Abstract：
: Erythropoietin (EPO) is the major hormone stimulating the production and differentiation of red blood cells. EPO is used widely for treating anemia of critical illness or anemia induced by chemotherapy. EPO at pharmacological doses is used in this setting to raise hemoglobin levels (by preventing the apoptosis of erythroid progenitor cells) and is designed to reduce patient exposure to allogenic blood through transfusions. Stroke, heart failure, and acute kidney injury are a frequently encountered clinical problem. Unfortunately, in the intensive care unit advances in supportive interventions have done little to reduce the high mortality associated with these conditions. Tissue protection with EPO at high, nonpharmacological doses after injury has been found in the brain, heart, and kidney of several animal models. It is now well known that EPO has anti-apoptotic effects in cells other than erythroid progenitor cells, which is considered to be independent of EPOs erythropoietic activities. This review article summarizes what is known in preclinical models of critical illness and discusses why this does not correlate with randomized, controlled clinical trials.
journal_name
Ann Intensive Carejournal_title
Annals of intensive careauthors
Patel NS,Collino M,Yaqoob MM,Thiemermann Cdoi
10.1186/2110-5820-1-40subject
Has Abstractpub_date
2011-09-23 00:00:00pages
40issn
2110-5820pii
2110-5820-1-40journal_volume
1pub_type
杂志文章abstract：BACKGROUND AND AIMS:Data on outcome of critically ill children with cirrhosis are scarce. We aimed to evaluate the prognostic accuracy of sequential organs scoring systems in children with cirrhosis admitted to Paediatric Intensive Care Units (PICU). METHODS:We performed a multicentre retrospective analysis of childre...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00753-w
更新日期：2020-10-14 00:00:00
abstract：BACKGROUND:Pneumonia is one of the major complications of drowning, but the optimal empirical antibiotic treatment is not clearly defined. Multidrug-resistant (MDR) bacteria and fungi have been identified in a recent series of freshwater drowning-associated pneumonia. However, microbial data in seawater drowning are sc...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-017-0267-4
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:The importance of intra-abdominal pressure (IAP) and abdominal perfusion pressure (APP) in cirrhotic patients with septic shock is not well studied. We evaluated the relationship between IAP and APP and outcomes of cirrhotic septic patients, and assessed the ability of these measures compared to other common...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/2110-5820-2-S1-S4
更新日期：2012-07-05 00:00:00
abstract：:In the past, the only treatment of acute exacerbations of obstructive diseases with hypercapnic respiratory failure refractory to medical treatment was invasive mechanical ventilation (IMV). Considerable technical improvements transformed extracorporeal techniques for carbon dioxide removal in an attractive option to ...
journal_title：Annals of intensive care
pub_type： 杂志文章,评审
doi：10.1186/s13613-019-0551-6
更新日期：2019-07-02 00:00:00
abstract：: Human serum albumin (HSA) has been used for a long time as a resuscitation fluid in critically ill patients. It is known to exert several important physiological and pharmacological functions. Among them, the antioxidant properties seem to be of paramount importance as they may be implied in the potential beneficial ...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/2110-5820-3-4
更新日期：2013-02-15 00:00:00
abstract：BACKGROUND:Empirical antimicrobial therapy (EAT) is a challenge for community-acquired, hospital-acquired and ventilator-associated pneumonia, particularly in the context of the increasing occurrence of third-generation cephalosporin-resistant Enterobacterales (3GCR-E), including extended-spectrum beta-lactamase Entero...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00754-9
更新日期：2020-10-29 00:00:00
abstract：BACKGROUND:SARS coronavirus 2 (SARS-CoV-2) is responsible for high morbidity and mortality worldwide, mostly due to the exacerbated inflammatory response observed in critically ill patients. However, little is known about the kinetics of the systemic immune response and its association with survival in SARS-CoV-2+ pati...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00798-x
更新日期：2021-01-13 00:00:00
abstract：:Jean-Luc Diehl The French Intensive Care Society organized on 5th and 6th June 2014 its 4th "Paris International Conference in Intensive Care", whose principle is to bring together the best international experts on a hot topic in critical care medicine. The 2014 theme was "Breakthrough in cardiac arrest", with many hi...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-015-0064-x
更新日期：2015-12-01 00:00:00
abstract：:Although chest X-ray remains a fundamental lung imaging technique, through the years, CT scan has significantly improved our knowledge of the pathophysiological process and currently is the reference lung imaging tool for both a visual and quantitative computer-based analysis. The application of lung CT in the early p...
journal_title：Annals of intensive care
pub_type： 社论
doi：10.1186/s13613-019-0497-8
更新日期：2019-01-22 00:00:00
abstract：BACKGROUND:Venous thromboembolism (VTE) is one of the most common preventable causes of in-hospital death in trauma patients surviving their injuries. We assessed the prevalence, incidence and risk factors for deep venous thrombosis (DVT) and pulmonary embolism (PE) in critically ill trauma patients, in the setting of ...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-017-0315-0
更新日期：2017-09-12 00:00:00
abstract：BACKGROUND:Critical illness has detrimental effects on the diaphragm, but the impact of critical illness on other major muscles of the respiratory pump has been largely neglected. This study aimed to determine the impact of critical illness on the most important muscles of the respiratory muscle pump, especially on the...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00731-2
更新日期：2020-08-27 00:00:00
abstract：BACKGROUND:Patients in the intensive care unit (ICU) are more prone to drug-drug interactions (DDIs). The software and charts that indicate all interactions may not be proper for clinical usage. This study aimed to identify the main drug classes associated with clinically significant DDIs in cardiothoracic ICU and cate...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-015-0086-4
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Sepsis is a common condition that has a high mortality and morbidity that need prompt diagnosis and treatment. Biomarkers like Soluble CD14 subtype (sCD14-ST, presepsin) may be useful in identifying patients with sepsis and its diagnostic superiority has been confirmed by several preliminary studies. The aim...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-015-0089-1
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Hypoxic hepatitis (HH) is a type of acute hepatic injury that is histologically characterized by centrilobular liver cell necrosis and that is caused by insufficient oxygen delivery to the hepatocytes. Typical for HH is the sudden and significant increase of aspartate aminotransferase (AST) in response to ca...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-018-0356-z
更新日期：2018-01-30 00:00:00
abstract：:The death of a loved one is often an ordeal and a tragedy for those who witness it, as death is not merely the end of a life, but also the end of an existence, the loss of a unique individual who is special and irreplaceable. In some situations, end-of-life signs, such as agonal gasps, can be an almost unbearable "sig...
journal_title：Annals of intensive care
pub_type： 杂志文章,评审
doi：10.1186/2110-5820-4-23
更新日期：2014-07-08 00:00:00
abstract：BACKGROUND:Sepsis-associated acute kidney injury (SA-AKI) is an independent risk factor for death in patients with sepsis, but treatment for it is limited. To improve the diagnosis and treatment of SA-AKI, we must first understand its pathogenesis. Recently, interleukin (IL)-17A has been shown to be associated with the...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-016-0157-1
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:The clinical interest of using bubble humidification of oxygen remains controversial. This study was designed to further explore whether delivering dry oxygen instead of bubble-moistened oxygen had an impact on discomfort of ICU patients. METHODS:This randomized multicenter non-inferiority open trial includ...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-018-0472-9
更新日期：2018-12-17 00:00:00
abstract：BACKGROUND:The effects of perioperative statin therapy on clinical outcome after cardiac or non-cardiac surgery are controversial. We aimed to assess the association between perioperative statin therapy and postoperative outcome. METHODS:Electronic databases were searched up to May 1, 2018, for randomized controlled t...
journal_title：Annals of intensive care
pub_type： 杂志文章,评审
doi：10.1186/s13613-018-0441-3
更新日期：2018-09-27 00:00:00
abstract：BACKGROUND:Data on respiratory mechanics of COVID-19 ARDS patients are scarce. Respiratory mechanics and response to positive expiratory pressure (PEEP) may be different in obese and non-obese patients. METHODS:We investigated esophageal pressure allowing determination of transpulmonary pressures (PL ) and elastances ...
journal_title：Annals of intensive care
pub_type： 信件
doi：10.1186/s13613-020-00745-w
更新日期：2020-10-01 00:00:00
abstract：:This review examines the available evidence for targeting a specific mean arterial pressure (MAP) in sepsis resuscitation. The clinical data suggest that targeting an MAP of 65-70 mmHg in patients with septic shock who do not have chronic hypertension is a reasonable first approximation. Whereas in patients with chron...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-015-0085-5
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Knowledge of patients' height is essential for daily practice in the intensive care unit. However, actual height measurements are unavailable on a daily routine in the ICU and measured height in the supine position and/or visual estimates may lack consistency. Clinicians do need simple and rapid methods to e...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-016-0154-4
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Hyponatremia occurring as a result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or cerebral salt wasting syndrome is a common complication in patients with subarachnoid hemorrhage (SAH). The efficacy and safety of urea as treatment for SIADH-induced hyponatremia has not been report...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/2110-5820-2-13
更新日期：2012-05-30 00:00:00
abstract：BACKGROUND:Optimal anti-bacterial activity of meropenem requires maintenance of its plasma concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at least 40% of the dosing interval (fT > MIC > 40). We aimed to determine whether a 3-h extended infusion (EI) of meropenem achieves fT > MI...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-019-0622-8
更新日期：2020-01-10 00:00:00
abstract：BACKGROUND:The initial management of a trauma patient is a critical and demanding period. The use of extended focused assessment sonography for trauma (eFAST) has become more prevalent in trauma rooms, raising questions about the real "added value" of chest X-rays (CXRs) and pelvic X-rays (PXR), particularly in haemody...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-016-0166-0
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Despite advances in supportive care, moderate-severe acute respiratory distress syndrome (ARDS) is associated with high mortality rates, and novel therapies to treat this condition are needed. Compelling pre-clinical data from mouse, rat, sheep and ex vivo perfused human lung models support the use of human ...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-014-0022-z
更新日期：2014-07-03 00:00:00
abstract：BACKGROUND:The consequences of the ageing population concerning ICU hospitalisation need to be adequately described. We believe that this discussion should be disease specific. A focus on respiratory infections is of particular interest, because it is strongly associated with old age. Our objective was to assess trends...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-018-0430-6
更新日期：2018-08-15 00:00:00
abstract：BACKGROUND:Despite improvements in intermittent hemodialysis management, intradialytic hemodynamic instability (IHI) remains a common issue that could account for increased mortality and delayed renal recovery. However, predictive factors of IHI remain poorly explored. The objective of this study was to evaluate the re...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00663-x
更新日期：2020-04-22 00:00:00
abstract：BACKGROUND:Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sepsis and septic shock, and a rat sepsis model revealed that PMX-HP treatment can maintain a better mi...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00699-z
更新日期：2020-06-12 00:00:00
abstract：INTRODUCTION:Capillary leak in critically ill patients leads to interstitial edema. Fluid overload is independently associated with poor prognosis. Bedside measurement of intra-abdominal pressure (IAP), extravascular lung water index (EVLWI), fluid balance, and capillary leak index (CLI) may provide a valuable prognost...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/2110-5820-2-S1-S1
更新日期：2012-07-05 00:00:00
abstract：BACKGROUND:The impact of neutropenia in critically ill immunocompromised patients admitted in a context of acute respiratory failure (ARF) remains uncertain. The primary objective was to assess the prognostic impact of neutropenia on outcomes of these patients. Secondary objective was to assess etiology of ARF accordin...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00764-7
更新日期：2020-10-22 00:00:00
