Abstract:
BACKGROUND:To report patients with age-related macular degeneration and atypical central retinal pigment epithelium (RPE) defects not attributable to geographic atrophy (GA) or RPE-tears with overlying preserved photoreceptor layers. METHODS:Multimodal imaging case-series evaluating the course of atypical RPE- defects in patients with AMD using Color fundus images, Optical coherence tomography (OCT), OCT-Angiography, fundus autofluorescence (FAF) and fluorescein-angiography (FA). RESULTS:Ten patients were identified. Three patients had a prior RPE-rip and were excluded. Seven patients with a mean follow-up period of 47 ± 38 months after the occurrence of the RPE-defect were included (age range 71-87 years). Mean distance Best corrected visual acuity (BCVA) at initial presentation was 0.36 ± 0.29logMAR and at last follow-up visit 0.51 ± 0.43logMAR. Patients presented with clinically apparent GA on funduscopy and FAF, but preserved photoreceptor layers on optical coherence tomography (OCT). On FA there was early hyperfluorescence and late pooling visible. Over time, migration of RPE/drusenoid material right above the Bruch's membrane with concomitant decrease of hypoautofluorescence was detectable in 4 cases. An enlargement of the RPE-defect was apparent in the remaining 3 cases. The majority (n = 4) showed a drusenoid pigment epithelium detachment (PED) preceding the lesion. CONCLUSIONS:Beside GA and characteristic RPE-tears, another atypical form of RPE-defect with overlying preserved photoreceptor layers are found in AMD. This so far disregarded subgroup of patients present with reasonable visual function and long-term survival of photoreceptors layers. Repair mechanisms such as ingrowth of RPE/drusenoid material and persistent subretinal fluid (SRF), but also a RPE-independent visual cycle for cone photopigment within the neurosensory retina may contribute to their favorable course.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Giannakaki-Zimmermann H,Querques G,Munch IC,Shroff D,Sarraf D,Chen X,Cunha-Souza E,Mrejen S,Capuano V,Rodrigues MW,Gupta C,Ebneter A,Zinkernagel MS,Munk MRdoi
10.1186/s12886-017-0452-0subject
Has Abstractpub_date
2017-05-15 00:00:00pages
67issue
1issn
1471-2415pii
10.1186/s12886-017-0452-0journal_volume
17pub_type
杂志文章,多中心研究abstract:BACKGROUND:To describe the spectral domain optical coherence tomography (SD-OCT) findings of a patient who developed pigmentary retinopathy following high-dose deferoxamine administration. CASE PRESENTATION:A 34-year-old man with thalassemia major complained of nyctalopia and decreased vision following high-dose intra...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-88
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-90
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-165
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journal_title:BMC ophthalmology
pub_type: 杂志文章
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abstract:BACKGROUND:To evaluate the efficacy and safety of intravitreal conbercept (KH902) as the primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy. METHODS:This study was a retrospective, consecutive, observational case series. We reviewed medical records of 16 eyes (16 patients) with...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0481-8
更新日期:2017-06-12 00:00:00
abstract:BACKGROUND:To investigate the effect of idiopathic epiretinal membrane (ERM) on the retinal-image quality and psychophysical contrast sensitivity function (CSF). METHODS:Forty-four subjects with diagnosis of idiopathic unilateral ERM were enrolled in this cross-sectional observational clinical study. The fellow unaffe...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0957-1
更新日期:2018-11-07 00:00:00
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pub_type: 杂志文章
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0613-1
更新日期:2017-11-25 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-91
更新日期:2014-07-12 00:00:00
abstract:BACKGROUND:Endogenous endophthalmitis could lead to a devastating outcome without a prompt and appropriate management. We report a case of advanced endogenous Klebsiella pneumoniae endophthalmitis with extensive subretinal abscess that was successfully treated with a vitrectomy. CASE PRESENTATION:A systemically well 6...
journal_title:BMC ophthalmology
pub_type: 杂志文章
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更新日期:2018-09-05 00:00:00
abstract:BACKGROUND:The aim of this study was to compare superior and temporal clear corneal incisions of uneventful phacoemulsification and in-the-bag intraocular lens implantation on intraocular pressure control and the bleb morphology in eyes that have undergone previous successful trabeculectomy. METHODS:In this Prospectiv...
journal_title:BMC ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12886-017-0500-9
更新日期:2017-06-26 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
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更新日期:2015-12-17 00:00:00
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更新日期:2015-08-08 00:00:00
abstract:BACKGROUND:Acute acquired comitant esotropia (AACE) is a type of strabismus characterized by a sudden onset of large angle esotropia with diplopia, which often occurs in children after infancy, teenagers, and young adolescents. However, studies on the surgical outcomes of only adults are rare. The purpose of this artic...
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更新日期:2021-01-18 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-03-03 00:00:00
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journal_title:BMC ophthalmology
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pub_type: 杂志文章,评审
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更新日期:2017-03-14 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2018-01-30 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
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更新日期:2018-11-23 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-10-6
更新日期:2010-03-19 00:00:00
abstract:BACKGROUND:While pars plana vitrectomy (PPV) has become the third most commonly performed surgery in the world, it can also induce multiple post complications easily. Among them, cataract progression is the most frequent one that can lead to blindness eventually. METHODS:To understand the underlying mechanisms of post...
journal_title:BMC ophthalmology
pub_type: 杂志文章
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更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:To evaluate the long-term outcomes of Argon laser photocoagulation compared to surgical direct cyclopexy in small-size cyclodialysis cleft patients. METHODS:This is a retrospective study. Small-size cyclodialysis cleft patients who underwent Argon laser photocoagulation and surgical direct cyclopexy were re...
journal_title:BMC ophthalmology
pub_type: 杂志文章
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更新日期:2015-09-24 00:00:00
abstract:BACKGROUND:To investigate the expression and significance of mechanistic target of rapamycin complex 1(mTORC1) in diabetic retinopathy (DR), and to find new targets and new methods for the treatment of DR. METHODS:A DR rat model was prepared by general feeding combined with intraperitoneal injection of 10% streptozoto...
journal_title:BMC ophthalmology
pub_type: 杂志文章
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更新日期:2020-07-20 00:00:00
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journal_title:BMC ophthalmology
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更新日期:2015-10-13 00:00:00
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journal_title:BMC ophthalmology
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