Abstract:
:A partial reduction in food intake has been found to increase lifespan in many different organisms. We report here a new dietary restriction regimen in the nematode Caenorhabditis elegans, based on the standard agar plate lifespan assay, in which adult worms are maintained in the absence of a bacterial food source. These findings represent the first report in any organism of lifespan extension in response to prolonged starvation. Removal of bacterial food increases lifespan to a greater extent than partial reduction of food through a mechanism that is distinct from insulin/IGF-like signaling and the Sir2-family deacetylase, SIR-2.1. Removal of bacterial food also increases lifespan when initiated in postreproductive adults, suggesting that dietary restriction started during middle age can result in a substantial longevity benefit that is independent of reproduction.
journal_name
Aging Celljournal_title
Aging cellauthors
Kaeberlein TL,Smith ED,Tsuchiya M,Welton KL,Thomas JH,Fields S,Kennedy BK,Kaeberlein Mdoi
10.1111/j.1474-9726.2006.00238.xsubject
Has Abstractpub_date
2006-12-01 00:00:00pages
487-94issue
6eissn
1474-9718issn
1474-9726pii
ACE238journal_volume
5pub_type
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