Dietary restriction of rodents decreases aging rate without affecting initial mortality rate -- a meta-analysis.

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting both the hippocampus and the cerebral cortex. Reduced synaptic density that occurs early in the disease process seems to be partially due to the overactivation of N-methyl-d-aspartate receptors (NMDARs) leading to excitotoxicity. Recently, ...

journal_title：Aging cell

authors： Costa RO,Lacor PN,Ferreira IL,Resende R,Auberson YP,Klein WL,Oliveira CR,Rego AC,Pereira CM

更新日期：2012-10-01 00:00:00

abstract：:The COVID-19 coronavirus is now spreading worldwide. Its pathogen, SARS-CoV-2, has been shown to use angiotensin-converting enzyme 2 (ACE2) as its host cell receptor, same as the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003. Epidemiology studies found males although only slightly more likely to be ...

journal_title：Aging cell

authors： Chen J,Jiang Q,Xia X,Liu K,Yu Z,Tao W,Gong W,Han JJ

更新日期：2020-07-01 00:00:00

abstract：:Growth hormone receptor knockout (GHRKO) mice are remarkably long-lived and have improved glucose homeostasis along with altered energy metabolism which manifests through decreased respiratory quotient (RQ) and increased oxygen consumption (VO2 ). Short-term exposure of these animals to increased environmental tempera...

journal_title：Aging cell

authors： Fang Y,McFadden S,Darcy J,Hascup ER,Hascup KN,Bartke A

更新日期：2020-05-01 00:00:00

abstract：:Protein synthesis is a regulated cellular process that links nutrients in the environment to organismal growth and development. Here we examine the role of genes that regulate mRNA translation in determining growth, reproduction, stress resistance and lifespan. Translational control of protein synthesis by regulators ...

journal_title：Aging cell

authors： Pan KZ,Palter JE,Rogers AN,Olsen A,Chen D,Lithgow GJ,Kapahi P

更新日期：2007-02-01 00:00:00

abstract：:A partial reduction in food intake has been found to increase lifespan in many different organisms. We report here a new dietary restriction regimen in the nematode Caenorhabditis elegans, based on the standard agar plate lifespan assay, in which adult worms are maintained in the absence of a bacterial food source. Th...

journal_title：Aging cell

authors： Kaeberlein TL,Smith ED,Tsuchiya M,Welton KL,Thomas JH,Fields S,Kennedy BK,Kaeberlein M

更新日期：2006-12-01 00:00:00

abstract：:In many tissues, mammalian aging is associated with a decline in the replicative and functional capacity of somatic stem cells and other self-renewing compartments. Understanding the basis of this decline is a major goal of aging research. In particular, therapeutic approaches to ameliorate or reverse the age-associat...

journal_title：Aging cell

authors： Sharpless NE

更新日期：2010-08-01 00:00:00

abstract：:Brain mitochondrial function has been posited to decline with aging. In order to test this hypothesis, cortical and striatal mitochondria were isolated from Fischer 344 rats at 2, 5, 11, 24 and 33 months of age. Mitochondrial membrane potential remained stable through 24 months, declining slightly in mitochondria from...

journal_title：Aging cell

authors： LaFrance R,Brustovetsky N,Sherburne C,Delong D,Dubinsky JM

更新日期：2005-06-01 00:00:00

abstract：:The impact of cellular senescence onto aging of organisms is not fully clear, not at least because of the scarcity of reliable data on the mere frequency of senescent cells in aging tissues. Activation of a DNA damage response including formation of DNA damage foci containing activated H2A.X (gamma-H2A.X) at either un...

journal_title：Aging cell

authors： Wang C,Jurk D,Maddick M,Nelson G,Martin-Ruiz C,von Zglinicki T

更新日期：2009-06-01 00:00:00

abstract：:This annual review focuses on invertebrate model organisms, which shed light on new mechanisms in aging and provide excellent systems for both genome-wide and in-depth analysis. This year, protein interaction networks have been used in a new bioinformatic approach to identify novel genes that extend replicative lifesp...

journal_title：Aging cell

authors： Partridge L

更新日期：2009-09-01 00:00:00

abstract：:The general control nonderepressible 2 (GCN2) kinase is a nutrient-sensing pathway that responds to amino acids deficiency and induces a genetic program to effectively maintain cellular homeostasis. Here we established the conserved role of Caenorhabditis elegans GCN-2 under amino acid limitation as a translation init...

journal_title：Aging cell

authors： Rousakis A,Vlassis A,Vlanti A,Patera S,Thireos G,Syntichaki P

更新日期：2013-10-01 00:00:00

abstract：:Skin hair follicles (HF) contain bulge stem cells (SC) that regenerate HFs during hair cycles, and repair skin epithelia following injury. As natural aging is associated with decreased skin repair capacity in humans, we have investigated the impact of age on human scalp HF bulge cell number and function. Here, we isol...

journal_title：Aging cell

authors： Rittié L,Stoll SW,Kang S,Voorhees JJ,Fisher GJ

更新日期：2009-12-01 00:00:00

abstract：:The frequently quoted figure for the fractional univalent reduction of oxygen to superoxide in mitochondria is certainly too high by at least one order of magnitude. This is so because the higher number (2%) was derived from mitochondria whose cytochrome c oxidase was blocked with cyanide. Nevertheless, even the more ...

journal_title：Aging cell

authors： Fridovich I

更新日期：2004-02-01 00:00:00

abstract：:Maternal age-related decline in oocyte quality is associated with meiotic defects, but the underlying mechanisms remain to be explored. Histone deacetylase 3 (HDAC3) has been shown to govern multiple cellular events via deacetylating diverse substrates. We previously found that HDAC3 could promote meiotic apparatus as...

journal_title：Aging cell

authors： He Y,Li X,Gao M,Liu H,Gu L

更新日期：2019-12-01 00:00:00

abstract：:Deficits in learning and memory accompanied by age-related neurodegenerative diseases are closely related to the impairment of synaptic plasticity. In this study, we investigated the role of thiol redox status in the modulation of the N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) in CA1 ...

journal_title：Aging cell

authors： Yang YJ,Wu PF,Long LH,Yu DF,Wu WN,Hu ZL,Fu H,Xie N,Jin Y,Ni L,Wang JZ,Wang F,Chen JG

更新日期：2010-10-01 00:00:00

abstract：:The aim of this study was to investigate changes in astrocyte density, morphology, proliferation and apoptosis occurring in the central nervous system during physiological aging. Astrocytes in retinal whole-mount preparations from Wistar rats aged 3 (young adult) to 25 months (aged) were investigated qualitatively and...

journal_title：Aging cell

authors： Mansour H,Chamberlain CG,Weible MW 2nd,Hughes S,Chu Y,Chan-Ling T

更新日期：2008-08-01 00:00:00

abstract：:Impaired osteoblast function is involved in osteoporosis, and microRNA (miRNA) dysregulation may cause abnormal osteoblast osteogenic activity. However, the influence of miRNA on osteoblast activity and the underlying mechanisms remain elusive. In this study, miR-103-3p was found to be negatively correlated with bone ...

journal_title：Aging cell

authors： Sun Z,Wang H,Wang Y,Yuan G,Yu X,Jiang H,Wu Q,Yang B,Hu Z,Shi F,Cao X,Zhang S,Guo T,Zhao J

更新日期：2021-01-13 00:00:00

abstract：:Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression of several age-related neurodegenerative disorders. However, the mechanisms linking proteasome dysfunction to cell degeneration are poorly understood. We examined in young and aged rat hippocampu...

journal_title：Aging cell

authors： Gavilán MP,Pintado C,Gavilán E,Jiménez S,Ríos RM,Vitorica J,Castaño A,Ruano D

更新日期：2009-12-01 00:00:00

abstract：:Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is variable, and this may be due to muscle inflammation susceptibility. Metformin reduces inflammation, so we hypothesized that metformin would ...

journal_title：Aging cell

authors： Walton RG,Dungan CM,Long DE,Tuggle SC,Kosmac K,Peck BD,Bush HM,Villasante Tezanos AG,McGwin G,Windham ST,Ovalle F,Bamman MM,Kern PA,Peterson CA

更新日期：2019-12-01 00:00:00

abstract：:The discovery of treatments to prevent or delay dementia and Alzheimer's disease is a priority. The gene APOE is associated with cognitive change and late-onset Alzheimer's disease, and epidemiological studies have provided strong evidence that the e2 allele of APOE has a neuroprotective effect, it is associated with ...

journal_title：Aging cell

authors： Sebastiani P,Monti S,Morris M,Gurinovich A,Toshiko T,Andersen SL,Sweigart B,Ferrucci L,Jennings LL,Glass DJ,Perls TT

更新日期：2019-12-01 00:00:00

abstract：:Endothelial oxidative stress develops with aging and reactive oxygen species impair endothelium-dependent relaxation (EDR) by decreasing nitric oxide (NO) availability. Endothelial KCa 3.1, which contributes to EDR, is upregulated by H2 O2 . We investigated whether KCa 3.1 upregulation compensates for diminished EDR t...

journal_title：Aging cell

authors： Choi S,Kim JA,Li HY,Shin KO,Oh GT,Lee YM,Oh S,Pewzner-Jung Y,Futerman AH,Suh SH

更新日期：2016-10-01 00:00:00

abstract：:Age-related thymic involution is characterized by reduction in T cell production together with ectopic adipocyte development within the hematopoietic and thymic niches. Peroxisome proliferator-activated receptor gamma (PPARgamma) is required for adipocyte development, glucose homeostasis and is a target for several in...

journal_title：Aging cell

authors： Youm YH,Yang H,Amin R,Smith SR,Leff T,Dixit VD

更新日期：2010-08-01 00:00:00

abstract：:Irregular menstrual cycles, reduced responses to exogenous hormonal treatments, and altered endocrine profiles (high FSH/high LH/low AMH) are observed in women with increasing age before menopause. In this study, because the granulosa cell-specific Nrg1 knockout mice (gcNrg1KO) presented ovarian and endocrine phenotyp...

journal_title：Aging cell

authors： Umehara T,Kawai T,Kawashima I,Tanaka K,Okuda S,Kitasaka H,Richards JS,Shimada M

更新日期：2017-12-01 00:00:00

abstract：:The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age-related chronic diseases. Here, we describe the rationale for identification and validation of a new class of d...

journal_title：Aging cell

authors： Zhu Y,Tchkonia T,Pirtskhalava T,Gower AC,Ding H,Giorgadze N,Palmer AK,Ikeno Y,Hubbard GB,Lenburg M,O'Hara SP,LaRusso NF,Miller JD,Roos CM,Verzosa GC,LeBrasseur NK,Wren JD,Farr JN,Khosla S,Stout MB,McGowan SJ,Fuh

更新日期：2015-08-01 00:00:00

abstract：:In this work we report that carnitines, in particular acetyl-l-carnitine (ALC), are able to prolong the chronological aging of yeast cells during the stationary phase. Lifespan extension is significantly reduced in yca1 mutants as well in rho(0) strains, suggesting that the protective effects pass through the Yca1 cas...

journal_title：Aging cell

authors： Palermo V,Falcone C,Calvani M,Mazzoni C

更新日期：2010-08-01 00:00:00

abstract：:Aging is associated with a large number of both phenotypic and molecular changes, but for most of these, it is not known whether these changes are detrimental, neutral, or protective. We have identified a conserved Caenorhabditis elegans GATA transcription factor/MTA-1 homolog egr-1 (lin-40) that extends lifespan and ...

journal_title：Aging cell

authors： Zimmerman SM,Kim SK

更新日期：2014-04-01 00:00:00

abstract：:The decrease in skeletal muscle mitochondrial oxidative capacity with age adversely affects muscle strength and physical performance. Factors that are associated with this decrease have not been well characterized. Low plasma lysophosphatidylcholines (LPC), a major class of systemic bioactive lipids, are predictive of...

journal_title：Aging cell

authors： Semba RD,Zhang P,Adelnia F,Sun K,Gonzalez-Freire M,Salem N Jr,Brennan N,Spencer RG,Fishbein K,Khadeer M,Shardell M,Moaddel R,Ferrucci L

更新日期：2019-04-01 00:00:00

abstract：:Little is known about how diet and energy metabolism interact in determination of lifespan under ad libitum feeding. From 12 weeks of age until death, male and female wild-type (WT) and transgenic (TG) mice with increased skeletal muscle mitochondrial uncoupling (HSA-mUCP1 mice) were fed one of three different semisyn...

journal_title：Aging cell

authors： Keipert S,Voigt A,Klaus S

更新日期：2011-02-01 00:00:00

abstract：:Little is known about the types and numbers of mutations that may accumulate in normal human cells with age. Such information would require obtaining enough DNA from a single cell to accurately carry out reliable analysis despite extensive amplification; and complete genomic coverage under these circumstances is diffi...

journal_title：Aging cell

authors： Hsieh JC,Van Den Berg D,Kang H,Hsieh CL,Lieber MR

更新日期：2013-04-01 00:00:00

abstract：:Caloric restriction (CR) can delay onset of several age-related pathophysiologies and extend lifespan in various species, including rodents. CR also induces metabolic remodeling involved in activation of lipid metabolism, enhancement of mitochondrial biogenesis, and reduction of oxidative stress in white adipose tissu...

journal_title：Aging cell

authors： Fujii N,Narita T,Okita N,Kobayashi M,Furuta Y,Chujo Y,Sakai M,Yamada A,Takeda K,Konishi T,Sudo Y,Shimokawa I,Higami Y

更新日期：2017-06-01 00:00:00

abstract：:Genetically identical organisms in homogeneous environments have different lifespans and healthspans. These differences are often attributed to stochastic events, such as mutations and 'epimutations', changes in DNA methylation and chromatin that change gene function and expression. But work in the last 10 years has r...

journal_title：Aging cell

authors： Mendenhall A,Driscoll M,Brent R

更新日期：2016-02-01 00:00:00