当前位置： SCI文献检索 > BMC GASTROENTEROLOGY期刊下所有文献 > The association of hepatitis c virus infection status with serum glucose levels.

The association of hepatitis c virus infection status with serum glucose levels.

Abstract：

BACKGROUND:Hepatitis C virus (HCV) infection is commonly associated with a disturbance of glucose metabolism. However, there have been conflicting reports on whether the clearance of the HCV may be followed by changes of serum blood glucose and insulin resistance. The aim of the present study was to evaluate the impact of HCV and antiviral treatment on serum glucose levels and other glucose metabolism parameters. METHODS:A retrospective analysis of 306 HCV-infected patients was performed. Fasting serum blood glucose (FBG) levels in these patients were compared with that of 325 healthy individuals. Serum parameters of glucose metabolism were measured in 183 patients with chronic hepatitis C at baseline, at the end of interferon α-2b plus ribavirin treatment, and at 24 weeks post-treatment. RESULTS:Patients with HCV infection had significantly higher FBG level than healthy controls (5.57 ± 0.74 vs. 5.11 ± 0.83 mmol/l, P < 0.001). After antiviral treatment, we found a significant reduction in FBG levels regardless of the outcome of treatment. However, after stopping treatment the serum FBG levels were significantly elevated in the sustained virological response (SVR) and non-responder groups, and maintained high level until week 24 post-treatment. In both groups, the levels of serum FBG after 24 weeks post-treatment were still lower than pre-treatment levels. In sustained responders, fasting insulin (P = 0.007), C-peptide (P < 0.001) and HOMA-IR (P < 0.001) significantly decreased, and the insulin sensitivity index (ISI) increased (P < 0.001) at the end of the treatment comparing with pre-treatment levels, while no significant difference was observed in non-responder group. HOMA-β values were increased in both groups at the end of treatment (both P < 0.001). CONCLUSION:The total serum FBG level in HCV infected patients was higher than that in healthy controls. Clearance of HCV was associated with reduced glucose and improved insulin resistance.

journal_name

BMC Gastroenterol

journal_title

BMC gastroenterology

authors

Li Y,Wang X,Yu G,Sun H,Lv J,Chi X,Wu R,Gao X,Niu J

doi

10.1186/s12876-019-1003-3

subject

Has Abstract

pub_date

2019-06-13 00:00:00

pages

issue

issn

1471-230X

pii

10.1186/s12876-019-1003-3

journal_volume

pub_type

杂志文章

在线工具

The association of hepatitis c virus infection status with serum glucose levels.