Abstract：
:Animal experiments are widely used in preclinical medical research with the goal of disease modeling and exploration of novel therapeutic approaches. In the context of sepsis and septic shock, the translation into clinical practice has been disappointing. Classical animal models of septic shock usually involve one-sex-one-age animal models, mostly in mice or rats, contrasting with the heterogeneous population of septic shock patients. Many other factors limit the reliability of preclinical models and may contribute to preclinical research failure in critical care, including the host specificity of several pathogens, the fact that laboratory animals are raised in pathogen-free facilities and that organ support techniques are either absent or minimal. Advanced animal models have been developed with the aim of improving the clinical translatability of experimental findings. So-called animal ICUs refer to the preclinical investigation of adult or even aged animals of either sex, using-in case of rats and mice-miniaturized equipment allowing for reproducing an ICU environment at a small animal scale and integrating chronic comorbidities to more closely reflect the clinical conditions studied. Strength and limitations of preclinical animal models designed to decipher the mechanisms involved in septic cardiomyopathy are discussed. This article reviews the current status and the challenges of setting up an animal ICU.
journal_name
Ann Intensive Carejournal_title
Annals of intensive careauthors
Guillon A,Preau S,Aboab J,Azabou E,Jung B,Silva S,Textoris J,Uhel F,Vodovar D,Zafrani L,de Prost N,Radermacher P,Translational Research Committee of the French Intensive Care Society (Société de Réanimation de Langue Française).doi
10.1186/s13613-019-0543-6subject
Has Abstractpub_date
2019-06-10 00:00:00pages
66issue
1issn
2110-5820pii
10.1186/s13613-019-0543-6journal_volume
9pub_type
杂志文章,评审abstract：BACKGROUND:Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict intubation in immunocompromised patients. The study is a secondary analysis of randomized trials in ...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-021-00801-z
更新日期：2021-01-27 00:00:00
abstract：BACKGROUND:Critical illness has detrimental effects on the diaphragm, but the impact of critical illness on other major muscles of the respiratory pump has been largely neglected. This study aimed to determine the impact of critical illness on the most important muscles of the respiratory muscle pump, especially on the...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00731-2
更新日期：2020-08-27 00:00:00
abstract：:Jean-Luc Diehl The French Intensive Care Society organized on 5th and 6th June 2014 its 4th "Paris International Conference in Intensive Care", whose principle is to bring together the best international experts on a hot topic in critical care medicine. The 2014 theme was "Breakthrough in cardiac arrest", with many hi...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-015-0064-x
更新日期：2015-12-01 00:00:00
abstract：: Multiple experimental and human trials have shown that microcirculatory alterations are frequent in sepsis. In this review, we discuss the characteristics of these alterations, the various mechanisms potentially involved, and the implications for therapy. Sepsis-induced microvascular alterations are characterized by ...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/2110-5820-1-27
更新日期：2011-07-19 00:00:00
abstract：BACKGROUND:The initial management of a trauma patient is a critical and demanding period. The use of extended focused assessment sonography for trauma (eFAST) has become more prevalent in trauma rooms, raising questions about the real "added value" of chest X-rays (CXRs) and pelvic X-rays (PXR), particularly in haemody...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-016-0166-0
更新日期：2016-12-01 00:00:00
abstract：:Although improving, the mortality from septic shock still remains high despite increased international awareness. As a consequence, much effort has focused on alternative treatment strategies in an effort to improve outcomes. The application of blood purification therapies to improve immune homeostasis has been sugges...
journal_title：Annals of intensive care
pub_type： 杂志文章,评审
doi：10.1186/s13613-019-0530-y
更新日期：2019-05-14 00:00:00
abstract：BACKGROUND:Occlusion pressure at 100 ms (P0.1), defined as the negative pressure measured 100 ms after the initiation of an inspiratory effort performed against a closed respiratory circuit, has been shown to be well correlated with central respiratory drive and respiratory effort. Automated P0.1 measurement is availab...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-019-0576-x
更新日期：2019-09-13 00:00:00
abstract：BACKGROUND:Intensivists' clinical decision making pursues two main goals for patients: to decrease mortality and to improve quality of life and functional status in survivors. Patient-important outcomes are gaining wide acceptance in most fields of clinical research. We sought to systematically review how well patient-...
journal_title：Annals of intensive care
pub_type： 杂志文章,评审
doi：10.1186/s13613-017-0243-z
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Data on outcome of critically ill children with cirrhosis are scarce. We aimed to evaluate the prognostic accuracy of sequential organs scoring systems in children with cirrhosis admitted to Paediatric Intensive Care Units (PICU). METHODS:We performed a multicentre retrospective analysis of childre...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00753-w
更新日期：2020-10-14 00:00:00
abstract：BACKGROUND:Acute kidney injury (AKI) occurs in up to 50% of all critically ill patients and hemodynamic abnormalities are assumed to contribute, but their nature and share is still unclear. We explored the associations between hemodynamic variables, including cardiac index and right ventricular function, and the occurr...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-019-0513-z
更新日期：2019-03-13 00:00:00
abstract：BACKGROUND:Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Adequate dosing of antimicrobial therapy is of central importance to improve outcome. Liver failure may alter antibiotic drug concentrations via changes of drug distribution and elimination. We studied the pharmacokinetics of mer...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00666-8
更新日期：2020-04-22 00:00:00
abstract：BACKGROUND:Red blood cell (RBC) transfusion has been associated with nosocomial infection in the critically ill patients. However, this association may be confounded by length of stay, as prolonged intensive care unit (ICU stay) increases both risk of infection and risk of transfusion. Also, it is not known whether spe...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-016-0173-1
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:In randomised controlled trials, procalcitonin (PCT)-guided antibiotic treatment has been proven to significantly reduce length of antibiotic therapy in intensive care unit (ICU) patients. However, concern was raised on low protocol adherence and high rates of overruling, and thus the value of PCT-guided tre...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-018-0415-5
更新日期：2018-06-04 00:00:00
abstract：BACKGROUND:Mortality of critically ill hematology (HM) patients has improved over time. Thus, those patients require an extensive diagnostic workup and the optimal use of available treatments. There are no data regarding nutrition strategy for critically ill HM patients, while nutritional support is crucial for both HM...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-019-0527-6
更新日期：2019-05-07 00:00:00
abstract：BACKGROUND:As the population ages and cancer therapies improve, there is an increased call for elderly cancer patients to be admitted to the intensive care unit (ICU). This study aimed to assess short-term survival and prognostic factors in critically ill patients with solid tumors aged ≥65 years. METHODS:We conducted...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-017-0250-0
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Lactate is a robust prognostic marker for the outcome of critically ill patients. Several small studies reported that metformin users have higher lactate levels at ICU admission without a concomitant increase in mortality. However, this has not been investigated in a larger cohort. We aimed to determine whet...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00652-0
更新日期：2020-03-26 00:00:00
abstract：BACKGROUND:The impact on infectious risk of ultrasound guidance at insertion remains controversial in short-term arterial catheters (ACs). The present study investigated the association between ultrasound guidance (US) during AC insertion and major catheter-related infections (MCRI), catheter-related bloodstream infect...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00705-4
更新日期：2020-07-08 00:00:00
abstract：BACKGROUND:The data on incidence, clinical presentation, and outcomes of ventilator-associated pneumonia (VAP) in patients with severe coronavirus disease 2019 (COVID-19) pneumonia requiring mechanical ventilation (MV) are limited. We performed this retrospective cohort study to assess frequency, clinical characteristi...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00775-4
更新日期：2020-11-23 00:00:00
abstract：:This review examines the available evidence for targeting a specific mean arterial pressure (MAP) in sepsis resuscitation. The clinical data suggest that targeting an MAP of 65-70 mmHg in patients with septic shock who do not have chronic hypertension is a reasonable first approximation. Whereas in patients with chron...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-015-0085-5
更新日期：2015-12-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via the original article. ...
journal_title：Annals of intensive care
pub_type： 已发布勘误
doi：10.1186/s13613-020-00691-7
更新日期：2020-06-02 00:00:00
abstract：BACKGROUND:Hyperglycaemia is commonplace in the adult intensive care unit (ICU), associated with increased morbidity and mortality. Effective glycaemic control (GC) can reduce morbidity and mortality, but has proven difficult. STAR is a proven, effective model-based ICU GC protocol that uniquely maintains normo-glycaem...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-017-0351-9
更新日期：2018-01-10 00:00:00
abstract：BACKGROUND:Intravenous crystalloid solutions are administered commonly for critically ill patients. We performed this meta-analysis of randomized trials with trial sequential analysis (TSA) to evaluate effects of chloride content of intravenous crystalloid solutions on clinical outcomes among critically ill adult patie...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-019-0506-y
更新日期：2019-02-13 00:00:00
abstract：BACKGROUND:Empirical antimicrobial therapy (EAT) is a challenge for community-acquired, hospital-acquired and ventilator-associated pneumonia, particularly in the context of the increasing occurrence of third-generation cephalosporin-resistant Enterobacterales (3GCR-E), including extended-spectrum beta-lactamase Entero...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00754-9
更新日期：2020-10-29 00:00:00
abstract：: Thrombocytopenia is a very frequent disorder in the intensive care unit. Many etiologies should be searched, and therapeutic approaches differ according to these different causes. However, no guideline exists regarding optimum practices for these situations in critically ill patients. We present recommendations for t...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/2110-5820-2-42
更新日期：2012-08-28 00:00:00
abstract：BACKGROUND:Glucose control is an important issue in post-operative patients. The objective here was to compare two insulin infusion lines by syringe pumps to assess the impact of medical devices on glycaemic variability in surgical patients under intensive insulin therapy. This open, prospective, single-centre randomis...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-017-0298-x
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:SARS coronavirus 2 (SARS-CoV-2) is responsible for high morbidity and mortality worldwide, mostly due to the exacerbated inflammatory response observed in critically ill patients. However, little is known about the kinetics of the systemic immune response and its association with survival in SARS-CoV-2+ pati...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00798-x
更新日期：2021-01-13 00:00:00
abstract：BACKGROUND:We assessed the association of intravenous insulin and glucose infusion with intensive care unit (ICU) and hospital mortality. METHODS:For this retrospective association study, we used data from all patients admitted to a medical-surgical ICU between January 2012 and September 2017. We excluded patients adm...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-019-0507-x
更新日期：2019-02-11 00:00:00
abstract：BACKGROUND:Venous thromboembolism (VTE) is one of the most common preventable causes of in-hospital death in trauma patients surviving their injuries. We assessed the prevalence, incidence and risk factors for deep venous thrombosis (DVT) and pulmonary embolism (PE) in critically ill trauma patients, in the setting of ...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-017-0315-0
更新日期：2017-09-12 00:00:00
abstract：BACKGROUND:Despite improvements in intermittent hemodialysis management, intradialytic hemodynamic instability (IHI) remains a common issue that could account for increased mortality and delayed renal recovery. However, predictive factors of IHI remain poorly explored. The objective of this study was to evaluate the re...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/s13613-020-00663-x
更新日期：2020-04-22 00:00:00
abstract：: Cancer is a leading cause of death in children. In the past decades, there has been a marked increase in overall survival of children with cancer. However, children whose treatment includes hematopoietic stem cell transplantation still represent a subpopulation with a higher risk of mortality. These improvements in m...
journal_title：Annals of intensive care
pub_type： 杂志文章
doi：10.1186/2110-5820-2-14
更新日期：2012-06-12 00:00:00
