Stevens-Johnson syndrome/toxic epidermal necrolysis and erythema multiforme drug-related hospitalisations in a national administrative database.

abstract：BACKGROUND:Recently we reported the validation of the "Allergy-Control-SCORE© (ACS)" which assesses symptom severity as well as medication use on three dimensions lung, nose and eyes. The aim of this study was to test the validity of the score for eyes and nose. METHODS:One-hundred-twenty-one consenting subjects (age ...

journal_title：Clinical and translational allergy

authors： Häfner D,Reich K,Zschocke I,Lotzin A,Meyer H,Kettner J,Narkus A

更新日期：2012-09-19 00:00:00

abstract：Background:Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may be challenge-negative, indicating that the skin test may be falsely positive. Objective:To investi...

journal_title：Clinical and translational allergy

authors： Tannert LK,Falkencrone S,Mortz CG,Bindslev-Jensen C,Skov PS

更新日期：2017-11-17 00:00:00

abstract：:Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In particular T-cell mediated delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse pathogenesis and result in a considerable burden of morbidity and mortality not only driven by the reactions ...

journal_title：Clinical and translational allergy

authors： Schrijvers R,Gilissen L,Chiriac AM,Demoly P

更新日期：2015-09-03 00:00:00

abstract：Background:Rhinitis is a common problem within the population. Many subjects with rhinitis also have atopic multimorbidity, such as asthma and eczema. The purpose of this investigation was to compare subjects with only rhinitis to those that have rhinitis, asthma and/or eczema in relation to immunoglobulin E (IgE) sens...

journal_title：Clinical and translational allergy

authors： Blöndal V,Sundbom F,Borres MP,Högman M,Alving K,Malinovschi A,Janson C

更新日期：2020-02-21 00:00:00

abstract：:On March 29, 2017, a European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases (CRD) was organized by the European Forum for Research and Education in Allergy and Airway Diseases. The event took place in the European Parliament of Brussels and was hosted by MEP David Borrelli and MEP Sirpa ...

journal_title：Clinical and translational allergy

authors： Hellings PW,Borrelli D,Pietikainen S,Agache I,Akdis C,Bachert C,Bewick M,Botjes E,Constantinidis J,Fokkens W,Haahtela T,Hopkins C,Illario M,Joos G,Lund V,Muraro A,Pugin B,Seys S,Somekh D,Stjärne P,Valiulis A,Val

更新日期：2017-12-27 00:00:00

abstract：:Rhinitis and rhinosinusitis are the two major clinical entities of chronic upper airway disease. Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) affect respectively up to 10 and 30% of the total population, hence being associated with an important socio-economic burden. Different phenotypes of rhinitis and CRS...

journal_title：Clinical and translational allergy

authors： De Greve G,Hellings PW,Fokkens WJ,Pugin B,Steelant B,Seys SF

更新日期：2017-07-12 00:00:00

abstract：BACKGROUND:A drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T cell mediated hypersensitivity reaction. Relapses of symptoms in the recovery phase are frequent and linked to the reduction of the corticosteroid treatment, to viral reactivations or to the exposure to new drugs. Here, we analyzed...

journal_title：Clinical and translational allergy

authors： Jörg L,Helbling A,Yerly D,Pichler WJ

更新日期：2020-11-23 00:00:00

abstract：Background:Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control. Objective:Our aim was to further characterize t...

journal_title：Clinical and translational allergy

authors： Tsolakis N,Nordvall L,Janson C,Rydell N,Malinovschi A,Alving K

更新日期：2019-02-22 00:00:00

abstract：:Oral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic proteins belonging to class 1 or to class 2 food allergens. OAS occurring when patients sensitized to pollens are ex...

journal_title：Clinical and translational allergy

authors： Alessandri C,Ferrara R,Bernardi ML,Zennaro D,Tuppo L,Giangrieco I,Ricciardi T,Tamburrini M,Ciardiello MA,Mari A

更新日期：2020-06-17 00:00:00

abstract：Background:Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has been argued that protocols used for this assessment should better reflect physiological conditions e...

journal_title：Clinical and translational allergy

authors： Akkerdaas J,Totis M,Barnett B,Bell E,Davis T,Edrington T,Glenn K,Graser G,Herman R,Knulst A,Ladics G,McClain S,Poulsen LK,Ranjan R,Rascle JB,Serrano H,Speijer D,Wang R,Pereira Mouriès L,Capt A,van Ree R

更新日期：2018-08-10 00:00:00

abstract：Background:In daily practice, one-third of sesame allergic patients, confirmed by clinical history or food challenge, do not show any detectable specific IgE using current diagnostics. Currently used sesame extracts are water-based and therefore lacking hydrophobic proteins like oleosins. Oleosins, the stabilizer of li...

journal_title：Clinical and translational allergy

authors： Ehlers AM,Rossnagel M,Brix B,Blankestijn MA,Le TM,Suer W,Otten HG,Knulst AC

更新日期：2019-06-28 00:00:00

abstract：Background:Pollen is a major cause of allergic respiratory diseases. In Qatar, data on the presence and prevalence of allergenic airborne types of pollen is quite limited. Methods:The study aimed to determine and correlate the most frequently implicated airborne pollen detected by aerobiological monitoring samplers in...

journal_title：Clinical and translational allergy

authors： Al-Nesf MA,Gharbi D,Mobayed HM,Dason BR,Mohammed Ali R,Taha S,Tuffaha A,Adeli M,Sattar HA,Trigo MDM

更新日期：2020-08-10 00:00:00

abstract：BACKGROUND:While Health Related Quality of Life has been investigated among children with IgE-mediated food allergy, less is known about quality of life among children with other types of hypersensitivity to food. The aim of this study was to investigate Health Related Quality of Life (HRQL) in children with and withou...

journal_title：Clinical and translational allergy

authors： Strinnholm Å,Hedman L,Winberg A,Jansson SA,Lindh V,Rönmark E

更新日期：2017-07-03 00:00:00

abstract：:Eosinophilic disorders represent a group of pathologic conditions with highly heterogeneous pathophysiology and clinical presentation and variable prognosis, ranging from asymptomatic or mild, to severe and complex cases, with fatal outcome. Interest in this group of disorders has increased during the last two decades...

journal_title：Clinical and translational allergy

authors： Leru PM

更新日期：2019-07-25 00:00:00

abstract：BACKGROUND:With the aim of actively contributing to the ongoing 11(th) International Classification of Diseases (ICD) revision, an international collaboration led by the European Academy of Allergy and Clinical Immunology (EAACI) has decided to revise the classification of hypersensitivity/allergic diseases and to vali...

journal_title：Clinical and translational allergy

authors： Tanno LK,Calderon M,Papadopoulos NG,Demoly P,EAACI\/WAO Task force of a Global Classification of Hypersensitivity\/Allergic diseases.

更新日期：2015-06-03 00:00:00

abstract：BACKGROUND:Although efforts to improve the classification of hypersensitivity/allergic diseases have been made, they have not been considered a top-level category in the International Classification of Diseases (ICD)-10 and still are not in the ICD-11 beta phase linearization. ICD-10 is the most used classification sys...

journal_title：Clinical and translational allergy

authors： Tanno LK,Calderon MA,Goldberg BJ,Akdis CA,Papadopoulos NG,Demoly P

更新日期：2014-11-28 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s13601-019-0303-6.]. ...

journal_title：Clinical and translational allergy

authors： Hox V,Lourijsen E,Jordens A,Aasbjerg K,Agache I,Alobid I,Bachert C,Boussery K,Campo P,Fokkens W,Hellings P,Hopkins C,Klimek L,Mäkelä M,Mösges R,Mullol J,Pujols L,Rondon C,Rudenko M,Toppila-Salmi S,Scadding G,Sch

更新日期：2020-09-28 00:00:00

abstract：Background:The relationship between smoking, household pollution, dual exposure and severity of asthma in adults has not been sufficiently studied. We examined and compared the effects of cigarette smoking, domestic wood burning pollution and dual exposure (tobacco and wood burning) upon asthma severity in adults. Met...

journal_title：Clinical and translational allergy

authors： Fernandes AGO,de Souza-Machado C,Pinheiro GP,de Oliva ST,Mota RCL,de Lima VB,Cruz CS,Chatkin JM,Cruz ÁA

更新日期：2018-12-10 00:00:00

abstract：BACKGROUND:The 300IR (index of reactivity) 5-grass pollen tablet has favorable short-term and sustained clinical efficacy in patients with grass pollen-induced allergic rhinoconjunctivitis (ARC). Here, we report maintenance of efficacy and safety over 2 years following treatment discontinuation. METHODS:Randomized, do...

journal_title：Clinical and translational allergy

authors： Didier A,Malling HJ,Worm M,Horak F,Sussman GL

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:Subcutaneous immunotherapy with high dose grass pollen (typically microgram quantities) was first described over 100 years ago. This treatment suppresses allergen-induced cutaneous late responses, with lesser effects on early responses. We previously reported that repeated 2-weekly intradermal injections of ...

journal_title：Clinical and translational allergy

authors： Slovick A,Douiri A,Kelly J,Guerra A,Muir R,Tsioulos K,Murphy C,Shamji MH,Ying S,Durham SR,Till SJ

更新日期：2013-08-21 00:00:00

abstract：Background:Fungal and bacterial microbiota play an important role in development of asthma. We aim to characterize airway microbiome (mycobiome, bacteriome) and functional genes in asthmatics and controls. Methods:Sputum microbiome of controls, untreated asthma patients and inhaled corticosteroid (ICS) receiving patie...

journal_title：Clinical and translational allergy

authors： Huang C,Yu Y,Du W,Liu Y,Dai R,Tang W,Wang P,Zhang C,Shi G

更新日期：2020-10-22 00:00:00

abstract：:We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients s...

journal_title：Clinical and translational allergy

authors： Brandt N,Garvey LH,Bindslev-Jensen U,Kjaer HF,Bindslev-Jensen C,Mortz CG

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catalyzing enzyme. It has been suggested that it has a role in lower airway allergic inflammations, but its role in allergic rhinitis has not been investigated. OBJECTIVE:Our aim was to evaluate the expression of IDO in the nasal mucosa of allergic rhinitis ...

journal_title：Clinical and translational allergy

authors： Luukkainen A,Karjalainen J,Honkanen T,Lehtonen M,Paavonen T,Toppila-Salmi S

更新日期：2011-12-12 00:00:00

abstract：BACKGROUND:Cow's milk allergy (CMA) is a common disease in infancy. Early environmental factors are likely to contribute to CMA. It is known that epigenetic gene regulation can be altered by environmental factors. We have set up a proof of concept study, aiming to detect epigenetic associations specific with CMA. METH...

journal_title：Clinical and translational allergy

authors： Petrus NCM,Henneman P,Venema A,Mul A,van Sinderen F,Haagmans M,Mook O,Hennekam RC,Sprikkelman AB,Mannens M

更新日期：2016-05-04 00:00:00

abstract：:Cosmetics and skin care products for neonates and infants are considered as ''hypoallergenic'', "tested" or ''safe''. Nevertheless, the prevalence of haptens in these products is a matter of concern, since allergic contact dermatitis in children is gaining an importance. We aimed to assess the prevalence of haptens in...

journal_title：Clinical and translational allergy

authors： Dumycz K,Kunkiel K,Feleszko W

更新日期：2019-03-08 00:00:00

abstract：Background:Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and comorbid asthma have more severe disease and are difficult to treat. However, the molecular endotypes associated with CRSwNP with comorbid asthma (CRSwNP + AS) are not clear. This study aimed to investigate the characteristics of type 2 infl...

journal_title：Clinical and translational allergy

authors： Wang M,Bu X,Luan G,Lin L,Wang Y,Jin J,Zhang L,Wang C

更新日期：2020-07-03 00:00:00

abstract：BACKGROUND:Asthma is a frequent chronic respiratory disease in both children and adults. However, few data on asthma prevalence are available in Portugal. The Portuguese National Asthma Survey is the first nationwide study that uses standardized methods. We aimed to estimate the prevalence of current asthma in the Port...

journal_title：Clinical and translational allergy

authors： Sa-Sousa A,Morais-Almeida M,Azevedo LF,Carvalho R,Jacinto T,Todo-Bom A,Loureiro C,Bugalho-Almeida A,Bousquet J,Fonseca JA

更新日期：2012-08-29 00:00:00

abstract：BACKGROUND:The FOXP3 gene is the master regulator for T regulatory cells and is under tight DNA methylation control at the Treg specific demethylated region (TSDR) in its first intron. This said, methylation of its promoter region, the significance of which is unknown, has also been associated with various immune-relat...

journal_title：Clinical and translational allergy

authors： Bégin P,Schulze J,Baron U,Olek S,Bauer RN,Passerini L,Baccheta R,Nadeau KC

更新日期：2015-10-20 00:00:00

abstract：UNLABELLED: BACKGROUND:The transition to adulthood can be particularly challenging for young people with severe allergies, who must learn to balance personal safety with independent living. Information and support for young people and their families are crucial to successfully managing this transition. We sought to: g...

journal_title：Clinical and translational allergy

authors： Worth A,Regent L,Levy M,Ledford C,East M,Sheikh A

更新日期：2013-01-22 00:00:00

abstract：BACKGROUND:The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy. METHODS:We w...

journal_title：Clinical and translational allergy

authors： Dhami S,Nurmatov U,Pajno GB,Fernandez-Rivas M,Muraro A,Roberts G,Akdis C,Alvaro-Lozano M,Beyer K,Bindslev-Jensen C,Burks W,du Toit G,Ebisawa M,Eigenmann P,Knol E,Makela M,Nadeau KC,O'Mahony L,Papadopoulos N,Poulsen

更新日期：2016-07-05 00:00:00