Acute-on-chronic liver failure alters meropenem pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study.

Abstract:

BACKGROUND:Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Adequate dosing of antimicrobial therapy is of central importance to improve outcome. Liver failure may alter antibiotic drug concentrations via changes of drug distribution and elimination. We studied the pharmacokinetics of meropenem in critically ill patients with ACLF during continuous veno-venous hemodialysis (CVVHD) and compared it to critically ill patients without concomitant liver failure (NLF). METHODS:In this prospective cohort study, patients received meropenem 1 g tid short-term infusion (SI). Meropenem serum samples were analyzed by high-performance liquid chromatography. A population pharmacokinetic analysis was performed followed by Monte Carlo simulations of (A) meropenem 1 g tid SI, (B) 2 g loading plus 1 g prolonged infusion tid (C) 2 g tid SI, and (D) 2 g loading and continuous infusion of 3 g/day on days 1 and 7. Probability of target attainment (PTA) was assessed for 4× the epidemiological cut-off values for Enterobacterales (4 × 0.25 mg/L) and Pseudomonas spp. (4 × 2 mg/L). RESULTS:Nineteen patients were included in this study. Of these, 8 patients suffered from ACLF. A two-compartment model with linear clearance from the central compartment described meropenem pharmacokinetics. The peripheral volume of distribution (V2) was significantly higher in ACLF compared to NLF (38.6L versus 19.7L, p = .05). PTA for Enterobacterales was achieved in 100% for all dosing regimens. PTA for Pseudomonas spp. in ACLF on day 1/7 was: A: 18%/80%, B: 94%/88%, C: 85%/98% D: 100%/100% and NLF: A: 48%/65%, B: 91%/83%, C: 91%/93%, D: 100%/100%. CONCLUSION:ALCF patients receiving CVVHD had a higher V2 and may require a higher loading dose of meropenem. For Pseudomonas, high doses or continuous infusion are required to reach PTA in ACLF patients.

journal_name

Ann Intensive Care

journal_title

Annals of intensive care

authors

Grensemann J,Busse D,König C,Roedl K,Jäger W,Jarczak D,Iwersen-Bergmann S,Manthey C,Kluge S,Kloft C,Fuhrmann V

doi

10.1186/s13613-020-00666-8

subject

Has Abstract

pub_date

2020-04-22 00:00:00

pages

48

issue

1

issn

2110-5820

pii

10.1186/s13613-020-00666-8

journal_volume

10

pub_type

杂志文章
  • The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure.

    abstract:BACKGROUND:Pre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could benefit the most from this treatment. The objective of this study was to evaluate the impact of endogen...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-017-0268-3

    authors: Martin-Loeches I,Muriel-Bombín A,Ferrer R,Artigas A,Sole-Violan J,Lorente L,Andaluz-Ojeda D,Prina-Mello A,Herrán-Monge R,Suberviola B,Rodriguez-Fernandez A,Merino P,Loza AM,Garcia-Olivares P,Anton E,Tamayo E,Trapiello W,

    更新日期:2017-12-01 00:00:00

  • Knockout of interleukin-17A protects against sepsis-associated acute kidney injury.

    abstract:BACKGROUND:Sepsis-associated acute kidney injury (SA-AKI) is an independent risk factor for death in patients with sepsis, but treatment for it is limited. To improve the diagnosis and treatment of SA-AKI, we must first understand its pathogenesis. Recently, interleukin (IL)-17A has been shown to be associated with the...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-016-0157-1

    authors: Luo CJ,Luo F,Zhang L,Xu Y,Cai GY,Fu B,Feng Z,Sun XF,Chen XM

    更新日期:2016-12-01 00:00:00

  • Specific antioxidant properties of human serum albumin.

    abstract:: Human serum albumin (HSA) has been used for a long time as a resuscitation fluid in critically ill patients. It is known to exert several important physiological and pharmacological functions. Among them, the antioxidant properties seem to be of paramount importance as they may be implied in the potential beneficial ...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/2110-5820-3-4

    authors: Taverna M,Marie AL,Mira JP,Guidet B

    更新日期:2013-02-15 00:00:00

  • Nutrition delivery of a model-based ICU glycaemic control system.

    abstract:BACKGROUND:Hyperglycaemia is commonplace in the adult intensive care unit (ICU), associated with increased morbidity and mortality. Effective glycaemic control (GC) can reduce morbidity and mortality, but has proven difficult. STAR is a proven, effective model-based ICU GC protocol that uniquely maintains normo-glycaem...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-017-0351-9

    authors: Stewart KW,Chase JG,Pretty CG,Shaw GM

    更新日期:2018-01-10 00:00:00

  • Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review.

    abstract:BACKGROUND:Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE). MAIN TEXT:We review the current data on the epidemiology, the possible underlying pathophysiologic mechanisms, and the therapeutic impl...

    journal_title:Annals of intensive care

    pub_type: 杂志文章,评审

    doi:10.1186/s13613-020-00741-0

    authors: Sakr Y,Giovini M,Leone M,Pizzilli G,Kortgen A,Bauer M,Tonetti T,Duclos G,Zieleskiewicz L,Buschbeck S,Ranieri VM,Antonucci E

    更新日期:2020-09-16 00:00:00

  • Goal-directed fluid restriction during brain surgery: a prospective randomized controlled trial.

    abstract:BACKGROUND:The value of goal-directed fluid therapy in neurosurgical patients, where brain swelling is a major concern, is unknown. The aim of our study was to evaluate the effect of an intraoperative goal-directed fluid restriction (GDFR) strategy on the postoperative outcome of high-risk patients undergoing brain sur...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-017-0239-8

    authors: Luo J,Xue J,Liu J,Liu B,Liu L,Chen G

    更新日期:2017-12-01 00:00:00

  • Fluid management in critically ill patients: the role of extravascular lung water, abdominal hypertension, capillary leak, and fluid balance.

    abstract:INTRODUCTION:Capillary leak in critically ill patients leads to interstitial edema. Fluid overload is independently associated with poor prognosis. Bedside measurement of intra-abdominal pressure (IAP), extravascular lung water index (EVLWI), fluid balance, and capillary leak index (CLI) may provide a valuable prognost...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/2110-5820-2-S1-S1

    authors: Cordemans C,De Laet I,Van Regenmortel N,Schoonheydt K,Dits H,Huber W,Malbrain ML

    更新日期:2012-07-05 00:00:00

  • Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury.

    abstract:BACKGROUND:Acute lung injury and the acute respiratory distress syndrome (ALI/ARDS) are characterized by pulmonary oedema, measured as extravascular lung water (EVLW). The chest radiograph (CXR) can potentially estimate the quantity of lung oedema while the transpulmonary thermodilution method measures the amount of EV...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/2110-5820-3-25

    authors: Brown LM,Calfee CS,Howard JP,Craig TR,Matthay MA,McAuley DF

    更新日期:2013-08-11 00:00:00

  • In-hospital and day-120 survival of critically ill solid cancer patients after discharge of the intensive care units: results of a retrospective multicenter study-A Groupe de recherche respiratoire en réanimation en Onco-Hématologie (Grrr-OH) study.

    abstract:OBJECTIVES:To assess outcomes at hospital discharge and day-120 after intensive care unit (ICU) discharge among patients with solid cancer admitted to ICU and to identify characteristics associated with in-hospital and day-120 after ICU discharge mortalities. DESIGN:International, multicenter, retrospective study. SE...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-018-0386-6

    authors: Vincent F,Soares M,Mokart D,Lemiale V,Bruneel F,Boubaya M,Gonzalez F,Cohen Y,Azoulay E,Darmon M,GrrrOH: Groupe de recherche respiratoire en réanimation en Onco-Hématologie (Group for respiratory research in intensive care in Onco-Hem

    更新日期:2018-03-27 00:00:00

  • Reliability of respiratory pressure measurements in ventilated and non-ventilated patients in ICU: an observational study.

    abstract:BACKGROUND:Assessment of maximum respiratory pressures is a common practice in intensive care because it can predict the success of weaning from ventilation. However, the reliability of measurements through an intubation catheter has not been compared with standard measurements. The aim of this study was to compare max...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-018-0362-1

    authors: Medrinal C,Prieur G,Combret Y,Quesada AR,Bonnevie T,Gravier FE,Frenoy E,Contal O,Lamia B

    更新日期:2018-01-30 00:00:00

  • Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: inflammatory response of SARS-CoV-2 patients.

    abstract:BACKGROUND:SARS coronavirus 2 (SARS-CoV-2) is responsible for high morbidity and mortality worldwide, mostly due to the exacerbated inflammatory response observed in critically ill patients. However, little is known about the kinetics of the systemic immune response and its association with survival in SARS-CoV-2+ pati...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-020-00798-x

    authors: Lavillegrand JR,Garnier M,Spaeth A,Mario N,Hariri G,Pilon A,Berti E,Fieux F,Thietart S,Urbina T,Turpin M,Darrivière L,Fartoukh M,Verdonk F,Dumas G,Tedgui A,Guidet B,Maury E,Chantran Y,Voiriot G,Ait-Oufella H

    更新日期:2021-01-13 00:00:00

  • The association of intravenous insulin and glucose infusion with intensive care unit and hospital mortality: a retrospective study.

    abstract:BACKGROUND:We assessed the association of intravenous insulin and glucose infusion with intensive care unit (ICU) and hospital mortality. METHODS:For this retrospective association study, we used data from all patients admitted to a medical-surgical ICU between January 2012 and September 2017. We excluded patients adm...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-019-0507-x

    authors: van Steen SC,Rijkenberg S,van der Voort PHJ,DeVries JH

    更新日期:2019-02-11 00:00:00

  • High-flow nasal oxygen versus noninvasive ventilation in adult patients with cystic fibrosis: a randomized crossover physiological study.

    abstract:BACKGROUND:Noninvasive ventilation (NIV) is the first-line treatment of adult patients with exacerbations of cystic fibrosis (CF). High-flow nasal oxygen therapy (HFNT) might benefit patients with hypoxemia and can reduce physiological dead space. We hypothesized that HFNT and NIV would similarly reduce work of breathi...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-018-0432-4

    authors: Sklar MC,Dres M,Rittayamai N,West B,Grieco DL,Telias I,Junhasavasdikul D,Rauseo M,Pham T,Madotto F,Campbell C,Tullis E,Brochard L

    更新日期:2018-09-05 00:00:00

  • Impact of a computer-assisted decision support system (CDSS) on nutrition management in critically ill hematology patients: the NUTCHOCO study (nutritional care in hematology oncologic patients and critical outcome).

    abstract:BACKGROUND:Mortality of critically ill hematology (HM) patients has improved over time. Thus, those patients require an extensive diagnostic workup and the optimal use of available treatments. There are no data regarding nutrition strategy for critically ill HM patients, while nutritional support is crucial for both HM...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-019-0527-6

    authors: Ettori F,Henin A,Zemmour C,Chow-Chine L,Sannini A,Bisbal M,Gonzalez F,Servan L,de Guibert JM,Faucher M,Boher JM,Mokart D

    更新日期:2019-05-07 00:00:00

  • Driving pressure and long-term outcomes in moderate/severe acute respiratory distress syndrome.

    abstract:BACKGROUND:Acute respiratory distress syndrome (ARDS) patients may present impaired in lung function and structure after hospital discharge that may be related to mechanical ventilation strategy. The aim of this study was to evaluate the association between functional and structural lung impairment, N-terminal-peptide ...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-018-0469-4

    authors: Toufen Junior C,De Santis Santiago RR,Hirota AS,Carvalho ARS,Gomes S,Amato MBP,Carvalho CRR

    更新日期:2018-12-07 00:00:00

  • Epidemiology, clinical characteristics, and outcome of candidemia in critically ill patients in Germany: a single-center retrospective 10-year analysis.

    abstract:BACKGROUND:Despite advances in the management of bloodstream infections (BSI) caused by Candida spp., the mortality still remains high in critically ill patients. The worldwide epidemiology of yeast-related BSI is subject to changing species distribution and resistance patterns, challenging antifungal treatment strateg...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-020-00755-8

    authors: Schroeder M,Weber T,Denker T,Winterland S,Wichmann D,Rohde H,Ozga AK,Fischer M,Kluge S

    更新日期:2020-10-16 00:00:00

  • The impact of critical illness on the expiratory muscles and the diaphragm assessed by ultrasound in mechanical ventilated children.

    abstract:BACKGROUND:Critical illness has detrimental effects on the diaphragm, but the impact of critical illness on other major muscles of the respiratory pump has been largely neglected. This study aimed to determine the impact of critical illness on the most important muscles of the respiratory muscle pump, especially on the...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-020-00731-2

    authors: IJland MM,Lemson J,van der Hoeven JG,Heunks LMA

    更新日期:2020-08-27 00:00:00

  • Intrahospital transport of critically ill patients (excluding newborns) recommendations of the Société de Réanimation de Langue Française (SRLF), the Société Française d'Anesthésie et de Réanimation (SFAR), and the Société Française de Médecine d'Urgence

    abstract:: Critically ill adult patients often require multiple examinations in the hospital and need transport from one department to another, or even between hospitals. However, to date, no guidelines exist regarding optimum practices for transport of these fragile patients. We present recommendations for intrahospital transp...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/2110-5820-2-1

    authors: Quenot JP,Milési C,Cravoisy A,Capellier G,Mimoz O,Fourcade O,Gueugniaud PY

    更新日期:2012-02-03 00:00:00

  • Accuracy of P0.1 measurements performed by ICU ventilators: a bench study.

    abstract:BACKGROUND:Occlusion pressure at 100 ms (P0.1), defined as the negative pressure measured 100 ms after the initiation of an inspiratory effort performed against a closed respiratory circuit, has been shown to be well correlated with central respiratory drive and respiratory effort. Automated P0.1 measurement is availab...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-019-0576-x

    authors: Beloncle F,Piquilloud L,Olivier PY,Vuillermoz A,Yvin E,Mercat A,Richard JC

    更新日期:2019-09-13 00:00:00

  • Hacking into bacterial biofilms: a new therapeutic challenge.

    abstract:: Microbiologists have extensively worked during the past decade on a particular phase of the bacterial cell cycle known as biofilm, in which single-celled individuals gather together to form a sedentary but dynamic community within a complex structure, displaying spatial and functional heterogeneity. In response to th...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/2110-5820-1-19

    authors: Bordi C,de Bentzmann S

    更新日期:2011-06-13 00:00:00

  • Pharmacological interventions in acute respiratory distress syndrome.

    abstract::Pharmacological interventions are commonly considered in acute respiratory distress syndrome (ARDS) patients. Inhaled nitric oxide (iNO) and neuromuscular blockers (NMBs) are used in patients with severe hypoxemia. No outcome benefit has been observed with the systematic use of iNO. However, a sometimes important impr...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/2110-5820-3-20

    authors: Roch A,Hraiech S,Dizier S,Papazian L

    更新日期:2013-07-03 00:00:00

  • Important drug classes associated with potential drug-drug interactions in critically ill patients: highlights for cardiothoracic intensivists.

    abstract:BACKGROUND:Patients in the intensive care unit (ICU) are more prone to drug-drug interactions (DDIs). The software and charts that indicate all interactions may not be proper for clinical usage. This study aimed to identify the main drug classes associated with clinically significant DDIs in cardiothoracic ICU and cate...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-015-0086-4

    authors: Baniasadi S,Farzanegan B,Alehashem M

    更新日期:2015-12-01 00:00:00

  • Anemia and red blood cell transfusion in critically ill cardiac patients.

    abstract::Anemia and red blood cell (RBC) transfusion occur frequently in hospitalized patients with cardiac disease. In this narrative review, we report the epidemiology of anemia and RBC transfusion in hospitalized adults and children (excluding premature neonates) with cardiac disease, and on the outcome of anemic and transf...

    journal_title:Annals of intensive care

    pub_type: 杂志文章,评审

    doi:10.1186/2110-5820-4-16

    authors: Du Pont-Thibodeau G,Harrington K,Lacroix J

    更新日期:2014-06-02 00:00:00

  • Performance of the ROX index to predict intubation in immunocompromised patients receiving high-flow nasal cannula for acute respiratory failure.

    abstract:BACKGROUND:Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict intubation in immunocompromised patients. The study is a secondary analysis of randomized trials in ...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-021-00801-z

    authors: Lemiale V,Dumas G,Demoule A,Pène F,Kouatchet A,Bisbal M,Nseir S,Argaud L,Kontar L,Klouche K,Barbier F,Seguin A,Louis G,Constantin JM,Mayaux J,Wallet F,Peigne V,Girault C,Oziel J,Nyunga M,Terzi N,Bouadma L,Laut

    更新日期:2021-01-27 00:00:00

  • Ethical reflections on end-of-life signs and symptoms in the intensive care setting: a place for neuromuscular blockers?

    abstract::The death of a loved one is often an ordeal and a tragedy for those who witness it, as death is not merely the end of a life, but also the end of an existence, the loss of a unique individual who is special and irreplaceable. In some situations, end-of-life signs, such as agonal gasps, can be an almost unbearable "sig...

    journal_title:Annals of intensive care

    pub_type: 杂志文章,评审

    doi:10.1186/2110-5820-4-23

    authors: Daubin C,Haddad L,Folscheid D,Boyer A,Chalumeau-Lemoine L,Guisset O,Hubert P,Pillot J,Robert R,Dreyfuss D

    更新日期:2014-07-08 00:00:00

  • Integrating eFAST in the initial management of stable trauma patients: the end of plain film radiography.

    abstract:BACKGROUND:The initial management of a trauma patient is a critical and demanding period. The use of extended focused assessment sonography for trauma (eFAST) has become more prevalent in trauma rooms, raising questions about the real "added value" of chest X-rays (CXRs) and pelvic X-rays (PXR), particularly in haemody...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-016-0166-0

    authors: Hamada SR,Delhaye N,Kerever S,Harrois A,Duranteau J

    更新日期:2016-12-01 00:00:00

  • Associations between tricuspid annular plane systolic excursion to reflect right ventricular function and acute kidney injury in critically ill patients: a SICS-I sub-study.

    abstract:BACKGROUND:Acute kidney injury (AKI) occurs in up to 50% of all critically ill patients and hemodynamic abnormalities are assumed to contribute, but their nature and share is still unclear. We explored the associations between hemodynamic variables, including cardiac index and right ventricular function, and the occurr...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-019-0513-z

    authors: Wiersema R,Koeze J,Hiemstra B,Pettilä V,Perner A,Keus F,van der Horst ICC,SICS Study Group.

    更新日期:2019-03-13 00:00:00

  • Occurrence of pendelluft under pressure support ventilation in patients who failed a spontaneous breathing trial: an observational study.

    abstract:BACKGROUND:Pendelluft, the movement of gas within different lung regions, is present in animal models of assisted mechanical ventilation and associated with lung overstretching. Due to rebreathing of CO2 as compared to fresh gas, pendelluft might reduce ventilatory efficiency possibly exacerbating patient's respiratory...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-020-00654-y

    authors: Coppadoro A,Grassi A,Giovannoni C,Rabboni F,Eronia N,Bronco A,Foti G,Fumagalli R,Bellani G

    更新日期:2020-04-07 00:00:00

  • Prognostic indicators of survival and survival prediction model following extracorporeal cardiopulmonary resuscitation in patients with sudden refractory cardiac arrest.

    abstract:BACKGROUND:Extracorporeal cardiopulmonary resuscitation (ECPR) has been considered in selected candidates with potentially reversible causes during a limited period. Candidate selection and the identification of predictable conditions are important factors in determining outcomes during CPR in the emergency department ...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-017-0309-y

    authors: Lee SW,Han KS,Park JS,Lee JS,Kim SJ

    更新日期:2017-08-30 00:00:00

  • Effects of chloride content of intravenous crystalloid solutions in critically ill adult patients: a meta-analysis with trial sequential analysis of randomized trials.

    abstract:BACKGROUND:Intravenous crystalloid solutions are administered commonly for critically ill patients. We performed this meta-analysis of randomized trials with trial sequential analysis (TSA) to evaluate effects of chloride content of intravenous crystalloid solutions on clinical outcomes among critically ill adult patie...

    journal_title:Annals of intensive care

    pub_type: 杂志文章

    doi:10.1186/s13613-019-0506-y

    authors: Xue M,Zhang X,Liu F,Chang W,Xie J,Xu J,Yang Y,Qiu H

    更新日期:2019-02-13 00:00:00