Abstract:
BACKGROUND:The rate of H. pylori infection in Vietnam is reportedly high, but the spectrum of H. pylori-associated gastroduodenal diseases has not been systematically investigated. Moreover, despite the similarities of ethnicity and diet, the age-standardized incidence rate of gastric cancer in the northern city of Hanoi is higher than that in the southern city of Ho Chi Minh, but the reason for this phenomenon is unknown. The virulence of Vietnamese H. pylori has also not been investigated in detail. METHODS:Individuals undergoing esophagogastroduodenoscopy were randomly recruited. H. pylori infection status was determined based on the combined results of culture, histology, immunohistochemistry, rapid urine test and serum ELISA. Peptic ulcer (PU) and gastroesophageal reflux disease was diagnosed by endoscopy, and chronic gastritis was determined histologically. H. pylori virulence factors were investigated by PCR and sequencing. RESULTS:Among the examined patients, 65.6% were infected with H. pylori. The prevalence of infection was significantly higher in those over 40 years of age than in those aged ≤40. Chronic gastritis was present in all H. pylori-infected individuals, 83.1% of whom had active gastritis, and 85.3% and 14.7% had atrophy and intestinal metaplasia, respectively. PU was present in 21% of infected patients, whereas its incidence was very low in non-infected individuals. The prevalence of PU was significantly higher in Hanoi than in Ho Chi Minh. The prevalence of vacA m1, which has been identified as an independent risk factor for PU in Vietnam, was significantly higher among H. pylori isolates from Hanoi than among those from Ho Chi Minh. CONCLUSIONS:H. pylori infection is common in Vietnam and is strongly associated with PU, active gastritis, atrophy and intestinal metaplasia. vacA m1 is associated with an increased risk for PU and might contribute to the difference in the prevalence of PU and gastric cancer between Hanoi and Ho Chi Minh.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Nguyen TL,Uchida T,Tsukamoto Y,Trinh DT,Ta L,Mai BH,Le SH,Thai KD,Ho DD,Hoang HH,Matsuhisa T,Okimoto T,Kodama M,Murakami K,Fujioka T,Yamaoka Y,Moriyama Mdoi
10.1186/1471-230X-10-114subject
Has Abstractpub_date
2010-09-30 00:00:00pages
114issn
1471-230Xpii
1471-230X-10-114journal_volume
10pub_type
杂志文章,多中心研究abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a very common functional bowel disorder. However, the difference of depression and anxiety comorbidities among different IBS subtypes is still not well evaluated. This study aims to investigate the difference in the level and prevalence of depression and anxiety among health...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01593-5
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Vedolizumab has become a standard treatment for the inflammatory bowel diseases ulcerative colitis (UC) and Crohn's disease (CD). However, there is an ongoing debate on the ideal individual treatment algorithms and means to predict treatment response are not routinely established. AIMS:We aimed to describe ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-021-01604-z
更新日期:2021-01-22 00:00:00
abstract:BACKGROUND:Gastric diseases are a worldwide problem in modern society, as reported in the USA, in the range of 0.5-2 episodes/year/person and an incidence of 5-100 episodes/1000/week according to seasons and age. There is convincing evidence that oxidative stress is involved in the pathogenesis of acute gastric injury....
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0543-z
更新日期:2016-10-07 00:00:00
abstract:BACKGROUND:Previous results have shown that in rats with non-ascitic cirrhosis there is an altered transport of sugars and amino acids associated with elongated microvilli. These alterations returned to normal with the administration of Insulin-Like Growth Factor-I (IGF-I). The aims of this study were to explore the ev...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-4-12
更新日期:2004-06-14 00:00:00
abstract:BACKGROUND:The value of abdominal echography in primary care is great because it is innocuous, inexpensive, easy to perform and provides a great deal of information making this the first examination to be requested in cases of probable abdominal disease. However, too many abdominal echographies are probably requested o...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-230X-10-101
更新日期:2010-09-06 00:00:00
abstract:BACKGROUND:The prevalence of esophageal neoplasia in head and neck (H&N) cancer patients is not low; however, routine esophageal surveillance is not included in staging of newly-diagnosed H&N cancers. We aimed to investigate the risk factors for synchronous esophageal neoplasia and the impact of endoscopy on management...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-154
更新日期:2013-10-25 00:00:00
abstract:BACKGROUND:Green tea has shown the role of chemoprevention for cancer. Recently, several studies suggested that green tea intake may have effect on esophageal cancer risk, whereas the results were inconsistent. METHODS:We performed a meta-analysis of all English and Chinese language studies of green tea consumption an...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析
doi:10.1186/1471-230X-12-165
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Systemic sclerosis (SSc) is a generalized disorder of unknown etiology affecting the connective tissue of the body. It affects the skin and various internal organs. Gastrointestinal tract involvement is seen in almost 90% of the patients. Esophagus is the most frequently affected part of the gastrointestinal...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0241-2
更新日期:2015-02-15 00:00:00
abstract:BACKGROUND:Efficacy of maintenance therapy in ulcerative colitis (UC) in the remission stage has been reported to depend on release profile or dosing regimen of oral 5-aminosalicylic acid (5-ASA) products used. Aim of this study is to investigate real life results in using oral 5-ASA products for maintaining mild to mo...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12876-017-0604-y
更新日期:2017-04-04 00:00:00
abstract:BACKGROUND:The clinical course of chronic pancreatitis is still unpredictable, which relates to the lack of the availability of a clinical classification. Therefore, patient populations cannot be compared, the course and the outcome of the disease remain undetermined in the individual patient, and treatment is not stan...
journal_title:BMC gastroenterology
pub_type: 信件
doi:10.1186/1471-230X-9-93
更新日期:2009-12-14 00:00:00
abstract:BACKGROUND:High dose intravenous proton pump inhibitor after endoscopic therapy for peptic ulcer bleeding has been recommended as adjuvant therapy. Whether oral proton pump inhibitor can replace intravenous proton pump inhibitor in this setting is unknown. This study aims to compare the clinical efficacy of oral and in...
journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-230X-12-66
更新日期:2012-06-08 00:00:00
abstract:BACKGROUND:Denmark has one of the highest alcohol consumption rates in Northern Europe. The overall per capita alcohol consumption has been stable in recent decades, but surveys have indicated that consumption has decreased in the young and increased in the old. However, there is no recent information on the epidemiolo...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-8-3
更新日期:2008-02-09 00:00:00
abstract:BACKGROUND:The gut microbiome is altered in Crohn's disease. Although individual taxa have been correlated with post-operative clinical course, global trends in microbial diversity have not been described in this context. METHODS:We collected mucosal biopsies from the terminal ileum and ascending colon during surgery ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-131
更新日期:2013-08-22 00:00:00
abstract:BACKGROUND:Tumor-to-tumor metastasis is a rare event. Rectal cancer to primary thyroid neoplasm metastasis is extremely rare. Herein, we reported a case of metastatic rectal adenocarcinoma to a papillary thyroid carcinoma. The incidence and clinicopathological characteristics of metastatic colorectal cancer to a thyroi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01286-z
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:Autoimmune hepatitis causes chronic hepatitis and often leads to cirrhosis and death without treatment. We wanted to see if having access to primary care or insurance prior to diagnosis is associated with better outcomes for patients in an urban, public hospital with mostly socioeconomically disadvantaged Hi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0318-y
更新日期:2015-07-28 00:00:00
abstract:BACKGROUND:Inflammatory Bowel Diseases (IBD) affect psychological, family, social and professional dimensions of patients' life, leading to disability which is essential to quantify as part of Patient-Reported Outcomes (PROs) newly included in the targets to reach in IBD patients. Up to now, the IBD-Disability Index (I...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01246-7
更新日期:2020-04-16 00:00:00
abstract:BACKGROUND:Gastroparesis (Gp) is a poorly understood chronic gastrointestinal medical condition for which patient reported outcomes (PRO) are lacking. Previously developed symptoms scoring has been used for several decades. Using symptoms scores as a basis for documentation, 12 years of support/focus group patient feed...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0523-3
更新日期:2016-08-31 00:00:00
abstract:BACKGROUND:Measurements of CFTR function in rectal biopsies ex vivo have been used for diagnosis and prognosis of Cystic Fibrosis (CF) disease. Here, we aimed to evaluate this procedure regarding: i) viability of the rectal specimens obtained by biopsy forceps for ex vivo bioelectrical and biochemical laboratory analys...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-91
更新日期:2013-05-20 00:00:00
abstract:BACKGROUND:Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from follicular dendritic cells in lymphoid tissue while paraneoplastic pemphigus (PNP) is an autoimmune blistering disease associated with neoplasms. Pancreatic FDCS associated with PNP and myasthenia gravis (MG) is even rarer and h...
journal_title:BMC gastroenterology
pub_type: 杂志文章,评审
doi:10.1186/s12876-019-1008-y
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:The occurrence of non-alcoholic fatty liver disease (NAFLD) is found to be higher in patients with obstructive sleep apnea (OSA), which is characterized by intermittent hypoxia. Activation of hypoxia-inducible factors has been shown in the development and progression of NAFLD, implying a cause and effects re...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01515-5
更新日期:2020-11-03 00:00:00
abstract:BACKGROUND:The nuclear protein high-mobility group box 1 (HMGB1) is a key trigger for the inflammatory reaction during liver ischemia reperfusion injury (IRI). Hydrogen treatment was recently associated with down-regulation of the expression of HMGB1 and pro-inflammatory cytokines during sepsis and myocardial IRI, but ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-12
更新日期:2014-01-12 00:00:00
abstract:BACKGROUND:There are obviously ethnic differences between the UGT1A1 gene polymorphisms. Due to the difference of genetic background and environment, the treatment with colorectal cancer patients of Guangxi Zhuang should not completely follow the Euramerican or Chinese han patients. The study aimed to explore the corre...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01227-w
更新日期:2020-04-07 00:00:00
abstract:BACKGROUND:The evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotics exert their beneficial effects are largely unknown. The aim of the study is to evaluate the role o...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0605-x
更新日期:2017-04-14 00:00:00
abstract:BACKGROUND:Carrageenan is a traditional ingredient that has been widely used in the food industry. In the present study, we propose a hypothesis that carrageenan is a conditional inflammatory agent. When the intestinal tract is in an "unhealthy" state such as that during bacterial infection or acute inflammation, carra...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0459-7
更新日期:2016-03-25 00:00:00
abstract:BACKGROUND:The elderly population presents higher morbidity of H. pylori associated diseases in proximal stomach. The specific pathogenesis and mechanism have not been clearly addressed. The gastric environment for H. pylori colonization is dynamic with increasing age. The aim of present study is to investigate the cor...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0883-y
更新日期:2018-10-29 00:00:00
abstract:BACKGROUND:Acute pancreatitis (AP) is associated with considerable morbidity and mortality. Current severity scores include multiple variables and some of them are only complete within 48 h of admission. Red cell distribution width (RDW) is a simple and routine parameter that seems to be related to inflammatory status....
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0834-7
更新日期:2018-07-05 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) is defined as a multifactorial disorder associated with visceral hypersensitivity, altered gut motility and dysfunction of the brain-gut axis. Gut microbiota and its metabolites are proposed as possible etiological factors of IBS. Short chain fatty acids (SCFAs) induce both inh...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-021-01613-y
更新日期:2021-01-26 00:00:00
abstract:BACKGROUND:Approximately 60% of patients presenting to dentists with erosive tooth wear have significant gastroesophageal reflux (GERD), despite minor reflux symptoms. No longitudinal studies of reflux-associated erosive tooth wear and of reflux characteristics have been reported to date. The aim of this study was to c...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0670-1
更新日期:2017-10-25 00:00:00
abstract:BACKGROUND:Microscopic colitis presents with similar symptoms to classic inflammatory bowel diseases. Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis. AIMS:The aim of the present study was to evaluate bone density and metabolism in patien...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-58
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND:A validated histopathological tool to precisely evaluate bowel fibrosis in patients with Crohn's disease is lacking. We attempted to establish a new index to quantify the severity of bowel fibrosis in patients with Crohn's disease-associated fibrostenosis. METHODS:We analyzed the histopathological data of 3...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1100-3
更新日期:2019-11-11 00:00:00