Driving pressure and long-term outcomes in moderate/severe acute respiratory distress syndrome.

abstract：BACKGROUND:The consequences of the ageing population concerning ICU hospitalisation need to be adequately described. We believe that this discussion should be disease specific. A focus on respiratory infections is of particular interest, because it is strongly associated with old age. Our objective was to assess trends...

journal_title：Annals of intensive care

authors： Laporte L,Hermetet C,Jouan Y,Gaborit C,Rouve E,Shea KM,Si-Tahar M,Dequin PF,Grammatico-Guillon L,Guillon A

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:Occlusion pressure at 100 ms (P0.1), defined as the negative pressure measured 100 ms after the initiation of an inspiratory effort performed against a closed respiratory circuit, has been shown to be well correlated with central respiratory drive and respiratory effort. Automated P0.1 measurement is availab...

journal_title：Annals of intensive care

authors： Beloncle F,Piquilloud L,Olivier PY,Vuillermoz A,Yvin E,Mercat A,Richard JC

更新日期：2019-09-13 00:00:00

abstract：BACKGROUND:cRel, a subunit of NF-κB, is implicated in the inflammatory response observed in autoimmune disease. Hence, knocked-out mice for cRel had a significantly higher mortality, providing new and important functions of cRel in the physiopathology of septic shock. Whether genetic variants in the human REL gene are ...

journal_title：Annals of intensive care

authors： Toubiana J,Courtine E,Tores F,Asfar P,Daubin C,Rousseau C,Ouaaz F,Marin N,Cariou A,Chiche JD,Mira JP

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The impact of neutropenia in critically ill immunocompromised patients admitted in a context of acute respiratory failure (ARF) remains uncertain. The primary objective was to assess the prognostic impact of neutropenia on outcomes of these patients. Secondary objective was to assess etiology of ARF accordin...

journal_title：Annals of intensive care

authors： Mokart D,Darmon M,Schellongowski P,Pickkers P,Soares M,Rello J,Bauer PR,van de Louw A,Lemiale V,Taccone FS,Martin-Loeches I,Salluh J,Rusinova K,Mehta S,Antonelli M,Kouatchet A,Barratt-Due A,Valkonen M,Landburg PP,Bu

更新日期：2020-10-22 00:00:00

abstract：BACKGROUND:Pneumonia is one of the major complications of drowning, but the optimal empirical antibiotic treatment is not clearly defined. Multidrug-resistant (MDR) bacteria and fungi have been identified in a recent series of freshwater drowning-associated pneumonia. However, microbial data in seawater drowning are sc...

journal_title：Annals of intensive care

authors： Robert A,Danin PÉ,Quintard H,Degand N,Martis N,Doyen D,Pulcini C,Ruimy R,Ichai C,Bernardin G,Dellamonica J

更新日期：2017-12-01 00:00:00

abstract：: Critically ill adult patients often require multiple examinations in the hospital and need transport from one department to another, or even between hospitals. However, to date, no guidelines exist regarding optimum practices for transport of these fragile patients. We present recommendations for intrahospital transp...

journal_title：Annals of intensive care

authors： Quenot JP,Milési C,Cravoisy A,Capellier G,Mimoz O,Fourcade O,Gueugniaud PY

更新日期：2012-02-03 00:00:00

abstract：: Erythropoietin (EPO) is the major hormone stimulating the production and differentiation of red blood cells. EPO is used widely for treating anemia of critical illness or anemia induced by chemotherapy. EPO at pharmacological doses is used in this setting to raise hemoglobin levels (by preventing the apoptosis of ery...

journal_title：Annals of intensive care

authors： Patel NS,Collino M,Yaqoob MM,Thiemermann C

更新日期：2011-09-23 00:00:00

abstract：BACKGROUND:Many maneuvers assessing fluid responsiveness (minifluid challenge, lung recruitment maneuver, end-expiratory occlusion test, passive leg raising) are considered as positive when small variations in cardiac index, stroke volume index, stroke volume variation or pulse pressure variation occur. Pulse contour a...

journal_title：Annals of intensive care

authors： de Courson H,Ferrer L,Cane G,Verchère E,Sesay M,Nouette-Gaulain K,Biais M

更新日期：2019-10-11 00:00:00

abstract：BACKGROUND:Ultrafast cooling by total liquid ventilation (TLV) provides potent cardio- and neuroprotection after experimental cardiac arrest. However, this was evaluated in animals with no initial lung injury, whereas out-of-hospital cardiac arrest is frequently associated with early-onset pneumonia, which may lead to ...

journal_title：Annals of intensive care

authors： Rambaud J,Lidouren F,Sage M,Kohlhauer M,Nadeau M,Fortin-Pellerin É,Micheau P,Zilberstein L,Mongardon N,Ricard JD,Terada M,Bruneval P,Berdeaux A,Ghaleh B,Walti H,Tissier R

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Despite improvements in intermittent hemodialysis management, intradialytic hemodynamic instability (IHI) remains a common issue that could account for increased mortality and delayed renal recovery. However, predictive factors of IHI remain poorly explored. The objective of this study was to evaluate the re...

journal_title：Annals of intensive care

authors： Bigé N,Lavillegrand JR,Dang J,Attias P,Deryckere S,Joffre J,Dubée V,Preda G,Dumas G,Hariri G,Pichereau C,Baudel JL,Guidet B,Maury E,Boelle PY,Ait-Oufella H

更新日期：2020-04-22 00:00:00

abstract：BACKGROUND:Optimal sedation and analgesia is a challenge in paediatric intensive care units (PICU) because of difficulties in scoring systems and specific metabolism inducing tolerance and withdrawal. Excessive sedation is associated with prolonged mechanical ventilation and hospitalisation. Adult and paediatric data s...

journal_title：Annals of intensive care

authors： Dreyfus L,Javouhey E,Denis A,Touzet S,Bordet F

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Despite advances in supportive care, moderate-severe acute respiratory distress syndrome (ARDS) is associated with high mortality rates, and novel therapies to treat this condition are needed. Compelling pre-clinical data from mouse, rat, sheep and ex vivo perfused human lung models support the use of human ...

journal_title：Annals of intensive care

authors： Liu KD,Wilson JG,Zhuo H,Caballero L,McMillan ML,Fang X,Cosgrove K,Calfee CS,Lee JW,Kangelaris KN,Gotts JE,Rogers AJ,Levitt JE,Wiener-Kronish JP,Delucchi KL,Leavitt AD,McKenna DH,Thompson BT,Matthay MA

更新日期：2014-07-03 00:00:00

abstract：OBJECTIVES:To assess outcomes at hospital discharge and day-120 after intensive care unit (ICU) discharge among patients with solid cancer admitted to ICU and to identify characteristics associated with in-hospital and day-120 after ICU discharge mortalities. DESIGN:International, multicenter, retrospective study. SE...

journal_title：Annals of intensive care

authors： Vincent F,Soares M,Mokart D,Lemiale V,Bruneel F,Boubaya M,Gonzalez F,Cohen Y,Azoulay E,Darmon M,GrrrOH: Groupe de recherche respiratoire en réanimation en Onco-Hématologie (Group for respiratory research in intensive care in Onco-Hem

更新日期：2018-03-27 00:00:00

abstract：: Multiple experimental and human trials have shown that microcirculatory alterations are frequent in sepsis. In this review, we discuss the characteristics of these alterations, the various mechanisms potentially involved, and the implications for therapy. Sepsis-induced microvascular alterations are characterized by ...

journal_title：Annals of intensive care

authors： De Backer D,Donadello K,Taccone FS,Ospina-Tascon G,Salgado D,Vincent JL

更新日期：2011-07-19 00:00:00

abstract：BACKGROUND:In randomised controlled trials, procalcitonin (PCT)-guided antibiotic treatment has been proven to significantly reduce length of antibiotic therapy in intensive care unit (ICU) patients. However, concern was raised on low protocol adherence and high rates of overruling, and thus the value of PCT-guided tre...

journal_title：Annals of intensive care

authors： Hohn A,Balfer N,Heising B,Hertel S,Wiemer JC,Hochreiter M,Schröder S

更新日期：2018-06-04 00:00:00

abstract：BACKGROUND:While the process of sepsis-induced immunosuppression is now well described in adults, very little information is available on immune functions in pediatric sepsis. The current study investigated this in children with septic shock by performing immunomonitoring, including both innate (monocyte human leukocyt...

journal_title：Annals of intensive care

authors： Remy S,Kolev-Descamps K,Gossez M,Venet F,Demaret J,Javouhey E,Monneret G

更新日期：2018-03-13 00:00:00

abstract：BACKGROUND:The use of novel sepsis biomarkers has increased in recent years. However, their prognostic value with respect to illness severity has not been explored. In this work, we examined the ability of mid-regional proadrenomedullin (MR-proADM) in predicting mortality in sepsis patients with different degrees of or...

journal_title：Annals of intensive care

authors： Andaluz-Ojeda D,Nguyen HB,Meunier-Beillard N,Cicuéndez R,Quenot JP,Calvo D,Dargent A,Zarca E,Andrés C,Nogales L,Eiros JM,Tamayo E,Gandía F,Bermejo-Martín JF,Charles PE

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Hyponatremia occurring as a result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or cerebral salt wasting syndrome is a common complication in patients with subarachnoid hemorrhage (SAH). The efficacy and safety of urea as treatment for SIADH-induced hyponatremia has not been report...

journal_title：Annals of intensive care

authors： Pierrakos C,Taccone FS,Decaux G,Vincent JL,Brimioulle S

更新日期：2012-05-30 00:00:00

abstract：BACKGROUND:The data on incidence, clinical presentation, and outcomes of ventilator-associated pneumonia (VAP) in patients with severe coronavirus disease 2019 (COVID-19) pneumonia requiring mechanical ventilation (MV) are limited. We performed this retrospective cohort study to assess frequency, clinical characteristi...

journal_title：Annals of intensive care

authors： Luyt CE,Sahnoun T,Gautier M,Vidal P,Burrel S,Pineton de Chambrun M,Chommeloux J,Desnos C,Arzoine J,Nieszkowska A,Bréchot N,Schmidt M,Hekimian G,Boutolleau D,Robert J,Combes A,Chastre J

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Acute lung injury and the acute respiratory distress syndrome (ALI/ARDS) are characterized by pulmonary oedema, measured as extravascular lung water (EVLW). The chest radiograph (CXR) can potentially estimate the quantity of lung oedema while the transpulmonary thermodilution method measures the amount of EV...

journal_title：Annals of intensive care

authors： Brown LM,Calfee CS,Howard JP,Craig TR,Matthay MA,McAuley DF

更新日期：2013-08-11 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) occurs in up to 50% of all critically ill patients and hemodynamic abnormalities are assumed to contribute, but their nature and share is still unclear. We explored the associations between hemodynamic variables, including cardiac index and right ventricular function, and the occurr...

journal_title：Annals of intensive care

authors： Wiersema R,Koeze J,Hiemstra B,Pettilä V,Perner A,Keus F,van der Horst ICC,SICS Study Group.

更新日期：2019-03-13 00:00:00

abstract：BACKGROUND:Data on respiratory mechanics of COVID-19 ARDS patients are scarce. Respiratory mechanics and response to positive expiratory pressure (PEEP) may be different in obese and non-obese patients. METHODS:We investigated esophageal pressure allowing determination of transpulmonary pressures (PL ) and elastances ...

journal_title：Annals of intensive care

authors： Mezidi M,Daviet F,Chabert P,Hraiech S,Bitker L,Forel JM,Yonis H,Gragueb I,Dhelft F,Papazian L,Richard JC,Guervilly C

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE) is one of the most common preventable causes of in-hospital death in trauma patients surviving their injuries. We assessed the prevalence, incidence and risk factors for deep venous thrombosis (DVT) and pulmonary embolism (PE) in critically ill trauma patients, in the setting of ...

journal_title：Annals of intensive care

authors： Hamada SR,Espina C,Guedj T,Buaron R,Harrois A,Figueiredo S,Duranteau J

更新日期：2017-09-12 00:00:00

abstract：: Thrombocytopenia is a very frequent disorder in the intensive care unit. Many etiologies should be searched, and therapeutic approaches differ according to these different causes. However, no guideline exists regarding optimum practices for these situations in critically ill patients. We present recommendations for t...

journal_title：Annals of intensive care

authors： Van der Linden T,Souweine B,Dupic L,Soufir L,Meyer P

更新日期：2012-08-28 00:00:00

abstract：:Animal experiments are widely used in preclinical medical research with the goal of disease modeling and exploration of novel therapeutic approaches. In the context of sepsis and septic shock, the translation into clinical practice has been disappointing. Classical animal models of septic shock usually involve one-sex...

journal_title：Annals of intensive care

authors： Guillon A,Preau S,Aboab J,Azabou E,Jung B,Silva S,Textoris J,Uhel F,Vodovar D,Zafrani L,de Prost N,Radermacher P,Translational Research Committee of the French Intensive Care Society (Société de Réanimation de Langue Française).

更新日期：2019-06-10 00:00:00

abstract：BACKGROUND:Healthcare-associated bloodstream infections are related to both increased antibiotic use and risk of adverse outcomes. An in-depth understanding of their epidemiology is essential to reduce occurrence and to improve outcomes by targeted prevention strategies. The objectives of the study were to determine th...

journal_title：Annals of intensive care

authors： Culshaw N,Glover G,Whiteley C,Rowland K,Wyncoll D,Jones A,Shankar-Hari M

更新日期：2014-11-25 00:00:00

abstract：Introduction:Acute respiratory failure is the main reason for admission to the intensive care unit (ICU) in HIV-infected adults. There is little data about the epidemiology of respiratory viruses in this population. Methods:HIV-infected adults admitted to two intensive care units over a 6-year period for an acute resp...

journal_title：Annals of intensive care

authors： Elabbadi A,Pichon J,Visseaux B,Schnuriger A,Bouadma L,Philippot Q,Patrier J,Labbé V,Ruckly S,Fartoukh M,Timsit JF,Voiriot G

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Adequate dosing of antimicrobial therapy is of central importance to improve outcome. Liver failure may alter antibiotic drug concentrations via changes of drug distribution and elimination. We studied the pharmacokinetics of mer...

journal_title：Annals of intensive care

authors： Grensemann J,Busse D,König C,Roedl K,Jäger W,Jarczak D,Iwersen-Bergmann S,Manthey C,Kluge S,Kloft C,Fuhrmann V

更新日期：2020-04-22 00:00:00

abstract：:Although improving, the mortality from septic shock still remains high despite increased international awareness. As a consequence, much effort has focused on alternative treatment strategies in an effort to improve outcomes. The application of blood purification therapies to improve immune homeostasis has been sugges...

journal_title：Annals of intensive care

authors： Honore PM,Hoste E,Molnár Z,Jacobs R,Joannes-Boyau O,Malbrain MLNG,Forni LG

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict intubation in immunocompromised patients. The study is a secondary analysis of randomized trials in ...

journal_title：Annals of intensive care

authors： Lemiale V,Dumas G,Demoule A,Pène F,Kouatchet A,Bisbal M,Nseir S,Argaud L,Kontar L,Klouche K,Barbier F,Seguin A,Louis G,Constantin JM,Mayaux J,Wallet F,Peigne V,Girault C,Oziel J,Nyunga M,Terzi N,Bouadma L,Laut

更新日期：2021-01-27 00:00:00