Abstract：
BACKGROUND:cRel, a subunit of NF-κB, is implicated in the inflammatory response observed in autoimmune disease. Hence, knocked-out mice for cRel had a significantly higher mortality, providing new and important functions of cRel in the physiopathology of septic shock. Whether genetic variants in the human REL gene are associated with severity of septic shock is unknown. METHODS:We genotyped a population of 1040 ICU patients with septic shock and 855 ICU controls for two known polymorphisms of REL; REL rs842647 and REL rs13031237. Outcome of patients according to the presence of REL variant alleles was compared. RESULTS:The distribution of REL variant alleles was not significantly different between patients and controls. Among the septic shock group, REL rs13031237*T minor allele was not associated with worse outcome. In contrast, REL rs842647*G minor allele was significantly associated with more multi-organ failure and early death [OR 1.4; 95 % CI (1.02-1.8)]. CONCLUSION:In a large ICU population, we report a significant clinical association between a variation in the human REL gene and severity and mortality of septic shock, suggesting for the first time a new insight into the role of cRel in response to infection in humans.
journal_name
Ann Intensive Carejournal_title
Annals of intensive careauthors
Toubiana J,Courtine E,Tores F,Asfar P,Daubin C,Rousseau C,Ouaaz F,Marin N,Cariou A,Chiche JD,Mira JPdoi
10.1186/s13613-016-0130-zsubject
Has Abstractpub_date
2016-12-01 00:00:00pages
28issue
1issn
2110-5820pii
10.1186/s13613-016-0130-zjournal_volume
6pub_type
杂志文章abstract：BACKGROUND:Glucose control is an important issue in post-operative patients. The objective here was to compare two insulin infusion lines by syringe pumps to assess the impact of medical devices on glycaemic variability in surgical patients under intensive insulin therapy. This open, prospective, single-centre randomis...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-017-0298-x
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Patients in the intensive care unit (ICU) are more prone to drug-drug interactions (DDIs). The software and charts that indicate all interactions may not be proper for clinical usage. This study aimed to identify the main drug classes associated with clinically significant DDIs in cardiothoracic ICU and cate...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-015-0086-4
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The value of goal-directed fluid therapy in neurosurgical patients, where brain swelling is a major concern, is unknown. The aim of our study was to evaluate the effect of an intraoperative goal-directed fluid restriction (GDFR) strategy on the postoperative outcome of high-risk patients undergoing brain sur...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-017-0239-8
更新日期：2017-12-01 00:00:00
abstract：:Jean-Luc Diehl The French Intensive Care Society organized on 5th and 6th June 2014 its 4th "Paris International Conference in Intensive Care", whose principle is to bring together the best international experts on a hot topic in critical care medicine. The 2014 theme was "Breakthrough in cardiac arrest", with many hi...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-015-0064-x
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:To assess the impact of a real-time random safety tool on structure, process and outcome indicators. METHODS:Prospective study conducted over a period of 12 months in two adult patient intensive care units. Safety rounds were conducted three days a week ascertaining 37 safety measures (grouped into 10 block...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-017-0245-x
更新日期：2017-12-01 00:00:00
abstract：: Cancer is a leading cause of death in children. In the past decades, there has been a marked increase in overall survival of children with cancer. However, children whose treatment includes hematopoietic stem cell transplantation still represent a subpopulation with a higher risk of mortality. These improvements in m...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/2110-5820-2-14
更新日期：2012-06-12 00:00:00
abstract：BACKGROUND:The impact on infectious risk of ultrasound guidance at insertion remains controversial in short-term arterial catheters (ACs). The present study investigated the association between ultrasound guidance (US) during AC insertion and major catheter-related infections (MCRI), catheter-related bloodstream infect...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00705-4
更新日期：2020-07-08 00:00:00
abstract：BACKGROUND:SARS coronavirus 2 (SARS-CoV-2) is responsible for high morbidity and mortality worldwide, mostly due to the exacerbated inflammatory response observed in critically ill patients. However, little is known about the kinetics of the systemic immune response and its association with survival in SARS-CoV-2+ pati...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00798-x
更新日期：2021-01-13 00:00:00
abstract：BACKGROUND:Intensivists' clinical decision making pursues two main goals for patients: to decrease mortality and to improve quality of life and functional status in survivors. Patient-important outcomes are gaining wide acceptance in most fields of clinical research. We sought to systematically review how well patient-...
journal_title：Annals of intensive care
pub_type： 杂志文章,评审
doi：10.1186/s13613-017-0243-z
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Optimal anti-bacterial activity of meropenem requires maintenance of its plasma concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at least 40% of the dosing interval (fT > MIC > 40). We aimed to determine whether a 3-h extended infusion (EI) of meropenem achieves fT > MI...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-019-0622-8
更新日期：2020-01-10 00:00:00
abstract：:Pharmacological interventions are commonly considered in acute respiratory distress syndrome (ARDS) patients. Inhaled nitric oxide (iNO) and neuromuscular blockers (NMBs) are used in patients with severe hypoxemia. No outcome benefit has been observed with the systematic use of iNO. However, a sometimes important impr...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/2110-5820-3-20
更新日期：2013-07-03 00:00:00
abstract：BACKGROUND:Empirical antimicrobial therapy (EAT) is a challenge for community-acquired, hospital-acquired and ventilator-associated pneumonia, particularly in the context of the increasing occurrence of third-generation cephalosporin-resistant Enterobacterales (3GCR-E), including extended-spectrum beta-lactamase Entero...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00754-9
更新日期：2020-10-29 00:00:00
abstract：BACKGROUND:Middle East respiratory syndrome coronavirus (MERS-CoV) has caused several hospital outbreaks, including a major outbreak at King Abdulaziz Medical City, a 940-bed tertiary-care hospital in Riyadh, Saudi Arabia (August-September 2015). To learn from our experience, we described the critical care response to ...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-016-0203-z
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Criteria for the Sepsis-3 definition of septic shock include vasopressor treatment to maintain a mean arterial pressure > 65 mmHg and a lactate concentration > 2 mmol/L. The impact of hyperoxia in patients with septic shock using these criteria is unknown. METHODS:A post hoc analysis was performed of the HY...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-018-0435-1
更新日期：2018-09-17 00:00:00
abstract：BACKGROUND:Despite advances in the management of bloodstream infections (BSI) caused by Candida spp., the mortality still remains high in critically ill patients. The worldwide epidemiology of yeast-related BSI is subject to changing species distribution and resistance patterns, challenging antifungal treatment strateg...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00755-8
更新日期：2020-10-16 00:00:00
abstract：BACKGROUND:Hyponatremia occurring as a result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or cerebral salt wasting syndrome is a common complication in patients with subarachnoid hemorrhage (SAH). The efficacy and safety of urea as treatment for SIADH-induced hyponatremia has not been report...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/2110-5820-2-13
更新日期：2012-05-30 00:00:00
abstract：BACKGROUND:The consequences of the ageing population concerning ICU hospitalisation need to be adequately described. We believe that this discussion should be disease specific. A focus on respiratory infections is of particular interest, because it is strongly associated with old age. Our objective was to assess trends...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-018-0430-6
更新日期：2018-08-15 00:00:00
abstract：BACKGROUND:Pendelluft, the movement of gas within different lung regions, is present in animal models of assisted mechanical ventilation and associated with lung overstretching. Due to rebreathing of CO2 as compared to fresh gas, pendelluft might reduce ventilatory efficiency possibly exacerbating patient's respiratory...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00654-y
更新日期：2020-04-07 00:00:00
abstract：BACKGROUND:While the process of sepsis-induced immunosuppression is now well described in adults, very little information is available on immune functions in pediatric sepsis. The current study investigated this in children with septic shock by performing immunomonitoring, including both innate (monocyte human leukocyt...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-018-0382-x
更新日期：2018-03-13 00:00:00
abstract：BACKGROUND:Despite improvements in intermittent hemodialysis management, intradialytic hemodynamic instability (IHI) remains a common issue that could account for increased mortality and delayed renal recovery. However, predictive factors of IHI remain poorly explored. The objective of this study was to evaluate the re...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00663-x
更新日期：2020-04-22 00:00:00
abstract：: Red blood cells (RBC) storage facilitates the supply of RBC to meet the clinical demand for transfusion and to avoid wastage. However, RBC storage is associated with adverse changes in erythrocytes and their preservation medium. These changes are responsible for functional alterations and for the accumulation of pote...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/2110-5820-3-2
更新日期：2013-01-15 00:00:00
abstract：Introduction:Acute respiratory failure is the main reason for admission to the intensive care unit (ICU) in HIV-infected adults. There is little data about the epidemiology of respiratory viruses in this population. Methods:HIV-infected adults admitted to two intensive care units over a 6-year period for an acute resp...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00738-9
更新日期：2020-09-14 00:00:00
abstract：BACKGROUND:The Lung Injury Score (LIS) remains a commonly utilized measure of lung injury severity though the additive value of LIS to predict ARDS outcomes over the recent Berlin definition of ARDS, which incorporates severity, is not known. METHODS:We tested the association of LIS (in which scores range from 0 to 4,...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/2110-5820-4-4
更新日期：2014-02-18 00:00:00
abstract：BACKGROUND:As the population ages and cancer therapies improve, there is an increased call for elderly cancer patients to be admitted to the intensive care unit (ICU). This study aimed to assess short-term survival and prognostic factors in critically ill patients with solid tumors aged ≥65 years. METHODS:We conducted...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-017-0250-0
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Data on outcome of critically ill children with cirrhosis are scarce. We aimed to evaluate the prognostic accuracy of sequential organs scoring systems in children with cirrhosis admitted to Paediatric Intensive Care Units (PICU). METHODS:We performed a multicentre retrospective analysis of childre...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00753-w
更新日期：2020-10-14 00:00:00
abstract：BACKGROUND:Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sepsis and septic shock, and a rat sepsis model revealed that PMX-HP treatment can maintain a better mi...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00699-z
更新日期：2020-06-12 00:00:00
abstract：BACKGROUND:Middle East respiratory syndrome (MERS) is caused by a coronavirus (MERS-CoV) and is characterized by hypoxemic respiratory failure. The objective of this study is to compare the outcomes of MERS-CoV patients before and after the availability of extracorporeal membrane oxygenation (ECMO) as a rescue therapy ...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-017-0350-x
更新日期：2018-01-10 00:00:00
abstract：:This review examines the available evidence for targeting a specific mean arterial pressure (MAP) in sepsis resuscitation. The clinical data suggest that targeting an MAP of 65-70 mmHg in patients with septic shock who do not have chronic hypertension is a reasonable first approximation. Whereas in patients with chron...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-015-0085-5
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The initial management of a trauma patient is a critical and demanding period. The use of extended focused assessment sonography for trauma (eFAST) has become more prevalent in trauma rooms, raising questions about the real "added value" of chest X-rays (CXRs) and pelvic X-rays (PXR), particularly in haemody...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-016-0166-0
更新日期：2016-12-01 00:00:00
abstract：:Although improving, the mortality from septic shock still remains high despite increased international awareness. As a consequence, much effort has focused on alternative treatment strategies in an effort to improve outcomes. The application of blood purification therapies to improve immune homeostasis has been sugges...
journal_title：Annals of intensive care
pub_type： 杂志文章,评审
doi：10.1186/s13613-019-0530-y
更新日期：2019-05-14 00:00:00
