Abstract:
BACKGROUND:Antibiotics are frequently used in intensive care units (ICUs), and their use is associated with the emergence of bacterial resistance to antibiotics. The aim of this study was to investigate the association between the emergence of Pseudomonas aeruginosa resistance and the duration of antibiotic exposure or mode of administration in an ICU unit. METHODS:A 4-year cohort study of intensive care unit was performed in patients with P. aeruginosa isolates from clinical specimens, initially susceptible to the investigated antibiotics (piperacillin/tazobactam, ceftazidime, ciprofloxacin, meropenem and amikacin). Odds ratios (ORs) with 95% confidence interval (95% CI) of emergence of resistance were calculated using logistic regression analysis for various exposure periods to antibiotics (1-3, 4-7, 8-15 and >15 days) relative to no exposure with adjustment for age, sex, Simplified Acute Physiology Score 3 (SAPS 3) and length of stay. ORs on the emergence of P. aeruginosa resistance were also calculated for the various modes of administration. RESULTS:Included were 187 patients [mean age 61 years, 69% male, mean SAPS 3 score (SD): 59 (12.3)]. None of the antibiotics investigated showed the emergence of resistance within 1-3 days. Significant meropenem resistance emerged within 8-15 days [OR 79.1 (14.9-421.0)] after antibiotic exposure unlike other antibiotics (>15 days). No difference was observed between intermittent and extended administration of meropenem and between beta-lactam mono- or combined therapy. CONCLUSIONS:Use of meropenem was associated with the emergence of resistance as soon as 8 days after exposure to the antibiotic.
journal_name
Ann Intensive Carejournal_title
Annals of intensive careauthors
Yusuf E,Van Herendael B,Verbrugghe W,Ieven M,Goovaerts E,Bergs K,Wouters K,Jorens PG,Goossens Hdoi
10.1186/s13613-017-0296-zsubject
Has Abstractpub_date
2017-12-01 00:00:00pages
72issue
1issn
2110-5820pii
10.1186/s13613-017-0296-zjournal_volume
7pub_type
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更新日期:2020-08-27 00:00:00
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journal_title:Annals of intensive care
pub_type: 信件
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更新日期:2020-10-01 00:00:00
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journal_title:Annals of intensive care
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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更新日期:2019-10-11 00:00:00
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journal_title:Annals of intensive care
pub_type: 杂志文章
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