Abstract:
BACKGROUND:Approximately 60% of patients presenting to dentists with erosive tooth wear have significant gastroesophageal reflux (GERD), despite minor reflux symptoms. No longitudinal studies of reflux-associated erosive tooth wear and of reflux characteristics have been reported to date. The aim of this study was to characterize the longitudinal course of GERD and of associated erosive tooth wear, as well as factors predictive of its progression, in a large group of patients. METHODS:Seventy-two patients presenting to dentists with clinically significant erosive tooth wear and increased esophageal acid exposure by 24-h multichannel intraluminal pH-impedance measurement (MII-pH) were re-assessed clinically and by MII-pH after 1 year treatment with esomeprazole 20 mg twice-daily. Predictive factors for erosive tooth wear were assessed by logistic regression. RESULTS:At follow-up, no further progression in erosive tooth wear was observed in 53 (74%) of patients. The percentage of time with a pH < 4, the number of acid reflux episodes and the percentage of proximal esophageal reflux off-PPI did not change significantly after one year, but the number of weakly acidic reflux episodes decreased significantly in the large subgroup without progression. None of the baseline demographic, clinical, endoscopic or esophageal acid exposure characteristics were significantly associated with progression of erosive tooth wear at follow-up. CONCLUSIONS:In this longitudinal study in patients with erosive tooth wear and oligosymptomatic GERD receiving esomeprazole for one year, erosive tooth wear did not progress further in the majority of patients. Background acidic esophageal reflux exposure appeared stable over time, whereas weakly acidic exposure decreased significantly in patients without erosion progression. MII-pH measurements on-PPI and with healthy controls will be useful in the further elucidation of the causal role of reflux in erosive tooth wear. TRIAL REGISTRATION:ClinicalTrials.gov , retrospectively registered: NCT02087345 .
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Wilder-Smith CH,Materna A,Martig L,Lussi Adoi
10.1186/s12876-017-0670-1subject
Has Abstractpub_date
2017-10-25 00:00:00pages
113issue
1issn
1471-230Xpii
10.1186/s12876-017-0670-1journal_volume
17pub_type
杂志文章abstract:BACKGROUND:The transitional-CpG sites between weakly methylated genes and densely methylated retroelements are overmethylated in the gastric mucosa infected with Helicobacter pylori (H. pylori) and they are undermethylated in the gastric cancers depending on the level of loss of heterozygosity (LOH) events. This study ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-137
更新日期:2010-11-20 00:00:00
abstract:BACKGROUND:Helicobacter pylori (H. pylori) has been etiologically linked with primary gastric lymphoma (PGL) and gastric carcinoma (GC). There are a few reports of occurrence of both diseases in the same patients with H. pylori infection. CASE PRESENTATION:We report a patient with PGL in whom the tumor regressed after...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230x-2-6
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Feeding related peptides have been shown to be additionally involved in the central autonomic control of gastrointestinal functions. Recent studies have shown that ghrelin, a stomach-derived orexigenic peptide, is involved in the autonomic regulation of GI function besides feeding behavior. Pharmacological e...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-5-5
更新日期:2005-02-18 00:00:00
abstract:BACKGROUND:The rate of H. pylori infection in Vietnam is reportedly high, but the spectrum of H. pylori-associated gastroduodenal diseases has not been systematically investigated. Moreover, despite the similarities of ethnicity and diet, the age-standardized incidence rate of gastric cancer in the northern city of Han...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-230X-10-114
更新日期:2010-09-30 00:00:00
abstract:BACKGROUND:Gastric diseases are a worldwide problem in modern society, as reported in the USA, in the range of 0.5-2 episodes/year/person and an incidence of 5-100 episodes/1000/week according to seasons and age. There is convincing evidence that oxidative stress is involved in the pathogenesis of acute gastric injury....
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0543-z
更新日期:2016-10-07 00:00:00
abstract:BACKGROUND:Perianal fistula surgery can damage the anal sphincters which may cause faecal incontinence. By measuring regional pressures, 3D-HRAM potentially provides better guidance for surgical strategy in patients with perianal fistulas. The aim was to measure regional anal pressures with 3D-HRAM and to compare these...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0770-6
更新日期:2018-04-04 00:00:00
abstract:BACKGROUND:Treatment effectiveness of Helicobacter pylori varies regionally and is decreasing worldwide, principally as a result of antibiotic resistant bacterium. Tetracycline is generally included in second line H. pylori eradication regimens. In Brazil, a high level of tetracycline resistance (TetR) is mainly associ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-49
更新日期:2012-05-17 00:00:00
abstract:BACKGROUND:The normal physiology of the gastrointestinal tract has been only cursorily examined. Consequently, the pathophysiology of disturbances of the gastrointestinal functions is poorly known. Recurrent vomiting is one of many functional conditions for which it is difficult to find an explanation and to treat. In ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-6-28
更新日期:2006-10-21 00:00:00
abstract:BACKGROUND:Inflammatory Bowel Diseases (IBD) affect psychological, family, social and professional dimensions of patients' life, leading to disability which is essential to quantify as part of Patient-Reported Outcomes (PROs) newly included in the targets to reach in IBD patients. Up to now, the IBD-Disability Index (I...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01246-7
更新日期:2020-04-16 00:00:00
abstract:BACKGROUND:The mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in Western Europe. Therefore, non-invasive screening markers for the presence of EV are of interest. Here, we aim to investigate whether non-inflammatory gall...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0852-5
更新日期:2018-08-02 00:00:00
abstract:BACKGROUND:Low 25-Hydroxy-vitamin-D; "25(OH)-D3" serum and vitamin D receptor (VDR) levels were recently correlated to advanced fibrosis. However, VDR mechanism in liver fibrosis modulations is not well understood. In this study, we aimed to evaluate changes in liver NK cells cytotoxicity due to modulations in VDR in C...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01248-5
更新日期:2020-04-10 00:00:00
abstract:BACKGROUND:Mini-Mental State Examination (MMSE) is one of the most commonly used methods in the assessment of cognitive mental status. MMSE has been used in hepatology but its usefulness in the evaluation of hepatic encephalopathy (HE) has never been properly assessed. The aim of the study was to investigate the value ...
journal_title:BMC gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-230X-13-107
更新日期:2013-07-02 00:00:00
abstract:BACKGROUND:Extramedullary plasmacytoma is a very rare tumor derived from plasma cells and found outside the bone marrow. Most have been identified in patients with the more aggressive anaplastic form of the disease. Only a few cases of primary pancreatic plasmacytoma have been reported. CASE PRESENTATION:We present a ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0729-z
更新日期:2017-12-20 00:00:00
abstract:BACKGROUND:Recent evidence cautions against the use of non-selective beta-blockers (NSBB) in patients with refractory ascites or spontaneous bacterial peritonitis while other data suggests a survival benefit in patients with advanced liver disease. The aim of this study was to describe the use and impact of NSBB in pat...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1155-1
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Approximately 0.2-1 % of children suffers from abdominal migraine (AM). Pathophysiology of AM has not been adequately studied. This study evaluated gastric motility in children with AM. METHODS:Seventeen children (6 boys), within an age range of 4-15 years, referred to a tertiary care paediatric unit, North...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0435-2
更新日期:2016-02-29 00:00:00
abstract:BACKGROUND:A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SMI and IMF on the survival of Indonesian HCC patients, whose characteristics differ from those of Jap...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1152-4
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:Gallstone disease (GSD) is a common gastrointestinal disorder throughout the world. The authors explored the incidence of GSD in Taiwan and its condition-associated predictive factors. METHODS:The initial study cohort comprised 2386 healthy adult participants, who were voluntarily admitted to a teaching hos...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-83
更新日期:2014-04-28 00:00:00
abstract:BACKGROUND:Hepatic artery dissection after liver transplantation is an uncommon morbidity. The onset mechanism and management for this disorder remain unclear. The present report describes the cases of two patients with hepatic artery dissection after living-donor liver transplantation (LDLT) with simultaneous splenect...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01528-0
更新日期:2020-11-12 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) symptoms often overlap. In some IBS cases there are subtle inflammatory changes similar to the immune-mediated pathophysiology of IBD, and the risk of both increases after infectious gastroenteritis (IGE). METHODS:To evaluate the effect of ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-55
更新日期:2012-05-28 00:00:00
abstract:BACKGROUND:Esophagogastroduodenoscopy is an often-used and safe diagnostic method in gastroenterology. Transnasal esophagogastroduodenoscopy is now an established addition to the endoscopic instrumentarium. Although the two examination methods can be used alongside each other, there is a lack of studies on the comparab...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-116
更新日期:2010-10-13 00:00:00
abstract:BACKGROUND:The association between proinflammatory cytokine gene polymorphisms and gastric diseases related to Helicobacter pylori varies by population and geographic area.Our objective was to determine if the IL-1B -511 T>C and -31 C>T polymorphisms and H. pylori vacA genotypes are associated with risk of chronic gast...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-126
更新日期:2010-10-27 00:00:00
abstract:BACKGROUND:Endoscopic nasobiliary drainage (ENBD) is widely used for biliary decompression in patients with biliary disease. However, it is difficult to reposition a nasobiliary catheter from the mouth to nostril. We developed a new device, which has a curved flexible loop and bar-handle, for repositioning of ENBD cath...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1148-0
更新日期:2019-12-21 00:00:00
abstract:BACKGROUND:Autoimmune hepatitis causes chronic hepatitis and often leads to cirrhosis and death without treatment. We wanted to see if having access to primary care or insurance prior to diagnosis is associated with better outcomes for patients in an urban, public hospital with mostly socioeconomically disadvantaged Hi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0318-y
更新日期:2015-07-28 00:00:00
abstract:BACKGROUND:The economic burden of ulcerative colitis (UC), specifically related to indirect costs, is not extensively documented. Understanding and quantifying it is required by health care decision makers. AIM:To assess the impact of indirect costs of UC in observation studies. METHOD:A systematic literature search ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1095-9
更新日期:2019-11-09 00:00:00
abstract:BACKGROUND:Diet may play a role in disease status in patients with inflammatory bowel disease. We tested whether the inflammatory potential of diet, based on a summation of pro- and anti-inflammatory nutrients, is associated with disease activity in patients with Crohn's disease and ulcerative colitis. METHODS:Partici...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01435-4
更新日期:2020-09-29 00:00:00
abstract:BACKGROUND:Gastric tuberculosis mimicking submucosal tumors is extremely rare and often misdiagnosed. CASE PRESENTATION:Three cases of gastric tuberculosis mimicking submucosal tumors were identified among patients admitted to local county hospitals because of upper abdominal discomfort and pain, with gastroscopy show...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-1175-x
更新日期:2020-01-30 00:00:00
abstract:BACKGROUND:Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotav...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-95
更新日期:2013-05-27 00:00:00
abstract:BACKGROUND:The assessment of residual gastric volume is common practice in critical care units. However, the effects and safety of discarding or returning gastric aspirates remain uncertain. Therefore, we aimed to evaluate the role of discarding or returning gastric aspirates on the gastric residual volumes in critical...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析
doi:10.1186/s12876-019-1028-7
更新日期:2019-06-28 00:00:00
abstract:BACKGROUND:Acute pancreatitis is the most common complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). In spite of continuing research, no pharmacologic agent capable of effectively reducing the incidence of ERCP-induced pancreatitis has found its way into clinical practise. ...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-230X-13-11
更新日期:2013-01-15 00:00:00
abstract:BACKGROUND:Efforts to identify cell sources and approaches for cell therapy of liver diseases are ongoing, taking into consideration the limits recognized for adult liver tissue and for other forms of stem cells. In the present study, we described the first procedure of via hepatic artery transplantation of human fetal...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-014-0204-z
更新日期:2014-12-04 00:00:00