Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health.

abstract：:Mitochondrial dysfunction plays a key pathogenic role in aging skeletal muscle resulting in significant healthcare costs in the developed world. However, there is no pharmacologic treatment to rapidly reverse mitochondrial deficits in the elderly. Here, we demonstrate that a single treatment with the mitochondrial-tar...

journal_title：Aging cell

authors： Siegel MP,Kruse SE,Percival JM,Goh J,White CC,Hopkins HC,Kavanagh TJ,Szeto HH,Rabinovitch PS,Marcinek DJ

更新日期：2013-10-01 00:00:00

abstract：:Accumulation of DNA damage may play an essential role in both cellular senescence and organismal aging. The ability of cells to sense and repair DNA damage declines with age. However, the underlying molecular mechanism for this age-dependent decline is still elusive. To understand quantitative and qualitative changes ...

journal_title：Aging cell

authors： Sedelnikova OA,Horikawa I,Redon C,Nakamura A,Zimonjic DB,Popescu NC,Bonner WM

更新日期：2008-01-01 00:00:00

abstract：:Age-related thymic involution is characterized by reduction in T cell production together with ectopic adipocyte development within the hematopoietic and thymic niches. Peroxisome proliferator-activated receptor gamma (PPARgamma) is required for adipocyte development, glucose homeostasis and is a target for several in...

journal_title：Aging cell

authors： Youm YH,Yang H,Amin R,Smith SR,Leff T,Dixit VD

更新日期：2010-08-01 00:00:00

abstract：:Older adults often show signs of impaired CD8+ T-cell immunity, reflected by weaker responses against new infections and vaccinations, and decreased protection against reinfection. This immune impairment is in part thought to be the consequence of a decrease in both T-cell numbers and repertoire diversity. If this is ...

journal_title：Aging cell

authors： Lanfermeijer J,Borghans JAM,van Baarle D

更新日期：2020-11-01 00:00:00

abstract：:Genetically identical organisms in homogeneous environments have different lifespans and healthspans. These differences are often attributed to stochastic events, such as mutations and 'epimutations', changes in DNA methylation and chromatin that change gene function and expression. But work in the last 10 years has r...

journal_title：Aging cell

authors： Mendenhall A,Driscoll M,Brent R

更新日期：2016-02-01 00:00:00

abstract：:Methionine restriction (MetR) extends lifespan across different species and exerts beneficial effects on metabolic health and inflammatory responses. In contrast, certain cancer cells exhibit methionine auxotrophy that can be exploited for therapeutic treatment, as decreasing dietary methionine selectively suppresses ...

journal_title：Aging cell

authors： Parkhitko AA,Jouandin P,Mohr SE,Perrimon N

更新日期：2019-12-01 00:00:00

abstract：:Disturbances of neuronal Ca2+ homeostasis are considered to be important determinants of age-related cognitive impairment. Cholinergic neurons of the basal forebrain (BF) are principal targets of decline associated with aging and dementia. During the last several years, we have attempted to link these concepts in a ra...

journal_title：Aging cell

authors： Murchison D,Griffith WH

更新日期：2007-06-01 00:00:00

abstract：:We used DNA microarrays to identify panels of transcriptional markers of aging that are differentially expressed in young (5 month) and old (25 month) mice of multiple inbred strains (129sv, BALB/c, CBA, DBA, B6, C3H and B6C3F(1)). In the heart, age-related changes of five genes were studied throughout the mouse lifes...

journal_title：Aging cell

authors： Park SK,Kim K,Page GP,Allison DB,Weindruch R,Prolla TA

更新日期：2009-08-01 00:00:00

abstract：:Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies metabolic disease susceptibility and age-dependent metabolic changes, but the mechanism is unknown. Here, we profile lamina-associated domains (LADs) using lamin B1 ChIP-Seq in young and old hepatocytes and find that, alt...

journal_title：Aging cell

authors： Whitton H,Singh LN,Patrick MA,Price AJ,Osorio FG,López-Otín C,Bochkis IM

更新日期：2018-06-01 00:00:00

abstract：:Protein synthesis is a regulated cellular process that links nutrients in the environment to organismal growth and development. Here we examine the role of genes that regulate mRNA translation in determining growth, reproduction, stress resistance and lifespan. Translational control of protein synthesis by regulators ...

journal_title：Aging cell

authors： Pan KZ,Palter JE,Rogers AN,Olsen A,Chen D,Lithgow GJ,Kapahi P

更新日期：2007-02-01 00:00:00

abstract：:Irregular menstrual cycles, reduced responses to exogenous hormonal treatments, and altered endocrine profiles (high FSH/high LH/low AMH) are observed in women with increasing age before menopause. In this study, because the granulosa cell-specific Nrg1 knockout mice (gcNrg1KO) presented ovarian and endocrine phenotyp...

journal_title：Aging cell

authors： Umehara T,Kawai T,Kawashima I,Tanaka K,Okuda S,Kitasaka H,Richards JS,Shimada M

更新日期：2017-12-01 00:00:00

abstract：:We previously reported that the canonical innate immune receptor toll-like receptor 4 (TLR4) is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 mediates its effect remained unclear. In the present study, we identified distinct contributions of lung endothelial cells (Ec) and ep...

journal_title：Aging cell

authors： Kim SJ,Shan P,Hwangbo C,Zhang Y,Min JN,Zhang X,Ardito T,Li A,Peng T,Sauler M,Lee PJ

更新日期：2019-06-01 00:00:00

abstract：:FOXO transcription factors (FOXOs) are central regulators of lifespan across species, yet they also have cell-specific functions, including adult stem cell homeostasis and immune function. Direct targets of FOXOs have been identified genome-wide in several species and cell types. However, whether FOXO targets are spec...

journal_title：Aging cell

authors： Webb AE,Kundaje A,Brunet A

更新日期：2016-08-01 00:00:00

abstract：:Replicative cellular senescence is an important tumor suppression mechanism and also contributes to aging. Progression of both cancer and aging include significant epigenetic components, but the chromatin changes that take place during cellular senescence are not known. We used formaldehyde assisted isolation of regul...

journal_title：Aging cell

authors： De Cecco M,Criscione SW,Peckham EJ,Hillenmeyer S,Hamm EA,Manivannan J,Peterson AL,Kreiling JA,Neretti N,Sedivy JM

更新日期：2013-04-01 00:00:00

abstract：:Intron retention (IR) is the least well-understood alternative splicing type in animals, and its prevalence and function in physiological and pathological processes have long been underestimated. Cellular senescence contributes to individual aging and age-related diseases and can also serve as an important cancer prev...

journal_title：Aging cell

authors： Yao J,Ding D,Li X,Shen T,Fu H,Zhong H,Wei G,Ni T

更新日期：2020-12-01 00:00:00

abstract：:Chromatin structure affects the accessibility of DNA to transcription, repair, and replication. Changes in chromatin structure occur during development, but less is known about changes during aging. We examined the state of chromatin structure and its effect on gene expression during aging in Drosophila at the whole g...

journal_title：Aging cell

authors： Wood JG,Hillenmeyer S,Lawrence C,Chang C,Hosier S,Lightfoot W,Mukherjee E,Jiang N,Schorl C,Brodsky AS,Neretti N,Helfand SL

更新日期：2010-12-01 00:00:00

abstract：:Little is known about how diet and energy metabolism interact in determination of lifespan under ad libitum feeding. From 12 weeks of age until death, male and female wild-type (WT) and transgenic (TG) mice with increased skeletal muscle mitochondrial uncoupling (HSA-mUCP1 mice) were fed one of three different semisyn...

journal_title：Aging cell

authors： Keipert S,Voigt A,Klaus S

更新日期：2011-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting both the hippocampus and the cerebral cortex. Reduced synaptic density that occurs early in the disease process seems to be partially due to the overactivation of N-methyl-d-aspartate receptors (NMDARs) leading to excitotoxicity. Recently, ...

journal_title：Aging cell

authors： Costa RO,Lacor PN,Ferreira IL,Resende R,Auberson YP,Klein WL,Oliveira CR,Rego AC,Pereira CM

更新日期：2012-10-01 00:00:00

abstract：:Dietary restriction (DR) extends lifespan in multiple species from various taxa. This effect can arise via two distinct but not mutually exclusive ways: a change in aging rate and/or vulnerability to the aging process (i.e. initial mortality rate). When DR affects vulnerability, this lowers mortality instantly, wherea...

journal_title：Aging cell

authors： Simons MJ,Koch W,Verhulst S

更新日期：2013-06-01 00:00:00

abstract：:Nutrient availability influences an organism's life history with profound effects on metabolism and lifespan. The association between a healthy lifespan and metabolism is incompletely understood, but a central factor is glucose metabolism. Although glucose is an important cellular energy source, glucose restriction is...

journal_title：Aging cell

authors： Tauffenberger A,Vaccaro A,Aulas A,Vande Velde C,Parker JA

更新日期：2012-10-01 00:00:00

abstract：:With aging, the kidney develops a progressive deterioration of several structures and functions. Proximal tubular acidification is impaired in old rats with a decrease in the activity of brush border Na+/H+ exchange and a fall of H-ion flux measured with micropuncture experiments. In the present work we evaluate the c...

journal_title：Aging cell

authors： Fiori M,Radrizzani M,Díaz-Sylvester P,Müller A,Corti T,Monserrat A,Amorena C

更新日期：2006-10-01 00:00:00

abstract：:Diabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on cognition. New findings have shown that the microtubule-associated protein tau is pathologically processe...

journal_title：Aging cell

authors： Trujillo-Estrada L,Nguyen C,da Cunha C,Cai L,Forner S,Martini AC,Ager RR,Prieto GA,Cotman CW,Baglietto-Vargas D,LaFerla FM

更新日期：2019-06-01 00:00:00

abstract：:Endothelial oxidative stress develops with aging and reactive oxygen species impair endothelium-dependent relaxation (EDR) by decreasing nitric oxide (NO) availability. Endothelial KCa 3.1, which contributes to EDR, is upregulated by H2 O2 . We investigated whether KCa 3.1 upregulation compensates for diminished EDR t...

journal_title：Aging cell

authors： Choi S,Kim JA,Li HY,Shin KO,Oh GT,Lee YM,Oh S,Pewzner-Jung Y,Futerman AH,Suh SH

更新日期：2016-10-01 00:00:00

abstract：:Short telomeres are thought to trigger senescence, most likely through a single - or a group of few - critically shortened telomeres. Such short telomeres are thought to result from a combination of gradual linear shortening resulting from the end replication problem, reflecting the division history of the cell, super...

journal_title：Aging cell

authors： Bendix L,Horn PB,Jensen UB,Rubelj I,Kolvraa S

更新日期：2010-06-01 00:00:00

abstract：:The progressively increasing frailty, morbidity and mortality of aging organisms coincides with, and may be causally related to, their waning ability to adapt to environmental perturbations. Transcriptional responses to challenges, such as oxidative stress or pathogens, diminish with age. This effect is manifest in th...

journal_title：Aging cell

authors： Cheng Y,Pitoniak A,Wang J,Bohmann D

更新日期：2021-01-20 00:00:00

abstract：:Upon oxidative challenge the genome accumulates adducts and breaks that activate the DNA damage response to repair, arrest, or eliminate the damaged cell. Thus, reactive oxygen species (ROS) generated by endogenous oxygen metabolism are thought to affect mutation frequency. However, few studies determined the mutation...

journal_title：Aging cell

authors： Beltrami E,Ruggiero A,Busuttil R,Migliaccio E,Pelicci PG,Vijg J,Giorgio M

更新日期：2013-04-01 00:00:00

abstract：:The insulin/insulin growth factor (IGF)-like signaling (IIS) pathway has a conserved role in regulating lifespan in Caenorhabditis elegans, Drosophila and mice. Extension of lifespan by reduced IIS has been shown in C. elegans to require the key IIS target, forkhead box class O (FOXO) transcription factor, DAF-16. dFO...

journal_title：Aging cell

authors： Giannakou ME,Goss M,Jacobson J,Vinti G,Leevers SJ,Partridge L

更新日期：2007-08-01 00:00:00

abstract：:Caloric restriction (CR) can delay onset of several age-related pathophysiologies and extend lifespan in various species, including rodents. CR also induces metabolic remodeling involved in activation of lipid metabolism, enhancement of mitochondrial biogenesis, and reduction of oxidative stress in white adipose tissu...

journal_title：Aging cell

authors： Fujii N,Narita T,Okita N,Kobayashi M,Furuta Y,Chujo Y,Sakai M,Yamada A,Takeda K,Konishi T,Sudo Y,Shimokawa I,Higami Y

更新日期：2017-06-01 00:00:00

abstract：:The COVID-19 coronavirus is now spreading worldwide. Its pathogen, SARS-CoV-2, has been shown to use angiotensin-converting enzyme 2 (ACE2) as its host cell receptor, same as the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003. Epidemiology studies found males although only slightly more likely to be ...

journal_title：Aging cell

authors： Chen J,Jiang Q,Xia X,Liu K,Yu Z,Tao W,Gong W,Han JJ

更新日期：2020-07-01 00:00:00

abstract：:The cell cycle and its regulators are validated targets for cancer drugs. Reagents that target cells in a specific cell cycle phase (e.g., antimitotics or DNA synthesis inhibitors/replication stress inducers) have demonstrated success as broad-spectrum anticancer drugs. Cyclin-dependent kinases (CDKs) are drivers of c...

journal_title：Aging cell

authors： Rao CV,Asch AS,Carr DJJ,Yamada HY

更新日期：2020-03-01 00:00:00