Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin.

abstract：:Astrocytes participate in numerous aspects of central nervous system (CNS) physiology ranging from ion balance to metabolism, and disruption of their physiological roles can therefore be a contributor to CNS dysfunction and pathology. Cellular senescence, one of the mechanisms of aging, has been proposed as a central ...

journal_title：Aging cell

authors： Cohen J,Torres C

更新日期：2019-06-01 00:00:00

abstract：:Lactic-acid bacteria are widely recognized beneficial host associated groups of the microbiota of humans and animals. Some lactic-acid bacteria have the ability to extend the lifespan of the model animals. The mechanisms behind the probiotic effects of bacteria are not entirely understood. Recently, we reported the be...

journal_title：Aging cell

authors： Nakagawa H,Shiozaki T,Kobatake E,Hosoya T,Moriya T,Sakai F,Taru H,Miyazaki T

更新日期：2016-04-01 00:00:00

abstract：:The IGF-1 signaling pathway plays an important role in regulating longevity. To identify the genetic loci and genes that regulate plasma IGF-1 levels, we intercrossed MRL/MpJ and SM/J, inbred mouse strains that differ in IGF-1 levels. Quantitative trait loci (QTL) analysis of IGF-1 levels of these F2 mice detected fou...

journal_title：Aging cell

authors： Leduc MS,Hageman RS,Meng Q,Verdugo RA,Tsaih SW,Churchill GA,Paigen B,Yuan R

更新日期：2010-10-01 00:00:00

abstract：:Most human tissues express low levels of telomerase and undergo telomere shortening and eventual senescence; the resulting limitation on tissue renewal can lead to a wide range of age-dependent pathophysiologies. Increasing evidence indicates that the decline in cell division capacity in cells that lack telomerase can...

journal_title：Aging cell

authors： Ballew BJ,Lundblad V

更新日期：2013-08-01 00:00:00

abstract：:Alogliptin is a commonly prescribed drug treating patients with type 2 diabetes. Here, we show that long-term intervention with alogliptin (0.03% w/w in diet) improves survival and health of mice on a high-fat diet. Alogliptin intervention takes beneficial effects associated with longevity, including increased insulin...

journal_title：Aging cell

authors： Zhu B,Li Y,Xiang L,Zhang J,Wang L,Guo B,Liang M,Chen L,Xiang L,Dong J,Liu M,Mei W,Li H,Xiang G

更新日期：2019-04-01 00:00:00

abstract：:Neurogenesis, which may contribute to the ability of the adult brain to function normally and adapt to disease, nevertheless declines with advancing age. Adult neurogenesis can be enhanced by administration of growth factors, but whether the aged brain remains responsive to these factors is unknown. We compared the ef...

journal_title：Aging cell

authors： Jin K,Sun Y,Xie L,Batteur S,Mao XO,Smelick C,Logvinova A,Greenberg DA

更新日期：2003-06-01 00:00:00

abstract：:Metformin and exercise independently improve insulin sensitivity and decrease the risk of diabetes. Metformin was also recently proposed as a potential therapy to slow aging. However, recent evidence indicates that adding metformin to exercise antagonizes the exercise-induced improvement in insulin sensitivity and car...

journal_title：Aging cell

authors： Konopka AR,Laurin JL,Schoenberg HM,Reid JJ,Castor WM,Wolff CA,Musci RV,Safairad OD,Linden MA,Biela LM,Bailey SM,Hamilton KL,Miller BF

更新日期：2019-02-01 00:00:00

abstract：:We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan. This enrichment is markedly higher than published genomewide longevity screens in...

journal_title：Aging cell

authors： Sutphin GL,Backer G,Sheehan S,Bean S,Corban C,Liu T,Peters MJ,van Meurs JBJ,Murabito JM,Johnson AD,Korstanje R,Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Gene Expression Working Group.

更新日期：2017-08-01 00:00:00

abstract：:Lifespan varies dramatically among species, but the biological basis is not well understood. Previous studies in model organisms revealed the importance of nutrient sensing, mTOR, NAD/sirtuins, and insulin/IGF1 signaling in lifespan control. By studying life-history traits and transcriptomes of 14 Drosophila species d...

journal_title：Aging cell

authors： Ma S,Avanesov AS,Porter E,Lee BC,Mariotti M,Zemskaya N,Guigo R,Moskalev AA,Gladyshev VN

更新日期：2018-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized clinically by memory loss and cognitive decline. Protein kinase A (PKA)-CREB signaling plays a critical role in learning and memory. It is known that glucose uptake and O-GlcNAcylation are reduced in AD brain. In this study, we found that PKA catalytic subunits (PKAcs) were po...

journal_title：Aging cell

authors： Xie S,Jin N,Gu J,Shi J,Sun J,Chu D,Zhang L,Dai CL,Gu JH,Gong CX,Iqbal K,Liu F

更新日期：2016-06-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is characterized by the formation of drusen, extracellular deposits associated with atrophy of the retinal pigmented epithelium (RPE), disturbance of the transepithelial barrier and photoreceptor death. Amyloid-beta (Abeta) is present in drusen but its role during AMD remains unk...

journal_title：Aging cell

authors： Bruban J,Glotin AL,Dinet V,Chalour N,Sennlaub F,Jonet L,An N,Faussat AM,Mascarelli F

更新日期：2009-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is a terminal age-associated dementia characterized by early synaptic dysfunction and late neurodegeneration. Although the presence of plaques of fibrillar aggregates of the amyloid beta peptide (Abeta) is a signature of AD, evidence suggests that the preplaque small oligomeric Abeta promotes ...

journal_title：Aging cell

authors： Reese LC,Zhang W,Dineley KT,Kayed R,Taglialatela G

更新日期：2008-12-01 00:00:00

abstract：:Aging is associated with increased vulnerability to inflammatory challenge. However, the effects of altered inflammatory response on the metabolic status of tissues or organs are not well documented. In this study, we present evidence demonstrating that lipopolysaccharide (LPS)-induced upregulation of the inflammasome...

journal_title：Aging cell

authors： Chung KW,Lee EK,Kim DH,An HJ,Kim ND,Im DS,Lee J,Yu BP,Chung HY

更新日期：2015-08-01 00:00:00

abstract：:Accumulation of DNA damage may play an essential role in both cellular senescence and organismal aging. The ability of cells to sense and repair DNA damage declines with age. However, the underlying molecular mechanism for this age-dependent decline is still elusive. To understand quantitative and qualitative changes ...

journal_title：Aging cell

authors： Sedelnikova OA,Horikawa I,Redon C,Nakamura A,Zimonjic DB,Popescu NC,Bonner WM

更新日期：2008-01-01 00:00:00

abstract：:The inhibitor of differentiation or DNA binding (Id) family of transcription regulators plays an important role in cell proliferation, differentiation, and senescence. However, regulation of Id expression during these processes is poorly understood. Id proteins are known to undergo rapid turnover mediated by the ubiqu...

journal_title：Aging cell

authors： Kong Y,Cui H,Zhang H

更新日期：2011-12-01 00:00:00

abstract：:In many tissues, mammalian aging is associated with a decline in the replicative and functional capacity of somatic stem cells and other self-renewing compartments. Understanding the basis of this decline is a major goal of aging research. In particular, therapeutic approaches to ameliorate or reverse the age-associat...

journal_title：Aging cell

authors： Sharpless NE

更新日期：2010-08-01 00:00:00

abstract：:The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approac...

journal_title：Aging cell

authors： van den Akker EB,Passtoors WM,Jansen R,van Zwet EW,Goeman JJ,Hulsman M,Emilsson V,Perola M,Willemsen G,Penninx BW,Heijmans BT,Maier AB,Boomsma DI,Kok JN,Slagboom PE,Reinders MJ,Beekman M

更新日期：2014-04-01 00:00:00

abstract：:Little is known about the types and numbers of mutations that may accumulate in normal human cells with age. Such information would require obtaining enough DNA from a single cell to accurately carry out reliable analysis despite extensive amplification; and complete genomic coverage under these circumstances is diffi...

journal_title：Aging cell

authors： Hsieh JC,Van Den Berg D,Kang H,Hsieh CL,Lieber MR

更新日期：2013-04-01 00:00:00

abstract：:Type 2 diabetes (T2D) is associated with increased risk of Alzheimer's disease (AD). There is evidence for impaired blood-brain barrier (BBB) in both diseases, but its role in the interplay between them is not clear. Here, we investigated the effects of high-fat diet (HFD), a model for T2D, on the Tg2576 mouse model o...

journal_title：Aging cell

authors： Elhaik Goldman S,Goez D,Last D,Naor S,Liraz Zaltsman S,Sharvit-Ginon I,Atrakchi-Baranes D,Shemesh C,Twitto-Greenberg R,Tsach S,Lotan R,Leikin-Frenkel A,Shish A,Mardor Y,Schnaider Beeri M,Cooper I

更新日期：2018-10-01 00:00:00

abstract：:mTOR signalling is implicated in the development of disease and in lifespan extension in model organisms. This pathway has been associated with human diseases such as diabetes and cancer, but has not been investigated for its impact on longevity per se. Here, we investigated whether transcriptional variation within th...

journal_title：Aging cell

authors： Passtoors WM,Beekman M,Deelen J,van der Breggen R,Maier AB,Guigas B,Derhovanessian E,van Heemst D,de Craen AJ,Gunn DA,Pawelec G,Slagboom PE

更新日期：2013-02-01 00:00:00

abstract：:This annual review focuses on invertebrate model organisms, which shed light on new mechanisms in aging and provide excellent systems for both genome-wide and in-depth analysis. This year, protein interaction networks have been used in a new bioinformatic approach to identify novel genes that extend replicative lifesp...

journal_title：Aging cell

authors： Partridge L

更新日期：2009-09-01 00:00:00

abstract：:Werner syndrome (WS) is an autosomal recessive disorder, the hallmarks of which are premature aging and early onset of neoplastic diseases (Orren, 2006; Bohr, 2008). The gene, whose mutation underlies the WS phenotype, is called WRN. The protein encoded by the WRN gene, WRNp, has DNA helicase activity (Gray et al., 19...

journal_title：Aging cell

authors： Smith JA,Ndoye AM,Geary K,Lisanti MP,Igoucheva O,Daniel R

更新日期：2010-08-01 00:00:00

abstract：:The population of brain pericytes, a cell type important for vessel stability and blood brain barrier function, has recently been shown altered in patients with Alzheimer's disease (AD). The underlying reason for this alteration is not fully understood, but progressive accumulation of the AD characteristic peptide amy...

journal_title：Aging cell

authors： Schultz N,Brännström K,Byman E,Moussaud S,Nielsen HM,Netherlands Brain Bank.,Olofsson A,Wennström M

更新日期：2018-06-01 00:00:00

abstract：:Disturbances of neuronal Ca2+ homeostasis are considered to be important determinants of age-related cognitive impairment. Cholinergic neurons of the basal forebrain (BF) are principal targets of decline associated with aging and dementia. During the last several years, we have attempted to link these concepts in a ra...

journal_title：Aging cell

authors： Murchison D,Griffith WH

更新日期：2007-06-01 00:00:00

abstract：:Reactive oxygen species (ROS) play important signaling roles in metazoans, but also cause significant molecular damage. Animals tightly control ROS levels using sophisticated defense mechanisms, yet the transcriptional pathways that induce ROS defense remain incompletely understood. In the nematode Caenorhabditis eleg...

journal_title：Aging cell

authors： Goh GY,Martelli KL,Parhar KS,Kwong AW,Wong MA,Mah A,Hou NS,Taubert S

更新日期：2014-02-01 00:00:00

abstract：:The accumulation of mitochondrial DNA (mtDNA) mutations has been proposed as an underlying cause of the aging process. Such mutations are thought to be generated principally through mechanisms involving oxidative stress. Skin is frequently exposed to a potent mutagen in the form of ultraviolet (UV) radiation and mtDNA...

journal_title：Aging cell

authors： Birket MJ,Birch-Machin MA

更新日期：2007-08-01 00:00:00

abstract：:Exposure to sub-lethal levels of stress, or hormesis, was a means to induce longevity. By screening for mutations that enhance resistance to multiple stresses, we identified multiple alleles of alpha-1,2-mannosidase I (mas1) which, in addition to promoting stress resistance, also extended longevity. Longevity enhancem...

journal_title：Aging cell

authors： Liu YL,Lu WC,Brummel TJ,Yuh CH,Lin PT,Kao TY,Li FY,Liao PC,Benzer S,Wang HD

更新日期：2009-08-01 00:00:00

abstract：:Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair-deficient mice dramatically extended healthspan and trippled life span. Here, we show that rapamycin, while significantly lowering mTOR signaling, failed to improve lif...

journal_title：Aging cell

authors： Birkisdóttir MB,Jaarsma D,Brandt RMC,Barnhoorn S,van Vliet N,Imholz S,van Oostrom CT,Nagarajah B,Portilla Fernández E,Roks AJM,Elgersma Y,van Steeg H,Ferreira JA,Pennings JLA,Hoeijmakers JHJ,Vermeij WP,Dollé MET

更新日期：2021-01-23 00:00:00

abstract：:The hypoxia-inducible factor HIF-1 has recently been identified as an important modifier of longevity in the roundworm Caenorhabditis elegans. Studies have reported that HIF-1 can function as both a positive and negative regulator of life span, and several disparate models have been proposed for the role of HIF in agi...

journal_title：Aging cell

authors： Leiser SF,Begun A,Kaeberlein M

更新日期：2011-04-01 00:00:00

abstract：:Dietary restriction (DR) extends lifespan in multiple species from various taxa. This effect can arise via two distinct but not mutually exclusive ways: a change in aging rate and/or vulnerability to the aging process (i.e. initial mortality rate). When DR affects vulnerability, this lowers mortality instantly, wherea...

journal_title：Aging cell

authors： Simons MJ,Koch W,Verhulst S

更新日期：2013-06-01 00:00:00