Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans.

abstract：:During aging, decreases in energy expenditure and locomotor activity lead to body weight and fat gain. Aging is also associated with decreases in muscle strength and endurance leading to functional decline. Here, we show that lifelong deletion of ghrelin prevents development of obesity associated with aging by modulat...

journal_title：Aging cell

authors： Guillory B,Chen JA,Patel S,Luo J,Splenser A,Mody A,Ding M,Baghaie S,Anderson B,Iankova B,Halder T,Hernandez Y,Garcia JM

更新日期：2017-08-01 00:00:00

abstract：:Fibrosis is a hallmark of aging tissues which often leads to altered architecture and function. The ovary is the first organ to show overt signs of aging, including increased fibrosis in the ovarian stroma. How this fibrosis affects ovarian biomechanics and the underlying mechanisms are unknown. Using instrumental ind...

journal_title：Aging cell

authors： Amargant F,Manuel SL,Tu Q,Parkes WS,Rivas F,Zhou LT,Rowley JE,Villanueva CE,Hornick JE,Shekhawat GS,Wei JJ,Pavone ME,Hall AR,Pritchard MT,Duncan FE

更新日期：2020-11-01 00:00:00

abstract：:Age-related increase in L-type Ca(2+) channel (LTCC) expression in hippocampal pyramidal neurons has been hypothesized to underlie the increased Ca(2+) influx and subsequent reduced intrinsic neuronal excitability of these neurons that lead to age-related cognitive deficits. Here, using specific antibodies against Cav...

journal_title：Aging cell

authors： Núñez-Santana FL,Oh MM,Antion MD,Lee A,Hell JW,Disterhoft JF

更新日期：2014-02-01 00:00:00

abstract：:Upon oxidative challenge the genome accumulates adducts and breaks that activate the DNA damage response to repair, arrest, or eliminate the damaged cell. Thus, reactive oxygen species (ROS) generated by endogenous oxygen metabolism are thought to affect mutation frequency. However, few studies determined the mutation...

journal_title：Aging cell

authors： Beltrami E,Ruggiero A,Busuttil R,Migliaccio E,Pelicci PG,Vijg J,Giorgio M

更新日期：2013-04-01 00:00:00

abstract：:In this, the fourth installment of our annual Hot Topics review on mRNA translation and aging, we have decided to expand our scope to include recent findings related to the role of TOR signaling in aging. As new data emerge, it is clear that TOR signaling acts upstream of mRNA translation, as well as a variety of othe...

journal_title：Aging cell

authors： Kaeberlein M,Kennedy BK

更新日期：2011-04-01 00:00:00

abstract：:Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies metabolic disease susceptibility and age-dependent metabolic changes, but the mechanism is unknown. Here, we profile lamina-associated domains (LADs) using lamin B1 ChIP-Seq in young and old hepatocytes and find that, alt...

journal_title：Aging cell

authors： Whitton H,Singh LN,Patrick MA,Price AJ,Osorio FG,López-Otín C,Bochkis IM

更新日期：2018-06-01 00:00:00

abstract：:Older adults universally suffer from sarcopenia and approximately 60-70% are diabetic or prediabetic. Nonetheless, the mechanisms underlying these aging-related metabolic disorders are unknown. NFκB has been implicated in the pathogenesis of several aging-related pathologies including sarcopenia and type 2 diabetes an...

journal_title：Aging cell

authors： Zhang N,Valentine JM,Zhou Y,Li ME,Zhang Y,Bhattacharya A,Walsh ME,Fischer KE,Austad SN,Osmulski P,Gaczynska M,Shoelson SE,Van Remmen H,Chen HI,Chen Y,Liang H,Musi N

更新日期：2017-08-01 00:00:00

abstract：:Aging impairs arterial function through oxidative stress and diminished nitric oxide (NO) bioavailability. Life-long caloric restriction (CR) reduces oxidative stress, but its impact on arterial aging is incompletely understood. We tested the hypothesis that life-long CR attenuates key features of arterial aging. Bloo...

journal_title：Aging cell

authors： Donato AJ,Walker AE,Magerko KA,Bramwell RC,Black AD,Henson GD,Lawson BR,Lesniewski LA,Seals DR

更新日期：2013-10-01 00:00:00

abstract：:The population of brain pericytes, a cell type important for vessel stability and blood brain barrier function, has recently been shown altered in patients with Alzheimer's disease (AD). The underlying reason for this alteration is not fully understood, but progressive accumulation of the AD characteristic peptide amy...

journal_title：Aging cell

authors： Schultz N,Brännström K,Byman E,Moussaud S,Nielsen HM,Netherlands Brain Bank.,Olofsson A,Wennström M

更新日期：2018-06-01 00:00:00

abstract：:The aim of this study was to investigate changes in astrocyte density, morphology, proliferation and apoptosis occurring in the central nervous system during physiological aging. Astrocytes in retinal whole-mount preparations from Wistar rats aged 3 (young adult) to 25 months (aged) were investigated qualitatively and...

journal_title：Aging cell

authors： Mansour H,Chamberlain CG,Weible MW 2nd,Hughes S,Chu Y,Chan-Ling T

更新日期：2008-08-01 00:00:00

abstract：:Calorie restriction (CR) without malnutrition slows aging in animal models. Oxidative stress reduction was proposed to mediate CR effects. CR effect on urinary F2-isoprostanes, validated oxidative stress markers, was assessed in CALERIE, a two-year randomized controlled trial. Healthy volunteers (n = 218) were randomi...

journal_title：Aging cell

authors： Il'yasova D,Fontana L,Bhapkar M,Pieper CF,Spasojevic I,Redman LM,Das SK,Huffman KM,Kraus WE,CALERIE Study Investigators.

更新日期：2018-04-01 00:00:00

abstract：:Aging involves coordinated yet distinct changes in organs and systems throughout life, including changes in essential trace elements. However, how aging affects tissue element composition (ionome) and how these changes lead to dysfunction and disease remain unclear. Here, we quantified changes in the ionome across eig...

journal_title：Aging cell

authors： Zhang B,Podolskiy DI,Mariotti M,Seravalli J,Gladyshev VN

更新日期：2020-05-01 00:00:00

abstract：:The G protein-coupled receptor (GPCR) encoding family of genes constitutes more than 6% of genes in Caenorhabditis elegans genome. GPCRs control behavior, innate immunity, chemotaxis, and food search behavior. Here, we show that C. elegans longevity is regulated by a chemosensory GPCR STR-2, expressed in AWC and ASI a...

journal_title：Aging cell

authors： Dixit A,Sandhu A,Modi S,Shashikanth M,Koushika SP,Watts JL,Singh V

更新日期：2020-06-01 00:00:00

abstract：:Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non-neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO+/- ) or homozygous (PerIR...

journal_title：Aging cell

authors： Merry TL,Kuhlow D,Laube B,Pöhlmann D,Pfeiffer AFH,Kahn CR,Ristow M,Zarse K

更新日期：2017-08-01 00:00:00

abstract：:Dietary restriction is arguably the most promising nonpharmacological intervention to extend human life and health span. Yet, only few genetic regulators mediating the cellular response to dietary restriction are known, and the question remains which other regulatory factors are involved. Here, we measured at the geno...

journal_title：Aging cell

authors： Campos SE,Avelar-Rivas JA,Garay E,Juárez-Reyes A,DeLuna A

更新日期：2018-06-01 00:00:00

abstract：:Impairments of dendritic trees and spines have been found in many neurodegenerative diseases, including Alzheimer's disease (AD), in which the deficits of melatonin signal pathway were reported. Melatonin receptor 2 (MT2) is widely expressed in the hippocampus and mediates the biological functions of melatonin. It is ...

journal_title：Aging cell

authors： Tang H,Ma M,Wu Y,Deng MF,Hu F,Almansoub HAMM,Huang HZ,Wang DQ,Zhou LT,Wei N,Man H,Lu Y,Liu D,Zhu LQ

更新日期：2019-04-01 00:00:00

abstract：:Translation of RNA to protein is essential for life. It should perhaps not be surprising, therefore, that appropriate regulation of translation plays a key role in determining longevity. This Hot Topic article discusses papers published in the last year related to the importance of translation and its regulation by si...

journal_title：Aging cell

authors： Kaeberlein M,Kennedy BK

更新日期：2007-12-01 00:00:00

abstract：:Moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance of healthy cognitive function. In advanced age, increased oxidative stress and cerebromicrovascular endothelial dysfunction impair neurovascular coupling, likely contributing to age-related decline ...

journal_title：Aging cell

authors： Tarantini S,Valcarcel-Ares NM,Yabluchanskiy A,Fulop GA,Hertelendy P,Gautam T,Farkas E,Perz A,Rabinovitch PS,Sonntag WE,Csiszar A,Ungvari Z

更新日期：2018-04-01 00:00:00

abstract：:The discovery of treatments to prevent or delay dementia and Alzheimer's disease is a priority. The gene APOE is associated with cognitive change and late-onset Alzheimer's disease, and epidemiological studies have provided strong evidence that the e2 allele of APOE has a neuroprotective effect, it is associated with ...

journal_title：Aging cell

authors： Sebastiani P,Monti S,Morris M,Gurinovich A,Toshiko T,Andersen SL,Sweigart B,Ferrucci L,Jennings LL,Glass DJ,Perls TT

更新日期：2019-12-01 00:00:00

abstract：:Aging is associated with a progressive loss of tissue and metabolic homeostasis. This loss can be delayed by single-gene perturbations, increasing lifespan. How such perturbations affect metabolic and proteostatic networks to extend lifespan remains unclear. Here, we address this question by comprehensively characteri...

journal_title：Aging cell

authors： Wang L,Davis SS,Borch Jensen M,Rodriguez-Fernandez IA,Apaydin C,Juhasz G,Gibson BW,Schilling B,Ramanathan A,Ghaemmaghami S,Jasper H

更新日期：2019-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized clinically by memory loss and cognitive decline. Protein kinase A (PKA)-CREB signaling plays a critical role in learning and memory. It is known that glucose uptake and O-GlcNAcylation are reduced in AD brain. In this study, we found that PKA catalytic subunits (PKAcs) were po...

journal_title：Aging cell

authors： Xie S,Jin N,Gu J,Shi J,Sun J,Chu D,Zhang L,Dai CL,Gu JH,Gong CX,Iqbal K,Liu F

更新日期：2016-06-01 00:00:00

abstract：:Age-related bone loss in mice results from a decrease in bone formation and an increase in cortical bone resorption. The former is accounted by a decrease in the number of postmitotic osteoblasts which synthesize the bone matrix and is thought to be the consequence of age-dependent changes in mesenchymal osteoblast pr...

journal_title：Aging cell

authors： Kim HN,Chang J,Shao L,Han L,Iyer S,Manolagas SC,O'Brien CA,Jilka RL,Zhou D,Almeida M

更新日期：2017-08-01 00:00:00

abstract：:Cellular senescence is a cellular program that prevents the proliferation of cells at risk of neoplastic transformation. On the other hand, age-related accumulation of senescent cells promotes aging at least partially due to the senescence-associated secretory phenotype, whereby cells secrete high levels of inflammato...

journal_title：Aging cell

authors： Takasugi M

更新日期：2018-04-01 00:00:00

abstract：:Downregulation of insulin-like growth factor (IGF) pathways prolongs lifespan in various species, including mammals. Still, the cellular mechanisms by which IGF signaling controls the aging trajectory of individual organs are largely unknown. Here, we asked whether suppression of IGF-I receptor (IGF-1R) in adult stem ...

journal_title：Aging cell

authors： Chaker Z,Aïd S,Berry H,Holzenberger M

更新日期：2015-10-01 00:00:00

abstract：:With reduced thymic activity, the population of naïve T cells in humans is maintained by homeostatic proliferation throughout adult life. In young adults, naïve CD4 T cells have enormous proliferative potential and plasticity to differentiate into different lineages. Here, we explored whether naïve CD4 T-cell aging is...

journal_title：Aging cell

authors： Hu B,Li G,Ye Z,Gustafson CE,Tian L,Weyand CM,Goronzy JJ

更新日期：2019-08-01 00:00:00

abstract：:Although it is known that the expression and activity of sirtuin 1 (Sirt1) decrease in the aged kidney, the role of interaction between Sirt1 and hypoxia-inducible factor (HIF)-1α is largely unknown. In this study, we investigated whether HIF-1α could be a deacetylation target of Sirt1 and the effect of their interact...

journal_title：Aging cell

authors： Ryu DR,Yu MR,Kong KH,Kim H,Kwon SH,Jeon JS,Han DC,Noh H

更新日期：2019-04-01 00:00:00

abstract：:Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression of several age-related neurodegenerative disorders. However, the mechanisms linking proteasome dysfunction to cell degeneration are poorly understood. We examined in young and aged rat hippocampu...

journal_title：Aging cell

authors： Gavilán MP,Pintado C,Gavilán E,Jiménez S,Ríos RM,Vitorica J,Castaño A,Ruano D

更新日期：2009-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) play important signaling roles in metazoans, but also cause significant molecular damage. Animals tightly control ROS levels using sophisticated defense mechanisms, yet the transcriptional pathways that induce ROS defense remain incompletely understood. In the nematode Caenorhabditis eleg...

journal_title：Aging cell

authors： Goh GY,Martelli KL,Parhar KS,Kwong AW,Wong MA,Mah A,Hou NS,Taubert S

更新日期：2014-02-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is the most common type of HF in older adults. Although no pharmacological therapy has yet improved survival in HFpEF, exercise training (ExT) has emerged as the most effective intervention to improving functional outcomes in this age-related disease. The molecula...

journal_title：Aging cell

authors： Roh JD,Houstis N,Yu A,Chang B,Yeri A,Li H,Hobson R,Lerchenmüller C,Vujic A,Chaudhari V,Damilano F,Platt C,Zlotoff D,Lee RT,Shah R,Jerosch-Herold M,Rosenzweig A

更新日期：2020-06-01 00:00:00

abstract：:The ING family of tumor suppressor proteins affects cell growth, apoptosis and response to DNA damage by modulating chromatin structure through association with different HAT and HDAC complexes. The major splicing isoforms of the ING1 locus are ING1a and INGlb. While INGlb plays a role in inducing apoptosis, the funct...

journal_title：Aging cell

authors： Soliman MA,Berardi P,Pastyryeva S,Bonnefin P,Feng X,Colina A,Young D,Riabowol K

更新日期：2008-12-01 00:00:00