Abstract:
:Our aim was to evaluate the cut-off value and efficiency of using reticulocyte hemoglobin content as a marker to diagnose iron deficiency anemia in Chinese adults. 140 adults who needed bone marrow aspiration for diagnosis at the hematology department of the Peking Union Medical College Hospital were enrolled according to the inclusive and exclusive criteria. Venous blood samples were collected to detect complete blood count, including hemoglobin, reticulocyte hemoglobin content, hematocrit, mean cellular volume, corpuscular hemoglobin concentration, hemoglobin content, free erythrocyte protoporphyrin; iron indexes of serum ferritin, serum transferrin receptor, and unsaturated iron-binding capacity; and inflammation markers of C-reactive protein and α-acid glycoprotein. Bone marrow samples were obtained for the bone marrow iron staining, which was used as the standard for the evaluation of iron status in this study. Subjects were divided into three groups according to hemoglobin levels and bone marrow iron staining results: the IDA (iron deficiency anemia) group, the NIDA (non-iron deficiency anemia) group, and the control group. The differences of the above-mentioned indexes were compared among the three groups and the effect of inflammation was also considered. The cut-off value of reticulocyte hemoglobin content was determined by receiver operation curves. The IDA group (n = 56) had significantly lower reticulocyte hemoglobin content, mean cellular volume, corpuscular hemoglobin concentration, hemoglobin content, and serum ferritin; and higher free erythrocyte protoporphyrin, unsaturated iron-binding capacity, and serum transferrin receptor (p < 0.05) compared with the NIDA group (n = 38) and control group (n = 46). Hematocrit, serum ferritin, and unsaturated iron-binding capacity were significantly affected by inflammation while reticulocyte hemoglobin content and other parameters were not. The cut-off value of reticulocyte hemoglobin content for diagnosing iron deficiency anemia was 27.2 pg, with a sensitivity of 87.5% and a specificity of 92.9%. The cut-off values for mean cellular volume, serum ferritin, and serum transferrin receptor were 76.6, 12.9, and 4.89 mg/L, respectively. Reticulocyte hemoglobin content had the largest area under the curve of 0.929, while those for mean cellular volume, serum ferritin, serum transferrin receptor were 0.922, 0.887, and 0.900, respectively. Reticulocyte hemoglobin content has a high sensitivity and specificity in the diagnosis of iron deficiency anemia, and its comprehensive diagnostic efficacy is better than other traditional indicators-such as serum ferritin and serum transferrin receptor.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Cai J,Wu M,Ren J,Du Y,Long Z,Li G,Han B,Yang Ldoi
10.3390/nu9050450subject
Has Abstractpub_date
2017-05-02 00:00:00issue
5issn
2072-6643pii
nu9050450journal_volume
9pub_type
杂志文章相关文献
Nutrients文献大全abstract::Children born from mothers with gestational diabetes mellitus (GDM) are at high-risk of obesity and type 2 diabetes. To date, there is a lack of effective strategies to prevent these complications. The aim of this study was to evaluate the association between diet quality and anthropometric and glycemic profiles of ch...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11030570
更新日期:2019-03-07 00:00:00
abstract::Dietary flavonoids are vasoactive phytochemicals with promising anti-inflammatory properties. We aimed to assess the associations between baseline intakes of six commonly consumed flavonoid subclasses and 10-year incidence of age-related hearing loss. At baseline, 1691 participants aged 50+ years had information on di...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113297
更新日期:2020-10-28 00:00:00
abstract::The management of enteral feeds in preterm infants with a hemodynamically significant patent ductus arteriosus (hs-PDA) is a major challenge for neonatologists due to the fear of gastrointestinal (GI) complications. This review aims to analyze the available evidence on the complex relation between the presence and man...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12010083
更新日期:2019-12-27 00:00:00
abstract::The importance of gut microbiota in health and disease is being highlighted by numerous research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke, is responsible for about 50% of all cardiovascular deaths. Recently, gut dysbiosis has been identified as a remarkable factor to be consider...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12030605
更新日期:2020-02-26 00:00:00
abstract::Necrotizing Enterocolitis (NEC) is associated with prematurity, enteral feedings, and enteral dysbiosis. Accordingly, we hypothesized that along with nutritional variability, metabolic dysfunction would be associated with NEC onset. Methods: We queried a multicenter longitudinal database that included 995 preterm infa...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051275
更新日期:2020-04-30 00:00:00
abstract::This cross-sectional study is aimed at assessing sodium (Na) and potassium (K) content and the molar Na:K ratios of the most commonly available ready-to-eat street foods in Tajikistan and Kyrgyzstan. Four different samples of each of these foods were collected and 62 food categories were evaluated through bromatologic...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10010098
更新日期:2018-01-16 00:00:00
abstract::Total iron intake is not strongly associated with iron stores, but haem iron intake may be more predictive. Haem iron is not available in most nutrient databases, so experimentally determined haem contents were applied to an Australian Food Frequency Questionnaire (FFQ) to estimate haem iron intake in a representative...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9050515
更新日期:2017-05-19 00:00:00
abstract::The lack of effective treatment for chronic discomfort without negative side effects highlights the need for alternative treatments. Pain Bloc-R is a natural health product composed of vitamins B6, B12, D, white willow bark extract, Angelica root extract, acetyl L-carnitine HCl, caffeine, L-theanine, Benfotiamine, and...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061831
更新日期:2020-06-19 00:00:00
abstract::Vitamin K is a composite term referring to a group of fat-soluble vitamins that function as a cofactor for the enzyme γ-glutamyl carboxylase (GGCX), which activates a number of vitamin K-dependent proteins (VKDPs) involved in haemostasis and vascular and bone health. Accumulating evidence demonstrates that chronic kid...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11010168
更新日期:2019-01-14 00:00:00
abstract::Anthocyanin consumption is linked to benefits in obesity-related metabolic alterations and non-alcoholic fatty liver disease (NAFLD), though the functional role of delphinidin (Dp) is yet to be established. Therefore, this study examined the effects of Dp on metabolic alterations associated with NAFLD, and molecular m...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10081060
更新日期:2018-08-10 00:00:00
abstract::We examined the impact of APOE genotype on plasma lipids and glucose in a secondary analysis of data from a five-arm, randomised controlled, parallel dietary intervention trial ('RISCK' study), to investigate the impact of replacing saturated fatty acids (SFA) with either monounsaturated fat (MUFA) or carbohydrate of ...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10101524
更新日期:2018-10-17 00:00:00
abstract::Inula japonica Thunb. (Asteraceae) is a flowering plant that grows mainly in Korea, Japan, and China and its flower extract has diverse biological effects such as anti-inflammatory and antioxidative activities. However, the effects on obesity and enhancement of endurance capacity have not been explored yet. This study...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11010017
更新日期:2018-12-20 00:00:00
abstract::microRNAs (miRNAs), a class of small RNAs, are important regulators of various developmental processes in both plants and animals. Several years ago, a report showed the detection of diet-derived plant miRNAs in mammalian tissues and their regulation of mammalian genes, challenging the traditional functions of plant m...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7053184
更新日期:2015-04-30 00:00:00
abstract::The indications for delaying the start of dialysis have revived interest in low-protein diets (LPDs). In this observational prospective study, we enrolled all patients with chronic kidney disease (CKD) who followed a moderately restricted LPD in 2007-2015 in a nephrology unit in Italy: 449 patients, 847 years of obser...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8120758
更新日期:2016-11-25 00:00:00
abstract::The objective of this study was to assess the effects of whole grain Tibetan hull-less barley on metabolic related syndrome induced by high-fat-sucrose diets in rats. The diets were designed to reflect the dietary patterns of Chinese individuals (>30% energy fat) with refined wheat flour (HFS-W) or Tibetan hull-less b...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6041635
更新日期:2014-04-21 00:00:00
abstract::The aim of this systematic review is to assess whether metformin could change the concentration of serum homocysteine (Hcy) with and without simultaneous supplementation of B-group vitamins or folic acid. A literature search was conducted in PubMed, EmBase, and Cochrane Central Register of Controlled Trials (CENTRAL) ...
journal_title:Nutrients
pub_type: 杂志文章,meta分析,评审
doi:10.3390/nu8120798
更新日期:2016-12-09 00:00:00
abstract::Adequate docosahexaenoic acid (DHA) is essential for the optimal growth and development of the fetus. Maternal DHA content fluctuates during pregnancy. The correlation of DHA content with dietary intake might be varied over the course of pregnancy. We aimed to compare the dietary DHA intake, estimated by a DHA-specifi...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9111256
更新日期:2017-11-16 00:00:00
abstract:BACKGROUND:Diet might influence the risk of allergic diseases. Evidence from developing countries with high prevalence of childhood asthma is scant. METHODS:Information on wheeze, rhinitis, and eczema was collected from 3209 children aged 6-7 years in 2005, who were taking part in the International Study on Asthma and...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7075098
更新日期:2015-06-25 00:00:00
abstract::Infants rely on their innate immune systems to protect them from infection. Human milk (HM) contains fatty acids (FAs) and monoacylglycerols that are known to exhibit antiviral and antibacterial properties in vitro. The specific fat content of HM may potentially affect the efficacy of this antimicrobial activity. This...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9091034
更新日期:2017-09-19 00:00:00
abstract::Raisins are dried grapes consumed worldwide that contain beneficial components for human health. They are rich in fiber and phytochemicals such as phenolic compounds. Despite a 60% sugar content, several studies have reported health-promoting properties for raisins and this review compiles the intervention studies, as...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12010054
更新日期:2019-12-24 00:00:00
abstract::Dietary Guidelines for Americans 2015-20 recommend replacing sugar sweetened beverages (SSBs) with plain water in order to promote adequate hydration while reducing added sugar intake. This study explored how water intakes from water, beverages, and foods are distributed across the day. The dietary intake data for 745...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11112707
更新日期:2019-11-08 00:00:00
abstract::Iodine is a microelement that is naturally present in some foods, added to others, and available as a dietary supplement [...]. ...
journal_title:Nutrients
pub_type: 社论
doi:10.3390/nu12051491
更新日期:2020-05-20 00:00:00
abstract::Obesity and weight gain in bipolar disorder (BD) have multifactorial underlying causes such as medication side effects, atypical depressive symptomatology, genetic variants, and disturbances in the neuro-endocrinal system. Therefore, we aim to explore the associations between food craving (FC), clinical parameters, ps...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu13010076
更新日期:2020-12-29 00:00:00
abstract::Dietary habits in adolescence persist into adulthood; thus, it is important to identify the factors that influence adolescent diet and establish a healthy diet. This study aimed to examine the association between mothers' nutrition knowledge and their children's nutrient intake inadequacy among Japanese junior high sc...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092801
更新日期:2020-09-13 00:00:00
abstract::Apart from optimal nutritional value, human milk is the feeding strategy to support the immature immunological system of developing newborns and infants. The most beneficial dietary carbohydrate components of breast milk are human milk oligosaccharides (HMOs) and glycoproteins (HMGs), involved in both specific and non...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12041105
更新日期:2020-04-16 00:00:00
abstract::Keratoconjunctivitis sicca (KCS) or dry eye is a disease characterized by ocular surface symptoms. This study aimed to investigate the effectiveness of oral choline alfoscerate (CA) administration as a treatment for KCS. The medical records of dry eye patients who were refractory to topical eyedrops and then took oral...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051526
更新日期:2020-05-23 00:00:00
abstract:BACKGROUND:The presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozoto...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11112720
更新日期:2019-11-09 00:00:00
abstract::A pro-coagulative state is related to increased risk of cardiovascular diseases but also certain cancers. Since experimental and smaller human studies suggest that diet, physical activity, and body weight may all affect coagulation, we evaluated associations between these lifestyle factors and hemostatic biomarkers in...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11092067
更新日期:2019-09-03 00:00:00
abstract::Agronomic biofortification (i.e., the application of fertilizer to elevate micronutrient concentrations in staple crops) is a recent strategy recommended for controlling Iodine Deficiency Disorders (IDDs). However, its success inevitably depends on stakeholders' appreciation and acceptance of it. By taking Northern Ug...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10040407
更新日期:2018-03-24 00:00:00
abstract::(1) Background: Pregnancy outcomes for both mother and child are affected by many environmental factors. The importance of pregnancy for 'early life programming' is well established and maternal nutrition is an important factor contributing to a favourable environment for developing offspring. We aim to assess whether...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11051098
更新日期:2019-05-17 00:00:00