The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

abstract：:Alzheimer's disease (AD) is characterized clinically by memory loss and cognitive decline. Protein kinase A (PKA)-CREB signaling plays a critical role in learning and memory. It is known that glucose uptake and O-GlcNAcylation are reduced in AD brain. In this study, we found that PKA catalytic subunits (PKAcs) were po...

journal_title：Aging cell

authors： Xie S,Jin N,Gu J,Shi J,Sun J,Chu D,Zhang L,Dai CL,Gu JH,Gong CX,Iqbal K,Liu F

更新日期：2016-06-01 00:00:00

abstract：:Although it is known that the expression and activity of sirtuin 1 (Sirt1) decrease in the aged kidney, the role of interaction between Sirt1 and hypoxia-inducible factor (HIF)-1α is largely unknown. In this study, we investigated whether HIF-1α could be a deacetylation target of Sirt1 and the effect of their interact...

journal_title：Aging cell

authors： Ryu DR,Yu MR,Kong KH,Kim H,Kwon SH,Jeon JS,Han DC,Noh H

更新日期：2019-04-01 00:00:00

abstract：:A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early-onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. H...

journal_title：Aging cell

authors： Yousefzadeh MJ,Schafer MJ,Noren Hooten N,Atkinson EJ,Evans MK,Baker DJ,Quarles EK,Robbins PD,Ladiges WC,LeBrasseur NK,Niedernhofer LJ

更新日期：2018-04-01 00:00:00

abstract：:Fibrosis is a hallmark of aging tissues which often leads to altered architecture and function. The ovary is the first organ to show overt signs of aging, including increased fibrosis in the ovarian stroma. How this fibrosis affects ovarian biomechanics and the underlying mechanisms are unknown. Using instrumental ind...

journal_title：Aging cell

authors： Amargant F,Manuel SL,Tu Q,Parkes WS,Rivas F,Zhou LT,Rowley JE,Villanueva CE,Hornick JE,Shekhawat GS,Wei JJ,Pavone ME,Hall AR,Pritchard MT,Duncan FE

更新日期：2020-11-01 00:00:00

abstract：:The discovery of biomarkers able to predict biological age of individuals is a crucial goal in aging research. Recently, researchers' attention has turn toward epigenetic markers of aging. Using the Illumina Infinium HumanMethylation450 BeadChip on whole blood DNA from a small cohort of 64 subjects of different ages, ...

journal_title：Aging cell

authors： Garagnani P,Bacalini MG,Pirazzini C,Gori D,Giuliani C,Mari D,Di Blasio AM,Gentilini D,Vitale G,Collino S,Rezzi S,Castellani G,Capri M,Salvioli S,Franceschi C

更新日期：2012-12-01 00:00:00

abstract：:Mitochondrial dysfunction plays a key pathogenic role in aging skeletal muscle resulting in significant healthcare costs in the developed world. However, there is no pharmacologic treatment to rapidly reverse mitochondrial deficits in the elderly. Here, we demonstrate that a single treatment with the mitochondrial-tar...

journal_title：Aging cell

authors： Siegel MP,Kruse SE,Percival JM,Goh J,White CC,Hopkins HC,Kavanagh TJ,Szeto HH,Rabinovitch PS,Marcinek DJ

更新日期：2013-10-01 00:00:00

abstract：:The COVID-19 coronavirus is now spreading worldwide. Its pathogen, SARS-CoV-2, has been shown to use angiotensin-converting enzyme 2 (ACE2) as its host cell receptor, same as the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003. Epidemiology studies found males although only slightly more likely to be ...

journal_title：Aging cell

authors： Chen J,Jiang Q,Xia X,Liu K,Yu Z,Tao W,Gong W,Han JJ

更新日期：2020-07-01 00:00:00

abstract：:Chromatin structure affects the accessibility of DNA to transcription, repair, and replication. Changes in chromatin structure occur during development, but less is known about changes during aging. We examined the state of chromatin structure and its effect on gene expression during aging in Drosophila at the whole g...

journal_title：Aging cell

authors： Wood JG,Hillenmeyer S,Lawrence C,Chang C,Hosier S,Lightfoot W,Mukherjee E,Jiang N,Schorl C,Brodsky AS,Neretti N,Helfand SL

更新日期：2010-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is a terminal age-associated dementia characterized by early synaptic dysfunction and late neurodegeneration. Although the presence of plaques of fibrillar aggregates of the amyloid beta peptide (Abeta) is a signature of AD, evidence suggests that the preplaque small oligomeric Abeta promotes ...

journal_title：Aging cell

authors： Reese LC,Zhang W,Dineley KT,Kayed R,Taglialatela G

更新日期：2008-12-01 00:00:00

abstract：:Inhibition of mammalian target of rapamycin, mTOR, extends lifespan and reduces age-related disease. It is not known what role mTOR plays in the arterial aging phenotype or if mTOR inhibition by dietary rapamycin ameliorates age-related arterial dysfunction. To explore this, young (3.8 ± 0.6 months) and old (30.3 ± 0....

journal_title：Aging cell

authors： Lesniewski LA,Seals DR,Walker AE,Henson GD,Blimline MW,Trott DW,Bosshardt GC,LaRocca TJ,Lawson BR,Zigler MC,Donato AJ

更新日期：2017-02-01 00:00:00

abstract：:A partial reduction in food intake has been found to increase lifespan in many different organisms. We report here a new dietary restriction regimen in the nematode Caenorhabditis elegans, based on the standard agar plate lifespan assay, in which adult worms are maintained in the absence of a bacterial food source. Th...

journal_title：Aging cell

authors： Kaeberlein TL,Smith ED,Tsuchiya M,Welton KL,Thomas JH,Fields S,Kennedy BK,Kaeberlein M

更新日期：2006-12-01 00:00:00

abstract：:Pairing two animals in parabiosis to test for systemic or circulatory factors from one animal affecting the other animal has been used in scientific studies for at least 150 years. These studies have led to advances in fields as diverse as endocrinology, immunology, and oncology. A variation on the technique, heteroch...

journal_title：Aging cell

authors： Conboy MJ,Conboy IM,Rando TA

更新日期：2013-06-01 00:00:00

abstract：:Aging causes cardiac dysfunction, often leading to heart failure and death. The molecular basis of age-associated changes in cardiac structure and function is largely unknown. The fruit fly, Drosophila melanogaster, is well-suited to investigate the genetics of cardiac aging. Flies age rapidly over the course of weeks...

journal_title：Aging cell

authors： Cannon L,Zambon AC,Cammarato A,Zhang Z,Vogler G,Munoz M,Taylor E,Cartry J,Bernstein SI,Melov S,Bodmer R

更新日期：2017-02-01 00:00:00

abstract：:Mitochondrial dysfunction is often observed in aging skeletal muscle and is implicated in age-related declines in physical function. Early evidence suggests that dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) improve mitochondrial function. Here, we show that 10 weeks of dietary eicosapentaenoic acid (EPA) su...

journal_title：Aging cell

authors： Johnson ML,Lalia AZ,Dasari S,Pallauf M,Fitch M,Hellerstein MK,Lanza IR

更新日期：2015-10-01 00:00:00

abstract：:The goal of this study is to test the role of mitochondria and of mitochondrial metabolism in determining the processes that influence aging of female and male Drosophila. We observe that Drosophila simulans females tended to have shorter lifespan, higher levels of hydrogen peroxide production and significantly lower ...

journal_title：Aging cell

authors： Ballard JW,Melvin RG,Miller JT,Katewa SD

更新日期：2007-10-01 00:00:00

abstract：:The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide...

journal_title：Aging cell

authors： Teumer A,Qi Q,Nethander M,Aschard H,Bandinelli S,Beekman M,Berndt SI,Bidlingmaier M,Broer L,CHARGE Longevity Working Group.,Cappola A,Ceda GP,Chanock S,Chen MH,Chen TC,Chen YD,Chung J,Del Greco Miglianico F,Eriksson J

更新日期：2016-10-01 00:00:00

abstract：:Upon oxidative challenge the genome accumulates adducts and breaks that activate the DNA damage response to repair, arrest, or eliminate the damaged cell. Thus, reactive oxygen species (ROS) generated by endogenous oxygen metabolism are thought to affect mutation frequency. However, few studies determined the mutation...

journal_title：Aging cell

authors： Beltrami E,Ruggiero A,Busuttil R,Migliaccio E,Pelicci PG,Vijg J,Giorgio M

更新日期：2013-04-01 00:00:00

abstract：:The frequently quoted figure for the fractional univalent reduction of oxygen to superoxide in mitochondria is certainly too high by at least one order of magnitude. This is so because the higher number (2%) was derived from mitochondria whose cytochrome c oxidase was blocked with cyanide. Nevertheless, even the more ...

journal_title：Aging cell

authors： Fridovich I

更新日期：2004-02-01 00:00:00

abstract：:We previously reported that the canonical innate immune receptor toll-like receptor 4 (TLR4) is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 mediates its effect remained unclear. In the present study, we identified distinct contributions of lung endothelial cells (Ec) and ep...

journal_title：Aging cell

authors： Kim SJ,Shan P,Hwangbo C,Zhang Y,Min JN,Zhang X,Ardito T,Li A,Peng T,Sauler M,Lee PJ

更新日期：2019-06-01 00:00:00

abstract：:Pre-lamin A and progerin have been implicated in normal aging, and the pathogenesis of age-related degenerative diseases is termed 'laminopathies'. Here, we show that mature lamin A has an essential role in cellular fitness and that oxidative damage to lamin A is involved in cellular senescence. Primary human dermal f...

journal_title：Aging cell

authors： Pekovic V,Gibbs-Seymour I,Markiewicz E,Alzoghaibi F,Benham AM,Edwards R,Wenhert M,von Zglinicki T,Hutchison CJ

更新日期：2011-12-01 00:00:00

abstract：:In a previous study, we reported that a deficiency in MnSOD activity (approximately 80% reduction) targeted to type IIB skeletal muscle fibers was sufficient to elevate oxidative stress and to reduce muscle function in young adult mice (TnIFastCreSod2(fl/fl) mice). In this study, we used TnIFastCreSod2(fl/fl) mice to ...

journal_title：Aging cell

authors： Lustgarten MS,Jang YC,Liu Y,Qi W,Qin Y,Dahia PL,Shi Y,Bhattacharya A,Muller FL,Shimizu T,Shirasawa T,Richardson A,Van Remmen H

更新日期：2011-06-01 00:00:00

abstract：:Little is known about the types and numbers of mutations that may accumulate in normal human cells with age. Such information would require obtaining enough DNA from a single cell to accurately carry out reliable analysis despite extensive amplification; and complete genomic coverage under these circumstances is diffi...

journal_title：Aging cell

authors： Hsieh JC,Van Den Berg D,Kang H,Hsieh CL,Lieber MR

更新日期：2013-04-01 00:00:00

abstract：:The cerebral amyloid-β accumulation that begins in middle age is considered the critical triggering event in the pathogenesis of late-onset Alzheimer's disease (LOAD). However, the molecular mechanism remains elusive. The Shugoshin 1 (Sgo1-/+ ) mouse model, a model for mitotic cohesinopathy-genomic instability that is...

journal_title：Aging cell

authors： Rao CV,Farooqui M,Madhavaram A,Zhang Y,Asch AS,Yamada HY

更新日期：2020-10-01 00:00:00

abstract：:SARS-CoV-2 is a novel betacoronavirus which infects the lower respiratory tract and can cause coronavirus disease 2019 (COVID-19), a complex respiratory distress syndrome. Epidemiological data show that COVID-19 has a rising mortality particularly in individuals with advanced age. Identifying a functional association ...

journal_title：Aging cell

authors： Nehme J,Borghesan M,Mackedenski S,Bird TG,Demaria M

更新日期：2020-10-01 00:00:00

abstract：:Downregulation of insulin-like growth factor (IGF) pathways prolongs lifespan in various species, including mammals. Still, the cellular mechanisms by which IGF signaling controls the aging trajectory of individual organs are largely unknown. Here, we asked whether suppression of IGF-I receptor (IGF-1R) in adult stem ...

journal_title：Aging cell

authors： Chaker Z,Aïd S,Berry H,Holzenberger M

更新日期：2015-10-01 00:00:00

abstract：:Age-related bone loss in mice results from a decrease in bone formation and an increase in cortical bone resorption. The former is accounted by a decrease in the number of postmitotic osteoblasts which synthesize the bone matrix and is thought to be the consequence of age-dependent changes in mesenchymal osteoblast pr...

journal_title：Aging cell

authors： Kim HN,Chang J,Shao L,Han L,Iyer S,Manolagas SC,O'Brien CA,Jilka RL,Zhou D,Almeida M

更新日期：2017-08-01 00:00:00

abstract：:Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with the effects of cal...

journal_title：Aging cell

authors： García-Matas S,Paul RK,Molina-Martínez P,Palacios H,Gutierrez VM,Corpas R,Pallas M,Cristòfol R,de Cabo R,Sanfeliu C

更新日期：2015-06-01 00:00:00

abstract：:Sarcopenia, loss of skeletal muscle mass, is a hallmark of aging commonly attributed to a decreased capacity to maintain muscle tissue in senescence, yet the mechanism behind the muscle wasting remains unresolved. To address these issues we have explored a rodent model of sarcopenia and age-related sensorimotor impair...

journal_title：Aging cell

authors： Edström E,Ulfhake B

更新日期：2005-04-01 00:00:00

abstract：:Although dietary restriction (DR) is known to extend lifespan across species, from yeast to mammals, the signalling events downstream of food/nutrient perception are not well understood. In Caenorhabditis elegans, DR is typically attained either by using the eat-2 mutants that have reduced pharyngeal pumping leading t...

journal_title：Aging cell

authors： Chamoli M,Singh A,Malik Y,Mukhopadhyay A

更新日期：2014-08-01 00:00:00

abstract：:Modest dietary restriction extends lifespan (LS) in a diverse range of taxa and typically has a larger effect in females than males. Traditionally, this has been attributed to a stronger trade-off between LS and reproduction in females than in males that is mediated by the intake of calories. Recent studies, however, ...

journal_title：Aging cell

authors： Jensen K,McClure C,Priest NK,Hunt J

更新日期：2015-08-01 00:00:00