Abstract:
BACKGROUND:Previous work has suggested that in the liver, adenosine preconditioning is mediated by nitric oxide. Whether the endothelial isoform of nitric oxide synthase plays a part in this mechanism has however not yet been investigated. METHODS:Wistar rats were used (6 in each group)--Groups: (1) sham, (2) ischemia-reperfusion, (3) adenosine + ischemia-reperfusion, (4) endothelial isoform inhibitor + adenosine + ischemia-reperfusion. RESULTS:Using immunohistochemistry, this study has revealed a decrease in the expression of endothelial nitric oxide synthase following hepatic ischemia-reperfusion. This was prevented by adenosine pre-treatment. When an inhibitor of endothelial nitric oxide synthase was administered prior to adenosine pre-treatment, pre-conditioning did not occur despite normal expression of endothelial nitric oxide synthase. CONCLUSIONS:These findings suggest that adenosine attenuates hepatic injury by preventing the downregulation of endothelial nitric oxide synthase that occurs during ischemia-reperfusion.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Serracino-Inglott F,Virlos IT,Habib NA,Williamson RC,Mathie RTdoi
10.1186/1471-230x-2-22keywords:
subject
Has Abstractpub_date
2002-09-20 00:00:00pages
22issn
1471-230Xjournal_volume
2pub_type
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