Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management.

Abstract:

:Neonatal encephalopathy (NE) is associated with high mortality and morbidity. Factors predisposing to NE can be antenatal, perinatal, or a combination of both. Antenatal maternal factors, familial factors, genetic predisposition, hypoxic ischemic encephalopathy, infections, placental abnormalities, thrombophilia, coagulation defects, and metabolic disorders all have been implicated in the pathogenesis of NE. At present, therapeutic hypothermia is the only treatment available, regardless of etiology. Recognizing the etiology of NE involved can also guide investigations such as metabolic and sepsis workups to ensure optimal management. Understanding the etiology of NE may allow the development of targeted adjunctive therapies related to the underlying mechanism and develop preventative strategies.

journal_name

Front Pediatr

journal_title

Frontiers in pediatrics

authors

Aslam S,Strickland T,Molloy EJ

doi

10.3389/fped.2019.00142

subject

Has Abstract

pub_date

2019-04-16 00:00:00

pages

142

issn

2296-2360

journal_volume

7

pub_type

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