Transpulmonary pressures in obese and non-obese COVID-19 ARDS.

Abstract:

BACKGROUND:Data on respiratory mechanics of COVID-19 ARDS patients are scarce. Respiratory mechanics and response to positive expiratory pressure (PEEP) may be different in obese and non-obese patients. METHODS:We investigated esophageal pressure allowing determination of transpulmonary pressures (PL ) and elastances (EL) during a decremental PEEP trial from 20 to 6 cm H2O in a cohort of COVID-19 ARDS patients. RESULTS:Fifteen patients were investigated, 8 obese and 7 non-obese patients. PEEP ≥ 16 cm H2O for obese patients and PEEP ≥10 cm H2O for non-obese patients were necessary to obtain positive expiratory PL. Change of PEEP did not alter significantly ΔPL or elastances in obese patients. However, in non-obese patients lung EL  and ΔPL increased significantly with PEEP increase. Chest wall EL was not affected by PEEP variations in both groups.

journal_name

Ann Intensive Care

journal_title

Annals of intensive care

authors

Mezidi M,Daviet F,Chabert P,Hraiech S,Bitker L,Forel JM,Yonis H,Gragueb I,Dhelft F,Papazian L,Richard JC,Guervilly C

doi

10.1186/s13613-020-00745-w

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

129

issue

1

issn

2110-5820

pii

10.1186/s13613-020-00745-w

journal_volume

10

pub_type

信件
  • Ultrasound guidance and risk for intravascular catheter-related infections among peripheral arterial catheters: a post-hoc analysis of two large randomized-controlled trials.

    abstract:BACKGROUND:The impact on infectious risk of ultrasound guidance at insertion remains controversial in short-term arterial catheters (ACs). The present study investigated the association between ultrasound guidance (US) during AC insertion and major catheter-related infections (MCRI), catheter-related bloodstream infect...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-020-00705-4

    authors: Buetti N,Ruckly S,Lucet JC,Bouadma L,Schwebel C,Mimoz O,Timsit JF

    更新日期:2020-07-08 00:00:00

  • Nutrition delivery of a model-based ICU glycaemic control system.

    abstract:BACKGROUND:Hyperglycaemia is commonplace in the adult intensive care unit (ICU), associated with increased morbidity and mortality. Effective glycaemic control (GC) can reduce morbidity and mortality, but has proven difficult. STAR is a proven, effective model-based ICU GC protocol that uniquely maintains normo-glycaem...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-017-0351-9

    authors: Stewart KW,Chase JG,Pretty CG,Shaw GM

    更新日期:2018-01-10 00:00:00

  • Efficacy of chlorhexidine bathing for reducing healthcare associated bloodstream infections: a meta-analysis.

    abstract:BACKGROUND:We performed a meta-analysis of randomized controlled trials (RCTs) to determine if daily bathing with chlorhexidine decreased hospital-acquired BSIs in critically ill patients. METHODS:We searched the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases to identify randomized contr...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-015-0073-9

    authors: Choi EY,Park DA,Kim HJ,Park J

    更新日期:2015-12-01 00:00:00

  • The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study.

    abstract:BACKGROUND:Middle East respiratory syndrome coronavirus (MERS-CoV) has caused several hospital outbreaks, including a major outbreak at King Abdulaziz Medical City, a 940-bed tertiary-care hospital in Riyadh, Saudi Arabia (August-September 2015). To learn from our experience, we described the critical care response to ...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-016-0203-z

    authors: Al-Dorzi HM,Aldawood AS,Khan R,Baharoon S,Alchin JD,Matroud AA,Al Johany SM,Balkhy HH,Arabi YM

    更新日期:2016-12-01 00:00:00

  • Acute-on-chronic liver failure alters meropenem pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study.

    abstract:BACKGROUND:Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Adequate dosing of antimicrobial therapy is of central importance to improve outcome. Liver failure may alter antibiotic drug concentrations via changes of drug distribution and elimination. We studied the pharmacokinetics of mer...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-020-00666-8

    authors: Grensemann J,Busse D,König C,Roedl K,Jäger W,Jarczak D,Iwersen-Bergmann S,Manthey C,Kluge S,Kloft C,Fuhrmann V

    更新日期:2020-04-22 00:00:00

  • Erythropoietin in the intensive care unit: beyond treatment of anemia.

    abstract:: Erythropoietin (EPO) is the major hormone stimulating the production and differentiation of red blood cells. EPO is used widely for treating anemia of critical illness or anemia induced by chemotherapy. EPO at pharmacological doses is used in this setting to raise hemoglobin levels (by preventing the apoptosis of ery...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/2110-5820-1-40

    authors: Patel NS,Collino M,Yaqoob MM,Thiemermann C

    更新日期:2011-09-23 00:00:00

  • The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure.

    abstract:BACKGROUND:Pre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could benefit the most from this treatment. The objective of this study was to evaluate the impact of endogen...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-017-0268-3

    authors: Martin-Loeches I,Muriel-Bombín A,Ferrer R,Artigas A,Sole-Violan J,Lorente L,Andaluz-Ojeda D,Prina-Mello A,Herrán-Monge R,Suberviola B,Rodriguez-Fernandez A,Merino P,Loza AM,Garcia-Olivares P,Anton E,Tamayo E,Trapiello W,

    更新日期:2017-12-01 00:00:00

  • Effects of chloride content of intravenous crystalloid solutions in critically ill adult patients: a meta-analysis with trial sequential analysis of randomized trials.

    abstract:BACKGROUND:Intravenous crystalloid solutions are administered commonly for critically ill patients. We performed this meta-analysis of randomized trials with trial sequential analysis (TSA) to evaluate effects of chloride content of intravenous crystalloid solutions on clinical outcomes among critically ill adult patie...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-019-0506-y

    authors: Xue M,Zhang X,Liu F,Chang W,Xie J,Xu J,Yang Y,Qiu H

    更新日期:2019-02-13 00:00:00

  • Patient-important outcomes in randomized controlled trials in critically ill patients: a systematic review.

    abstract:BACKGROUND:Intensivists' clinical decision making pursues two main goals for patients: to decrease mortality and to improve quality of life and functional status in survivors. Patient-important outcomes are gaining wide acceptance in most fields of clinical research. We sought to systematically review how well patient-...

    journal_title:Annals of intensive care

    pub_type: 杂志文章,评审

    doi:10.1186/s13613-017-0243-z

    authors: Gaudry S,Messika J,Ricard JD,Guillo S,Pasquet B,Dubief E,Boukertouta T,Dreyfuss D,Tubach F

    更新日期:2017-12-01 00:00:00

  • Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury.

    abstract:BACKGROUND:Acute lung injury and the acute respiratory distress syndrome (ALI/ARDS) are characterized by pulmonary oedema, measured as extravascular lung water (EVLW). The chest radiograph (CXR) can potentially estimate the quantity of lung oedema while the transpulmonary thermodilution method measures the amount of EV...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/2110-5820-3-25

    authors: Brown LM,Calfee CS,Howard JP,Craig TR,Matthay MA,McAuley DF

    更新日期:2013-08-11 00:00:00

  • Update in Neurocritical Care: a summary of the 2018 Paris international conference of the French Society of Intensive Care.

    abstract::The 2018 Paris Intensive Care symposium entitled "Update in Neurocritical Care" was organized in Paris, June 21-22, 2018, under the auspices of the French Intensive Care Society. This 2-day post-graduate educational symposium comprised several chapters, aiming first to provide all-board intensivists with current stand...

    journal_title:Annals of intensive care

    pub_type: 杂志文章,评审

    doi:10.1186/s13613-019-0523-x

    authors: Oddo M,Bracard S,Cariou A,Chanques G,Citerio G,Clerckx B,Godeau B,Godier A,Horn J,Jaber S,Jung B,Kuteifan K,Leone M,Mailles A,Mazighi M,Mégarbane B,Outin H,Puybasset L,Sharshar T,Sandroni C,Sonneville R,Weiss N

    更新日期:2019-04-16 00:00:00

  • Hacking into bacterial biofilms: a new therapeutic challenge.

    abstract:: Microbiologists have extensively worked during the past decade on a particular phase of the bacterial cell cycle known as biofilm, in which single-celled individuals gather together to form a sedentary but dynamic community within a complex structure, displaying spatial and functional heterogeneity. In response to th...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/2110-5820-1-19

    authors: Bordi C,de Bentzmann S

    更新日期:2011-06-13 00:00:00

  • Integrating eFAST in the initial management of stable trauma patients: the end of plain film radiography.

    abstract:BACKGROUND:The initial management of a trauma patient is a critical and demanding period. The use of extended focused assessment sonography for trauma (eFAST) has become more prevalent in trauma rooms, raising questions about the real "added value" of chest X-rays (CXRs) and pelvic X-rays (PXR), particularly in haemody...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-016-0166-0

    authors: Hamada SR,Delhaye N,Kerever S,Harrois A,Duranteau J

    更新日期:2016-12-01 00:00:00

  • Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study.

    abstract:BACKGROUND:The clinical interest of using bubble humidification of oxygen remains controversial. This study was designed to further explore whether delivering dry oxygen instead of bubble-moistened oxygen had an impact on discomfort of ICU patients. METHODS:This randomized multicenter non-inferiority open trial includ...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-018-0472-9

    authors: Poiroux L,Piquilloud L,Seegers V,Le Roy C,Colonval K,Agasse C,Zinzoni V,Hodebert V,Cambonie A,Saletes J,Bourgeon I,Beloncle F,Mercat A,REVA Network.

    更新日期:2018-12-17 00:00:00

  • Goal-directed fluid restriction during brain surgery: a prospective randomized controlled trial.

    abstract:BACKGROUND:The value of goal-directed fluid therapy in neurosurgical patients, where brain swelling is a major concern, is unknown. The aim of our study was to evaluate the effect of an intraoperative goal-directed fluid restriction (GDFR) strategy on the postoperative outcome of high-risk patients undergoing brain sur...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-017-0239-8

    authors: Luo J,Xue J,Liu J,Liu B,Liu L,Chen G

    更新日期:2017-12-01 00:00:00

  • Effects of endotoxin adsorber hemoperfusion on sublingual microcirculation in patients with septic shock: a randomized controlled trial.

    abstract:BACKGROUND:Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sepsis and septic shock, and a rat sepsis model revealed that PMX-HP treatment can maintain a better mi...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-020-00699-z

    authors: Chen SH,Chan WS,Liu CM,Chiu CT,Chao A,Wu VC,Sheng WH,Lai CH,Wang MJ,Yeh YC

    更新日期:2020-06-12 00:00:00

  • Anemia and red blood cell transfusion in critically ill cardiac patients.

    abstract::Anemia and red blood cell (RBC) transfusion occur frequently in hospitalized patients with cardiac disease. In this narrative review, we report the epidemiology of anemia and RBC transfusion in hospitalized adults and children (excluding premature neonates) with cardiac disease, and on the outcome of anemic and transf...

    journal_title:Annals of intensive care

    pub_type: 杂志文章,评审

    doi:10.1186/2110-5820-4-16

    authors: Du Pont-Thibodeau G,Harrington K,Lacroix J

    更新日期:2014-06-02 00:00:00

  • Feasibility of an alternative, physiologic, individualized open-lung approach to high-frequency oscillatory ventilation in children.

    abstract:BACKGROUND:High-frequency oscillatory ventilation (HFOV) is a common but unproven management strategy in paediatric critical care. Oscillator settings have been traditionally guided by patient age and/or weight rather than by lung mechanics, thereby potentially negating any beneficial effects. We have adopted an open-l...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-019-0492-0

    authors: de Jager P,Kamp T,Dijkstra SK,Burgerhof JGM,Markhorst DG,Curley MAQ,Cheifetz IM,Kneyber MCJ

    更新日期:2019-01-18 00:00:00

  • Personalizing blood pressure management in septic shock.

    abstract::This review examines the available evidence for targeting a specific mean arterial pressure (MAP) in sepsis resuscitation. The clinical data suggest that targeting an MAP of 65-70 mmHg in patients with septic shock who do not have chronic hypertension is a reasonable first approximation. Whereas in patients with chron...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-015-0085-5

    authors: Kato R,Pinsky MR

    更新日期:2015-12-01 00:00:00

  • The association of intravenous insulin and glucose infusion with intensive care unit and hospital mortality: a retrospective study.

    abstract:BACKGROUND:We assessed the association of intravenous insulin and glucose infusion with intensive care unit (ICU) and hospital mortality. METHODS:For this retrospective association study, we used data from all patients admitted to a medical-surgical ICU between January 2012 and September 2017. We excluded patients adm...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-019-0507-x

    authors: van Steen SC,Rijkenberg S,van der Voort PHJ,DeVries JH

    更新日期:2019-02-11 00:00:00

  • Intrahospital transport of critically ill patients (excluding newborns) recommendations of the Société de Réanimation de Langue Française (SRLF), the Société Française d'Anesthésie et de Réanimation (SFAR), and the Société Française de Médecine d'Urgence

    abstract:: Critically ill adult patients often require multiple examinations in the hospital and need transport from one department to another, or even between hospitals. However, to date, no guidelines exist regarding optimum practices for transport of these fragile patients. We present recommendations for intrahospital transp...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/2110-5820-2-1

    authors: Quenot JP,Milési C,Cravoisy A,Capellier G,Mimoz O,Fourcade O,Gueugniaud PY

    更新日期:2012-02-03 00:00:00

  • Impaired aspirin-mediated platelet function inhibition in resuscitated patients with acute myocardial infarction treated with therapeutic hypothermia: a prospective, observational, non-randomized single-centre study.

    abstract::The majority of resuscitated patients present with underlying cardiac disease, and out of these myocardial infarction is most common. Immediate interventional treatment is recommended and routinely requires dual antiplatelet therapy including aspirin and a P2Y12-inhibitor. Therapeutic hypothermia or target temperature...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-018-0366-x

    authors: Prüller F,Milke OL,Bis L,Fruhwald F,Scherr D,Eller P,Pätzold S,Altmanninger-Sock S,Rainer P,Siller-Matula J,von Lewinski D

    更新日期:2018-02-21 00:00:00

  • Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.

    abstract:BACKGROUND:Despite advances in supportive care, moderate-severe acute respiratory distress syndrome (ARDS) is associated with high mortality rates, and novel therapies to treat this condition are needed. Compelling pre-clinical data from mouse, rat, sheep and ex vivo perfused human lung models support the use of human ...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-014-0022-z

    authors: Liu KD,Wilson JG,Zhuo H,Caballero L,McMillan ML,Fang X,Cosgrove K,Calfee CS,Lee JW,Kangelaris KN,Gotts JE,Rogers AJ,Levitt JE,Wiener-Kronish JP,Delucchi KL,Leavitt AD,McKenna DH,Thompson BT,Matthay MA

    更新日期:2014-07-03 00:00:00

  • Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: inflammatory response of SARS-CoV-2 patients.

    abstract:BACKGROUND:SARS coronavirus 2 (SARS-CoV-2) is responsible for high morbidity and mortality worldwide, mostly due to the exacerbated inflammatory response observed in critically ill patients. However, little is known about the kinetics of the systemic immune response and its association with survival in SARS-CoV-2+ pati...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-020-00798-x

    authors: Lavillegrand JR,Garnier M,Spaeth A,Mario N,Hariri G,Pilon A,Berti E,Fieux F,Thietart S,Urbina T,Turpin M,Darrivière L,Fartoukh M,Verdonk F,Dumas G,Tedgui A,Guidet B,Maury E,Chantran Y,Voiriot G,Ait-Oufella H

    更新日期:2021-01-13 00:00:00

  • Implementation and evaluation of a paediatric nurse-driven sedation protocol in a paediatric intensive care unit.

    abstract:BACKGROUND:Optimal sedation and analgesia is a challenge in paediatric intensive care units (PICU) because of difficulties in scoring systems and specific metabolism inducing tolerance and withdrawal. Excessive sedation is associated with prolonged mechanical ventilation and hospitalisation. Adult and paediatric data s...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-017-0256-7

    authors: Dreyfus L,Javouhey E,Denis A,Touzet S,Bordet F

    更新日期:2017-12-01 00:00:00

  • Intra-abdominal pressure and abdominal perfusion pressure in cirrhotic patients with septic shock.

    abstract:BACKGROUND:The importance of intra-abdominal pressure (IAP) and abdominal perfusion pressure (APP) in cirrhotic patients with septic shock is not well studied. We evaluated the relationship between IAP and APP and outcomes of cirrhotic septic patients, and assessed the ability of these measures compared to other common...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/2110-5820-2-S1-S4

    authors: Al-Dorzi HM,Tamim HM,Rishu AH,Aljumah A,Arabi YM

    更新日期:2012-07-05 00:00:00

  • Perioperative statin therapy in cardiac and non-cardiac surgery: a systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:The effects of perioperative statin therapy on clinical outcome after cardiac or non-cardiac surgery are controversial. We aimed to assess the association between perioperative statin therapy and postoperative outcome. METHODS:Electronic databases were searched up to May 1, 2018, for randomized controlled t...

    journal_title:Annals of intensive care

    pub_type: 杂志文章,评审

    doi:10.1186/s13613-018-0441-3

    authors: Putzu A,de Carvalho E Silva CMPD,de Almeida JP,Belletti A,Cassina T,Landoni G,Hajjar LA

    更新日期:2018-09-27 00:00:00

  • Reliability of respiratory pressure measurements in ventilated and non-ventilated patients in ICU: an observational study.

    abstract:BACKGROUND:Assessment of maximum respiratory pressures is a common practice in intensive care because it can predict the success of weaning from ventilation. However, the reliability of measurements through an intubation catheter has not been compared with standard measurements. The aim of this study was to compare max...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-018-0362-1

    authors: Medrinal C,Prieur G,Combret Y,Quesada AR,Bonnevie T,Gravier FE,Frenoy E,Contal O,Lamia B

    更新日期:2018-01-30 00:00:00

  • Performance of the ROX index to predict intubation in immunocompromised patients receiving high-flow nasal cannula for acute respiratory failure.

    abstract:BACKGROUND:Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict intubation in immunocompromised patients. The study is a secondary analysis of randomized trials in ...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-021-00801-z

    authors: Lemiale V,Dumas G,Demoule A,Pène F,Kouatchet A,Bisbal M,Nseir S,Argaud L,Kontar L,Klouche K,Barbier F,Seguin A,Louis G,Constantin JM,Mayaux J,Wallet F,Peigne V,Girault C,Oziel J,Nyunga M,Terzi N,Bouadma L,Laut

    更新日期:2021-01-27 00:00:00

  • Accuracy of height estimation and tidal volume setting using anthropometric formulas in an ICU Caucasian population.

    abstract:BACKGROUND:Knowledge of patients' height is essential for daily practice in the intensive care unit. However, actual height measurements are unavailable on a daily routine in the ICU and measured height in the supine position and/or visual estimates may lack consistency. Clinicians do need simple and rapid methods to e...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-016-0154-4

    authors: L'her E,Martin-Babau J,Lellouche F

    更新日期:2016-12-01 00:00:00