Abstract:
BACKGROUND:Irritable bowel syndrome (IBS) is a very common functional bowel disorder. However, the difference of depression and anxiety comorbidities among different IBS subtypes is still not well evaluated. This study aims to investigate the difference in the level and prevalence of depression and anxiety among healthy controls and patients with different subtypes of IBS. METHODS:PubMed, EMBASE and the Cochrane library were searched systematically until August 17, 2020. Studies that investigated depression and/or anxiety levels or prevalence among different IBS-subtype patients measured at baseline or the same point were included. Network meta-analysis was conducted to analyze standardized mean difference (SMD) of anxiety and depression levels, and single arm meta-analysis was performed for prevalence of anxiety and depression among different IBS subtypes. RESULTS:Eighteen studies involving 7095 participants were included. Network meta-analyses results showed healthy controls had a lower level of depression than IBS with mixed symptoms of constipation and diarrhea (IBS-M) [SMD = - 1.57; 95% confidence interval (CI) - 2.21, - 0.92], IBS with constipation (IBS-C) (SMD = - 1.53; 95% CI - 2.13, - 0.93) and IBS with diarrhea (IBS-D)(SMD = - 1.41; 95% CI - 1.97, - 0.85), while no significant difference was found between IBS unclassified (IBS-U) and healthy controls (SMD = - 0.58; 95% CI - 2.15, 1.00). There was also no significant difference in the level of depression among different IBS subtypes patients. The results of anxiety were similar to depression. Ranking probability showed that IBS-M was associated with the highest level of depression and anxiety symptoms, followed by IBS-C/IBS-D and IBS-U. Single-arm meta-analysis showed IBS-C had the highest prevalence of depression (38%) and anxiety (40%), followed by IBS-D, IBS-M and IBS-U. CONCLUSION:The results indicated that IBS-M was more likely to be associated with a higher level of depression and anxiety, and the prevalence of depression and anxiety in IBS-C was highest. The psychological screening and appropriate psychotherapy are needed for patients with IBS-C, IBS-D and IBS-M instead of IBS-U.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Hu Z,Li M,Yao L,Wang Y,Wang E,Yuan J,Wang F,Yang K,Bian Z,Zhong LLDdoi
10.1186/s12876-020-01593-5subject
Has Abstractpub_date
2021-01-07 00:00:00pages
23issue
1issn
1471-230Xpii
10.1186/s12876-020-01593-5journal_volume
21pub_type
杂志文章abstract:BACKGROUND:Gas-related symptoms represent very common complaints in children. The reduction of gas production can be considered as a valuable target in controlling symptoms. α-galactosidase has been shown to reduce gas production and related symptoms in adults. To evaluate the efficacy and tolerability of α-galactosida...
journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-230X-13-142
更新日期:2013-09-24 00:00:00
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doi:10.1186/s12876-017-0605-x
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1186/1471-230X-4-16
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doi:10.1186/1471-230X-12-6
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01495-6
更新日期:2020-10-28 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-230X-4-12
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pub_type: 杂志文章
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journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12876-015-0260-z
更新日期:2015-03-20 00:00:00
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-09-30 00:00:00
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doi:10.1186/1471-230X-12-45
更新日期:2012-05-08 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2004-05-18 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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