Abstract:
BACKGROUND:To investigate the effect of albumin infusion on cirrhotic patients admitted for acute gastrointestinal bleeding. METHODS:Medical records of cirrhotic patients who admitted due to acute gastrointestinal bleeding through January 2009 to December 2018 were reviewed. Clinical data and the total amount of albumin and red blood cell used during hospitalization were recorded. For patients with rebleeding, the amount of albumin and red blood cell used before rebleeding was also documented. The primary outcome was the occurrence of rebleeding, and the second outcome was in-hospital mortality. Univariate and multivariate logistic analysis was performed to identify risk factors associated with rebleeding and in-hospital mortality. RESULTS:A total of 1503 cirrhotic patients were included in the analysis. There were 146 episodes of in-patient rebleeding occurred, while 81 patients died. Overall, more red blood cells and albumin were prescribed to patients who suffered rebleeding. In terms of the amount before rebleeding, the red blood cell was higher in patients with rebleeding, but the albumin infusion was similar. In the multivariate model, the albumin infusion before rebleeding was an independent risk factor associated with rebleeding (adjusted OR for ≤40 g vs 0 g, 0.469 [0.269-0.793], p = 0.006; adjusted OR for > 40 g vs 0 g, 0.272 [0.115-0.576], p = 0.001). In Child-Pugh C class patients, the use of albumin more than 40 g during hospitalization associated with a lower risk of in-patient mortality (adjusted OR for > 40 g vs 0 g, 0.136 [0.019-0.741], p = 0.031). CONCLUSIONS:Albumin infusion was associated with a lower risk of rebleeding and in-hospital deaths in cirrhosis admitted for acute gastrointestinal bleeding.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Wang Z,Xie YW,Lu Q,Yan HL,Liu XB,Long Y,Zhang X,Yang JLdoi
10.1186/s12876-020-01337-5subject
Has Abstractpub_date
2020-06-23 00:00:00pages
198issue
1issn
1471-230Xpii
10.1186/s12876-020-01337-5journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Capsule endoscopy (CE) is the preferred diagnostic test of choice in the investigation of obscure gastrointestinal bleeding (OGIB). Although, a conservative strategy is recommended in the short-term, for cases with a negative result from CE, the impact of CE on long-term re-bleeding still remains unclear. He...
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1186/1471-230X-10-74
更新日期:2010-07-07 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1186/s12876-020-01257-4
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pub_type: 杂志文章
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更新日期:2012-05-14 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
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