children, including for novel vaccines. Children cannot legally provide valid consent, but can assent to research participation. Informed consent and assent communications are frequently criticized for their lack of comprehensibility and often, researchers do not involve p...

journal_title：Frontiers in pediatrics

authors： Jackson SM,Daverio M,Perez SL,Gesualdo F,Tozzi AE

更新日期：2021-01-12 00:00:00

abstract：:Background: Despite the pandemic, data are limited regarding COVID-19 infection in pregnant women and newborns. This report aimed to bring new information about presentation that could modify precautionary measures for infants born of mothers with a remote history of COVID-19. Methods: We report two infants with possi...

journal_title：Frontiers in pediatrics

authors： Hascoët JM,Jellimann JM,Hartard C,Wittwer A,Jeulin H,Franck P,Morel O

更新日期：2020-09-29 00:00:00

abstract：:Pediatric neuro-oncology surgery continues to progress in sophistication, largely driven by advances in technology used to aid the following aspects of surgery: operative planning (advanced MRI techniques including fMRI and DTI), intraoperative navigation [preoperative MRI, intra-operative MRI (ioMRI) and intra-operat...

journal_title：Frontiers in pediatrics

authors： Foster MT,Harishchandra LS,Mallucci C

更新日期：2018-11-01 00:00:00

abstract：:Background: Mounting evidence suggests that childhood asthma is closely associated with maternal weight before pregnancy and gestational weight gain (GWG), yet the results are not often reproducible. Objectives: We conducted a comprehensive meta-analysis, aiming to evaluate the association of pre-pregnancy maternal ob...

journal_title：Frontiers in pediatrics

authors： Liu S,Zhou B,Wang Y,Wang K,Zhang Z,Niu W

更新日期：2020-04-03 00:00:00

abstract：:Background: The impact of a sedentary and unhealthy lifestyle on cardiovascular health is well-documented, however the current obesity and hypertension trends among children is concerning. The ExAMIN Youth SA study aims to investigate the impact of lifestyle behaviors (physical fitness/activity, dietary intake and psy...

journal_title：Frontiers in pediatrics

authors： Kruger R,Monyeki MA,Schutte AE,Smith W,Mels CMC,Kruger HS,Pienaar AE,Gafane-Matemane LF,Breet Y,Lammertyn L,Mokwatsi GG,Kruger A,Deacon E,Hanssen H

更新日期：2020-04-29 00:00:00

abstract：:Thrombocytopenia and pancytopenia, occurring in patients with Fanconi anemia (FA), are interpreted either as progression to bone marrow failure or as developing myelodysplasia. On the other hand, immune thrombocytopenia (ITP) represents an acquired and often self-limiting benign hematologic disorder, associated with p...

journal_title：Frontiers in pediatrics

authors： Karastaneva A,Lanz S,Wawer A,Behrends U,Schindler D,Dietrich R,Burdach S,Urban C,Benesch M,Seidel MG

更新日期：2015-06-08 00:00:00

abstract：:Background: Primary carnitine deficiency (PCD) is attributed to a variation in the SLC22A5 (OCTN2) gene which encodes the key protein of the carnitine cycle, the OCTN2 carnitine transporter. PCD is typically identified in childhood by either hypoketotic hypoglycemia, or skeletal and cardiac myopathy. The aim of this s...

journal_title：Frontiers in pediatrics

authors： Zhou W,Li H,Huang T,Zhang Y,Wang C,Gu M

更新日期：2019-02-26 00:00:00

abstract：:Neonatal encephalopathy (NE) is associated with high mortality and morbidity. Factors predisposing to NE can be antenatal, perinatal, or a combination of both. Antenatal maternal factors, familial factors, genetic predisposition, hypoxic ischemic encephalopathy, infections, placental abnormalities, thrombophilia, coag...

journal_title：Frontiers in pediatrics

authors： Aslam S,Strickland T,Molloy EJ

更新日期：2019-04-16 00:00:00

abstract：:Heart rate (HR) and blood pressure (BP) form the basis for monitoring the physiological state of patients. Although norms have been published for healthy and hospitalized children, little is known about their distributions in critically ill children. The objective of this study was to report the distributions of these...

journal_title：Frontiers in pediatrics

authors： Eytan D,Goodwin AJ,Greer R,Guerguerian AM,Laussen PC

更新日期：2017-03-17 00:00:00

abstract：:Background: Compared to breast-fed (BF), formula-fed (FF) infants exhibit more rapid weight gain, a different fecal microbial profile, as well as elevated serum insulin, insulin growth factor 1 (IGF-1), and branched chain amino acids (BCAAs). Since infant formula contains more protein and lower free amino acids than b...

journal_title：Frontiers in pediatrics

authors： He X,Sotelo-Orozco J,Rudolph C,Lönnerdal B,Slupsky CM

更新日期：2020-01-24 00:00:00

abstract：:Informed consent is a process ensuring that subjects enrolled in research are appropriately informed of the risks and benefits. While this process is well-defined when it is possible and practical to obtain consent prior to the research intervention, it can be less clear in cases of deferred or waived consent. Definin...

journal_title：Frontiers in pediatrics

authors： Rich WD,Katheria AC

更新日期：2019-11-26 00:00:00

abstract：:Minimal residual disease (MRD) by multiparametric flow cytometry (MFC) has been recently shown as a strong and independent prognostic marker of relapse in pediatric AML (pedAML) when measured at specific time points during Induction and/or Consolidation therapy. Hence, MFC-MRD has the potential to refine the current s...

journal_title：Frontiers in pediatrics

authors： Buldini B,Maurer-Granofszky M,Varotto E,Dworzak MN

更新日期：2019-10-11 00:00:00