Abstract:
BACKGROUND:Acute lung injury and the acute respiratory distress syndrome (ALI/ARDS) are characterized by pulmonary oedema, measured as extravascular lung water (EVLW). The chest radiograph (CXR) can potentially estimate the quantity of lung oedema while the transpulmonary thermodilution method measures the amount of EVLW. This study was designed to determine whether EVLW as estimated by a CXR score predicts EVLW measured by the thermodilution method and whether changes in EVLW by either approach predict mortality in ALI/ARDS. METHODS:Clinical data were collected within 48 hours of ALI/ARDS diagnosis and daily up to 14 days on 59 patients with ALI/ARDS. Two clinicians scored each CXR for the degree of pulmonary oedema, using a validated method. EVLW indexed to body weight was measured using the single indicator transpulmonary thermodilution technique. RESULTS:The CXR score had a modest, positive correlation with the EVLWI measurements (r = 0.35, p < 0.001). There was a 1.6 ml/kg increase in EVLWI per 10-point increase in the CXR score (p < 0.001, 95% confidence interval 0.92-2.35). The sensitivity of a high CXR score for predicting a high EVLWI was 93%; similarly the negative predictive value was high at 94%; the specificity (51%) and positive predictive value (50%) were lower. The CXR scores did not predict mortality but the EVLW thermodilution did predict mortality. CONCLUSION:EVLW measured by CXR was modestly correlated with thermodilution measured EVLW. Unlike CXR findings, transpulmonary thermodilution EVLWI measurements over time predicted mortality in patients with ALI/ARDS.
journal_name
Ann Intensive Carejournal_title
Annals of intensive careauthors
Brown LM,Calfee CS,Howard JP,Craig TR,Matthay MA,McAuley DFdoi
10.1186/2110-5820-3-25subject
Has Abstractpub_date
2013-08-11 00:00:00pages
25issue
1issn
2110-5820pii
2110-5820-3-25journal_volume
3pub_type
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pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00
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journal_title:Annals of intensive care
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更新日期:2016-12-01 00:00:00
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journal_title:Annals of intensive care
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 社论
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journal_title:Annals of intensive care
pub_type: 杂志文章
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更新日期:2018-09-17 00:00:00
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