Abstract:
BACKGROUND:Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict intubation in immunocompromised patients. The study is a secondary analysis of randomized trials in immunocompromised patients, including all patients who received high-flow nasal cannula (HFNC). The first objective was to evaluate the accuracy of the ROX index to predict intubation for patients with acute respiratory failure. RESULTS:In the study, 302 patients received HFNC. Acute respiratory failure was mostly related to pneumonia (n = 150, 49.7%). Within 2 (1-3) days, 115 (38.1%) patients were intubated. The ICU mortality rate was 27.4% (n = 83). At 6 h, the ROX index was lower for patients who needed intubation compared with those who did not [4.79 (3.69-7.01) vs. 6.10 (4.48-8.68), p < 0.001]. The accuracy of the ROX index to predict intubation was poor [AUC = 0.623 (0.557-0.689)], with low performance using the threshold previously found (4.88). In multivariate analysis, a higher ROX index was still independently associated with a lower intubation rate (OR = 0.89 [0.82-0.96], p = 0.04). CONCLUSION:A ROX index greater than 4.88 appears to have a poor ability to predict intubation in immunocompromised patients with acute respiratory failure, although it remains highly associated with the risk of intubation and may be useful to stratify such risk in future studies.
journal_name
Ann Intensive Carejournal_title
Annals of intensive careauthors
Lemiale V,Dumas G,Demoule A,Pène F,Kouatchet A,Bisbal M,Nseir S,Argaud L,Kontar L,Klouche K,Barbier F,Seguin A,Louis G,Constantin JM,Mayaux J,Wallet F,Peigne V,Girault C,Oziel J,Nyunga M,Terzi N,Bouadma L,Lautdoi
10.1186/s13613-021-00801-zsubject
Has Abstractpub_date
2021-01-27 00:00:00pages
17issue
1issn
2110-5820pii
10.1186/s13613-021-00801-zjournal_volume
11pub_type
杂志文章abstract:BACKGROUND:Acute lung injury and the acute respiratory distress syndrome (ALI/ARDS) are characterized by pulmonary oedema, measured as extravascular lung water (EVLW). The chest radiograph (CXR) can potentially estimate the quantity of lung oedema while the transpulmonary thermodilution method measures the amount of EV...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/2110-5820-3-25
更新日期:2013-08-11 00:00:00
abstract:BACKGROUND:Antibiotics are frequently used in intensive care units (ICUs), and their use is associated with the emergence of bacterial resistance to antibiotics. The aim of this study was to investigate the association between the emergence of Pseudomonas aeruginosa resistance and the duration of antibiotic exposure or...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-017-0296-z
更新日期:2017-12-01 00:00:00
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journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-016-0166-0
更新日期:2016-12-01 00:00:00
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journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-018-0469-4
更新日期:2018-12-07 00:00:00
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journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/2110-5820-3-20
更新日期:2013-07-03 00:00:00
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journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-017-0350-x
更新日期:2018-01-10 00:00:00
abstract:: Human serum albumin (HSA) has been used for a long time as a resuscitation fluid in critically ill patients. It is known to exert several important physiological and pharmacological functions. Among them, the antioxidant properties seem to be of paramount importance as they may be implied in the potential beneficial ...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/2110-5820-3-4
更新日期:2013-02-15 00:00:00
abstract::Although chest X-ray remains a fundamental lung imaging technique, through the years, CT scan has significantly improved our knowledge of the pathophysiological process and currently is the reference lung imaging tool for both a visual and quantitative computer-based analysis. The application of lung CT in the early p...
journal_title:Annals of intensive care
pub_type: 社论
doi:10.1186/s13613-019-0497-8
更新日期:2019-01-22 00:00:00
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journal_title:Annals of intensive care
pub_type: 杂志文章,评审
doi:10.1186/s13613-019-0523-x
更新日期:2019-04-16 00:00:00
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journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-018-0432-4
更新日期:2018-09-05 00:00:00
abstract:Introduction:Acute respiratory failure is the main reason for admission to the intensive care unit (ICU) in HIV-infected adults. There is little data about the epidemiology of respiratory viruses in this population. Methods:HIV-infected adults admitted to two intensive care units over a 6-year period for an acute resp...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-020-00738-9
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:The effects of perioperative statin therapy on clinical outcome after cardiac or non-cardiac surgery are controversial. We aimed to assess the association between perioperative statin therapy and postoperative outcome. METHODS:Electronic databases were searched up to May 1, 2018, for randomized controlled t...
journal_title:Annals of intensive care
pub_type: 杂志文章,评审
doi:10.1186/s13613-018-0441-3
更新日期:2018-09-27 00:00:00
abstract:BACKGROUND:The echocardiography working group of the European Society of Intensive Care Medicine recognized the need to provide structured guidance for future CCE research methodology and reporting based on a systematic appraisal of the current literature. Here is reported this systematic appraisal. METHODS:We conduct...
journal_title:Annals of intensive care
pub_type: 杂志文章,评审
doi:10.1186/s13613-020-00662-y
更新日期:2020-04-25 00:00:00
abstract:BACKGROUND:Despite improvements in intermittent hemodialysis management, intradialytic hemodynamic instability (IHI) remains a common issue that could account for increased mortality and delayed renal recovery. However, predictive factors of IHI remain poorly explored. The objective of this study was to evaluate the re...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-020-00663-x
更新日期:2020-04-22 00:00:00
abstract:BACKGROUND:Pneumonia is one of the major complications of drowning, but the optimal empirical antibiotic treatment is not clearly defined. Multidrug-resistant (MDR) bacteria and fungi have been identified in a recent series of freshwater drowning-associated pneumonia. However, microbial data in seawater drowning are sc...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-017-0267-4
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) occurs in up to 50% of all critically ill patients and hemodynamic abnormalities are assumed to contribute, but their nature and share is still unclear. We explored the associations between hemodynamic variables, including cardiac index and right ventricular function, and the occurr...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-019-0513-z
更新日期:2019-03-13 00:00:00
abstract:: Critically ill adult patients often require multiple examinations in the hospital and need transport from one department to another, or even between hospitals. However, to date, no guidelines exist regarding optimum practices for transport of these fragile patients. We present recommendations for intrahospital transp...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/2110-5820-2-1
更新日期:2012-02-03 00:00:00
abstract::Although improving, the mortality from septic shock still remains high despite increased international awareness. As a consequence, much effort has focused on alternative treatment strategies in an effort to improve outcomes. The application of blood purification therapies to improve immune homeostasis has been sugges...
journal_title:Annals of intensive care
pub_type: 杂志文章,评审
doi:10.1186/s13613-019-0530-y
更新日期:2019-05-14 00:00:00
abstract:BACKGROUND:We performed a meta-analysis of randomized controlled trials (RCTs) to determine if daily bathing with chlorhexidine decreased hospital-acquired BSIs in critically ill patients. METHODS:We searched the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases to identify randomized contr...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-015-0073-9
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Knowledge of patients' height is essential for daily practice in the intensive care unit. However, actual height measurements are unavailable on a daily routine in the ICU and measured height in the supine position and/or visual estimates may lack consistency. Clinicians do need simple and rapid methods to e...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-016-0154-4
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVES:To assess outcomes at hospital discharge and day-120 after intensive care unit (ICU) discharge among patients with solid cancer admitted to ICU and to identify characteristics associated with in-hospital and day-120 after ICU discharge mortalities. DESIGN:International, multicenter, retrospective study. SE...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-018-0386-6
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:Sepsis is a common condition that has a high mortality and morbidity that need prompt diagnosis and treatment. Biomarkers like Soluble CD14 subtype (sCD14-ST, presepsin) may be useful in identifying patients with sepsis and its diagnostic superiority has been confirmed by several preliminary studies. The aim...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-015-0089-1
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE). MAIN TEXT:We review the current data on the epidemiology, the possible underlying pathophysiologic mechanisms, and the therapeutic impl...
journal_title:Annals of intensive care
pub_type: 杂志文章,评审
doi:10.1186/s13613-020-00741-0
更新日期:2020-09-16 00:00:00
abstract:BACKGROUND:Lactate is a robust prognostic marker for the outcome of critically ill patients. Several small studies reported that metformin users have higher lactate levels at ICU admission without a concomitant increase in mortality. However, this has not been investigated in a larger cohort. We aimed to determine whet...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-020-00652-0
更新日期:2020-03-26 00:00:00
abstract:BACKGROUND:Healthcare-associated bloodstream infections are related to both increased antibiotic use and risk of adverse outcomes. An in-depth understanding of their epidemiology is essential to reduce occurrence and to improve outcomes by targeted prevention strategies. The objectives of the study were to determine th...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-014-0034-8
更新日期:2014-11-25 00:00:00
abstract:BACKGROUND:Hyperglycaemia is commonplace in the adult intensive care unit (ICU), associated with increased morbidity and mortality. Effective glycaemic control (GC) can reduce morbidity and mortality, but has proven difficult. STAR is a proven, effective model-based ICU GC protocol that uniquely maintains normo-glycaem...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-017-0351-9
更新日期:2018-01-10 00:00:00
abstract::The bedside hemodynamic assessment of the critically ill remains challenging since blood volume, arterial-venous interaction and compliance are not measured directly. Mean circulatory filling pressure (Pmcf) is the blood pressure throughout the vascular system at zero flow. Animal studies have shown Pmcf provides info...
journal_title:Annals of intensive care
pub_type: 杂志文章,评审
doi:10.1186/s13613-018-0418-2
更新日期:2018-06-20 00:00:00
abstract:BACKGROUND:The use of novel sepsis biomarkers has increased in recent years. However, their prognostic value with respect to illness severity has not been explored. In this work, we examined the ability of mid-regional proadrenomedullin (MR-proADM) in predicting mortality in sepsis patients with different degrees of or...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/s13613-017-0238-9
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:Capillary leak in critically ill patients leads to interstitial edema. Fluid overload is independently associated with poor prognosis. Bedside measurement of intra-abdominal pressure (IAP), extravascular lung water index (EVLWI), fluid balance, and capillary leak index (CLI) may provide a valuable prognost...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/2110-5820-2-S1-S1
更新日期:2012-07-05 00:00:00
abstract:: Cancer is a leading cause of death in children. In the past decades, there has been a marked increase in overall survival of children with cancer. However, children whose treatment includes hematopoietic stem cell transplantation still represent a subpopulation with a higher risk of mortality. These improvements in m...
journal_title:Annals of intensive care
pub_type: 杂志文章
doi:10.1186/2110-5820-2-14
更新日期:2012-06-12 00:00:00